Weiling Huang
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View article: PPM1G promotes chemoresistance in triple negative breast cancer by enhancing YAP signaling
PPM1G promotes chemoresistance in triple negative breast cancer by enhancing YAP signaling Open
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with the poorest prognosis. The frequent development of chemoresistance is a major therapeutic challenge, yet the underlying mechanisms remain unclear. Here, we…
View article: Iso-seq profiling of the alternative splicing provides insights into dose-dependent potentiation of sublethal effects in Thrips palmi
Iso-seq profiling of the alternative splicing provides insights into dose-dependent potentiation of sublethal effects in Thrips palmi Open
Sublethal insecticide exposure drives rapid environmental adaptation through transcriptional diversification, yet its molecular mechanisms remain poorly characterized. Here, we integrated Iso-seq full-length transcriptomics and analyses to…
View article: Longitudinal changes in gut microbiota composition during endocrine therapy in hormone receptor-positive breast cancer patients
Longitudinal changes in gut microbiota composition during endocrine therapy in hormone receptor-positive breast cancer patients Open
This prospective study of 90 breast cancer patients examined gut microbiota composition relative to hormone receptor status and endocrine therapy changes. Initial analysis suggested hormone receptor-negative patients had higher Fusobacteri…
View article: The molecular mechanisms and physiological roles of mitochondria dynamics in Saccharomyces cerevisiae
The molecular mechanisms and physiological roles of mitochondria dynamics in Saccharomyces cerevisiae Open
Mitochondria are essential organelles that form a dynamic network within cells. The fusion, fission, and transport processes among mitochondria must reach a balance, which is achieved through complex regulatory mechanisms. These dynamic pr…
View article: Unveiling the anticancer potential of flavonoids in hepatocellular carcinoma through microbiome and spatially resolved metabolomics analysis
Unveiling the anticancer potential of flavonoids in hepatocellular carcinoma through microbiome and spatially resolved metabolomics analysis Open
This research sheds new light on Artemisia rupestris L.'s anticancer potential, setting the platform for a more in-depth knowledge of its influence on hepatocellular carcinoma using a multi-omics approach.
View article: Retrospective comparative survival analysis of ablation plus systemic therapy versus systemic therapy alone for breast cancer liver metastases, stratified by extrahepatic metastases status
Retrospective comparative survival analysis of ablation plus systemic therapy versus systemic therapy alone for breast cancer liver metastases, stratified by extrahepatic metastases status Open
Among patients with BCLM (≤3 tumors, each ≤3 cm), AS provide longer survival compared to systemic therapy alone, even with extrahepatic metastases. For patients with larger or more numerous metastases (>3 cm or >3 lesions), AS may provide …
View article: Lethal and Sublethal Effects of the Novel Cis-Nitromethylene Neonicotinoid Cycloxaprid on the Green Peach Aphid, Myzus Persicae (Sulzer) (Hemiptera: Aphididae)
Lethal and Sublethal Effects of the Novel Cis-Nitromethylene Neonicotinoid Cycloxaprid on the Green Peach Aphid, Myzus Persicae (Sulzer) (Hemiptera: Aphididae) Open
View article: Automated chain architecture screening for discovery of block copolymer assembly with graph enhanced self-consistent field theory
Automated chain architecture screening for discovery of block copolymer assembly with graph enhanced self-consistent field theory Open
The diverse chain architectures of block copolymers makes them important for exploring new self-assembly, but poses significant challenges for identifying the stability windows of desired mesophases within the vast parameter space. Here, w…
View article: Metastatic dedifferentiated liposarcoma of the mediastinum with osteosarcomatous differentiation: A case report
Metastatic dedifferentiated liposarcoma of the mediastinum with osteosarcomatous differentiation: A case report Open
Rationale: Liposarcoma is a malignant tumor of adipocytic differentiation that rarely arises within the mediastinum. Most of the existing data available comes from scattered case reports and a few small series. Patient concerns: A 51-year-…
View article: Soft X-ray tomography analysis of mitochondria dynamics in Saccharomyces cerevisiae
