Weiling He
YOU?
Author Swipe
View article: DLGAP5 Promotes Acute Liver Injury via Hepatocyte Pyroptosis-Driven Macrophage Metabolic Reprogramming and M1 Polarization
DLGAP5 Promotes Acute Liver Injury via Hepatocyte Pyroptosis-Driven Macrophage Metabolic Reprogramming and M1 Polarization Open
Pyroptosis is a novel programmed cell death that exists in inflammatory diseases and methyltransferase-like 3 (METTL3) is a core N6-methyladenosine (m6A) modified methyltransferase that has been shown to regulate cell fate. However, the ro…
View article: Beyond polarization: macrophage senescence in immunoregulation and cancer therapy
Beyond polarization: macrophage senescence in immunoregulation and cancer therapy Open
Cancer incidence is increasing globally, presenting significant health challenges due to its severe impact on morbidity and mortality. As a disease closely linked to aging, the prevalence of cancer is expected to increase with increasing a…
View article: NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis
NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis Open
Metastatic colorectal cancer (CRC) cells endure survival challenges, including treatment-induced ferroptosis. While adaptation to ferroptosis stress facilitates metastasis, reciprocal regulatory mechanisms remain unclear. Here, a CRISPR-Ca…
View article: Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription
Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription Open
Hypoxia-induced metabolic reprogramming is closely linked to breast cancer progression. Through transcriptomic analysis, we identified PRMT1 as a direct target of hypoxia-inducible factor 1α (HIF1α) under hypoxic conditions in breast cance…
View article: Single-cell and spatial-resolved profiling reveals cancer-associated fibroblast heterogeneity in colorectal cancer metabolic subtypes
Single-cell and spatial-resolved profiling reveals cancer-associated fibroblast heterogeneity in colorectal cancer metabolic subtypes Open
Our study identified and described the potential protumor biological properties of SFRP2 + CAFs, and AGMAT may be a valuable target for disrupting their properties.
View article: Development and prospects of natural orifice specimen extraction surgery for colorectal cancer: a review article
Development and prospects of natural orifice specimen extraction surgery for colorectal cancer: a review article Open
The natural orifice specimen extraction surgery (NOSES) procedure is an innovative approach to treating colorectal cancer that offers several advantages. First, the NOSES technique is minimally invasive, reducing the incidence of postopera…
View article: Sustained Endocytosis Inhibition via Locally‐Injected Drug‐Eluting Hydrogel Improves ADCC‐Mediated Antibody Therapy in Colorectal Cancer
Sustained Endocytosis Inhibition via Locally‐Injected Drug‐Eluting Hydrogel Improves ADCC‐Mediated Antibody Therapy in Colorectal Cancer Open
The epidermal growth factor receptor (EGFR) is a validated therapeutic target for RAS/RAF wild‐type colorectal cancer (CRC). However, monoclonal antibody‐based anti‐EGFR therapies such as cetuximab have limited effectiveness. Herein, it is…
View article: Cleavage of Homonuclear Chalcogen‐Chalcogen Bonds in a Hybrid Platform in Response to X‐Ray Radiation Potentiates Tumor Radiochemotherapy
Cleavage of Homonuclear Chalcogen‐Chalcogen Bonds in a Hybrid Platform in Response to X‐Ray Radiation Potentiates Tumor Radiochemotherapy Open
Chalcogens are used as sensitive redox‐responsive reagents in tumor therapy. However, chalcogen bonds triggered by external ionizing radiation, rather than by internal environmental stimuli, enable site‐directed and real‐time drug degradat…
View article: MAPK Signaling‐Mediated RFNG Phosphorylation and Nuclear Translocation Restrain Oxaliplatin‐Induced Apoptosis and Ferroptosis
MAPK Signaling‐Mediated RFNG Phosphorylation and Nuclear Translocation Restrain Oxaliplatin‐Induced Apoptosis and Ferroptosis Open
Chemotherapy resistance remains a major challenge in the treatment of colorectal cancer (CRC). Therefore, it is crucial to develop novel strategies to sensitize cancer cells to chemotherapy. Here, the fringe family is screened to determine…
View article: Serotonin signalling in cancer: Emerging mechanisms and therapeutic opportunities
Serotonin signalling in cancer: Emerging mechanisms and therapeutic opportunities Open
Background Serotonin (5‐hydroxytryptamine) is a multifunctional bioamine serving as a neurotransmitter, peripheral hormone and mitogen in the vertebrate system. It has pleiotropic activities in central nervous system and gastrointestinal f…
View article: Transcriptome analysis reveals the molecular mechanism of differences in growth between photoautotrophy and heterotrophy in Chlamydomonas reinhardtii
Transcriptome analysis reveals the molecular mechanism of differences in growth between photoautotrophy and heterotrophy in Chlamydomonas reinhardtii Open
Background The green alga Chlamydomonas reinhardtii can grow photoautotrophically utilizing light and CO 2 , and heterotrophically utilizing acetate. The physiological and biochemical responses of autotrophy and heterotrophy are different …
View article: Prognostic and predictive value of examined lymph node count in stage III colorectal cancer: a population based study
Prognostic and predictive value of examined lymph node count in stage III colorectal cancer: a population based study Open
Background The role of tumor-draining lymph nodes in the progression of malignant tumors, including stage III colorectal cancer (CRC), is critical. However, the prognostic and predictive value of the number of examined lymph nodes (ELNs) a…
View article: A mitochondria-targeting heptamethine cyanine-chlorambucil formulated polymeric nanoparticle to potentiate native tumor chemotherapeutic efficacy
A mitochondria-targeting heptamethine cyanine-chlorambucil formulated polymeric nanoparticle to potentiate native tumor chemotherapeutic efficacy Open
Facile conjugation of chlorambucil with IR775 chloride can afford IR775-Cbl with mitochondria-targeting potency for tumor cells, exhibiting distinct “1 + 1 > 2” tumor inhibition.
