Weihui Lu
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View article: Clinical features and laboratory findings of Kawasaki disease with aseptic meningitis: a retrospective case–control study
Clinical features and laboratory findings of Kawasaki disease with aseptic meningitis: a retrospective case–control study Open
Background Kawasaki disease (KD) is an acute systemic vasculitis that primarily affects children; aseptic meningitis is the most common neurological complication of KD. This study aims to describe the clinical features, treatment, and prog…
View article: Immunoregulation by ESAT-6: From Pathogenesis of Tuberculosis to Potential Anti-Inflammatory and Anti-Rejection Application
Immunoregulation by ESAT-6: From Pathogenesis of Tuberculosis to Potential Anti-Inflammatory and Anti-Rejection Application Open
The early secreted antigenic target of 6 kDa (ESAT-6), a main effector molecule of the ESX-1 secretion system, is identified as a virulence determinant and immunoregulatory protein of Mycobacterium tuberculosis (Mtb), affecting the interac…
View article: Cardiopulmonary and hemodynamic responses to Baduanjin exercise and cycle ergometer exercise among chronic heart failure patients: a comparison
Cardiopulmonary and hemodynamic responses to Baduanjin exercise and cycle ergometer exercise among chronic heart failure patients: a comparison Open
Objective Baduanjin is a traditional Chinese exercise and serves as an alternative to conventional cardiac rehabilitation in China. In this study, we compare the cardiopulmonary and hemodynamic responses of Baduanjin to those of cycle ergo…
View article: Dusp15 Dephosphorylates mtHsp70 at Thr116 to Prevent Its Proteasomal Degradation and Maintain Mitochondrial Unfolded Protein Response in Diabetic Cardiomyopathy
Dusp15 Dephosphorylates mtHsp70 at Thr116 to Prevent Its Proteasomal Degradation and Maintain Mitochondrial Unfolded Protein Response in Diabetic Cardiomyopathy Open
Diabetic cardiomyopathy (DCM) is driven by mitochondrial dysfunction and impaired proteostasis. This study investigates Dusp15’s role in regulating the mitochondrial unfolded protein response (mito-UPR) via its interaction with mtHsp70 and…
View article: Qu-shi-hua-tan decoction's efficacy and safety for patients with angina following coronary revascularization: a randomized, double-blind, placebo-controlled trial study protocol
Qu-shi-hua-tan decoction's efficacy and safety for patients with angina following coronary revascularization: a randomized, double-blind, placebo-controlled trial study protocol Open
Introduction The Qu-shi-hua-tan decoction (QSHTD), formulated by academician Chen Keji, is an empirical decoction for coronary heart disease (CHD). We conducted a randomized controlled trial to assess the effectiveness and safety of QSHTD …
View article: Case report: Diversity of imaging in cardiac angiosarcoma: two cases with disparate enhancement and metabolic manifestations
Case report: Diversity of imaging in cardiac angiosarcoma: two cases with disparate enhancement and metabolic manifestations Open
Cardiac angiosarcoma, a rare and aggressive malignancy arising from endothelial cells, is difficult to diagnose owing to its nonspecific clinical symptoms and variable imaging features. Two cases of cardiac angiosarcoma (CA) are presented,…
View article: Impact of statin use on short- and long-term outcomes in patients with sepsis-induced myocardial injury: insights from the MIMIC-IV database
Impact of statin use on short- and long-term outcomes in patients with sepsis-induced myocardial injury: insights from the MIMIC-IV database Open
Background Sepsis-induced myocardial injury (SIMI) is a critical complication of sepsis, marked by high mortality rates, and lacks effective treatments. The impact of statin therapy on mortality in SIMI patients remains unclear. This study…
View article: Elevated body roundness index increases the risk of cardiovascular disease in Chinese patients with circadian syndrome
Elevated body roundness index increases the risk of cardiovascular disease in Chinese patients with circadian syndrome Open
Objective The body roundness index (BRI) and circadian syndrome (CircS) are considered new risk factors for cardiovascular disease (CVD), yet it remains uncertain whether elevated BRI is associated with CVD incidence in CircS patients. In …
View article: Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise
Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise Open
Objective To explore the impact of type 2 diabetes mellitus (T2DM) on exercise tolerance and fat oxidation capacity in patients with heart failure (HF). Methods We retrospectively analyzed 108 Chinese patients with HF who were divided into…
View article: The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases
The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases Open
Scoparone (SCO), also known as 6,7-Dimethoxycoumarin, is a naturally occurring bioactive ingredient originally derived from Chinese herb Artemisiae Scopariae Herba (Yin-Chen-Hao). Previous studies have shown that it is effective in treatin…
View article: Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of Psoriasis
Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of Psoriasis Open
Psoriasis is a chronic, recurrent and inflammatory skin disease. Although conventional immunosuppressants can ameliorate psoriatic symptoms, it tends to relapse over time. Previous studies have shown that exosomes from both immune and non-…
View article: Bioactive Flavonoids From Tsaoko Fructus: Antioxidant Capacity and Protection on UV‐Damaged Cells and Stimulation to <i>Caenorhabditis elegans</i> Antioxidant System
Bioactive Flavonoids From Tsaoko Fructus: Antioxidant Capacity and Protection on UV‐Damaged Cells and Stimulation to <i>Caenorhabditis elegans</i> Antioxidant System Open
Tsaoko Fructus (TF), the dried ripe fruit of Amomum tsaoko Crevost et Lemarie (A. tsaoko) , a dietary medicine plant, has been demonstrated to have high antioxidant activity. The main objective of this research was to investigate the isola…
View article: Exposure to high-temperature and high-humidity environments associated with cardiovascular mortality
