Weiliang Song
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View article: Viral evolution prediction identifies broadly neutralizing antibodies to existing and prospective SARS-CoV-2 variants
Viral evolution prediction identifies broadly neutralizing antibodies to existing and prospective SARS-CoV-2 variants Open
View article: Antigenic and virological characteristics of SARS-CoV-2 variants BA.3.2, XFG, and NB.1.8.1
Antigenic and virological characteristics of SARS-CoV-2 variants BA.3.2, XFG, and NB.1.8.1 Open
View article: Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1
Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 Open
The emergence of the SARS-CoV-2 saltation variant BA.3.2, which harbors over 50 mutations relative to its ancestral BA.3 lineage, has raised concerns about its potential to drive outbreaks similar to BA.2.86/JN.1. Concurrently, variants su…
View article: Virological and antigenic characteristics of SARS-CoV-2 variants LF.7.2.1, NP.1, and LP.8.1
Virological and antigenic characteristics of SARS-CoV-2 variants LF.7.2.1, NP.1, and LP.8.1 Open
XEC and KP.3.1.1 have surpassed KP.3 to become the globally dominant lineages due to their unique NTD mutations. However, several emerging JN.1 sublineages, such as LF.7.2.1, MC.10.1, NP.1, and, especially, LP.8.1, have demonstrated superi…
View article: Non-invasive Preimplantation Genetic Testing of Embryonic Genome in Spent Culture Medium
Non-invasive Preimplantation Genetic Testing of Embryonic Genome in Spent Culture Medium Open
Traditionally, preimplantation genetic testing (PGT) for in vitro fertilization (IVF) requires invasive trophectoderm (TE) biopsy, which might be detrimental to the embryo. Recently proposed non-invasive PGT (ni-PGT) utilizing cell-free DN…
View article: Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1
Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1 Open
View article: Enhanced immune evasion of SARS-CoV-2 KP.3.1.1 and XEC through NTD glycosylation
Enhanced immune evasion of SARS-CoV-2 KP.3.1.1 and XEC through NTD glycosylation Open
KP.3.1.1 has surpassed KP.3 to become the new globally dominant strain, while XEC, a recombinant variant of KS.1.1/KP.3.3, is rapidly expanding across Europe and North America. Notably, both variants carry mutations, S31del of KP.3.1.1 and…
View article: Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain
Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain Open
A multitude of functional mutations continue to emerge on the N-terminal domain (NTD) of the spike protein in SARS-CoV-2 Omicron subvariants. Understanding the immunogenicity of Omicron NTD and the properties of antibodies elicited by it i…
View article: Prolonged Omicron-specific B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine
Prolonged Omicron-specific B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine Open
SARS-CoV-2 ancestral strain-induced immune imprinting poses great challenges to updating vaccines for new variants. Studies showed that repeated Omicron exposures could override immune imprinting induced by inactivated vaccines but not mRN…
View article: Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain
Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain Open
A multitude of functional mutations continue to emerge on the N-terminal domain (NTD) of the spike protein in SARS-CoV-2 Omicron subvariants. Understanding the immunogenicity of Omicron NTD and the properties of antibodies elicited by it i…
View article: Omicron-specific naive B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine
Omicron-specific naive B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine Open
SARS-CoV-2 ancestral strain-induced immune imprinting poses great challenges to vaccine updates. Studies showed that repeated Omicron exposures could override immune imprinting induced by inactivated vaccines but not mRNA vaccines, a dispa…
View article: Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1
Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1 Open
The continuous evolution of SARS-CoV-2, particularly the emergence of the BA.2.86/JN.1 lineage replacing XBB lineages, necessitates re-evaluation of current vaccine compositions. Here, we provide a comprehensive analysis of the humoral imm…
View article: Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants
Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants Open
Monoclonal antibodies (mAbs) targeting the SARS-CoV-2 receptor-binding domain (RBD) are used to treat and prevent COVID-19. However, the rapid evolution of SARS-CoV-2 drives continuous escape from therapeutic mAbs. Therefore, the ability t…
View article: Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1
Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1 Open
The recent emergence of a SARS-CoV-2 saltation variant, BA.2.87.1, which features 65 spike mutations relative to BA.2, has attracted worldwide attention. In this study, we elucidate the antigenic characteristics and immune evasion capabili…
View article: Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1
Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1 Open
