Song Wu
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View article: Neuroprotective properties of extra virgin olive oil polyphenols in Alzheimer’s disease: a multi-target mechanistic review
Neuroprotective properties of extra virgin olive oil polyphenols in Alzheimer’s disease: a multi-target mechanistic review Open
Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by β-amyloid (Aβ) deposition, hyperphosphorylated tau protein, neuroinflammation, and mitochondrial dysfunction. The limited efficacy of single-target pharmacol…
View article: Induction chemotherapy plus camrelizumab followed by concurrent chemoradiotherapy in unresectable locally advanced esophageal squamous cell carcinoma: a single-arm phase II trial
Induction chemotherapy plus camrelizumab followed by concurrent chemoradiotherapy in unresectable locally advanced esophageal squamous cell carcinoma: a single-arm phase II trial Open
Concurrent chemoradiotherapy (CCRT) has remained the standard treatment for unresectable locally advanced esophageal squamous cell carcinoma (ESCC), yet survival remains poor. This single-arm, phase II trial aims to evaluate the efficacy a…
View article: Thermal analysis in the diamond turning of HMX crystals: An entropy-based approach for safety evaluation
Thermal analysis in the diamond turning of HMX crystals: An entropy-based approach for safety evaluation Open
To prevent thermal explosions in octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) crystals during diamond turning, it is essential to manage the energy dissipation process at cutting hotspots located at the tip of the diamond tool. I…
View article: Inhibitory Effect of Amentoflavone on the Virulence of <scp>MRSA</scp> by Targeting <scp>ClpP</scp>
Inhibitory Effect of Amentoflavone on the Virulence of <span>MRSA</span> by Targeting <span>ClpP</span> Open
Methicillin‐resistant Staphylococcus aureus (MRSA) poses significant therapeutic challenges due to its global spread and virulence. Targeting the critical virulence regulator ClpP presents a promising antivirulence strategy. This study inv…
View article: Development of B-to-A base editors by leveraging translesion synthesis polymerase
Development of B-to-A base editors by leveraging translesion synthesis polymerase Open
Base editing technology enables single-nucleotide conversions without donor templates or DNA double-strand breaks (DSBs), yet current base editors lack the capacity to efficiently address C-to-A, G-to-A, or T-to-A conversion. Here we repor…
View article: CircRNAs: a novel potential strategy to treat breast cancer
CircRNAs: a novel potential strategy to treat breast cancer Open
Breast cancer is among the most prevalent malignant tumors worldwide, with triple-negative breast cancer (TNBC) being the most aggressive subtype and lacking effective treatment options. Circular RNAs (circRNAs) are noncoding RNAs that pla…
View article: Microstructure changes of the brain preceded glymphatic function changes in young obesity with and without food addiction
Microstructure changes of the brain preceded glymphatic function changes in young obesity with and without food addiction Open
Background and aims: Obesity in young adults has become a public health issue that cannot be ignored. Previous studies have shown that obesity, emotional stress and food addiction can interact with each other. However, the underlying patho…
View article: Prospective Evaluation of Radical Surgery for Adenocarcinoma of Esophagogastric Junction: Real-World Insights from the CLAEG Study
Prospective Evaluation of Radical Surgery for Adenocarcinoma of Esophagogastric Junction: Real-World Insights from the CLAEG Study Open
View article: PRMT1-Mediated PARP1 Methylation Drives Lung Metastasis and Chemoresistance via P65 Activation in Triple-Negative Breast Cancer
PRMT1-Mediated PARP1 Methylation Drives Lung Metastasis and Chemoresistance via P65 Activation in Triple-Negative Breast Cancer Open
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, characterized by a high propensity for metastasis, poor prognosis, and limited treatment options. Research has demonstrated a substantial correlation betwee…
View article: Antitumor Effects of Photoreceptor Protein Under Far-Red Light Through the Precise Regulation of M1 Differentiation of Engineered Macrophages
