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View article: Cross-sectional and longitudinal network analyses depict variations of symptom networks in depression patients across the lifespan: insight from a large-scale sample
Cross-sectional and longitudinal network analyses depict variations of symptom networks in depression patients across the lifespan: insight from a large-scale sample Open
This study emphasises the dynamic and developmentally specific structuring of depressive symptom networks across the lifespan. Distinct central symptoms and varying levels of symptom connectivity across age groups suggest stage-specific ps…
View article: Triple-targeting nanosystems with synergistic effects on iron Trojan horse, fluoroquinolone antibiotics, and photodynamic therapy specifically kill intracellular MRSA
Triple-targeting nanosystems with synergistic effects on iron Trojan horse, fluoroquinolone antibiotics, and photodynamic therapy specifically kill intracellular MRSA Open
Rationale: Iron is necessary for the survival of microorganisms. The uptake network is highly expressed by host cells and methicillin-resistant Staphylococcus aureus (MRSA) and competes with heme iron. Gallium porphyrin (GaPR…
View article: Increased Serum EphA2 is Associated with Disease Severity in Pediatric Patients with Asthma
Increased Serum EphA2 is Associated with Disease Severity in Pediatric Patients with Asthma Open
Our research suggests that EphA2 might be a valuable marker for assessing the risk of exacerbation, inflammation of the airways, and airway remodelling in asthma patients.
View article: Cardiovascular comorbidities in Chinese inpatients with schizophrenia spectrum disorders
Cardiovascular comorbidities in Chinese inpatients with schizophrenia spectrum disorders Open
Cardiovascular diseases (CVDs) are the leading cause of premature mortality in patients with schizophrenia spectrum disorders (SSDs). However, the detailed categorization of these conditions remains insufficiently explored. This study aims…
View article: Thermal History Behavior of Aluminothermic Reduction of Rare Earth-containing Blast Furnace Slag During Heating Process
Thermal History Behavior of Aluminothermic Reduction of Rare Earth-containing Blast Furnace Slag During Heating Process Open
View article: Androgen receptor expression distribution characteristics in young female breast cancer patients in China: a study of clinicopathological features
Androgen receptor expression distribution characteristics in young female breast cancer patients in China: a study of clinicopathological features Open
This study revealed that in young female breast cancer patients in China, AR-positive breast cancer was significantly associated with the high expression of HRs, increased P53 expression and reduced EGFR expression. The expression status o…
View article: A Case Report on the Intervention of Academic Aversion Among Senior High School Students Using Chinese Chess Psychological Counseling Method
A Case Report on the Intervention of Academic Aversion Among Senior High School Students Using Chinese Chess Psychological Counseling Method Open
View article: Switching to Conbercept in Diabetic Macular Edema After Unsatisfactory Response to Previous Intravitreal Injection of Ranibizumab
Switching to Conbercept in Diabetic Macular Edema After Unsatisfactory Response to Previous Intravitreal Injection of Ranibizumab Open
Switching to Conbercept effectively improved visual and anatomical structure in DME patients who had not responded satisfactorily to previous anti-VEGF injections.
View article: Review of Influenza Prediction
Review of Influenza Prediction Open
Influenza is a common respiratory disease caused by the influenza virus, and each outbreak can result in a large number of infections and deaths worldwide.Predicting the dynamics of influenza outbreaks could be useful for decision-making r…
View article: A study on the accuracy of a new fluorescent detection method for vaginal fungi
A study on the accuracy of a new fluorescent detection method for vaginal fungi Open
View article: New insights into the diagnostic characteristics and clinical application of serum biomarkers for lung cancer, and human epididymis protein 4 as a new biomarker?