The recent emergence of a SARS-CoV-2 saltation variant, BA.2.87.1, which features 65 spike mutations relative to BA.2, has attracted worldwide attention. In this study, we elucidate the antigenic characteristics and immune evasion capabili…
View article: Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455–456 synergistically enhances antibody evasion and ACE2 binding
Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455–456 synergistically enhances antibody evasion and ACE2 binding Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) XBB lineages have achieved dominance worldwide and keep on evolving. Convergent evolution of XBB lineages on the receptor-binding domain (RBD) L455F and F456L is observed, result…
View article: Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure
Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure Open
View article: Single-cell bisulfite-free 5mC and 5hmC sequencing with high sensitivity and scalability
Single-cell bisulfite-free 5mC and 5hmC sequencing with high sensitivity and scalability Open
Existing single-cell bisulfite-based DNA methylation analysis is limited by low DNA recovery, and the measurement of 5hmC at single-base resolution remains challenging. Here, we present a bisulfite-free single-cell whole-genome 5mC and 5hm…
View article: Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting Open
The continuing emergence of SARS-CoV-2 variants highlights the need to update COVID-19 vaccine compositions. However, immune imprinting induced by vaccination based on the ancestral (hereafter referred to as WT) strain would compromise the…
View article: Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure
Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure Open
While the BA.2.86 variant demonstrated significant antigenic drift and enhanced ACE2 binding affinity, its ability to evade humoral immunity was relatively moderate compared to dominant strains like EG.5 and HK.3. However, the emergence of…
View article: Single-cell bisulfite-free 5mC and 5hmC sequencing with high sensitivity and scalability
Single-cell bisulfite-free 5mC and 5hmC sequencing with high sensitivity and scalability Open
Existing single cell bisulfite-based DNA methylation analysis is limited by low DNA recovery, and the measurement of 5hmC at single-base resolution remains challenging. Here we present a bisulfite-free single-cell whole-genome 5mC and 5hmC…
View article: Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting Open
Code and source data for the article "Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting" (Yisimayi et al. Nature 2023)
View article: Antigenicity and infectivity characterisation of SARS-CoV-2 BA.2.86
Antigenicity and infectivity characterisation of SARS-CoV-2 BA.2.86 Open
View article: Antigenicity and infectivity characterization of SARS-CoV-2 BA.2.86
Antigenicity and infectivity characterization of SARS-CoV-2 BA.2.86 Open
The recently identified SARS-CoV-2 variant, BA.2.86, which carries a substantial number of Spike mutations, has raised a global alarm. An immediate assessment of its antigenic properties and infectivity is necessary. Here, we reveal the di…
View article: Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding
Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding Open
Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) XBB lineages have achieved dominance worldwide and keep on evolving. Convergent evolution of XBB lineages on the receptor-binding domain (RBD) L455F and F456L is observed…
View article: Repeated Omicron infection alleviates SARS-CoV-2 immune imprinting
Repeated Omicron infection alleviates SARS-CoV-2 immune imprinting Open
The continuous emergence of highly immune evasive SARS-CoV-2 variants, like XBB.1.5 and XBB.1.16, highlights the need to update COVID-19 vaccine compositions. However, immune imprinting induced by wildtype (WT)-based vaccination would comp…
View article: Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting Open
The continuous emergence of highly immune evasive SARS-CoV-2 variants, like XBB.1.5 1,2 and XBB.1.16 3,4 , highlights the need to update COVID-19 vaccine compositions. However, immune imprinting induced by wildtype (WT)-based vaccination w…
View article: Protective effect of plasma neutralization from prior SARS-CoV-2 Omicron infection against BA.5 subvariant symptomatic reinfection
Protective effect of plasma neutralization from prior SARS-CoV-2 Omicron infection against BA.5 subvariant symptomatic reinfection Open
View article: Protective effect of plasma neutralization from prior SARS-CoV-2 Omicron infection against BA.5 subvariant symptomatic reinfection
Protective effect of plasma neutralization from prior SARS-CoV-2 Omicron infection against BA.5 subvariant symptomatic reinfection Open
From December 2022 to January 2023, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections caused by BA.5 and BF.7 subvariants of B.1.1.529 (Omicron) swept across mainland China. It is crucial to estimate the protective ef…
View article: ACE2 binding and antibody evasion in enhanced transmissibility of XBB.1.5
ACE2 binding and antibody evasion in enhanced transmissibility of XBB.1.5 Open