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View article: Physical modalities for the treatment of knee osteoarthritis: a network meta-analysis
Physical modalities for the treatment of knee osteoarthritis: a network meta-analysis Open
View article: LRP1 mitigates intervertebral disc degeneration by inhibiting endoplasmic reticulum stress through stabilizing the PPARγ
LRP1 mitigates intervertebral disc degeneration by inhibiting endoplasmic reticulum stress through stabilizing the PPARγ Open
View article: A two-step neural network-based guiding system for obtaining reliable radiographs for critical shoulder angle measurement
A two-step neural network-based guiding system for obtaining reliable radiographs for critical shoulder angle measurement Open
BACKGROUND: The critical shoulder angle (CSA) has been reported to be highly associated with rotator cuff tears (RCTs) and an increased risk of RCT re-tears. However, the measurement of the CSA is greatly affected by the malpositioning of …
View article: A comparative metabolomics analysis of domestic yak (Bos grunniens) milk with human breast milk
A comparative metabolomics analysis of domestic yak (Bos grunniens) milk with human breast milk Open
Yaks are tough animals living in Tibet’s hypoxic stress environment. However, the metabolite composition of yak milk and its role in hypoxic stress tolerance remains largely unexplored. The similarities and differences between yak and huma…
View article: Emodin ameliorates matrix degradation and apoptosis of nucleus pulposus cell and attenuates degeneration of intervertebral disc through LRP1 in vitro and in vivo
Emodin ameliorates matrix degradation and apoptosis of nucleus pulposus cell and attenuates degeneration of intervertebral disc through LRP1 in vitro and in vivo Open
Intervertebral disc degeneration (IDD) is closely correlated with Low back pain. Apoptosis and extracellular matrix (ECM) degradation caused by inflammation-mediated NF-ĸB has been reported to promote IDD. Low-density lipoprotein receptor-…
View article: Data from Targeting the Lymphotoxin-β Receptor with Agonist Antibodies as a Potential Cancer Therapy
Data from Targeting the Lymphotoxin-β Receptor with Agonist Antibodies as a Potential Cancer Therapy Open
The lymphotoxin-β receptor (LTβR) is a tumor necrosis factor receptor family member critical for the development and maintenance of various lymphoid microenvironments. Herein, we show that agonistic anti-LTβR monoclonal antibody (mAb) CBE1…
View article: Supplementary Tables 1-3, Figure 1 from Targeting the Lymphotoxin-β Receptor with Agonist Antibodies as a Potential Cancer Therapy
Supplementary Tables 1-3, Figure 1 from Targeting the Lymphotoxin-β Receptor with Agonist Antibodies as a Potential Cancer Therapy Open
Supplementary Tables 1-3, Figure 1 from Targeting the Lymphotoxin-β Receptor with Agonist Antibodies as a Potential Cancer Therapy
View article: Data from Targeting the Lymphotoxin-β Receptor with Agonist Antibodies as a Potential Cancer Therapy
Data from Targeting the Lymphotoxin-β Receptor with Agonist Antibodies as a Potential Cancer Therapy Open
The lymphotoxin-β receptor (LTβR) is a tumor necrosis factor receptor family member critical for the development and maintenance of various lymphoid microenvironments. Herein, we show that agonistic anti-LTβR monoclonal antibody (mAb) CBE1…
View article: Supplementary Tables 1-3, Figure 1 from Targeting the Lymphotoxin-β Receptor with Agonist Antibodies as a Potential Cancer Therapy
Supplementary Tables 1-3, Figure 1 from Targeting the Lymphotoxin-β Receptor with Agonist Antibodies as a Potential Cancer Therapy Open
Supplementary Tables 1-3, Figure 1 from Targeting the Lymphotoxin-β Receptor with Agonist Antibodies as a Potential Cancer Therapy
View article: TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo
TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo Open
View article: Alternative 3′-untranslated regions regulate high-salt tolerance of <i>Spartina alterniflora</i>