New insights into the diagnostic characteristics and clinical application of serum biomarkers for lung cancer, and human epididymis protein 4 as a new biomarker? Open
The value of serum tumor biomarkers used for lung cancer diagnosis is still controversial in clinical practice. This study aimed to further dissect and evaluate the clinical value of serum progastrin-releasing peptide (ProGRP), neuron-spec…
View article: [99mTc]Tc-Galacto-RGD2 integrin αvβ3-targeted imaging as a surrogate for molecular phenotyping in lung cancer: real-world data
[99mTc]Tc-Galacto-RGD2 integrin αvβ3-targeted imaging as a surrogate for molecular phenotyping in lung cancer: real-world data Open
Background Epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) are beneficial in patients with lung cancer. We explored the clinical value of [ 99m Tc]Tc-Galacto-RGD 2 single-photon emission computed tomography (SPECT/CT) in…
View article: Characteristics of Argininemia and Effect of Liver Transplantation-the Largest Experience in China
Characteristics of Argininemia and Effect of Liver Transplantation-the Largest Experience in China Open
Background: Argininemia is a rare urea cycle disorder due to arginase-1 deficiency, characterized by progressive spastic paraplegia. Coagulation dysfunction has been reported in few researches, and the pathophysiology is still unclear. Adv…
View article: Age‐stratified and gender‐specific reference intervals of six tumor markers panel of lung cancer: A geographic‐based multicenter study in China
Age‐stratified and gender‐specific reference intervals of six tumor markers panel of lung cancer: A geographic‐based multicenter study in China Open
Background Serum biomarkers have been widely adopted in clinical practice for assisting lung cancer diagnoses, therapeutic monitoring, and prognostication. The function of a well‐performing tumor biomarker depends on a reliable reference i…
View article: 99mTc-Galacto-RGD2 Integrin αvβ3 Targeted Imaging as a Surrogate for Molecular Phenotyping in Lung Cancer: Prospective Study in the Real World
99mTc-Galacto-RGD2 Integrin αvβ3 Targeted Imaging as a Surrogate for Molecular Phenotyping in Lung Cancer: Prospective Study in the Real World Open
Purpose: Epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) are beneficial in patients with lung cancer. We explored the clinical value of 99m Tc-Galacto-RGD 2 single-photon emission computed tomography (SPECT/CT) in patien…
View article: Circ-AFF2/miR-650/CNP axis promotes proliferation, inflammatory response, migration, and invasion of rheumatoid arthritis synovial fibroblasts
Circ-AFF2/miR-650/CNP axis promotes proliferation, inflammatory response, migration, and invasion of rheumatoid arthritis synovial fibroblasts Open
Background Circular RNAs (circRNAs) are associated with rheumatoid arthritis (RA) development. The purpose of this study is to explore the function and mechanism of circRNA fragile mental retardation 2 (circ-AFF2) in the processes of rheum…
View article: Comparison of accuracy in three versions of simplified sequential organ failure assessment scores to predict prognosis of septic patients
Comparison of accuracy in three versions of simplified sequential organ failure assessment scores to predict prognosis of septic patients Open
Background: Evidence shows that simplified SOFA scoring system has better clinical practice. Objective: This study aimed to compare the scores acquired with the simplified sequential organ failure assessment (sSOFA), simplified organ dysfu…
View article: Primary giant cell malignant fibrous histiocytoma of the lung: a rare case report and literature review
Primary giant cell malignant fibrous histiocytoma of the lung: a rare case report and literature review Open
Malignant fibrous histiocytoma (MFH) usually involves the extremities. Among MFH, primary giant cell malignant fibrous histiocytoma of the lung is extremely rare, with nonspecific symptoms. A 45-year-old woman was first diagnosed as sclero…
View article: <p>Atrophic Corpus Callosum Associated with Altered Functional Asymmetry in Major Depressive Disorder</p>
Atrophic Corpus Callosum Associated with Altered Functional Asymmetry in Major Depressive Disorder Open
These findings provide robust evidence that intra- and inter-hemispheric disconnections are involved in MDD, and that functional disruptions in the left hemisphere may be more relevant to the pathophysiology of MDD. Furthermore, imbalanced…
