Weijun Jiang
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View article: Clinical and molecular features of 40 Chinese patients with idiopathic hypogonadotropic hypogonadism
Clinical and molecular features of 40 Chinese patients with idiopathic hypogonadotropic hypogonadism Open
The study aims to expand the genotype mutation spectrum of IHH and provide evidence for the follow-up clinical treatment and genetic counseling of the disease.
View article: Continuous In Vitro Culture of Babesia duncani in a Serum-Free Medium
Continuous In Vitro Culture of Babesia duncani in a Serum-Free Medium Open
Human babesiosis is an emerging tick-borne disease, caused by haemoprotozoa genus of Babesia. Cases of transfusion-transmitted and naturally acquired Babesia infection have been reported worldwide in recent years and causing a serious publ…
View article: A method comparison of three immunoassays for detection of neutralizing antibodies against SARS‐CoV‐2 receptor‐binding domain in individuals with adenovirus type‐5‐vectored COVID‐19 vaccination
A method comparison of three immunoassays for detection of neutralizing antibodies against SARS‐CoV‐2 receptor‐binding domain in individuals with adenovirus type‐5‐vectored COVID‐19 vaccination Open
Objective Detecting neutralizing antibodies targeting receptor‐binding domain (RBD) is important for the assessment of humoral protection and vaccine efficacy after vaccination. We compared the performance of three surrogate immunoassays f…
View article: ZFP57 dictates allelic expression switch of target imprinted genes
ZFP57 dictates allelic expression switch of target imprinted genes Open
Significance This study provides further proof for ZFP57 as a master regulator of genomic imprinting since it maintains DNA methylation at most known imprinted regions and regulates allelic expression of the corresponding imprinted genes. …
View article: The clinical efficacy of acupoint sticking combined with massage to treatment functional dyspepsia
The clinical efficacy of acupoint sticking combined with massage to treatment functional dyspepsia Open
Background: The objective of this meta-analysis was to summarize and identify the available evidence from studies to estimate the clinical value of acupoint sticking combined with massage (ASM) in the treatment of functional dyspepsia (FD)…
View article: Dynamic monitoring of KRAS, NRAS, BRAF and PIK3CA mutations in circulating cell-free DNA for metastatic colorectal cancer patients treated with cetuximab
Dynamic monitoring of KRAS, NRAS, BRAF and PIK3CA mutations in circulating cell-free DNA for metastatic colorectal cancer patients treated with cetuximab Open
Background: Genomic heterogeneity affects response to targeted agents. Liquid biopsy is a promising approach to detect genetic mutations in circulating cellfree DNA (cfDNA) and allows the tracking of treatment-induced genetic evolution in …
View article: Polymorphisms of protamine genes contribute to male infertility susceptibility in the Chinese Han population
Polymorphisms of protamine genes contribute to male infertility susceptibility in the Chinese Han population Open
Protamine (PRM) plays important roles in the packaging of DNA within the sperm nucleus. To investigate the role of PRM1/2 and transition protein 1 (TNP1) polymorphisms in male infertility, 636 infertile men and 442 healthy individuals were…
View article: Application of next-generation sequencing for molecular diagnosis in a large family with osteogenesis imperfecta type I
Application of next-generation sequencing for molecular diagnosis in a large family with osteogenesis imperfecta type I Open
Increased bone fragility and low bone mass are common features of osteogenesis imperfecta (OI), which is associated with connective tissue. Its type is distinguished by clinical phenotypes and molecular genetics. Although fifteen types (I‑…
View article: Long-term prognosis in patients continuing taking antithrombotics after peptic ulcer bleeding
Long-term prognosis in patients continuing taking antithrombotics after peptic ulcer bleeding Open
After the occurrence of peptic ulcer bleeding, continuing antithrombotics increases the risk of recurrent bleeding events, while discontinuing antithrombotics would increase the risk of death and developing cardiovascular disease. This sug…
View article: Hyperhomocysteinaemia in rats is associated with erectile dysfunction by impairing endothelial nitric oxide synthase activity
Hyperhomocysteinaemia in rats is associated with erectile dysfunction by impairing endothelial nitric oxide synthase activity Open
To investigate the effect of hyperhomocysteinaemia (HHCy) on penile erectile function in a rat model, a methionine-rich diet was used in which erectile function, the reproductive system, and nitric oxide synthase were characterized. The in…