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View article: Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins
Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins Open
Base editing stands at the forefront of genetic engineering, heralding precise genetic modifications with broad implications. While CRISPR-based DNA and RNA base editing systems capitalize on sgRNA-guided specificity and diverse deaminase …
View article: Efficacy and safety of Bufei Huoxue capsules in the treatment of stable COPD: A multicenter, double-blind, placebo-controlled, randomized clinical trial
Efficacy and safety of Bufei Huoxue capsules in the treatment of stable COPD: A multicenter, double-blind, placebo-controlled, randomized clinical trial Open
Introduction: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory condition characterized by irreversible airflow limitation, resulting in significant morbidity and mortality. Bufei Huoxue capsules (BFHX) have demonstrat…
View article: Statistical evaluation of accuracy of cross-hole CT method in identifying karst caves
Statistical evaluation of accuracy of cross-hole CT method in identifying karst caves Open
Karst geological hazards pose a significant challenge for the urban construction and underground space development and utilization in the Guangdong-Hong Kong-Macao Greater Bay Area, especially in Guangzhou and Shenzhen. Karst exploration g…
View article: Transcriptome analysis of long non-coding RNA and mRNA Profiles in VSV-infected BHK-21 Cells
Transcriptome analysis of long non-coding RNA and mRNA Profiles in VSV-infected BHK-21 Cells Open
Background Vesicular stomatitis virus (VSV) is a typical non-segmented negative-sense RNA virus of the genus Vesiculovirus in the family Rhabdoviridae . VSV can infect a wide range of animals, including humans, with oral blister epithelial…
View article: Additional file 1 of Transcriptome analysis of long non-coding RNA and mRNA Profiles in VSV-infected BHK-21 Cells
Additional file 1 of Transcriptome analysis of long non-coding RNA and mRNA Profiles in VSV-infected BHK-21 Cells Open
Additional file 1.
View article: The Multiplicity of Infection of Recombinant Vaccinia Virus Expressing the T7 RNA Polymerase Determines the Rescue Efficiency of Vesicular Stomatitis Virus
The Multiplicity of Infection of Recombinant Vaccinia Virus Expressing the T7 RNA Polymerase Determines the Rescue Efficiency of Vesicular Stomatitis Virus Open
Vesicular stomatitis virus (VSV) has a wide range of cell tropism, making it a prototype of studying the negative-strand RNA virus (NSRV), including virus–host interactions and vaccine development. Although VSV rescue systems have been pro…
View article: A neutron diffraction investigation of high valent doped barium ferrite with wideband tunable microwave absorption
A neutron diffraction investigation of high valent doped barium ferrite with wideband tunable microwave absorption Open
The barium ferrite BaTi x Fe 12− x O 19 ( x = 0.2, 0.4, 0.6, 0.8) (BFTO- x ) ceramics doped by Ti 4+ were synthesized by a modified sol—gel method. The crystal structure and magnetic structure of the samples were determined by neutron diff…
View article: Instability Mode and Movement Characteristics of Dangerous Rock Body in Steep Rock Slope
Instability Mode and Movement Characteristics of Dangerous Rock Body in Steep Rock Slope Open
The cutting relationship and development degree of structural plane control the instability mode and scale of rock slope. The trajectory of rock mass after instability is an important basis for the design of dangerous rock prevention. The …
View article: A Neutron Diffraction Investigation of High Valent Doped Barium Ferrite With Super-wide Tunable Microwave Absorption
A Neutron Diffraction Investigation of High Valent Doped Barium Ferrite With Super-wide Tunable Microwave Absorption Open
The Barium ferrite BaTixFe12-xO19 (x = 0.2, 0.4, 0.6, 0.8) ceramics doped by Ti4+ (BFTO-x) were synthesized by a modified sol-gel method. The crystal structure and magnetic structure of the samples were determined by neutron diffraction, a…
View article: P108 and T109 on E2 Glycoprotein Domain I Are Critical for the Adaptation of Classical Swine Fever Virus to Rabbits but Not for Virulence in Pigs
