Wei‐Ming Chen
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View article: Comparative Analysis of Potential Fire Behavior Among Three Typical Tree Species Fuel Loads in Central Yunnan Region
Comparative Analysis of Potential Fire Behavior Among Three Typical Tree Species Fuel Loads in Central Yunnan Region Open
Potential fire behavior varied significantly among tree species, directly influencing forest fire intensity and spread. To quantify these differences and evaluate species-specific fuel traits for fire management applications, this study co…
View article: Circulating miRNAs as potentially predictive biomarkers for chemoimmunotherapy in advanced biliary tract cancer: a post-hoc analysis of the phase II T1219 study
Circulating miRNAs as potentially predictive biomarkers for chemoimmunotherapy in advanced biliary tract cancer: a post-hoc analysis of the phase II T1219 study Open
View article: Transcriptome sequencing reveals significant RNA variation in human sperm samples
Transcriptome sequencing reveals significant RNA variation in human sperm samples Open
View article: Prognostic nomogram for overall survival in pediatric osteosarcoma with pulmonary metastases: a SEER database analysis
Prognostic nomogram for overall survival in pediatric osteosarcoma with pulmonary metastases: a SEER database analysis Open
Background Pulmonary metastasis (PM) is the most common site of distant metastasis in osteosarcoma (OS), particularly in pediatric cases, which are associated with poor prognosis. However, limited research has focused on identifying progno…
View article: The Extract of <em>Polygonum capitatum</em> Alleviates Hyperoxaluria-Induced Oxidative Stress by Targeting the PI3K-ERK-NRF2 Signaling Pathway.
The Extract of <em>Polygonum capitatum</em> Alleviates Hyperoxaluria-Induced Oxidative Stress by Targeting the PI3K-ERK-NRF2 Signaling Pathway. Open
View article: Transcriptome Sequencing Reveals Significant RNA Variation in Human Sperm Samples
Transcriptome Sequencing Reveals Significant RNA Variation in Human Sperm Samples Open
As spermatocytes mature, they shed substantial cellular material, resulting in sperm cells that primarily contain DNA. Sperm cells variation in RNA has not been addressed in the literature. We analyzed semen samples from 83 males, with nor…
View article: High-dose chemotherapy with autologous stem cell rescue in children and young adults with high-risk Ewing sarcoma
High-dose chemotherapy with autologous stem cell rescue in children and young adults with high-risk Ewing sarcoma Open
Background: A combination treatment of surgery, chemotherapy, and radiotherapy can improve the survivals of pediatric patients with Ewing sarcoma (ES). However, prognosis remains poor for patients with metastatic disease at diagnosis or re…
View article: Evaluating the Effectiveness of a Structural Allograft in Medial Open Wedge High Tibial Osteotomy in Patients With and Without a Lateral Hinge Fracture
Evaluating the Effectiveness of a Structural Allograft in Medial Open Wedge High Tibial Osteotomy in Patients With and Without a Lateral Hinge Fracture Open
Background: A lateral hinge fracture is a common complication in medial open wedge high tibial osteotomy (MOWHTO) and is associated with delayed union or nonunion. A comparison of outcomes between patients with or without a lateral hinge f…
View article: Novel DPY19L2 mutation locus causes globozoospermia
Novel DPY19L2 mutation locus causes globozoospermia Open
Spermatozoa acrosome abnormalities are a rare and severe form of male infertility caused by structural abnormalities of the sperm acrosome or acrosomal enzyme abnormalities, which usually present as round-headed spermatozoa with loss of sp…
View article: Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp
Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp Open
The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 plays a pivotal role in the life cycle of the novel coronavirus and stands as a significant and promising target for anti-SARS-CoV-2 drugs. Non-nucleoside inhibitors (NNIs), as a catego…
View article: Weight Gain and Increased Body Mass Index in Patients with Hepatitis C after Eradication Using Direct-Acting Antiviral Therapy in Taiwan
Weight Gain and Increased Body Mass Index in Patients with Hepatitis C after Eradication Using Direct-Acting Antiviral Therapy in Taiwan Open
Few studies have reported weight gain in patients with hepatitis C virus (HCV) infection treated with direct-acting antiviral agents (DAAs). This retrospective cohort study identified factors associated with substantial weight gain after D…
View article: Safety and Tolerability of Intra-Articular Injection of Adipose-Derived Mesenchymal Stem Cells GXCPC1 in 11 Subjects With Knee Osteoarthritis: A Nonrandomized Pilot Study Without a Control Arm
