Weiming Yuan
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View article: Characterizing Kupffer Cell Production of CD5 Antigen-Like and Its Function on Regulating Migration of Natural Killer T Cells
Characterizing Kupffer Cell Production of CD5 Antigen-Like and Its Function on Regulating Migration of Natural Killer T Cells Open
View article: Proinflammatory macrophages release CXCL5 to regulate T cell function and limit effects of αPD-1 in steatosis-driven liver cancer
Proinflammatory macrophages release CXCL5 to regulate T cell function and limit effects of αPD-1 in steatosis-driven liver cancer Open
In this study, we investigated the role of CXCL5 in the progression from steatosis to liver cancer. We uncovered a novel inhibitory role of CXCL5 in T cell recruitment, with implications for NAC-targeted therapy and immune checkpoint syner…
View article: HSV-1 UL56 protein recruits cellular NEDD4-family ubiquitin ligases to suppress CD1d expression and NKT cell function
HSV-1 UL56 protein recruits cellular NEDD4-family ubiquitin ligases to suppress CD1d expression and NKT cell function Open
Herpesviruses, including α-herpesvirus and herpes simplex virus (HSV-1), are masters of immune evasion. Previously we demonstrated that CD1d-restricted NKT cells are required for optimal anti-HSV-1 immune responses and HSV-1 efficiently do…
View article: A Mouse-adapted SARS-CoV-2 Model for Investigating Post-acute Sequelae of COVID infection
A Mouse-adapted SARS-CoV-2 Model for Investigating Post-acute Sequelae of COVID infection Open
The coronavirus disease of 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), remains a major health issue after nearly 7 millions of death toll in the last four years. As the world is recovering w…
View article: SARS‐CoV‐2 induces blood‐brain barrier and choroid plexus barrier impairments and vascular inflammation in mice
SARS‐CoV‐2 induces blood‐brain barrier and choroid plexus barrier impairments and vascular inflammation in mice Open
The coronavirus disease of 2019 (COVID‐19) pandemic has led to more than 700 million confirmed cases and nearly 7 million deaths. Although severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) virus mainly infects the respiratory sy…
View article: Preclinical evaluation of therapeutic vaccines for chronic hepatitis B that stimulate antiviral activities of T cells and NKT cells
Preclinical evaluation of therapeutic vaccines for chronic hepatitis B that stimulate antiviral activities of T cells and NKT cells Open
Although there are effective prophylactic vaccines for HBV infection, it is estimated that 350-400 million people worldwide have chronic hepatitis B, putting these individuals at significant risk of life-threatening liver diseases. Therape…
View article: SARS-COV-2 induces blood-brain barrier and choroid plexus barrier impairments and vascular inflammation in mice
SARS-COV-2 induces blood-brain barrier and choroid plexus barrier impairments and vascular inflammation in mice Open
The coronavirus disease of 2019 (COVID-19) pandemic that has led to more than 700 million confirmed cases and near 7 million deaths. Although Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus mainly infects the respiratory…
View article: Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection
Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection Open
View article: Potent NKT cell ligands overcome SARS-CoV-2 immune evasion to mitigate viral pathogenesis in mouse models
Potent NKT cell ligands overcome SARS-CoV-2 immune evasion to mitigate viral pathogenesis in mouse models Open
One of the major pathogenesis mechanisms of SARS-CoV-2 is its potent suppression of innate immunity, including blocking the production of type I interferons. However, it is unknown whether and how the virus interacts with different innate-…
View article: <i>N</i> <sup>6</sup> -Methyladenosine and Reader Protein YTHDF2 Enhance the Innate Immune Response by Mediating DUSP1 mRNA Degradation and Activating Mitogen-Activated Protein Kinases during Bacterial and Viral Infections
<i>N</i> <sup>6</sup> -Methyladenosine and Reader Protein YTHDF2 Enhance the Innate Immune Response by Mediating DUSP1 mRNA Degradation and Activating Mitogen-Activated Protein Kinases during Bacterial and Viral Infections Open
Innate immunity is central to controlling pathogenic infections and maintaining the homeostasis of the host. In this study, we have revealed a novel mechanism regulating innate immune responses during viral and bacterial infections.
