Weilu Kuang
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View article: A novel telomere-associated genes signature for the prediction of prognosis and treatment responsiveness of hepatocellular carcinoma
A novel telomere-associated genes signature for the prediction of prognosis and treatment responsiveness of hepatocellular carcinoma Open
In this study, we developed a novel prognostic model comprising 18 TRGs for HCC, which exhibited remarkable accuracy in predicting HCC patients' prognosis. Additionally, through MR analysis, we have successfully established a causal relati…
View article: Valproic acid regulates the miR-155/Jarid2 axis by affecting miR-155 promoter methylation in glioma
Valproic acid regulates the miR-155/Jarid2 axis by affecting miR-155 promoter methylation in glioma Open
The most frequent primary brain tumor in adults is glioma, yet no effective curative treatments are currently available. Our previous study demonstrated the enhancing effects of JARID2 on glioma sensitivity to TMZ treatment. In this study,…
View article: Prediction of a lncRNA-miRNA co-expression network as a prognostic marker in glioblastoma
Prediction of a lncRNA-miRNA co-expression network as a prognostic marker in glioblastoma Open
Glioblastoma has the characteristics of high proliferation and high metastasis; it has become one of the most difficult tumors to treat in clinic. Recently, more and more attention has been paid to the role of competitive endogenous RNA (c…
View article: [Retracted] MicroRNA‑181 serves an oncogenic role in breast cancer via the inhibition of SPRY4
[Retracted] MicroRNA‑181 serves an oncogenic role in breast cancer via the inhibition of SPRY4 Open
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the Transwell cell migration assay data shown in Figs. 3B and 9B were strikingly similar to data appearing in different form in othe…
View article: The function and mechanism of the JARID2/CCND1 axis in modulating glioma cell growth and sensitivity to temozolomide (TMZ)
The function and mechanism of the JARID2/CCND1 axis in modulating glioma cell growth and sensitivity to temozolomide (TMZ) Open
A maximal surgical resection followed by radiotherapy and chemotherapy with temozolomide (TMZ) as the representative agent is the standard therapy for gliomas. However, tumor cell resistance to radiotherapy and chemotherapy leads to poor p…
View article: LncRNA H19 promotes glioma angiogenesis through miR-138/HIF-1α/VEGF axis
LncRNA H19 promotes glioma angiogenesis through miR-138/HIF-1α/VEGF axis Open
Glioma is one of the most common and aggressive malignant primary brain tumors with high recurrence rate and mortality rate and heavily depends on the angiogenesis. LncRNA H19 has many diverse biological functions, including the regulation…
View article: Long non‑coding RNA DLX6‑AS1 silencing inhibits malignant phenotypes of gastric cancer cells
Long non‑coding RNA DLX6‑AS1 silencing inhibits malignant phenotypes of gastric cancer cells Open
It has been revealed that long non-coding RNAs (lncRNAs) serve a key role in various malignancies, including gastric cancer (GC). In the present study, the expression and function of lncRNA distal-less homeobox 6 antisense 1 (DLX6-AS1) in …
View article: Downregulation of iASPP Expression Suppresses Proliferation, Invasion and Increases Chemosensitivity to Paclitaxel of Head and Neck Squamous Cell Carcinoma In Vitro
Downregulation of iASPP Expression Suppresses Proliferation, Invasion and Increases Chemosensitivity to Paclitaxel of Head and Neck Squamous Cell Carcinoma In Vitro Open
Objective Our previous study has revealed that iASPP is elevated in human head and neck squamous cell carcinoma (HNSCC) and iASPP overexpression signifcantly correlates with tumor malignant progression and poor survival of HNSCC. This stud…
View article: MicroRNA‑181 serves an oncogenic role in breast cancer via the inhibition of SPRY4
MicroRNA‑181 serves an oncogenic role in breast cancer via the inhibition of SPRY4 Open
Numerous microRNAs (miRs) have been implicated in breast cancer; however, the molecular mechanism is not fully understood. The present study examined the function and regulatory mechanism of miR‑181 in breast cancer. Reverse transcription‑…
View article: TGF-β1 secreted by M2 phenotype macrophages enhances the stemness and migration of glioma�cells via the SMAD2/3 signalling pathway
TGF-β1 secreted by M2 phenotype macrophages enhances the stemness and migration of glioma�cells via the SMAD2/3 signalling pathway Open
The positive correlation between the number of M2 phenotype TAMs (M2‑TAMs) and tumour development suggests a supportive role of M2‑TAMs in glioma progression. In the present study, the molecular link between glioma cells and M2‑TAMs was in…