Wei‐jie Guan
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View article: Environmental exposure augments the abundance and transferability of antibiotic resistance genes in the respiratory tract
Environmental exposure augments the abundance and transferability of antibiotic resistance genes in the respiratory tract Open
Exposure to environmental pollutants has been linked to increased antibiotic resistance, a critical global health challenge. The respiratory microbiome constitutes a key reservoir of antibiotic resistance genes (ARGs). Here, we constructed…
View article: Treatment needs in mild-to-moderate chronic obstructive pulmonary disease: evidence from longitudinal studies
Treatment needs in mild-to-moderate chronic obstructive pulmonary disease: evidence from longitudinal studies Open
In patients with mild-to-moderate COPD, half may experience disease progression and are characterized by continued smoking, a smoking history of ≥30 pack-years, and a positive BDR. These risks of disease progression could be partly decreas…
View article: Dipeptidyl peptidase 1 inhibitors and neutrophilic inflammation in bronchiectasis: a narrative review
Dipeptidyl peptidase 1 inhibitors and neutrophilic inflammation in bronchiectasis: a narrative review Open
DPP-1 inhibitors have exhibited promising effects in improving several major clinical outcomes in bronchiectasis via suppressing the activity of NSPs.
View article: Risk of remnant cholesterol and chronic obstructive pulmonary disease: a mendelian randomization study
Risk of remnant cholesterol and chronic obstructive pulmonary disease: a mendelian randomization study Open
High RC levels might increase the risk of developing COPD. Whether reducing RC levels among the population contributes to a lower risk of COPD remains to be investigated.
View article: Corrigendum to “The effect of oral bacterial lysates on the respiratory microbiome in patients with chronic obstructive pulmonary disease exacerbations – A pilot study” [Med Microecol, Volume 14, December 2022, 100067]
Corrigendum to “The effect of oral bacterial lysates on the respiratory microbiome in patients with chronic obstructive pulmonary disease exacerbations – A pilot study” [Med Microecol, Volume 14, December 2022, 100067] Open
View article: Sputum Microbiota Compositions Correlate With Metabolome and Clinical Outcomes of COPD‐Bronchiectasis Association: A Prospective Cohort Study
Sputum Microbiota Compositions Correlate With Metabolome and Clinical Outcomes of COPD‐Bronchiectasis Association: A Prospective Cohort Study Open
Bronchiectasis frequently co‐exists with chronic obstructive pulmonary disease (COPD‐bronchiectasis association [CBA]). We compared the microbiota and metabolome of bronchiectasis with (BO) and without airflow obstruction (BNO), COPD, and …
View article: Pulmonary Artery Stent Implantation for Fibrosing Mediastinitis: Our Clinical Experience
Pulmonary Artery Stent Implantation for Fibrosing Mediastinitis: Our Clinical Experience Open
Fibrosing mediastinitis (FM) can block pulmonary vessels and airways, hindering treatment efficacy. Pulmonary artery (PA) stenting might provide a solution in such cases. This study involved 30 patients who had 49 PA stenting procedures fo…
View article: Association between chronic respiratory diseases and the attributable risk of long-term exposure to atmospheric particulate matters among middle-aged and elderly Chinese population
Association between chronic respiratory diseases and the attributable risk of long-term exposure to atmospheric particulate matters among middle-aged and elderly Chinese population Open
View article: Respiratory Airway Secretory Cells act as Immune Sentinels in Human Distal Airways
Respiratory Airway Secretory Cells act as Immune Sentinels in Human Distal Airways Open
Pulmonary immunity in the human distal respiratory airways is essential for lung function but remains less explored. Here we report that respiratory airway secretory (RAS) cells, a newly identified lung epithelial population unique to huma…
View article: Applications and prospects of biomaterials in diabetes management
Applications and prospects of biomaterials in diabetes management Open
Diabetes is a widespread metabolic disorder that presents considerable challenges in its management. Recent advancements in biomaterial research have shed light on innovative approaches for the treatment of diabetes. This review examines t…
View article: Is Tiotropium Necessary For All Patients with Mild-to-Moderate COPD To Prevent Disease Progression?