Alternative 3′-untranslated regions regulate high-salt tolerance of <i>Spartina alterniflora</i> Open
High-salt stress continues to challenge the growth and survival of many plants. Alternative polyadenylation (APA) produces mRNAs with different 3′-untranslated regions (3′ UTRs) to regulate gene expression at the post-transcriptional level…
View article: Biomechanical effects of cement discoplasty on the lumbar spinal unit
Biomechanical effects of cement discoplasty on the lumbar spinal unit Open
Background Percutaneous cement discoplasty (PCD) is used to treat patients with low back and leg pain due to the intervertebral disc vacuum phenomena. Whether PCD can restore lumbar spinal stability remains unknown. Objective The purpose o…
View article: High-Altitude Stress Orchestrates mRNA Expression and Alternative Splicing of Ovarian Follicle Development Genes in Tibetan Sheep
High-Altitude Stress Orchestrates mRNA Expression and Alternative Splicing of Ovarian Follicle Development Genes in Tibetan Sheep Open
High-altitude stress threatens the survival rate of Tibetan sheep and reduces their fertility. However, the molecular basis of this phenomenon remains elusive. Here, we used RNA-seq to elucidate the transcriptome dynamics of high-altitude …
View article: Alternative mRNA polyadenylation bridges mitochondrion-to-nucleus communication in Arabidopsis
Alternative mRNA polyadenylation bridges mitochondrion-to-nucleus communication in Arabidopsis Open
Mitochondria produce signals besides energy and metabolites that influence plant growth and fitness. However, how mitochondrial signals are relayed to other cellular compartments is largely unknown. By applying poly(A)-site RNA-sequencing …
View article: TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo
TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo Open
Background Intervertebral disc degeneration (IDD) is one of the most common disorders related to the spine. Inflammation, apoptosis and extracellular matrix (ECM) degradation contribute to disc degeneration in nucleus pulposus cells (NPCs)…
View article: Alternative 3′ UTRs contributes to post-transcriptional gene expression regulation under high salt stress
Alternative 3′ UTRs contributes to post-transcriptional gene expression regulation under high salt stress Open
High salt stress continually challenges growth and survival of many plants, but the underlying molecular basis is not fully explored. Alternative polyadenylation (APA) produces mRNAs with different 3′UTRs (alternative 3′UTRs) to regulate g…
View article: Changing epidemiology of calcific aortic valve disease: 30-year trends of incidence, prevalence, and deaths across 204 countries and territories
Changing epidemiology of calcific aortic valve disease: 30-year trends of incidence, prevalence, and deaths across 204 countries and territories Open
Calcific aortic valve disease (CAVD) is associated with increased morbidity and mortality. We aimed to elucidate the 30-year epidemiology of CAVD globally. Global CAVD incidence, prevalence, and deaths increased 3.51-, 4.43-, and 1.38-fold…
View article: A Novel Extreme Lateral Approach for Needle Puncture Model of Lumbar Disc Degeneration in SD Rats.
A Novel Extreme Lateral Approach for Needle Puncture Model of Lumbar Disc Degeneration in SD Rats. Open
Background : Various animal models have been proposed to investigate several aspects of intervertebral disc degeneration (IDD). As for needle puncture model, literatures have mentioned the needle puncture in percutaneous posterolateral app…
View article: R2* value derived from multi-echo Dixon technique can aid discrimination between benign and malignant focal liver lesions
R2* value derived from multi-echo Dixon technique can aid discrimination between benign and malignant focal liver lesions Open
R2* derived from multi-echo Dixon imaging whether by 2D-ROI or VOI can aid in differentiation between benign and malignant FLLs.
