Weihui Qi
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View article: Chinese leek-derived extracellular vesicles ameliorate sarcopenia by regulating mitochondrial biogenesis and autophagy via AMPK and maintaining myosin homeostasis
Chinese leek-derived extracellular vesicles ameliorate sarcopenia by regulating mitochondrial biogenesis and autophagy via AMPK and maintaining myosin homeostasis Open
View article: Research progress on sarcopenia in the musculoskeletal system
Research progress on sarcopenia in the musculoskeletal system Open
View article: Mendelian Randomization and Drug Repurposing Analysis Identifies APOE as a Potential Therapeutic Target for Low Back Pain
Mendelian Randomization and Drug Repurposing Analysis Identifies APOE as a Potential Therapeutic Target for Low Back Pain Open
Background: Low back pain (LBP) is a prevalent chronic pain syndrome primarily driven by spinal degeneration, causing persistent disability and reduced quality of life. Despite available interventions, identifying novel therapeutic targets…
View article: A multifaceted strategy for intra- and extracellular nucleic acid regulation to alleviate intervertebral disc degeneration
A multifaceted strategy for intra- and extracellular nucleic acid regulation to alleviate intervertebral disc degeneration Open
Abnormal accumulation of both intracellular and extracellular free nucleic acids drives chronic inflammation in intervertebral disc degeneration (IVDD). Despite the development of numerous minimally invasive treatments for IVDD, systematic…
View article: Nanodrugs Targeting Key Factors of Ferroptosis Regulation for Enhanced Treatment of Osteoarthritis
Nanodrugs Targeting Key Factors of Ferroptosis Regulation for Enhanced Treatment of Osteoarthritis Open
Osteoarthritis (OA) is a globally prevalent degenerative joint disease. Recent studies highlight the role of ferroptosis in OA progression. Targeting ferroptosis regulation presents a promising therapeutic strategy for OA; however, current…
View article: Causal Relationship Between Circulating Metabolites and Sarcopenia‐Related Traits: A Mendelian Randomization and Experimental Study
Causal Relationship Between Circulating Metabolites and Sarcopenia‐Related Traits: A Mendelian Randomization and Experimental Study Open
Sarcopenia (SP), an age‐associated condition marked by muscle weakness and loss has been strongly connected with metabolic factors according to substantial evidence. Nevertheless, the causal correlation between SP and serum metabolites, an…
View article: Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis
Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis Open
View article: Advances in the study of plant-derived extracellular vesicles in the skeletal muscle system
Advances in the study of plant-derived extracellular vesicles in the skeletal muscle system Open
Plant-derived extracellular vesicles (PDEV) constitute nanoscale entities comprising lipids, proteins, nucleic acids and various components enveloped by the lipid bilayers of plant cells. These vesicles play a crucial role in facilitating …
View article: Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis
Investigating the causal relationship between thyroid dysfunction diseases and osteoporosis: a two-sample Mendelian randomization analysis Open
Background Thyroid dysfunction diseases (TDFDs) and osteoporosis (OP) have a high prevalence in the population. Previous studies have indicated a potential association between TDFDs and OP, yet the causal direction remains unclear. This st…
View article: Establishment and validation of nomogram models for overall survival and cancer-specific survival in spindle cell sarcoma patients
Establishment and validation of nomogram models for overall survival and cancer-specific survival in spindle cell sarcoma patients Open
Spindle cell sarcoma (SCS) is rare in clinical practice. The objective of this study was to establish nomograms to predict the OS and CSS prognosis of patients with SCS based on the Surveillance, Epidemiology, and End Results (SEER) databa…
View article: Candida parapsilosis-Caused Arthritis with Rice Body Formation: A Case Presentation and Literature Review
Candida parapsilosis-Caused Arthritis with Rice Body Formation: A Case Presentation and Literature Review Open
A 68-year-old male patient came to the orthopedics department because of swelling and pain in his left shoulder joint. He received more than 15 intraarticular steroid injections in the shoulder joint at a local private hospital. MRI showed…
View article: Lycopene inhibits IL‐1β‐induced inflammation in mouse chondrocytes and mediates murine osteoarthritis
Lycopene inhibits IL‐1β‐induced inflammation in mouse chondrocytes and mediates murine osteoarthritis Open
Osteoarthritis (OA) is a common chronic degenerative condition in the elderly, in which inflammation plays a key role in disease pathology. Lycopene (Lye), a member of the carotenoid family, has been reported to have anti‐inflammatory effe…
View article: Inhibiting TLR4 signaling by linarin for preventing inflammatory response in osteoarthritis
Inhibiting TLR4 signaling by linarin for preventing inflammatory response in osteoarthritis Open
Osteoarthritis (OA) is one of the most common degenerative diseases, ultimately leading to long-term joint pain and severe articular malformation. Controlling local chronic inflammation is a crucial strategy for delaying OA development. Li…
View article: Astilbin prevents osteoarthritis development through the TLR4/MD‐2 pathway
Astilbin prevents osteoarthritis development through the TLR4/MD‐2 pathway Open
Osteoarthritis has become one of the main diseases affecting the life of many elderly people with high incidence of disability, and local chronic inflammation in the joint cavity is the most crucial pathological feature of osteoarthritis. …
View article: Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation
Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation Open
Osteoarthritis (OA), which is characterized by proliferation of subchondral bone and the degeneration of articular cartilage, is the most prevalent human arthritis. Nod‐like receptor pyrin domain 3 (NLRP3) inflammasome is a hot spot in rec…
View article: The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head
The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head Open
Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a frequently occurring type of nontraumatic osteonecrosis. A failure of the timely treatment can eventually result in the collapse of the subchondral bone structure. Lute…
View article: A technique combining “U” shape suture and shared tunneling to treat the posterior cruciate ligament rupture and posterior root tears of the medial meniscus
A technique combining “U” shape suture and shared tunneling to treat the posterior cruciate ligament rupture and posterior root tears of the medial meniscus Open
With an ideal therapeutic effect, this technique is worthy to be promoted for patients with the PCL rupture and PRMM tears.