Antitumor Effects of Photoreceptor Protein Under Far-Red Light Through the Precise Regulation of M1 Differentiation of Engineered Macrophages Open
View article: A New Perspective on Gas Chromatography-Mass Spectrometry Urinary Metabolomic Analysis and Efficient Risk Assessment of Urolithiasis: Morning Urine Organic Acid Profiles
A New Perspective on Gas Chromatography-Mass Spectrometry Urinary Metabolomic Analysis and Efficient Risk Assessment of Urolithiasis: Morning Urine Organic Acid Profiles Open
Introduction: Urolithiasis is characterized by a high morbidity and recurrence rate, primarily attributed to metabolic disorders. The identification of more metabolic biomarkers would provide valuable insights into the etiology of stone fo…
View article: Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer
Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer Open
Microsatellite stable (MSS) colorectal cancers (CRCs) are often resistant to anti-programmed death-1 (PD-1) therapy. Here, we show that a CRC pathogen, Fusobacterium nucleatum (Fn), paradoxically sensitizes MSS CRC to anti-PD-1. Fecal micr…
View article: Mechanical and thermal properties of rice husk/glass fiber/polylactic acid composites
Mechanical and thermal properties of rice husk/glass fiber/polylactic acid composites Open
Polylactic acid (PLA) composites reinforced with rice husk and glass fiber can improve the properties in the aera of the material for vehicle application. In this work, the PLA composite was made and its properties were evaluated using sca…
View article: A tumor targeted nano micelle carrying astragaloside IV for combination treatment of bladder cancer
A tumor targeted nano micelle carrying astragaloside IV for combination treatment of bladder cancer Open
View article: Portal Venous and Hepatic Arterial Coefficients Predict Post-Hepatectomy Overall and Recurrence-Free Survival in Patients with Hepatocellular Carcinoma: A Retrospective Study
Portal Venous and Hepatic Arterial Coefficients Predict Post-Hepatectomy Overall and Recurrence-Free Survival in Patients with Hepatocellular Carcinoma: A Retrospective Study Open
Tumor PVC or HAC before hepatectomy is valuable for independently predicting postoperative survival of HCC patients.
View article: Gastric cancer immune microenvironment score predicts neoadjuvant chemotherapy efficacy and prognosis
Gastric cancer immune microenvironment score predicts neoadjuvant chemotherapy efficacy and prognosis Open
The efficacy of neoadjuvant chemotherapy (NACT) in patients with advanced gastric cancer (GC) varies greatly. Thus, we aimed to verify the predictive value of tumor‐infiltrating immune cells (TIICs) on the treatment response to NACT and th…
View article: Quantitative Indicators of as and Cd Release from Various Soils Under Flooding Condition
Quantitative Indicators of as and Cd Release from Various Soils Under Flooding Condition Open
View article: Prediction of as and Cd Dissolution in Various Soils Under Flooding Condition
Prediction of as and Cd Dissolution in Various Soils Under Flooding Condition Open
View article: The Dynamic Changes of Glycoside and Related Enzyme Activities During the Pile-Fermentation Process of Post-Fermentation Tea
The Dynamic Changes of Glycoside and Related Enzyme Activities During the Pile-Fermentation Process of Post-Fermentation Tea Open
View article: Development and Validation of a Blood-Biomarker-Based Predictive Model for HBV-Associated Hepatocellular Carcinoma
Development and Validation of a Blood-Biomarker-Based Predictive Model for HBV-Associated Hepatocellular Carcinoma Open
Objective This study aims to explore the optimal predictors of HBV-associated HCC using Lasso, and establish a prediction model. Methods A retrospective analysis was conducted on patients who underwent CBC and CRP testing between January 2…
View article: Gastric residual volume, safety, and effectiveness of drinking 250 mL of glucose solution 2–3 hours before surgery in gastric cancer patients: a multicenter, single-blind, randomized–controlled trial
Gastric residual volume, safety, and effectiveness of drinking 250 mL of glucose solution 2–3 hours before surgery in gastric cancer patients: a multicenter, single-blind, randomized–controlled trial Open