Soft X-ray tomography analysis of mitochondria dynamics in Saccharomyces cerevisiae Open
Background Mitochondria are highly dynamic organelles that constantly undergo processes of fission and fusion. The changes in mitochondrial dynamics shape the organellar morphology and influence cellular activity regulation. Soft X-ray tom…
View article: Contrast-enhanced ultrasound findings of sclerotic nodules in Wilson disease: A case report
Contrast-enhanced ultrasound findings of sclerotic nodules in Wilson disease: A case report Open
Rationale: Wilson disease is an autosomal recessive genetic disease found by Samuel Alexander Kinnier Wilson and prevalent in childhood and adolescents. Patient concerns: An 18-year-old female patient presented to our hospital with a conti…
View article: Prediction model of in‐hospital cardiac arrest using machine learning in the early phase of hospitalization
Prediction model of in‐hospital cardiac arrest using machine learning in the early phase of hospitalization Open
In hospitals, the deterioration of a patient's condition leading to death is often preceded by physiological abnormalities in the hours to days beforehand. Several risk‐scoring systems have been developed to identify patients at risk of ma…
View article: The first embryonic landscape of G-quadruplexes related to myogenesis
The first embryonic landscape of G-quadruplexes related to myogenesis Open
This comprehensive study unravels the first embryonic genomic G4s landscape, highlighting the regulatory role of NFATC2 G4 in orchestrating transcriptional activity through promoter DNA methylation during myogenesis.
View article: SDHAF2 facilitates mitochondrial respiration through stabilizing succinate dehydrogenase and cytochrome c oxidase assemblies
SDHAF2 facilitates mitochondrial respiration through stabilizing succinate dehydrogenase and cytochrome c oxidase assemblies Open
Succinate dehydrogenase (SDH) plays pivotal roles in maintaining cellular metabolism, modulating regulatory control over both the tricarboxylic acid cycle and oxidative phosphorylation to facilitate energy production within mitochondria. G…
View article: MCMV-infected maize attracts its insect vector Frankliniella occidentalis by inducing β-myrcene
MCMV-infected maize attracts its insect vector Frankliniella occidentalis by inducing β-myrcene Open
Maize lethal necrosis is attributed to the accumulation of maize chlorotic mottle virus (MCMV), an invasive virus transmitted by insect vectors. The western flower thrips (WFT) can shift host to maize, thus promoting the spread of MCMV. Ho…
View article: Insights into distinct signaling profiles of the µOR activated by diverse agonists
Insights into distinct signaling profiles of the µOR activated by diverse agonists Open
Drugs targeting the μ-opioid receptor (μOR) are the most effective analgesics available but are also associated with fatal respiratory depression through a pathway that remains unclear. Here we investigated the mechanistic basis of action …
View article: Development of a nomogram for predicting survival of breast cancer patients with neoadjuvant chemotherapy: a dynamic analysis for systemic inflammation response index
Development of a nomogram for predicting survival of breast cancer patients with neoadjuvant chemotherapy: a dynamic analysis for systemic inflammation response index Open
The baseline SIRI and SIRI change after NACT could act as potential biomarkers for predicting survival outcomes in breast cancer. Besides, the nomogram with SIRI is an economic and convenient tool for predicting DFS. Larger prospective stu…
View article: Prognostic value of comprehensive typing based on m6A and gene cluster in TNBC
Prognostic value of comprehensive typing based on m6A and gene cluster in TNBC Open
View article: A missense mutation in ISPD contributes to maintain muscle fiber stability
A missense mutation in ISPD contributes to maintain muscle fiber stability Open
View article: Chicken Protein S Gene Regulates Adipogenesis and Affects Abdominal Fat Deposition
Chicken Protein S Gene Regulates Adipogenesis and Affects Abdominal Fat Deposition Open
(1) Background: Excessive abdominal fat deposition in broilers not only causes feed waste but also leads to a series of metabolic diseases. It has gradually become a new breeding goal of the broiler industry to improve growth rates and to …
View article: A nomogram based on clinical factors for preoperative prediction of nipple involvement in breast cancer
