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View article: Additional Cover
Additional Cover Open
Cover legend: The cover image is based on the article The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging by Muthu Saravanan Manoharan et al., https://doi.org/10.1111/acel.70063. [Image: see text]
View article: The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging
The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging Open
Human aging presents an evolutionary paradox: while aging rates remain constant, healthspan and lifespan vary widely. We address this conundrum via salutogenesis—the active production of health—through immune resilience (IR), the capacity …
View article: Correction: Zhang et al. Clinical Management of Low Anterior Resection Syndrome: Review of the Current Diagnosis and Treatment. Cancers 2023, 15, 5011
Correction: Zhang et al. Clinical Management of Low Anterior Resection Syndrome: Review of the Current Diagnosis and Treatment. Cancers 2023, 15, 5011 Open
In the published publication [...]
View article: Health-related quality of life in children after surgical repair of esophageal atresia: a cross-sectional study in China
Health-related quality of life in children after surgical repair of esophageal atresia: a cross-sectional study in China Open
Objective To investigate health-related quality of life (HRQOL) in patients after surgical repair for esophageal atresia (EA) and identify its potential influencing factors. Methods A total of 102 EA children who had previously visited our…
View article: Effective-components combination alleviates PM2.5-induced inflammation by evoking macrophage autophagy in COPD
Effective-components combination alleviates PM2.5-induced inflammation by evoking macrophage autophagy in COPD Open
ECC-BYF can ameliorate PM2.5-aggravated inflammation in COPD, which might be associated with the enhancement of autophagy flux in alveolar macrophages through the activation of Foxo3 signals.
View article: Clinical Management of Low Anterior Resection Syndrome: Review of the Current Diagnosis and Treatment
Clinical Management of Low Anterior Resection Syndrome: Review of the Current Diagnosis and Treatment Open
Background: Low anterior resection syndrome (LARS) is a series of bowel dysfunction symptoms, including altered bowel frequency, irregular bowel rhythms, fecal incontinence, and constipation. LARS occurs in 80% of patients undergoing sphin…
View article: Health-Related Quality of Life in Children after Surgical Repair of Esophageal Atresia: A Single Tertiary Center Cross-sectional Study
Health-Related Quality of Life in Children after Surgical Repair of Esophageal Atresia: A Single Tertiary Center Cross-sectional Study Open
Objective To investigate health-related quality of life (HRQOL) of in postoperative esophageal atresia (EA) patients and to identify its potential influencing factors. Methods A total of 102 EA children who had previously visited our hospi…
View article: circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer
circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer Open
Background Circular RNAs (circRNAs) generated by back‐splicing of precursor mRNAs (pre‐mRNAs) are often aberrantly expressed in cancer cells. Accumulating evidence has revealed that circRNAs play a critical role in the progression of sever…
View article: A widespread length-dependent splicing dysregulation in cancer
A widespread length-dependent splicing dysregulation in cancer Open
Dysregulation of alternative splicing is a key molecular hallmark of cancer. However, the common features and underlying mechanisms remain unclear. Here, we report an intriguing length-dependent splicing regulation in cancers. By systemati…
View article: Intestinal epithelial glucocorticoid receptor promotes chronic inflammation–associated colorectal cancer
Intestinal epithelial glucocorticoid receptor promotes chronic inflammation–associated colorectal cancer Open
Synthetic immunosuppressive glucocorticoids (GCs) are widely used to control inflammatory bowel disease (IBD). However, the impact of GC signaling on intestinal tumorigenesis remains controversial. Here, we report that intestinal epithelia…
View article: CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1–infected individuals
CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1–infected individuals Open
The basis for the extensive variability seen in the reconstitution of CD4+ T cell counts in HIV-infected individuals receiving highly active antiretroviral therapy (HAART) is not fully known. Here, we show that variations in CCL3L1 gene do…
View article: Reduced Graphene Oxide-Gold Nanoparticle Nanoframework as a Highly Selective Separation Material for Aflatoxins
Reduced Graphene Oxide-Gold Nanoparticle Nanoframework as a Highly Selective Separation Material for Aflatoxins Open
Graphene-based materials have been studied in many applications, owing to the excellent electrical, mechanical, and thermal properties of graphene. In the current study, an environmentally friendly approach to the preparation of a reduced …
View article: A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs
A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs Open
Our results suggest that among PWID CCL5 haplotype D and CCR5 HHG*1 independently protects against HCV. Our findings highlight the importance of CCL5 genetic variability and CCL5-CCR5 axis on the susceptibility to HCV.
View article: Epigenetic mechanisms, T-cell activation, and<i>CCR5</i>genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor
Epigenetic mechanisms, T-cell activation, and<i>CCR5</i>genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor Open
Significance Levels of CC chemokine receptor 5 (CCR5) on T cells are a critical factor influencing HIV/AIDS susceptibility. DNA methylation is an epigenetic feature associated with lower gene expression. Here we show that the DNA methylati…