Background Carbohydrate drinking 2–3 hours before surgery has been widely adopted in colorectal operations. However, there is little direct evidence regarding its application in gastric cancer surgery. We aimed to evaluate the gastric resi…
View article: Response of Spider and Epigaeic Beetle Assemblages to Overwinter Planting Regimes and Surrounding Landscape Compositions
Response of Spider and Epigaeic Beetle Assemblages to Overwinter Planting Regimes and Surrounding Landscape Compositions Open
The rotation patterns of summer rice–winter oil seed rape and summer rice–winter fallow are the main planting regimes in the rice ecosystem in southern China. However, the impact of local rotation patterns and landscape factors on the over…
View article: Characteristics of hematological parameters on admission in COVID-19 Omicron variant infected in Chinese population: a large-scale retrospective study
Characteristics of hematological parameters on admission in COVID-19 Omicron variant infected in Chinese population: a large-scale retrospective study Open
View article: Risk factors for anastomotic leak and postoperative morbidity after right hemicolectomy for colon cancer: results from a prospective, multi-centre, snapshot study in China
Risk factors for anastomotic leak and postoperative morbidity after right hemicolectomy for colon cancer: results from a prospective, multi-centre, snapshot study in China Open
Background Right hemicolectomy is the standard treatment for right-sided colon cancer. There is variation in the technical aspects of performing right hemicolectomy as well as in short-term outcomes. It is therefore necessary to explore be…
View article: RP11-789C1.1 inhibits gastric cancer cell proliferation and accelerates apoptosis via the ATR/CHK1 signaling pathway
RP11-789C1.1 inhibits gastric cancer cell proliferation and accelerates apoptosis via the ATR/CHK1 signaling pathway Open
Background: Long non-coding RNAs (lncRNAs) plays an important role in the progression of gastric cancer (GC). Their involvement ranges from genetic regulation to cancer progression. However, the mechanistic roles of RP11-789C1.1 in GC are …
View article: LINC01343 targets miR-526b-5p to facilitate the development of hepatocellular carcinoma by upregulating ROBO1
LINC01343 targets miR-526b-5p to facilitate the development of hepatocellular carcinoma by upregulating ROBO1 Open
Long noncoding RNAs (lncRNAs) contribute to hepatocellular carcinoma (HCC) progression and development. However, the function and molecular mechanisms of action of LINC01343 in HCC remain unclear. qRT-PCR and western blotting were performe…
View article: Inhibitory Effect of Salicin on <i>Staphylococcus aureus</i> Coagulase
Inhibitory Effect of Salicin on <i>Staphylococcus aureus</i> Coagulase Open
The massive use of antibiotics has resulted in an alarming increase in antibiotic resistance in Staphylococcus aureus ( S. aureus ). This study aimed to identify the inhibitory effect of salicin on S. aureus . Coagulase (Coa) activity was …
View article: Incidence, prevention, risk factors, and prediction of venous thromboembolism in Chinese patients after colorectal cancer surgery: a prospective, multicenter cohort study
Incidence, prevention, risk factors, and prediction of venous thromboembolism in Chinese patients after colorectal cancer surgery: a prospective, multicenter cohort study Open
Background: Venous thromboembolism (VTE) is a common and serious complication after colorectal cancer (CRC) surgery. Few large-sample studies have reported VTE incidence and management status after CRC surgery in China. This study aimed to…
View article: CD-20-0047R2_Supplementary_Figure_2.pdf from Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade
CD-20-0047R2_Supplementary_Figure_2.pdf from Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade Open
Figure S2
View article: Data from Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade
Data from Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade Open
The utility of circulating tumor DNA (ctDNA) as a biomarker in patients with advanced cancers receiving immunotherapy is uncertain. We therefore analyzed pretreatment (n = 978) and on-treatment (n = 171) ctDNA samples across …