Weiming Lai
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View article: A retrospective study on pediatric pertussis: comprehensive evaluation of symptoms, laboratory indicators, and diagnostic efficacy of case definitions
A retrospective study on pediatric pertussis: comprehensive evaluation of symptoms, laboratory indicators, and diagnostic efficacy of case definitions Open
Objective This study aimed to characterize the epidemiology of pertussis in children, evaluate the diagnostic performance of clinical and laboratory features, assess the effectiveness of different suspected-case criteria, and identify inde…
View article: Detection of Salmonella spp. Related Co-Infections Among Children with Diarrheal Diseases in Guangzhou, China
Detection of Salmonella spp. Related Co-Infections Among Children with Diarrheal Diseases in Guangzhou, China Open
This study provides a comprehensive understanding of the nature of Salmonella spp. co-infections in diarrheal diseases, and the possibility of clinical symptoms and enhanced treatments.
View article: Prevalence, Serotypes and Antimicrobial Resistance of Salmonella Isolated from Children in Guangzhou, China, 2018–2023
Prevalence, Serotypes and Antimicrobial Resistance of Salmonella Isolated from Children in Guangzhou, China, 2018–2023 Open
Salmonella Typhimurium was the most common serotype isolated from children in Guangzhou, China, and it may mainly account for the high drug resistance rate in Salmonella spp. to most of the antimicrobial profiles. For controlling the high …
View article: Pathogenic and clinical features of neonatal bacterial conjunctivitis in southern China: a retrospective study
Pathogenic and clinical features of neonatal bacterial conjunctivitis in southern China: a retrospective study Open
Background: Bacterial conjunctivitis is one of the most common ocular problems of neonates. The aim of this study was to retrospectively analyse the clinical and pathogenic characteristics of neonatal bacterial conjunctivitis in southern C…
View article: Evaluation of microbiological epidemiology and clinical characteristics of maternal bloodstream infection: a 10 years retrospective study
Evaluation of microbiological epidemiology and clinical characteristics of maternal bloodstream infection: a 10 years retrospective study Open
Objective Although the incidence of bloodstream infection (BSI) during pregnancy is relatively low, it can lead to unfavorable outcomes. The aim of our study was to analyze the clinical and microbiological characteristics of maternal bacte…
View article: Comparative analysis of <i>Streptococcus agalactiae</i> S03 and S07 isolated from <i>Schizothorax spp.</i> with different antibiotic resistance and virulence
Comparative analysis of <i>Streptococcus agalactiae</i> S03 and S07 isolated from <i>Schizothorax spp.</i> with different antibiotic resistance and virulence Open
Streptococcus agalactiae (GBS) is an important Gram-positive pathogen of fish aquaculture worldwide. In this study, we performed a comparative analysis of GBS S03 (serotype III) and S07 (serotype Ia) isolated from Schizothorax spp.. We expl…
View article: CCDC 2288609: Experimental Crystal Structure Determination
CCDC 2288609: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2288610: Experimental Crystal Structure Determination
CCDC 2288610: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Association between metabolites in tryptophan-kynurenine pathway and inflammatory bowel disease: A two-sample mendelian randomization
Association between metabolites in tryptophan-kynurenine pathway and inflammatory bowel disease: A two-sample mendelian randomization Open
Previous observational studies have suggested an association between tryptophan (TRP) -kynurenine (KYN) pathway and inflammatory bowel disease (IBD). However, whether there is a causal relationship among them remains unclear. Therefore, a …
View article: Glutamine Regulates Gene Expression Profiles to Increase the Proliferation of Porcine Intestinal Epithelial Cells and the Expansion of Intestinal Stem Cells
Glutamine Regulates Gene Expression Profiles to Increase the Proliferation of Porcine Intestinal Epithelial Cells and the Expansion of Intestinal Stem Cells Open
The intestinal epithelium is known for its rapid self-renewal, and glutamine is crucial in providing carbon and nitrogen for biosynthesis. However, understanding how glutamine affects gene expression in the intestinal epithelium is limited…
View article: Establish and apply ISI pathological method to evaluate the intestinal health of largemouth bass ( <i>Micropterus salmoides</i> ) and channel catfish ( <i>Ictalurus punctatus</i> ) challenged with <i>Aeromonas hydrophila</i>
Establish and apply ISI pathological method to evaluate the intestinal health of largemouth bass ( <i>Micropterus salmoides</i> ) and channel catfish ( <i>Ictalurus punctatus</i> ) challenged with <i>Aeromonas hydrophila</i> Open
Gut health is essential for animal growth because it can absorb nutrients more efficiently, promote growth, and protect the body from invasion by pathogenic microorganisms. Temperature, dissolved oxygen, water quality, nutrition level, pat…
View article: Autophagy-mediated ferroptosis involved in nickel-induced nephrotoxicity in the mice
Autophagy-mediated ferroptosis involved in nickel-induced nephrotoxicity in the mice Open
Nickel, as a widely polluted metal, has been shown nephrotoxicity. Ferroptosis is a new type of cell death driven by iron-dependent lipid peroxidation. Our study found that nickel chloride (NiCl2) induced ferroptosis in mouse kidney and TC…
View article: Dual Charge Transfer Generated from Stable Mixed‐Valence Radical Crystals for Boosting Solar‐to‐Thermal Conversion
Dual Charge Transfer Generated from Stable Mixed‐Valence Radical Crystals for Boosting Solar‐to‐Thermal Conversion Open