Safety and Tolerability of Intra-Articular Injection of Adipose-Derived Mesenchymal Stem Cells GXCPC1 in 11 Subjects With Knee Osteoarthritis: A Nonrandomized Pilot Study Without a Control Arm Open
The current study aimed to determine the safety profile of intra-articular-injected allogeneic adipose-derived mesenchymal stem cells (ADSCs) GXCPC1 in subjects with knee osteoarthritis (OA) and its preliminary efficacy outcome. The 3 + 3 …
View article: Research on Expansion of the Export Paths of Developing Aquatic Products in Hainan Province
Research on Expansion of the Export Paths of Developing Aquatic Products in Hainan Province Open
Hainan Province is rich in marine resources, and the marine economy is one of the exceptional advantages of Hainan Province's economic development. As the eleventh free trade zone opened by China, Hainan Province, as a province supported b…
View article: Perioperative complications of using freezing nitrogen ethanol composite to treat bone tumors: Clinical experience from a single center
Perioperative complications of using freezing nitrogen ethanol composite to treat bone tumors: Clinical experience from a single center Open
Background: The cryoablation efficacy of semisolid freezing nitrogen ethanol composite (FNEC) has been demonstrated. We aimed to investigate the feasibility of adjuvant FNEC–assisted cryoablation in different bone cavity types by assessing…
View article: Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies
Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies Open
Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators (e.g., inhibitors)…
View article: A therapeutic dose and its pharmacokinetics of ropeginterferon Alfa-2b for hepatitis C treatment
A therapeutic dose and its pharmacokinetics of ropeginterferon Alfa-2b for hepatitis C treatment Open
Ropeginterferon alfa-2b at 400 μg led to PK exposures associated with safety and notable clinical activity in patients with chronic HCV. This study suggests that ropeginterferon alfa-2b at 400 μg is an acceptable dosing regimen for treatin…
View article: Melittin acupoint injection in attenuating bone erosion in collagen-induced arthritis mice via inhibition of the RANKL/NF-κB signaling pathway
Melittin acupoint injection in attenuating bone erosion in collagen-induced arthritis mice via inhibition of the RANKL/NF-κB signaling pathway Open
Based on our findings, MAI could suppress joint inflammation and inhibit RANKL/NF-κB-mediated osteoclast differentiation to rescue bone erosion in CIA mice, suggesting that MAI can be a potentially therapeutic substance for RA.
View article: Combination of enoxaparin and low-dose aspirin for thromboprophylaxis in selective patients after primary total joint arthroplasty in a Taiwanese population
Combination of enoxaparin and low-dose aspirin for thromboprophylaxis in selective patients after primary total joint arthroplasty in a Taiwanese population Open
Background: The incidence of deep vein thrombosis (DVT) and pulmonary embolism (PE) after total joint arthroplasty (TJA) procedures are lower in Asian populations than in Caucasian populations. Therefore, the need for thromboprophylaxis in…
View article: A case report of Ovarian hyperstimulation syndrome and corpus luteum rupture in twin pregnancies with IVF-ET
A case report of Ovarian hyperstimulation syndrome and corpus luteum rupture in twin pregnancies with IVF-ET Open
Introduction: Ovarian hyperstimulation syndrome (OHSS) is a common complication during assisted conception treatment, mostly seen in patients with ovarian hyperresponsiveness such as polycystic ovary syndrome, especially in post-invitro fe…
View article: Case report: The clinical utility of metagenomic next-generation sequencing in mucormycosis diagnosis caused by fatal Lichtheimia ramosa infection in pediatric neuroblastoma
Case report: The clinical utility of metagenomic next-generation sequencing in mucormycosis diagnosis caused by fatal Lichtheimia ramosa infection in pediatric neuroblastoma Open
Lichtheimia ramosa ( L. ramosa ) is an opportunistic fungal pathogen of the order Mucorales that may result in a rare but serious mucormycosis infection. Mucormycosis could be angioinvasive, causing thrombosis and necrosis in the nose, bra…
View article: GuiLu-ErXian Glue extract promotes mesenchymal stem cells (MSC)-Induced chondrogenesis via exosomes release and delays aging in the MSC senescence process
GuiLu-ErXian Glue extract promotes mesenchymal stem cells (MSC)-Induced chondrogenesis via exosomes release and delays aging in the MSC senescence process Open
we conclude that GLEXG promotes in vitro MSC-induced chondrogenesis possibly via exosomes release and delays aging in the MSC senescence process and that treatment with GLEXG (0.3 μg, i.a.) rescued cartilage defects in rat OA knee model.
