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View article: The genetic architecture of brainstem structures
The genetic architecture of brainstem structures Open
The brainstem houses numerous nuclei and tracts that serve vital functions. Genome-wide associations with brainstem substructure volumes have been explored in European individuals, yet other ancestries remain under-represented. Here, we co…
View article: Sarcopenia risk along the cardiovascular-kidney-metabolic syndrome spectrum: synergistic effects of multisystem burden and physical inactivity
Sarcopenia risk along the cardiovascular-kidney-metabolic syndrome spectrum: synergistic effects of multisystem burden and physical inactivity Open
View article: Mitigating Inter-Scanner Heterogeneity in Brain MRI Data: Assessing Its Impact on Association Analyses and the Effectiveness of ComBat Harmonization in Multi-Site Neuroimaging Studies
Mitigating Inter-Scanner Heterogeneity in Brain MRI Data: Assessing Its Impact on Association Analyses and the Effectiveness of ComBat Harmonization in Multi-Site Neuroimaging Studies Open
View article: Genome‐Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes
Genome‐Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes Open
Brain structure and function show substantial individual differences, finely controlled by genes, environments, and their interactions. Despite the increasing knowledge about genetic and environmental main effects, gene‐environment interac…
View article: Resolving the heterogeneity of dopamine subsystems dysfunction in schizophrenia: a PET meta-analysis
Resolving the heterogeneity of dopamine subsystems dysfunction in schizophrenia: a PET meta-analysis Open
The “dopamine hypothesis” of schizophrenia suggests the imbalance of the brain dopamine system plays a crucial role in the development of this disorder. Although this hypothesis has been partly supported by early studies, the brain region-…
View article: Genetic underpinnings and causal effects of brain structure and function on chronic pain intensity
Genetic underpinnings and causal effects of brain structure and function on chronic pain intensity Open
View article: Structural atrophy and functional disturbance in the thalamic nuclei of patients with amyotrophic lateral sclerosis
Structural atrophy and functional disturbance in the thalamic nuclei of patients with amyotrophic lateral sclerosis Open
Selective structural and functional damage to thalamic subregions is a feature of ALS and could potentially contribute to future diagnostic approaches and assessments of disease severity.
View article: Altered brain structural covariance networks of the thalamic subfields in right chronic capsular stroke
Altered brain structural covariance networks of the thalamic subfields in right chronic capsular stroke Open
Background The thalamus, along with its component nuclei, possesses extensive connections with various brain regions and is engaged in diverse functions. However, it is unknown whether the gray matter volume (GMV) covariance networks of th…
View article: A Chain-of-thought Reasoning Breast Ultrasound Dataset Covering All Histopathology Categories
A Chain-of-thought Reasoning Breast Ultrasound Dataset Covering All Histopathology Categories Open
Breast ultrasound (BUS) is an essential tool for diagnosing breast lesions, with millions of examinations per year. However, publicly available high-quality BUS benchmarks for AI development are limited in data scale and annotation richnes…
View article: Potential effects of future climate change on global <i>Taxus</i> distributions and diversity
Potential effects of future climate change on global <i>Taxus</i> distributions and diversity Open
Taxus has unique survival adaptability and climate sensitivity, reflecting the evolutionary characteristics of gymnosperms. It is also an indicator species threatened by climate change, with the most representative endangered species. Beca…
View article: An adaptive traditional Chinese herbal medicine image recognition model via ED-HLOA-optimized DenseNet201
An adaptive traditional Chinese herbal medicine image recognition model via ED-HLOA-optimized DenseNet201 Open
Research shows that ginseng, fritillaria cirrhosa and other Chinese herbal medicines and their active components can fight tumors via immune regulation, apoptosis induction, and signaling pathway modulation. Thus, deep learning-based for a…
View article: Genetic Susceptibility to Cardio‐Cerebrovascular Diseases and White Matter Integrity in Asymptomatic Older Adults: A <scp>UK</scp> Biobank Observational Cohort Study
Genetic Susceptibility to Cardio‐Cerebrovascular Diseases and White Matter Integrity in Asymptomatic Older Adults: A <span>UK</span> Biobank Observational Cohort Study Open
Background Cardio‐cerebrovascular diseases are linked to neuroanatomical changes that may arise from genetic risk profiles, with structural brain alterations often preceding clinical onset. The pathways connecting genetic susceptibility to…
View article: High-speed coherent optical encryption/decryption system based on cross-phase encoding
High-speed coherent optical encryption/decryption system based on cross-phase encoding Open
The optical network supporting emerging bandwidth-intensive services has become the cornerstone of the 5G era. However, the development of optical fiber eavesdropping and quantum computing has brought huge security challenges to traditiona…
View article: Personalized brain functional sectors guided theta burst transcranial magnetic stimulation for treatment-resistant depression: a study protocol for a multi-centre, randomised, double-blind, sham-controlled clinical trial
Personalized brain functional sectors guided theta burst transcranial magnetic stimulation for treatment-resistant depression: a study protocol for a multi-centre, randomised, double-blind, sham-controlled clinical trial Open
Introduction Depression is characterised by disruptions in brain circuitry, and interventions like intermittent theta burst stimulation (iTBS) offer the potential for normalising these circuits and improving clinical symptoms. However, per…
View article: Deep-learning segmentation and multi-ancestry GWAS enhance genetic discovery of the cerebellum