Exposure to high-temperature and high-humidity environments associated with cardiovascular mortality Open
Aging populations are susceptible to climate change due to physiological factors and comorbidities. Most relevant studies reported the effect of temperature on cardiovascular disease (CVD)-related mortality in aging populations. However, t…
View article: Phosphoglycerate mutase 1-mediated dephosphorylation and degradation of Dusp1 disrupt mitochondrial quality control and exacerbate endotoxemia-induced myocardial dysfunction
Phosphoglycerate mutase 1-mediated dephosphorylation and degradation of Dusp1 disrupt mitochondrial quality control and exacerbate endotoxemia-induced myocardial dysfunction Open
Rationale: Endotoxemia, caused by lipopolysaccharides, triggers systemic inflammation and myocardial injury by disrupting mitochondrial homeostasis. This study examines the roles of dual specificity phosphatase 1 (Dusp1) and phosphoglycera…
View article: Integrating Network Pharmacology and Experimental Validation to Investigate the Mechanism of Qushi Huatan Decoction Against Coronary Heart Disease
Integrating Network Pharmacology and Experimental Validation to Investigate the Mechanism of Qushi Huatan Decoction Against Coronary Heart Disease Open
Based on network pharmacology, molecular docking and experimental verification, this study demonstrated that QSHT could improve cardiac function and attenuate cardiac fibrosis by regulating TLR4/NF-κB and AKT/HIF-1α signaling pathway in po…
View article: Establishing a novel model to assess exercise capacity in chronic heart failure based on stress echocardiography
Establishing a novel model to assess exercise capacity in chronic heart failure based on stress echocardiography Open
Aims The aim of this study was to develop a simple, fast and efficient clinical diagnostic model, composed of exercise stress echocardiography (ESE) indicators, of the exercise capacity of patients with chronic heart failure (CHF) by compa…
View article: Huxin Formula Inhibits Oxidized low-Density Lipoprotein-Induced Foam Cell Formation in THP-1 Macrophages via the LOX-1/NF-κB Pathway
Huxin Formula Inhibits Oxidized low-Density Lipoprotein-Induced Foam Cell Formation in THP-1 Macrophages via the LOX-1/NF-κB Pathway Open
Background Macrophage-derived foam cells are essential in the progression of atherosclerosis (AS). Based on our previous study, the Huxin Formula (HXF), a traditional Chinese medicine formula, demonstrates potential in anti-atherosclerosis…
View article: The association between frailty and the risk of mortality in critically ill congestive heart failure patients: findings from the MIMIC-IV database
The association between frailty and the risk of mortality in critically ill congestive heart failure patients: findings from the MIMIC-IV database Open
Background Frailty is a severe, common co-morbidity associated with congestive heart failure (CHF). This retrospective cohort study assesses the association between frailty and the risk of mortality in critically ill CHF patients. Methods …
View article: Figure S7 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Figure S7 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells Open
Continuous treatment with HI-TOPK-032 increases the expression of effector molecules but reduces some of the exhaustion molecules in CAR-T cells in vitro.
View article: Figure S4 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Figure S4 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells Open
HI-TOPK-032 decreases the expression of LAG-3 and TIM-3 and frequencies of CCR7+PD-1+ subset in CD8+ CAR-T cells of mice bearing subcutaneous Huh7-HCC.
View article: Data from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Data from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells Open
Chimeric antigen receptor (CAR) T cells are emerging as an effective antitumoral therapy. However, their therapeutic effects on solid tumors are limited because of their short survival time and the immunosuppressive tumor microenvironment.…
View article: Figure S3 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Figure S3 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells Open
The gene or protein expression of GPC3-CAR.
View article: Figure S1 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Figure S1 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells Open
Gating strategy used for CD8+ CAR-T cells from the tumor-bearing mice
View article: Figure S4 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Figure S4 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells Open
HI-TOPK-032 decreases the expression of LAG-3 and TIM-3 and frequencies of CCR7+PD-1+ subset in CD8+ CAR-T cells of mice bearing subcutaneous Huh7-HCC.
View article: Figure S6 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Figure S6 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells Open
HI-TOPK-032 enhances the specific effector responses of CAR-T cells to GPC3.
View article: Figure S8 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Figure S8 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells Open
Activation of mTOR diminishes the effects of HI-TOPK-032 on GPC3-CAR-T therapy and reduces CD8+ TCM frequency in tumor-bearing mice.
View article: Figure S8 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Figure S8 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells Open
Activation of mTOR diminishes the effects of HI-TOPK-032 on GPC3-CAR-T therapy and reduces CD8+ TCM frequency in tumor-bearing mice.
View article: Figure S2 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Figure S2 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells Open
Gating strategy used for CD8+ CAR-T cells in vitro.
View article: Figure S3 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Figure S3 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells Open
The gene or protein expression of GPC3-CAR.
View article: Figure S6 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Figure S6 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells Open
HI-TOPK-032 enhances the specific effector responses of CAR-T cells to GPC3.