Is Tiotropium Necessary For All Patients with Mild-to-Moderate COPD To Prevent Disease Progression? Open
View article: Identifying Patients with Mild-to-Moderate COPD Who Require Intensified Initial Treatment to Control Clinically Important Deterioration
Identifying Patients with Mild-to-Moderate COPD Who Require Intensified Initial Treatment to Control Clinically Important Deterioration Open
View article: NLRP3 Inflammasome Activation Modulates Neutrophil Extracellular Trap Formation and Aggravates Airway Inflammation in Bronchiectasis
NLRP3 Inflammasome Activation Modulates Neutrophil Extracellular Trap Formation and Aggravates Airway Inflammation in Bronchiectasis Open
Neutrophilic inflammation and Pseudomonas aeruginosa infection have been implicated in the pathogenesis and progression of bronchiectasis. However, the mechanisms underlying the inflammasome activation and neutrophil extracellular traps (N…
View article: The Phenotypes of Asthma-Bronchiectasis Overlap: Clinical Characteristics and Outcomes
The Phenotypes of Asthma-Bronchiectasis Overlap: Clinical Characteristics and Outcomes Open
The radiologic severity of bronchiectasis and the use of systemic corticosteroids can identify the clinical phenotypes of ABO. The heterogeneity of clinical manifestations may help formulate personalized management strategies and predict t…
View article: Autologous transplantation of lung progenitor cells comes into reality for bronchiectasis
Autologous transplantation of lung progenitor cells comes into reality for bronchiectasis Open
Stem and progenitor cell-based regenerative therapies have the potential to cure chronic respiratory diseases. Yan et al.1 reported a clinical trial of autologous P63+ progenitor cell transplantation in bronchiectasis…
View article: An intranasally administered adenovirus-vectored SARS-CoV-2 vaccine induces robust mucosal secretory IgA
An intranasally administered adenovirus-vectored SARS-CoV-2 vaccine induces robust mucosal secretory IgA Open
BACKGROUNDThe level of nasal spike-specific secretory IgA (sIgA) is inversely correlated with the risk of SARS-CoV-2 Omicron infection. This study aimed to evaluate the safety and immunogenicity of intranasal vaccination using Ad5-S-Omicro…
View article: Oncology-respirology: a discipline in dire need
Oncology-respirology: a discipline in dire need Open
View article: Microbiological characteristics of the lower airway in adults with bronchiectasis: a prospective cohort study
Microbiological characteristics of the lower airway in adults with bronchiectasis: a prospective cohort study Open
View article: SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration
SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration Open
View article: Long-term associations of PM<sub>1</sub><i>versus</i>PM<sub>2.5</sub>and PM<sub>10</sub>with asthma and asthma-related respiratory symptoms in the middle-aged and elderly population
Long-term associations of PM<sub>1</sub><i>versus</i>PM<sub>2.5</sub>and PM<sub>10</sub>with asthma and asthma-related respiratory symptoms in the middle-aged and elderly population Open
Background Few studies have compared the associations between long-term exposures to particulate matters (aerodynamic diameter ≤1, ≤2.5 and ≤10 µm: PM 1 , PM 2.5 and PM 10 , respectively) and asthma and asthma-related respiratory symptoms.…
View article: Smoking Cessation in Chinese Patients Undergoing Thoracic Surgery: A Multicenter Prospective Observational Study
Smoking Cessation in Chinese Patients Undergoing Thoracic Surgery: A Multicenter Prospective Observational Study Open
In patients undergoing lung surgery with a low risk of PCs, active smoking does not significantly increase the risk of PCs or PPCs relative to quitters, suggesting that there is likely no need to postpone lung surgery for those who have no…
View article: Effects of occupational exposure to dust, gas, vapor and fumes on chronic bronchitis and lung function
Effects of occupational exposure to dust, gas, vapor and fumes on chronic bronchitis and lung function Open
VGDF exposure is associated with chronic bronchitis, respiratory symptoms and decreased lung function, suggesting that VGDF contributes to the pathogenesis and progression of COPD.
