Explanipedia

Alpha-lipoic acid alleviates cognitive deficits in transgenic APP23/PS45 mice through a mitophagy-mediated increase in ADAM10 α-secretase cleavage of APP Open

Jie Zhang, Yanshuang Jiang, Xiangjun Dong, Zijun Meng, Liangye Ji , et al. · 2024

ICA1 affects APP processing through the PICK1‐PKCα signaling pathway Open

Liangye Ji, ZiJun Meng, Xiangjun Dong, Qunxian Wang, Yanshuang Jiang , et al. · 2024

Aims Islet cell autoantigen 1 (ICA1) is involved in autoimmune diseases and may affect synaptic plasticity as a neurotransmitter. Databases related to Alzheimer's disease (AD) have shown decreased ICA1 expression in patients with AD. Howev…

SIL1 improves cognitive impairment in APP23/PS45 mice by regulating amyloid precursor protein processing and Aβ generation Open

Qunxian Wang, Yanshuang Jiang, Zijun Meng, Xiangjun Dong, Dongjie Hu , et al. · 2024

SIL1, an endoplasmic reticulum (ER)-resident protein, is reported to play a protective role in Alzheimer's disease (AD). However, the effect of SIL1 on amyloid precursor protein (APP) processing remains unclear. In this study, the role of …

CSTB accelerates the progression of hepatocellular carcinoma via the ERK/AKT/mTOR signaling pathway Open

Weiyi Zhu, Xiangjun Dong, Na Tian, Zijuan Feng, Weihui Zhou , et al. · 2023

Hepatocellular carcinoma (HCC) is a significant contributor to global cancer-related deaths, leading to high mortality rates. However, the pathogenesis of HCC remains unclear. In this research, by the bioinformatics data analysis, we found…

Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like Behavior in Adult Male Mice Open

Zijun Meng, Shipeng Guo, Xiangjun Dong, Qunxian Wang, Dongjie Hu , et al. · 2023

Background: Astrocytes are essential for synaptic transmission, and their dysfunction can result in neuropsychiatric disorders such as anxiety and depression. Many studies have shown that global knockout of Melatonin receptor 2 (Mtnr1b) is…

Transcriptional activation of CSTB gene expression by transcription factor Sp3 Open

Weiyi Zhu, Xiangjun Dong, Shuyue Luo, Shipeng Guo, Weihui Zhou , et al. · 2023

CSTB has been reported to be associated with the pathogenesis of many malignant tumors, especially hepatocellular carcinoma (HCC). However, how the expression of this gene is regulated is largely unknown. We initially cloned and analyzed t…

Piston gas flow standard Facility Open

Lingshan Yang, Xin Liu, Yang Xiang, Meimei Jian, Weihui Zhou · 2023

Some gas flowmeters such as standard wet gas meter and critical flow Venturi nozzles are often used in the main standard of standard facility, and their accuracy is high, so its value transmission is particularly important.This paper intro…

Gallic acid inhibits neuroinflammation and reduces neonatal hypoxic-ischemic brain damages Open

Xiangjun Dong, Shuyue Luo, Dongjie Hu, Ruixue Cao, Qunxian Wang , et al. · 2022

Neuroinflammation is a leading cause of secondary neuronal injury in neonatal hypoxic-ischemic encephalopathy (HIE). Regulation of neuroinflammation may be beneficial for treatment of HIE and its secondary complications. Gallic acid (GA) h…

POS-082 RacGAP1 ameliorates acute kidney injury by promoting proliferation and suppressing apoptosis of renal tubular cells Open

Weihui Zhou, Z. Shuan, Xiaoqiang Ding · 2022

Acute kidney injury (AKI) remains correlated with high mortality. Novel therapeutic strategies are urgently needed for AKI patients. Rac GTPase-activating protein 1 (RacGAP1) regulates the activity of RhoGTPase and acts as a predictive bio…

The c.863A>G (p.Glu288Gly) variant of the CTSD gene is not associated with CLN10 disease Open

Juan Yang, Xiaoting Ding, Shasha Meng, Jinhua Cai, Weihui Zhou · 2021

Background Cathepsin D is a lysosomal aspartic protease encoded by the CTSD gene. It plays important roles in many biological processes. Biallelic loss‐of‐function mutation of CTSD is considered a cause of CLN10 disease. CLN10 is a rare au…

Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia Open

Dan Wang, Huan Yang, Yun Zhang, Rong Hu, Dongjie Hu , et al. · 2021

Increased endogenous hydrogen sulfide (H 2 S) level by cystathionine β-synthase (CBS) has been shown to closely relate tumorigenesis. H 2 S promotes angiogenesis, stimulates bioenergy metabolism and inhibits selective phosphatases. However…

Micromechanical Analysis of Detachment Mechanisms of Suffusion Open

Shaolin Mao, Antoine Wautier, Weihui Zhou · 2021

Suffusion is a typical phenomenon of seepage-induced internal erosion, corresponding to fine particles erosion from the coarse matrix under the action of a fluid. A three-dimensional and spatially resolved fluid-solid coupling method based…

Research on hybrid of ALOHA and multi-fork tree Anti-collision algorithm for RFID Open

Weihui Zhou, Niande Jiang · 2021

The work aims at the problem of multi-tag collision in RFID system, then analysis the binary tree algorithm and ALOHA and points out their shortcomings, we proposed a Hybrid of ALOHA and Tree (HAMT) Algorithm. The algorithm first uses the …

Translational Inhibition of α-Neurexin 2 Open

Xiaoting Ding, Shasha Meng, Jiahong Zhou, Juan Yang, Hongmei Li , et al. · 2020

Neurexins are extensively investigated presynaptic cell-adhesion molecules which play important roles in transmitting signals and processing information at synapses that connect neurons into a vast network of cellular communications. Synap…

A novel de novo nonsense mutation in ZC4H2 causes Wieacker‐Wolff Syndrome Open

Dan Wang, Dongjie Hu, Zhichao Guo, Rong Hu, Qunxian Wang , et al. · 2019

Background Wieacker‐Wolff syndrome (WWS) is a congenital X‐linked neuromuscular disorder, which was firstly reported in 1985. Zinc finger C4H2‐type containing ( ZC4H2 ) gene has been found to be associated with the disease pathogenesis. Ho…

Transcriptional activation of USP16 gene expression by NFκB signaling Open

Shou Yang, Juelu Wang, Shipeng Guo, Daochao Huang, Isabel Bestard‐Lorigados , et al. · 2019

MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation Open

Binglin Zhu, Yan Long, Wei Luo, Zhen Yan, Yujie Lai , et al. · 2018

MMP13 (matrix metallopeptidase 13) plays a key role in bone metabolism and cancer development, but has no known functions in Alzheimer’s disease. In this study, we used high-throughput small molecule screening in SH-SY5Y cells that stably …

Ketamine Modulates Zic5 Expression via the Notch Signaling Pathway in Neural Crest Induction Open

Yu Shi, Jiejing Li, Chunjiang Chen, Yongwu Xia, Yanxi Li , et al. · 2018

Ketamine is a potent dissociative anesthetic and the most commonly used illicit drug. Many addicts are women at childbearing age. Although ketamine has been extensively studied as a clinical anesthetic, its effects on embryonic development…

Regulation of global gene expression and cell proliferation by APP Open

Yili Wu, Si Zhang, Qin Xu, Haiyan Zou, Weihui Zhou , et al. · 2016

Microarray data analysis reveals differentially expressed genes in prolactinoma Open

Weihui Zhou, Chi Ma, Ziqian Yan · 2015

prolactinoma, differentially expressed genes, protein-protein interaction network, protein complex.

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