Realizing dual charge transfer (CT) based on stable organic radicals in one system is a long‐sought goal, however, remains challenging. In this work, a stable mixed‐valence radical crystal is designed via a surfactant‐assisted method, name…
View article: Characteristics of pathology and transcriptome profiling reveal features of immune response of acutely infected and asymptomatic infected of carp edema virus in Koi
Characteristics of pathology and transcriptome profiling reveal features of immune response of acutely infected and asymptomatic infected of carp edema virus in Koi Open
Koi sleepy disease (KSD) is a high mortality and infection viral disease caused by carp edema virus (CEV), which was a serious threat to aquaculture of common carp and export trade of Koi worldwide. Asymptomatic infection is an important c…
View article: A novel alkaloid compound, DCZ0358, exerts significant antitumor activity in bortezomib-resistant multiple myeloma cells through inhibition of JAK2/STAT3 pathway
A novel alkaloid compound, DCZ0358, exerts significant antitumor activity in bortezomib-resistant multiple myeloma cells through inhibition of JAK2/STAT3 pathway Open
Multiple myeloma (MM), the second most common haematological malignancy, is currently incurable because patients often develop multiple drug resistance and experience subsequent relapse of the disease. This study aims to identify a potenti…
View article: Change of serum lipoproteins and its potential use in stratifying patients with sepsis among neonates
Change of serum lipoproteins and its potential use in stratifying patients with sepsis among neonates Open
Background: Changes of serum lipoprotein concentration during bacteremia or sepsis is observed and lipoproteins concentration facilitate the evaluation severity of sepsis in adults, but its clinical usage is still unclear. Here, we analyze…
View article: DCZ0014, a novel compound in the therapy of diffuse large B-cell lymphoma via the B cell receptor signaling pathway
DCZ0014, a novel compound in the therapy of diffuse large B-cell lymphoma via the B cell receptor signaling pathway Open
Diffuse large B cell lymphoma (DLBCL) is a clinical and genetically heterogeneous lymphoid malignancy. Although R-CHOP (rituximab plus cyclophosphamide, vincristine, doxorubicin, and prednisone) treatment can improve the survival rate of p…
View article: Comparison the function of Cyprinid herpesvirus 3 encoded two viral tumor necrosis factor receptors
Comparison the function of Cyprinid herpesvirus 3 encoded two viral tumor necrosis factor receptors Open
To avoid immune surveillance and elimination from the host, many viruses encode homologues of host cytokines and cytokine receptors to regulate the host immune response. Viral encoded tumor necrosis factor receptor (vTNFR) homologues are i…
View article: A Fluorogenic Labeling of Live Viruses
A Fluorogenic Labeling of Live Viruses Open
Viruses are an important class of pathogens that can cause serious infectious diseases. The ability to directly analyze viral particles in real time is essential to understand their pathological functions. In this work, we developed a stra…
View article: A Fluorogenic Labeling of Live Viruses
A Fluorogenic Labeling of Live Viruses Open
Viruses are an important class of pathogens that can cause serious infectious diseases. The ability to directly analyze viral particles in real time is essential to understand their pathological functions. In this work, we developed a stra…
View article: Comparative Analysis of Streptococcus Agalactiae S03 and S07 Isolated From Schizothorax Prenanti With Different Antibiotic Resistance and Virulence
Comparative Analysis of Streptococcus Agalactiae S03 and S07 Isolated From Schizothorax Prenanti With Different Antibiotic Resistance and Virulence Open
Streptococcus agalactiae (GBS), is an important Gram-positive pathogen of fish aquaculture worldwide. In this study, we performed a comparative analysis of GBS S03 and S07 isolated from Schizothorax prenanti and explored the association bet…
View article: Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells
Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells Open
Resveratrol, a natural compound extracted from the skins of grapes, berries, or other fruits, has been shown to have anti-tumor effects against multiple myeloma (MM) via promoting apoptosis and inhibiting cell viability. In addition to apo…
View article: DCZ0014, A Novel Compound in the Therapy of Diffuse Large B-Cell Lymphoma via the B Cell Receptor Signaling Pathway
DCZ0014, A Novel Compound in the Therapy of Diffuse Large B-Cell Lymphoma via the B Cell Receptor Signaling Pathway Open
Background: Diffuse large B cell lymphoma (DLBCL) is a clinical and genetically heterogeneous lymphoid malignancy. Although the R-CHOP (rituximab plus cyclophosphamide, vincristine, doxorubicin, and prednisone) treatment can improve the su…
View article: Immunologic Improvement of Vaccine for Newcastle Disease via Co-Inoculation of Cattle Transfer Factor in Broilers
Immunologic Improvement of Vaccine for Newcastle Disease via Co-Inoculation of Cattle Transfer Factor in Broilers Open
Background: Transfer factors (TFs), a novel immunostimulatory reagent, have found use as auxiliary or primary therapy for many diseases. The aim of this study was to explore whether TFs are able to strengthen immune responses of Newcastle …
View article: Preliminary Evaluation of Recombinant EPC1 and TPx for Serological Diagnosis of Animal Cystic Echinococcosis
Preliminary Evaluation of Recombinant EPC1 and TPx for Serological Diagnosis of Animal Cystic Echinococcosis Open
Animal cystic echinococcosis (CE) is one of the most important helminthic diseases and affects many mammalian intermediate hosts. Practical and effective diagnosis is crucial for animal CE control. Two different recombinant antigens derive…