View article: Serum chromogranin A for the diagnosis of gastroenteropancreatic neuroendocrine neoplasms and its association with tumour expression
Serum chromogranin A for the diagnosis of gastroenteropancreatic neuroendocrine neoplasms and its association with tumour expression Open
The aim of the present study was to assess the clinical value of serum chromogranin A (CgA) levels in patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) and to compare them with tumour expression of CgA. A total of 10…
View article: Asymmetry in cortical thickness and subcortical volume in treatment-naïve major depressive disorder
Asymmetry in cortical thickness and subcortical volume in treatment-naïve major depressive disorder Open
These findings provide further evidence for the altered morphological interhemispheric imbalances in depression and these alterations were independent of depressive symptom severity, suggesting that cerebral asymmetry could be an appropria…
View article: Role of blood urea nitrogen in predicting the post-discharge prognosis in elderly patients with acute decompensated heart failure
Role of blood urea nitrogen in predicting the post-discharge prognosis in elderly patients with acute decompensated heart failure Open
Blood urea nitrogen (BUN) is a surrogate marker for neurohormonal activation, but the association between BUN and the post-discharge prognosis in elderly patients with acute decompensated heart failure (ADHF) is not well defined. We explor…
View article: Altered Structural Covariance Among the Dorsolateral Prefrontal Cortex and Amygdala in Treatment-Naïve Patients With Major Depressive Disorder
Altered Structural Covariance Among the Dorsolateral Prefrontal Cortex and Amygdala in Treatment-Naïve Patients With Major Depressive Disorder Open
Background: Impairments in cognitive and emotional processing are a characteristic of major depressive disorder (MDD), and the dorsolateral prefrontal cortex (DLPFC) and amygdala are involved in these processes. However, the structu…
View article: Folic acid-conjugated mesoporous silica nanoparticles for enhanced therapeutic efficacy of topotecan in retina cancers
Folic acid-conjugated mesoporous silica nanoparticles for enhanced therapeutic efficacy of topotecan in retina cancers Open
In this study, topotecan-loaded mesoporous silica nanoparticles were prepared and surface conjugated with folic acid (FTMN) to enhance the therapeutic efficacy of topotecan for the treatment of retinoblastoma (RB) cancers. The particles we…
View article: Pyrrolidine Dithiocarbamate (PDTC) Inhibits DON‐Induced Mitochondrial Dysfunction and Apoptosis via the NF‐<i>κ</i>B/iNOS Pathway
Pyrrolidine Dithiocarbamate (PDTC) Inhibits DON‐Induced Mitochondrial Dysfunction and Apoptosis via the NF‐<i>κ</i>B/iNOS Pathway Open
Oxidative stress is closely linked to the toxic responses of various cell types in normal and pathophysiological conditions. Deoxynivalenol (DON), an inducer of stress responses in the ribosome and the endoplasmic reticulum (ER), causes mi…
View article: Cytotoxic Tirucallane and Apotirucallane Triterpenoidsfrom the Stems of Picrasma quassioides
Cytotoxic Tirucallane and Apotirucallane Triterpenoidsfrom the Stems of Picrasma quassioides Open
Phytochemical investigation on the\nstems of Picrasma quassioides led to the isolation\nof a novel compound, picraquassin A (1), with an unprecedented\n21,24-cycloapotirucallane skeleton,\nand four new apotirucallane-type tri…
View article: Urachal adenocarcinoma that metastasized to breast was misinterpreted as primary breast mucinous carcinoma
Urachal adenocarcinoma that metastasized to breast was misinterpreted as primary breast mucinous carcinoma Open
Pathologic and immunohistochemical examination confirmed that the mass was urachal mucinous adenocarcinoma and mucinous adenocarcinoma to the right breast. The patient has been followed up without recurrence for 8 months.
View article: Postoperative Radiotherapy for the Treatment of Solitary Fibrous Tumor With Malignant Transformation of the Pelvic
Postoperative Radiotherapy for the Treatment of Solitary Fibrous Tumor With Malignant Transformation of the Pelvic Open
Solitary fibrous tumor of the pelvic is an uncommon neoplasm with nonspecific symptoms. Reports of malignant transformation are especially rare. We report a case of solitary fibrous tumor in pelvic. A unique feature of our case compared wi…