Deep-learning segmentation and multi-ancestry GWAS enhance genetic discovery of the cerebellum Open
The genetic architecture of cerebellar substructure volumes is crucial for understanding their functions in cognition, emotion, and neuropsychiatric disorders. We utilized deep-learning segmentation and multi-ancestry analysis to identify …
View article: Deciphering the Heterogeneity of Schizophrenia: A Multimodal and Multivariate Neuroimaging Framework for Unveiling Brain-Symptom Relationships and Underlying Subtypes
Deciphering the Heterogeneity of Schizophrenia: A Multimodal and Multivariate Neuroimaging Framework for Unveiling Brain-Symptom Relationships and Underlying Subtypes Open
Background and Hypothesis Schizophrenia manifests large heterogeneities in either symptoms or brain abnormalities. However, the neurobiological basis of symptomatic diversity remains poorly understood. We hypothesized that schizophrenia’s …
View article: Regional Gene Expression Patterns are Associated with Functional Connectivity Alterations in Major Depressive Disorder with Anxiety Symptoms
Regional Gene Expression Patterns are Associated with Functional Connectivity Alterations in Major Depressive Disorder with Anxiety Symptoms Open
Background: Understanding gene expression and functional connectivity (FC) changes in depressed patients with anxiety can help develop personalized therapies. Herein we examine the link between transcriptome data and FC differences in pati…
View article: A Foundational Generative Model for Breast Ultrasound Image Analysis
A Foundational Generative Model for Breast Ultrasound Image Analysis Open
Foundational models have emerged as powerful tools for addressing various tasks in clinical settings. However, their potential development to breast ultrasound analysis remains untapped. In this paper, we present BUSGen, the first foundati…
View article: Identification of genetic architecture shared between schizophrenia and Alzheimer’s disease
Identification of genetic architecture shared between schizophrenia and Alzheimer’s disease Open
Both schizophrenia (SCZ) and Alzheimer's disease (AD) are highly heritable brain disorders. Despite of the observed comorbidity and shared psychosis and cognitive decline between the two disorders, the genetic risk architecture shared by S…
View article: Cross-ancestry and sex-stratified genome-wide association analyses of brain white matter principal components
Cross-ancestry and sex-stratified genome-wide association analyses of brain white matter principal components Open
White matter microstructure determines effective communications across brain regions, which can be better characterized by tract-specific principal components from diffusion tensor imaging data. Although genome-wide associations with tract…
View article: Genetic and neural mechanisms shared by schizophrenia and depression
Genetic and neural mechanisms shared by schizophrenia and depression Open
Schizophrenia (SCZ) and depression are two prevalent mental disorders characterized by comorbidity and overlapping symptoms, yet the underlying genetic and neural mechanisms remain largely elusive. Here, we investigated the genetic variant…
View article: Application progress and future prospects of smart wearable devices in postoperative rehabilitation of lower limb fractures: A mini review
Application progress and future prospects of smart wearable devices in postoperative rehabilitation of lower limb fractures: A mini review Open
View article: Subjective Well-being: A Key to Bridge Urbanization, Brain and Mental Health
Subjective Well-being: A Key to Bridge Urbanization, Brain and Mental Health Open
The pursuit of happiness is a lifelong endeavor for everyone; nevertheless, elucidating its etiology, neurobiological substrates, and implications for mental health continues to pose significant challenges in contemporary research. This st…
View article: Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis
Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis Open
Treating osteoarthritis (OA) associated pain is a challenge with the potential to significantly improve patients lives. Here, we report on a hydrogel for extracellular RNA scavenging and releasing bevacizumab to block neurovascularization …
View article: A Foundational Generative Model for Breast Ultrasound Image Analysis
A Foundational Generative Model for Breast Ultrasound Image Analysis Open
Foundational models have emerged as powerful tools for addressing various tasks in clinical settings. However, their potential development to breast ultrasound analysis remains untapped. In this paper, we present BUSGen, the first foundati…
View article: Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain
Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain Open
Temporomandibular joint osteoarthritis (TMJ-OA) is a common disease often accompanied by pain, seriously affecting physical and mental health of patients. Abnormal innervation at the osteochondral junction has been considered as a predomin…
View article: Associations of plasma biomarkers with cerebral perfusion and structure in Alzheimer’s disease
Associations of plasma biomarkers with cerebral perfusion and structure in Alzheimer’s disease Open
View article: Reorganization of cortical individualized differential structural covariance network is associated with regional morphometric changes in chronic subcortical stroke
Reorganization of cortical individualized differential structural covariance network is associated with regional morphometric changes in chronic subcortical stroke Open
View article: Reduced Cortical Surface Area in the Frontal Operculum as a Causal Risk Predictor for Chronic Pain
Reduced Cortical Surface Area in the Frontal Operculum as a Causal Risk Predictor for Chronic Pain Open
Chronic pain is a prevalent and debilitating condition that imposes substantial personal and societal burdens. Despite its significance, the neural mechanisms underlying individual susceptibility to chronic pain remain inadequately underst…
View article: Architectural Form Generation Driven by Text-Guided Generative Modeling Based on Intent Image Reconstruction and Multi-Criteria Evaluation
Architectural Form Generation Driven by Text-Guided Generative Modeling Based on Intent Image Reconstruction and Multi-Criteria Evaluation Open