View article: A phase 4 multicentre, 2×2 factorial randomised, double-blind, placebo-controlled trial to investigate the efficacy and safety of tobramycin inhalation solution for<i>Pseudomonas aeruginosa</i>eradication in bronchiectasis: ERASE
A phase 4 multicentre, 2×2 factorial randomised, double-blind, placebo-controlled trial to investigate the efficacy and safety of tobramycin inhalation solution for<i>Pseudomonas aeruginosa</i>eradication in bronchiectasis: ERASE Open
Chronic Pseudomonas aeruginosa (PA) infection significantly contributes to morbidity and mortality in bronchiectasis patients. Initiating antibiotics early may lead to the eradication of PA. Here we outline the design of a trial (ERASE; NC…
View article: Bacteria and viruses and clinical outcomes of asthma‐bronchiectasis overlap syndrome: A cohort study
Bacteria and viruses and clinical outcomes of asthma‐bronchiectasis overlap syndrome: A cohort study Open
Background Despite the high prevalence of co‐existing bronchiectasis and asthma (asthma‐bronchiectasis overlap syndrome [ABOS]), little is known regarding the dominant pathogens and clinical correlates. Objective To investigate the bacteri…
View article: Effects of Lianhuaqingwen Capsules in adults with mild-to-moderate coronavirus disease 2019: an international, multicenter, double-blind, randomized controlled trial
Effects of Lianhuaqingwen Capsules in adults with mild-to-moderate coronavirus disease 2019: an international, multicenter, double-blind, randomized controlled trial Open
View article: Differential airway resistome and its correlations with clinical characteristics in Haemophilus- or Pseudomonas-predominant microbial subtypes of bronchiectasis
Differential airway resistome and its correlations with clinical characteristics in Haemophilus- or Pseudomonas-predominant microbial subtypes of bronchiectasis Open
The prevalence and clinical correlates of antibiotic resistance genes (ARGs) in bronchiectasis are not entirely clear. We aimed to profile the ARGs in sputum from adults with bronchiectasis, and explore the association with airway microbio…
View article: Association of Coffee and Caffeine Intake with Risk of Chronic Obstructive Pulmonary Disease: Findings Based on NHANES 2007-2012
Association of Coffee and Caffeine Intake with Risk of Chronic Obstructive Pulmonary Disease: Findings Based on NHANES 2007-2012 Open
Objectives This investigation aimed to examine the correlation between coffee and caffeine intake with the risk of COPD and lung function based on NHANES 2007-2012. Materials and Methods Exposure variables were established as coffee and ca…
View article: OC 63.1 The Plasma Proteome and Risk of Venous Thromboembolism (VTE)
OC 63.1 The Plasma Proteome and Risk of Venous Thromboembolism (VTE) Open
Results: Elevated levels of miR-145 expression in plasma were associated with decreased risk of VTE (Table 1).Participants with miR-145 levels in the highest quartile had a 50% lower risk of VTE (HR 0.50, 95% CI 0.37-0.66)compared with tho…
View article: Plasma exchange plus glucocorticoids in the treatment of immune checkpoint inhibitor‐induced myocarditis: A case series and review
Plasma exchange plus glucocorticoids in the treatment of immune checkpoint inhibitor‐induced myocarditis: A case series and review Open
Immune checkpoint inhibitors (ICIs), including antiprogrammed cell‐death (PD)‐1/anti‐PD‐ligand (PDL‐1) monoclonal antibodies, are effective at improving the prognosis of patients with cancer. Among immune‐related adverse events, myocarditi…
View article: Venovenous extracorporeal membrane oxygenation for COVID-19 and influenza H1N1 associated acute respiratory distress syndrome: A comparative cohort study in China
Venovenous extracorporeal membrane oxygenation for COVID-19 and influenza H1N1 associated acute respiratory distress syndrome: A comparative cohort study in China Open