A nomogram based on clinical factors for preoperative prediction of nipple involvement in breast cancer Open
Background At present, the indication for nipple-sparing mastectomy (NSM) remains inconclusive, and occult nipple involvement (NI) is one of the most important problems when carrying out NSM. Therefore, we aimed to identify the predictive …
View article: Prognostic value of comprehensive typing based on m6A and gene cluster
Prognostic value of comprehensive typing based on m6A and gene cluster Open
Background Triple-negative breast cancer (TNBC) is resistant to targeted therapy with HER2 monoclonal antibodies and endocrine therapy because it lacks the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth fact…
View article: Breast Cancer Subtypes Based on Hypoxia-Related Gene Sets Identify Potential Therapeutic Agents
Breast Cancer Subtypes Based on Hypoxia-Related Gene Sets Identify Potential Therapeutic Agents Open
Purpose: The hypoxic tumor microenvironment was reported to be involved in different tumorigenesis mechanisms of breast cancer (BC). We aimed to establish a hypoxia-related gene signature to identify a new BC subtype through the clustering…
View article: Peripheral blood lymphocytes subtypes as new predictors for neoadjuvant therapy efficacy in breast cancer
Peripheral blood lymphocytes subtypes as new predictors for neoadjuvant therapy efficacy in breast cancer Open
Background Host immunity plays an important role in tumor development and treatment. Tumor‐infiltrating lymphocytes (TILs) have been proven to predict the efficacy of neoadjuvant therapy (NAT) in breast cancer (BC) patients, but their appl…
View article: A Prognostic Model for Breast Cancer Based on Cancer Incidence-Related DNA Methylation Pattern
A Prognostic Model for Breast Cancer Based on Cancer Incidence-Related DNA Methylation Pattern Open
Breast cancer (BC) is the most diagnosed cancer and the leading cause of cancer-related deaths in women. The purpose of this study was to develop a prognostic model based on BC-related DNA methylation pattern. A total of 361 BC incidence-r…
View article: bFGF stimulated plasminogen activation factors, but inhibited alkaline phosphatase and SPARC in stem cells from apical Papilla: Involvement of MEK/ERK, TAK1 and p38 signaling
bFGF stimulated plasminogen activation factors, but inhibited alkaline phosphatase and SPARC in stem cells from apical Papilla: Involvement of MEK/ERK, TAK1 and p38 signaling Open
bFGF may regulate fibrinolysis and matrix turnover via modulation of PAI-1, uPA, uPAR, and TIMP-1, but bFGF inhibited the differentiation (ALP, SPARC) of SCAP. These events are mainly regulated by MEK/ERK, p38, and TAK1. Combined use of bF…
View article: Whole Transcriptome Analysis Reveals a Potential Regulatory Mechanism of LncRNA-FNIP2/miR-24-3p/FNIP2 Axis in Chicken Adipogenesis
Whole Transcriptome Analysis Reveals a Potential Regulatory Mechanism of LncRNA-FNIP2/miR-24-3p/FNIP2 Axis in Chicken Adipogenesis Open
Lipid biosynthesis is a complex process, which is regulated by multiple factors including lncRNA. However, the role of lncRNA in chicken abdominal fat accumulation is still unclear. In this research, we collected liver tissues from six hig…
View article: A Crucial Role of Mitochondrial Dynamics in Dehydration Resistance in Saccharomyces cerevisiae
A Crucial Role of Mitochondrial Dynamics in Dehydration Resistance in Saccharomyces cerevisiae Open
Mitochondria are dynamic organelles as they continuously undergo fission and fusion. These dynamic processes conduct not only mitochondrial network morphology but also activity regulation and quality control. Saccharomyces cerevisiae has a…
View article: The Associated Clinicopathologic Characteristics of Nipple-Areola Complex Involvement in Breast Cancer
The Associated Clinicopathologic Characteristics of Nipple-Areola Complex Involvement in Breast Cancer Open
Background. At present,the indication for nipple-sparing mastectomy（NSM）remains inconclusive,and the occult NAC involvement （NI）is one of the most considerable problem when carrying out NSM.We aimed at identifying the predictive factors of…
View article: Detector calibration based on secondary protons of Back-n white neutron source
Detector calibration based on secondary protons of Back-n white neutron source Open
At present, there exist few proton-beam terminals for the detector calibration in the world. Meanwhile, most of these terminals provide monoenergetic protons. Back-n white neutron source from China Spallation Neutron Source(CSNS) was put i…