View article: Differentiation between high-grade gliomas and solitary brain metastases: a comparison of five diffusion-weighted MRI models
Differentiation between high-grade gliomas and solitary brain metastases: a comparison of five diffusion-weighted MRI models Open
View article: Quantitative dynamic contrast-enhanced MR imaging can be used to predict the pathologic stages of oral tongue squamous cell carcinoma
Quantitative dynamic contrast-enhanced MR imaging can be used to predict the pathologic stages of oral tongue squamous cell carcinoma Open
Background To investigate whether quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic parameters can be used to predict the pathologic stages of oral tongue squamous cell carcinoma (OTSCC). Methods F…
View article: Quantitative dynamic contrast-enhanced MR imaging can be used to predict the pathologic stages of oral tongue squamous cell carcinoma
Quantitative dynamic contrast-enhanced MR imaging can be used to predict the pathologic stages of oral tongue squamous cell carcinoma Open
Background: To investigate whether quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic parameters can be used to predict the pathologic stages of oral tongue squamous cell carcinoma (OTSCC).Methods: …
View article: Quantitative dynamic contrast-enhanced MR imaging can be used to predict the pathologic stages of oral tongue squamous cell carcinoma
Quantitative dynamic contrast-enhanced MR imaging can be used to predict the pathologic stages of oral tongue squamous cell carcinoma Open
Background: To investigate whether quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic parameters can be used to predict the pathologic stages of oral tongue squamous cell carcinoma (OTSCC). Methods:…
View article: Mean Apparent Propagator MRI Is Better Than Conventional Diffusion Tensor Imaging for the Evaluation of Parkinson’s Disease: A Prospective Pilot Study
Mean Apparent Propagator MRI Is Better Than Conventional Diffusion Tensor Imaging for the Evaluation of Parkinson’s Disease: A Prospective Pilot Study Open
MAP MRI outperformed the conventional DTI in the diagnosis of PD and evaluation of the disease severity.
View article: Liver fat accumulation measured by high-speed T2-corrected multi-echo magnetic resonance spectroscopy can predict risk of cholelithiasis
Liver fat accumulation measured by high-speed T2-corrected multi-echo magnetic resonance spectroscopy can predict risk of cholelithiasis Open
PDFF derived from high speed T2-corrected multi-echo MRS can predict the risk of cholelithiasis.
View article: Quantitative dynamic contrast-enhanced MR imaging can be used to predict the pathologic stages of oral tongue squamous cell carcinoma
Quantitative dynamic contrast-enhanced MR imaging can be used to predict the pathologic stages of oral tongue squamous cell carcinoma Open
Background: To investigate whether quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic parameters can be used to predict the pathologic stages of oral tongue squamous cell carcinoma (OTSCC). Methods:…
View article: Quantitative dynamic contrast-enhanced MR imaging can be used to predict the pathologic stages of lingual squamous cell carcinoma
Quantitative dynamic contrast-enhanced MR imaging can be used to predict the pathologic stages of lingual squamous cell carcinoma Open
Background To investigate whether quantitative DCE-MRI pharmacokinetic parameters can be used to predict the pathologic stages of lingual squamous cell carcinoma (LSCC). Methods For this prospective study, DCE-MRI was performed in particip…
View article: Magnetic Resonance Imaging of Bilateral Hands Is More Optimal Than MRI of Unilateral Hands for Rheumatoid Arthritis
Magnetic Resonance Imaging of Bilateral Hands Is More Optimal Than MRI of Unilateral Hands for Rheumatoid Arthritis Open
Objective. To explore the advantages of magnetic resonance imaging (MRI) of bilateral hands in rheumatoid arthritis (RA). Methods. Consecutive patients with active RA were recruited for clinical assessments, radiographs, and MRI of bilater…
View article: DTI metrics can be used as biomarkers to determine the therapeutic effect of stem cells in acute peripheral nerve injury
DTI metrics can be used as biomarkers to determine the therapeutic effect of stem cells in acute peripheral nerve injury Open
Purpose To determine the role of diffusion tensor imaging (DTI) metrics as biomarkers for the therapeutic effects of mesenchymal stem cells (MSCs) in acute peripheral nerve injury. Materials and Methods Forty‐four adult rats received subep…