View article: New insights into the correlations between circulating tumor cells and target organ metastasis
New insights into the correlations between circulating tumor cells and target organ metastasis Open
Organ-specific metastasis is the primary cause of cancer patient death. The distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic factors in their microenvironme…
View article: Transcriptome analysis reveals the molecular mechanism of differences in growth between photoautotrophy and heterotrophy in Chlamydomonas reinhardtii
Transcriptome analysis reveals the molecular mechanism of differences in growth between photoautotrophy and heterotrophy in Chlamydomonas reinhardtii Open
Background Chlamydomonas reinhardtii can grow photoautotrophically and heterotrophically, and is the typical model species for heterotrophy increasingly cultured in commercial cultivation. By observing their growth changes, transcriptomic…
View article: Engineered a dual-targeting HA-TPP/A nanoparticle for combination therapy against KRAS-TP53 co-mutation in gastrointestinal cancers
Engineered a dual-targeting HA-TPP/A nanoparticle for combination therapy against KRAS-TP53 co-mutation in gastrointestinal cancers Open
KRAS-TP53 co-mutation is strongly associated with poor prognosis and high malignancy in gastrointestinal cancers. Therefore, a novel approach to oncotherapy may lie in combination therapy targeting both KRAS and TP53. Herein, we present a …
View article: Evaluation of colorectal cancer in ulcerative colitis reveals key immune factors during its malignant transformation
Evaluation of colorectal cancer in ulcerative colitis reveals key immune factors during its malignant transformation Open
BACKGROUND & AIMS: Ulcerative colitis (UC) is linked to an increased risk of colitis-associated colorectal cancer (CAC), which accounts for approximately 15% of UC-related deaths. Despite this significant impact on patients, the mechanism …
View article: Novel insights into anticancer mechanisms of elesclomol: More than a prooxidant drug
Novel insights into anticancer mechanisms of elesclomol: More than a prooxidant drug Open
As an essential micronutrient for humans, the metabolism of copper is fine-tuned by evolutionarily conserved homeostatic mechanisms. Copper toxicity occurs when its concentration exceeds a certain threshold, which has been exploited in the…
View article: Supplementary Figures from CD155T/TIGIT Signaling Regulates CD8<sup>+</sup> T-cell Metabolism and Promotes Tumor Progression in Human Gastric Cancer
Supplementary Figures from CD155T/TIGIT Signaling Regulates CD8<sup>+</sup> T-cell Metabolism and Promotes Tumor Progression in Human Gastric Cancer Open
This file includes supplementary data about cell isolation; characteristics of TIGIT+ T cells, T cell glucose metabolism.
View article: Supplementary materials and methods from CD155T/TIGIT Signaling Regulates CD8<sup>+</sup> T-cell Metabolism and Promotes Tumor Progression in Human Gastric Cancer
Supplementary materials and methods from CD155T/TIGIT Signaling Regulates CD8<sup>+</sup> T-cell Metabolism and Promotes Tumor Progression in Human Gastric Cancer Open
This file includes supplementary methods that describe the details of transwell assay, RT-PCR, western blotting, immunohistochemistry and CTC enrichment by NanoVelcro system.
View article: Supplementary Table 2 from CD155T/TIGIT Signaling Regulates CD8<sup>+</sup> T-cell Metabolism and Promotes Tumor Progression in Human Gastric Cancer
Supplementary Table 2 from CD155T/TIGIT Signaling Regulates CD8<sup>+</sup> T-cell Metabolism and Promotes Tumor Progression in Human Gastric Cancer Open
Supplementary Table 2 includes the primers for RT-PCR.
View article: Data from <i>N<sup>6</sup></i>-Methyladenosine Regulates mRNA Stability and Translation Efficiency of KRT7 to Promote Breast Cancer Lung Metastasis
Data from <i>N<sup>6</sup></i>-Methyladenosine Regulates mRNA Stability and Translation Efficiency of KRT7 to Promote Breast Cancer Lung Metastasis Open
The roles of RNA modification during organ metastasis of cancer cells are not known. Here we established breast cancer lung metastasis cells by three rounds of selection of lung metastatic subpopulations in vivo and designated them as BCLM…
View article: Data from CD155T/TIGIT Signaling Regulates CD8<sup>+</sup> T-cell Metabolism and Promotes Tumor Progression in Human Gastric Cancer
Data from CD155T/TIGIT Signaling Regulates CD8<sup>+</sup> T-cell Metabolism and Promotes Tumor Progression in Human Gastric Cancer Open
The T-cell surface molecule TIGIT is an immune checkpoint molecule that inhibits T-cell responses, but its roles in cancer are little understood. In this study, we evaluated the role TIGIT checkpoint plays in the development and progressio…
View article: 7 Supplementary Tables; 16 Supplementary Figures from Development and Validation of a Novel Signature to Predict Overall Survival in “Driver Gene–negative” Lung Adenocarcinoma (LUAD): Results of a Multicenter Study
7 Supplementary Tables; 16 Supplementary Figures from Development and Validation of a Novel Signature to Predict Overall Survival in “Driver Gene–negative” Lung Adenocarcinoma (LUAD): Results of a Multicenter Study Open
Supplementary Table S1 shows the list of primary antibodies used for immunohistochemical staining and immunoblotting assays. Supplementary Table S2 shows the clinical characteristics of 626"driver-gene-negative" LUAD patients from four coh…