View article: Associations of specific dietary unsaturated fatty acids with risk of overweight/obesity: population-based cohort study
Associations of specific dietary unsaturated fatty acids with risk of overweight/obesity: population-based cohort study Open
Background The role of specific unsaturated fatty acids (FAs) in the development of overweight/obesity remains unclear in the general population. Here, we aimed to explore the associations of different types of unsaturated FAs with overwei…
View article: THE IMPACT OF HUMAN PLATELET ANTIGEN ALLELE ON ANTIPLATELET ANTIBODIES AND CRYOGLOBULINS IN PATIENTS WITH PRIMARY IMMUNE THROMBOCYTOPENIA AND HEPATITIS C VIRUS-ASSOCIATED IMMUNE THROMBOCYTOPENIA
THE IMPACT OF HUMAN PLATELET ANTIGEN ALLELE ON ANTIPLATELET ANTIBODIES AND CRYOGLOBULINS IN PATIENTS WITH PRIMARY IMMUNE THROMBOCYTOPENIA AND HEPATITIS C VIRUS-ASSOCIATED IMMUNE THROMBOCYTOPENIA Open
Background
Human platelet antigens (HPAs) are alloantigens for antiplatelet alloantibodies and associated with the risk of immune thrombocytopenia (ITP). However, few studies have investigated associations among HPAs, antiplatelet autoant…
View article: Effect of c<scp>o‐medications</scp> and potential risk factors of <scp>high‐dose methotrexate‐mediated</scp> acute hepatotoxicity in patients with osteosarcoma
Effect of c<span>o‐medications</span> and potential risk factors of <span>high‐dose methotrexate‐mediated</span> acute hepatotoxicity in patients with osteosarcoma Open
Background Taiwanese patients frequently experience severe hepatotoxicity associated with high‐dose methotrexate (HD‐MTX) treatment, which interferes with subsequent treatment. Drug–drug interactions occur when MTX is used in combination w…
View article: The safety and cost-analysis of simultaneous versus staged bilateral total knee arthroplasty in a Taiwan population
The safety and cost-analysis of simultaneous versus staged bilateral total knee arthroplasty in a Taiwan population Open
Background: In patients with advanced osteoarthritis (OA) of the bilateral knees, uncertainty remains as to whether simultaneous bilateral total knee arthroplasty (SiTKA) or staged TKA (StTKA) is the treatment of choice. The purpose of thi…
View article: A Functional Polymorphism Downstream of Vitamin A Regulator Gene CYP26B1 Is Associated with Hand Osteoarthritis
A Functional Polymorphism Downstream of Vitamin A Regulator Gene CYP26B1 Is Associated with Hand Osteoarthritis Open
While genetic analyses have revealed ~100 risk loci associated with osteoarthritis (OA), only eight have been linked to hand OA. Besides, these studies were performed in predominantly European and Caucasian ancestries. Here, we conducted a…
View article: Factors Associated with Large Renal Function Decline in Patients with Chronic Hepatitis C Successfully Treated with Direct-Acting Antiviral Therapy
Factors Associated with Large Renal Function Decline in Patients with Chronic Hepatitis C Successfully Treated with Direct-Acting Antiviral Therapy Open
The findings regarding changes in renal function in patients with hepatitis C virus (HCV) infection treated with direct-acting antivirals (DAAs) are controversial. This study attempted to identify the factors associated with the large decl…
View article: Freezing nitrogen ethanol composite reduces periprosthetic infection caused by Staphylococcus aureus contaminated metal implants: An animal study
Freezing nitrogen ethanol composite reduces periprosthetic infection caused by Staphylococcus aureus contaminated metal implants: An animal study Open
Background: Implant-associated infection remains a major complication of orthopedic surgery. The treatment of such infection is complicated by bacterial biofilm formation on the metal surfaces of implants. Biofilm surrounds and protects th…
View article: Direct-Acting Antivirals Reduce the De Novo Development of Esophageal Varices in Patients with Hepatitis C Virus Related Liver Cirrhosis
Direct-Acting Antivirals Reduce the De Novo Development of Esophageal Varices in Patients with Hepatitis C Virus Related Liver Cirrhosis Open
The real-world benefits of direct-acting antiviral (DAA)-induced sustained virologic response (SVR) on the de novo occurrence and progression of esophageal varices (EV) remain unclear in patients with hepatitis C virus (HCV)-related liver …
View article: Melittin acupoint injection in attenuating bone erosion in collagen-induced arthritis mice via inhibition of the RANKL/NF-κB signaling pathway
Melittin acupoint injection in attenuating bone erosion in collagen-induced arthritis mice via inhibition of the RANKL/NF-κB signaling pathway Open
Fenfang Liu, Lu Yang, Fen Chen, Jiping Zhang, Le Yang, Fucheng Qiu, Guangen Zhong, Shan Gao, Weizhe Xi, Meilian Lai, Qiting He, Ying Chen, Weiming Chen