P108 and T109 on E2 Glycoprotein Domain I Are Critical for the Adaptation of Classical Swine Fever Virus to Rabbits but Not for Virulence in Pigs Open
Historically, live attenuated vaccines produced by blind passage usually undergo adaptation in cell cultures or nonsusceptible hosts and attenuation in natural hosts, with a classical example being the classical swine fever virus (CSFV) la…
View article: Peer Review #1 of "Differential responses of the acidobacterial community in the topsoil and subsoil to fire disturbance in Pinus tabulaeformis stands (v0.2)"
Peer Review #1 of "Differential responses of the acidobacterial community in the topsoil and subsoil to fire disturbance in Pinus tabulaeformis stands (v0.2)" Open
Acidobacteria is found to be dominant and abundant in forest soil, and performs specific ecological functions (such as cellulose decomposition and photosynthetic capacity, etc.).However, relative limited is known about its changing pattern…
View article: Peer Review #2 of "Differential responses of the acidobacterial community in the topsoil and subsoil to fire disturbance in Pinus tabulaeformis stands (v0.1)"
Peer Review #2 of "Differential responses of the acidobacterial community in the topsoil and subsoil to fire disturbance in Pinus tabulaeformis stands (v0.1)" Open
Acidobacteria is found to be dominant and abundant in forest soil, and performs specific ecological functions (such as cellulose decomposition and photosynthetic capacity, etc.).However, relative limited is known about its changing pattern…
View article: Peer Review #1 of "Differential responses of the acidobacterial community in the topsoil and subsoil to fire disturbance in Pinus tabulaeformis stands (v0.1)"
Peer Review #1 of "Differential responses of the acidobacterial community in the topsoil and subsoil to fire disturbance in Pinus tabulaeformis stands (v0.1)" Open
Acidobacteria is found to be dominant and abundant in forest soil, and performs specific ecological functions (such as cellulose decomposition and photosynthetic capacity, etc.).However, relative limited is known about its changing pattern…
View article: Differential responses of the acidobacterial community in the topsoil and subsoil to fire disturbance in <i>Pinus tabulaeformis</i> stands
Differential responses of the acidobacterial community in the topsoil and subsoil to fire disturbance in <i>Pinus tabulaeformis</i> stands Open
Acidobacteria is found to be dominant and abundant in forest soil, and performs specific ecological functions (such as cellulose decomposition and photosynthetic capacity, etc.). However, relative limited is known about its changing patter…
View article: Peer Review #2 of "Differential responses of the acidobacterial community in the topsoil and subsoil to fire disturbance in Pinus tabulaeformis stands (v0.2)"
Peer Review #2 of "Differential responses of the acidobacterial community in the topsoil and subsoil to fire disturbance in Pinus tabulaeformis stands (v0.2)" Open
Acidobacteria is found to be dominant and abundant in forest soil, and performs specific ecological functions (such as cellulose decomposition and photosynthetic capacity, etc.).However, relative limited is known about its changing pattern…
View article: Overexpression of Smac by an Armed Vesicular Stomatitis Virus Overcomes Tumor Resistance
Overexpression of Smac by an Armed Vesicular Stomatitis Virus Overcomes Tumor Resistance Open
Despite reports of successful clinical cases, many tumors appear to resist infection by oncolytic viruses (OVs). To circumvent this problem, an armed vesicular stomatitis virus was constructed by inserting a transgene to express Smac/DIABL…
View article: Experimental Study on Disintegration Characteristics of Soft Rock under Acidic Environment
Experimental Study on Disintegration Characteristics of Soft Rock under Acidic Environment Open
The Red-bed soft rock is widely distributed in South China, and it has been exposed to acid rain for a long time, which brings great risks to the stability of the engineerings. Therefore, the Red-bed soft rock in South China is selected as…
View article: Site test study of pile-soil stress ratio of composite foundation in karst area
Site test study of pile-soil stress ratio of composite foundation in karst area Open