View article: Microglia innate immune response contributes to the antiviral defense and blood–CSF barrier function in human choroid plexus organoids during HSV‐1 infection
Microglia innate immune response contributes to the antiviral defense and blood–CSF barrier function in human choroid plexus organoids during HSV‐1 infection Open
The choroid plexus (ChP) is the source of cerebrospinal fluid (CSF). The ChP–CSF system not only provides the necessary cushion for the brain but also works as a sink for waste clearance. During sepsis, pathogens and host immune cells can …
View article: <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) and reader protein YTHDF2 enhance innate immune response by mediating DUSP1 mRNA degradation and activating mitogen-activated protein kinases during bacterial and viral infections
<i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) and reader protein YTHDF2 enhance innate immune response by mediating DUSP1 mRNA degradation and activating mitogen-activated protein kinases during bacterial and viral infections Open
Mitogen-activated protein kinases (MAPKs) play critical roles in the induction of numerous cytokines, chemokines, and inflammatory mediators that mobilize the immune system to counter pathogenic infections. Dual-specificity phosphatase-1 (…
View article: The occupational exposure risk and inhalation risk due to ultrafine particles emitted during the powder-coating process
The occupational exposure risk and inhalation risk due to ultrafine particles emitted during the powder-coating process Open
Background Due to the rapid development of the powder-coating process and growing awareness of occupational health, the ultrafine particles (UFPs) generated during the powder-coating process have become a serious and urgent problem. Howeve…
View article: Applying kurtosis-adjusted equivalent continuous A-weighted sound pressure level to evaluate risk of occupational hearing loss associated with non-steady state noise
Applying kurtosis-adjusted equivalent continuous A-weighted sound pressure level to evaluate risk of occupational hearing loss associated with non-steady state noise Open
BackgroundEquivalent continuous A-weighted sound pressure level is not appropriate for evaluating the risk of non-steady noise exposure, and need to be corrected by noise time-domain structure, but the correction method and its applicabili…
View article: Global profiling reveals common and distinct N6-methyladenosine (m6A) regulation of innate immune responses during bacterial and viral infections
Global profiling reveals common and distinct N6-methyladenosine (m6A) regulation of innate immune responses during bacterial and viral infections Open
N 6 -methyladenosine (m 6 A) is a dynamic post-transcriptional RNA modification influencing all aspects of mRNA biology. While m 6 A modifications during numerous viral infections have been described, the role of m 6 A in innate immune res…
View article: SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response
SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response Open
The ongoing COVID-19 pandemic is caused by SARS-CoV-2, which is rapidly evolving with better transmissibility. Understanding the molecular basis of the SARS-CoV-2 interaction with host cells is of paramount significance, and development of…
View article: Editorial: NKT Cells in Cancer Immunotherapy
Editorial: NKT Cells in Cancer Immunotherapy Open
EDITORIAL article Front. Immunol., 23 June 2020Sec. Cancer Immunity and Immunotherapy Volume 11 - 2020 | https://doi.org/10.3389/fimmu.2020.01314
View article: Comment on “Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus ‐2 (SARS‐CoV‐2)”
Comment on “Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus ‐2 (SARS‐CoV‐2)” Open
The authors declare that there are no conflict of interests.
View article: Mathematical modeling of interaction between innate and adaptive immune responses in COVID‐19 and implications for viral pathogenesis
Mathematical modeling of interaction between innate and adaptive immune responses in COVID‐19 and implications for viral pathogenesis Open
We have applied mathematical modeling to investigate the infections of the ongoing coronavirus disease‐2019 (COVID‐19) pandemic caused by SARS‐CoV‐2 virus. We first validated our model using the well‐studied influenza viruses and then comp…
View article: α-GalCer and iNKT Cell-Based Cancer Immunotherapy: Realizing the Therapeutic Potentials
α-GalCer and iNKT Cell-Based Cancer Immunotherapy: Realizing the Therapeutic Potentials Open
NKT cells are CD1d-restricted innate-like T cells expressing both T cell receptor and NK cell markers. The major group of NKT cells in both human and mice is the invariant NKT (iNKT) cells and the best-known function of iNKT cells is their…
View article: Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance Open
Autophagy maintains homeostasis and is induced upon stress. Yet, its mechanistic interaction with oncogenic signaling remains elusive. Here, we show that in BRAF V600E -melanoma, autophagy is induced by BRAF inhibitor (BRAFi), as part of a…
View article: Herpes Simplex Virus 1 Specifically Targets Human CD1d Antigen Presentation To Enhance Its Pathogenicity
Herpes Simplex Virus 1 Specifically Targets Human CD1d Antigen Presentation To Enhance Its Pathogenicity Open
Herpes simplex virus 1 (HSV-1) is among the most common human pathogens. Little is known regarding the exact mechanism by which this virus evades the human immune system, particularly the innate immune system. We reported previously that H…
View article: Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity
Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity Open
View article: Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity
Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity Open
View article: Faculty Opinions recommendation of Asian Zika virus strains target CD14+ blood monocytes and induce M2-skewed immunosuppression during pregnancy.
Faculty Opinions recommendation of Asian Zika virus strains target CD14+ blood monocytes and induce M2-skewed immunosuppression during pregnancy. Open
Blood CD14+ monocytes are frontline immunomodulators categorized into classical, intermediate or non-classical subsets, and subsequently differentiated into M1 pro- or M2 anti-inflammatory macrophages on stimulation. Although the Zika viru…
View article: Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis
Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis Open
View article: A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation
A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation Open
View article: IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response
IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response Open
Activation of nuclear factor of activated T cells (NFAT) is crucial for immune responses. IKKε is an IκB kinase (IKK)-related kinase, and the function of IKKε remains obscure in T cells, despite its abundant expression. We report that IKKε…
View article: Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway
Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway Open
View article: Faculty Opinions recommendation of A new mouse strain for the analysis of invariant NKT cell function.
Faculty Opinions recommendation of A new mouse strain for the analysis of invariant NKT cell function. Open