Weilun Pan
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View article: Dual stimulus-responsive dECM cryogel sequentially regulate bone microenvironment for one-step surgical therapy of chronic osteomyelitis
Dual stimulus-responsive dECM cryogel sequentially regulate bone microenvironment for one-step surgical therapy of chronic osteomyelitis Open
Combining disinfection and bone regeneration in a one-step treatment is of significant clinical importance for chronic osteomyelitis, yet it remains a considerable challenge. To address this, we developed a dual stimulus-responsive decellu…
View article: Natural Turmeric‐Derived Nanovesicles‐Laden Metal‐Polyphenol Hydrogel Synergistically Restores Skin Barrier in Atopic Dermatitis via a Dual‐Repair Strategy
Natural Turmeric‐Derived Nanovesicles‐Laden Metal‐Polyphenol Hydrogel Synergistically Restores Skin Barrier in Atopic Dermatitis via a Dual‐Repair Strategy Open
Skin barrier impairment is critical in the development of atopic dermatitis (AD), increasing vulnerability to external pathogens and disrupting cell metabolism, which leads to inflammatory stress and immune imbalance. In this study, a natu…
View article: Hypoxia‐Responsive Covalent Organic Framework Nanoplatform for Breast‐Cancer‐Targeted Cocktail Immunotherapy via Triple Therapeutic Switch Mechanisms
Hypoxia‐Responsive Covalent Organic Framework Nanoplatform for Breast‐Cancer‐Targeted Cocktail Immunotherapy via Triple Therapeutic Switch Mechanisms Open
Covalent organic frameworks (COFs), known for their exceptional in situ encapsulation and precise release capabilities, are emerging as pioneering drug delivery systems. This study introduces a hypoxia‐responsive COF designed to encapsulat…
View article: Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility
Engineered RBC-derived nanovesicles functionalized with tumor-targeting ligands: A comparative study on breast cancer targeting efficiency and biocompatibility Open
Introduction Cell membrane-derived nanovesicles, particularly those originating from red blood cells (RNVs), have garnered considerable attention as innovative drug delivery vehicles in oncology, owing to their exceptional biocompatibility…
View article: Co-freezing localized CRISPR-Cas12a system enables rapid and sensitive nucleic acid analysis
Co-freezing localized CRISPR-Cas12a system enables rapid and sensitive nucleic acid analysis Open
Rapid and sensitive nucleic acid detection is vital in disease diagnosis and therapeutic assessment. Herein, we propose a co-freezing localized CRISPR-Cas12a (CL-Cas12a) strategy for sensitive nucleic acid detection. The CL-Cas12a was obta…
View article: Turmeric‐Derived Nanoparticles Functionalized Aerogel Regulates Multicellular Networks to Promote Diabetic Wound Healing
Turmeric‐Derived Nanoparticles Functionalized Aerogel Regulates Multicellular Networks to Promote Diabetic Wound Healing Open
Regulation of excessive inflammation and impaired cell proliferation is crucial for healing diabetic wounds. Although plant‐to‐mammalian regulation offers effective approaches for chronic wound management, the development of a potent plant…
View article: Biomimetic anisotropic macroporous cryogel promotes the repair of osteoporotic bone defects through altering the ROS niche via down-regulating the ROMO1
Biomimetic anisotropic macroporous cryogel promotes the repair of osteoporotic bone defects through altering the ROS niche via down-regulating the ROMO1 Open
Background Osteoporosis is a systemic bone disease prone to fractures due to decreased bone density and bone quality. The pathological environment of osteoporosis interferes with the normal process of fracture healing. The clinical regener…
View article: Selective Photothermal Therapy Based on Lipopolysaccharide Aptamer Functionalized MoS<sub>2</sub> Nanosheet‐Coated Gold Nanorods for Multidrug‐Resistant <i>Pseudomonas aeruginosa</i> Infection (Adv. Healthcare Mater. 15/2023)
Selective Photothermal Therapy Based on Lipopolysaccharide Aptamer Functionalized MoS<sub>2</sub> Nanosheet‐Coated Gold Nanorods for Multidrug‐Resistant <i>Pseudomonas aeruginosa</i> Infection (Adv. Healthcare Mater. 15/2023) Open
Targeted Photothermal Therapy Combined with the outstanding photothermal conversion efficiency of gold nanorods (AuNRs), superior biocompatibility of molybdenum disulfide (MoS2) nanosheets, and strong specificity of lipopolysaccharides apt…
View article: Immunogenic radiation therapy for enhanced anti-tumor immunity <i>via</i> core-shell nanocomposite-mediated multiple strategies
Immunogenic radiation therapy for enhanced anti-tumor immunity <i>via</i> core-shell nanocomposite-mediated multiple strategies Open
Background: Due to the immunosuppressive tumor microenvironment (TME), radiation therapy (RT)-mediated immune response is far from satisfactory. How to improve the efficacy of immunogenic RT by priming strong immunogenic cell death (ICD) i…
View article: Multiplexed analysis of small extracellular vesicle-derived mRNAs by droplet digital PCR and machine learning improves breast cancer diagnosis
Multiplexed analysis of small extracellular vesicle-derived mRNAs by droplet digital PCR and machine learning improves breast cancer diagnosis Open
Breast cancer has become the leading cause of global cancer incidence and a serious threat to women's health. Accurate diagnosis and early treatment are of great importance to prognosis. Although clinically used diagnostic approaches can b…
View article: EDTA-K2 Improves the Detection Sensitivity of SARS-CoV-2 IgM and IgG Antibodies by Chelating Colloidal Gold in the Immunochromatographic Assay
EDTA-K2 Improves the Detection Sensitivity of SARS-CoV-2 IgM and IgG Antibodies by Chelating Colloidal Gold in the Immunochromatographic Assay Open
GICA is widely used to detect antibodies for the advantages of convenient, fast, low cost, suitable for screening large sample and require minimal equipment. In this study, we found that EDTA-K2 amplified the positive antibody signal by ch…
View article: The future of Extracellular Vesicles as Theranostics – an ISEV meeting report
The future of Extracellular Vesicles as Theranostics – an ISEV meeting report Open
The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced in the past decade. In November 2018, the International Society for Extracellular Vesicles (ISEV) held a workshop on “EVs in Clinical Theranostic…