Aiming at the special geological conditions in Karst areas, the pile-soil stress ratio of composite foundation is analyzed. According to carry out the field test of composite foundation in Karst area, soil pressure boxes are arranged to me…
View article: Research on the Prevention of Coal Blocking in Power Plant Raw Coal Bunker
Research on the Prevention of Coal Blocking in Power Plant Raw Coal Bunker Open
[Introduction] Coal blocking of pulverizing system is a big problem in power plant, especially for coal bunker. At present, there are many types of anti-blocking coal technologies on the market, but there are different opinions on the use …
View article: Short-term response of the soil bacterial community to differing wildfire severity in Pinus tabulaeformis stands
Short-term response of the soil bacterial community to differing wildfire severity in Pinus tabulaeformis stands Open
In recent years, the investigation of fire disturbance of microbial communities has gained growing attention. However, how the bacterial community varies in response to different severities of fire at different soil depths is largely unkno…
View article: Exploration of Mechanical Behaviors of Argillaceous Siltstone through Photoelastic Model Test and DEM Modelling
Exploration of Mechanical Behaviors of Argillaceous Siltstone through Photoelastic Model Test and DEM Modelling Open
This paper aims at investigating mechanical behaviors of argillaceous siltstone through a photoelastic model test and DEM modelling. Both bonded and unbonded conditions were considered. The photoelastic model was fabricated in a controllab…
View article: Constraints of Viral RNA Synthesis on Codon Usage of Negative-Strand RNA Virus
Constraints of Viral RNA Synthesis on Codon Usage of Negative-Strand RNA Virus Open
Negative-strand RNA viruses (NSVs) include the most pathogenic viruses known. New methods to monitor their evolutionary trends are urgently needed for the development of antivirals and vaccines. The protein translation machinery of the hos…
View article: Different functional states of fusion protein gB revealed on human cytomegalovirus by cryo electron tomography with Volta phase plate
Different functional states of fusion protein gB revealed on human cytomegalovirus by cryo electron tomography with Volta phase plate Open
Human cytomegalovirus (HCMV) enters host by glycoprotein B (gB)-mediated membrane fusion upon receptor-binding to gH/gL-related complexes, causing devastating diseases such as birth defects. Although an X-ray crystal structure of the recom…
View article: Complementary Mutations in the N and L Proteins for Restoration of Viral RNA Synthesis
Complementary Mutations in the N and L Proteins for Restoration of Viral RNA Synthesis Open
During viral RNA synthesis of a negative-strand RNA virus, the viral RNA-dependent RNA polymerase (vRdRp) must gain access to the sequestered RNA in the nucleocapsid to use it as the template, but at the same time may not disrupt the nucle…
View article: A Polyamide Inhibits Replication of Vesicular Stomatitis Virus by Targeting RNA in the Nucleocapsid
A Polyamide Inhibits Replication of Vesicular Stomatitis Virus by Targeting RNA in the Nucleocapsid Open
Polyamides have been shown to bind double-stranded DNA by complementing the curvature of the minor groove and forming various hydrogen bonds with DNA. Several polyamide molecules have been found to have potent antiviral activities against …
View article: One-pot synthesis of redox-triggered biodegradable hybrid nanocapsules with a disulfide-bridged silsesquioxane framework for promising drug delivery
One-pot synthesis of redox-triggered biodegradable hybrid nanocapsules with a disulfide-bridged silsesquioxane framework for promising drug delivery Open
Redox-triggered biodegradable hybrid nanocapsules with the disulfide-bridged silsesquioxane framework were developed for promising drug delivery.
View article: Applications of Replicating-Competent Reporter-Expressing Viruses in Diagnostic and Molecular Virology
Applications of Replicating-Competent Reporter-Expressing Viruses in Diagnostic and Molecular Virology Open
Commonly used tests based on wild-type viruses, such as immunostaining, cannot meet the demands for rapid detection of viral replication, high-throughput screening for antivirals, as well as for tracking viral proteins or virus transport i…