Weina Chen
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View article: Proinflammatory GSDMD activation in live macrophages and DLBCL cells marks cognate interactions and better prognosis
Proinflammatory GSDMD activation in live macrophages and DLBCL cells marks cognate interactions and better prognosis Open
Pyroptosis is a form of programmed cell death characterized by the cleavage of gasdermin (GSDM) family proteins that form pores in the plasma membrane, cell rupture, and the release of pro-inflammatory cytokines. In this study, we performe…
View article: EZH2 molecular alterations drive micromegakaryocyte expansion in MDS defining a specific high-risk group
EZH2 molecular alterations drive micromegakaryocyte expansion in MDS defining a specific high-risk group Open
BackgroundMyelodysplastic neoplasm/syndrome (MDS) subtypes are categorized by genetic aberrations leading to specific morphological dysplastic features. Micromegakaryocytes (microMK) are a defining morphological alteration of myeloid dyspl…
View article: The presence of SH2B3 mutations identifies a distinct subtype of myelodysplastic neoplasms
The presence of SH2B3 mutations identifies a distinct subtype of myelodysplastic neoplasms Open
Background & aim: While SH2B3 gene mutations have been identified in myeloproliferative neoplasms, where they negatively regulate the TPO/MPL/JAK2 pathway, their pathogenic mechanism and clinical implications in MDS remain unknown. This st…
View article: Hi-c FFPE sequencing analysis is highly concordant with FISH and detects additional variants informing diagnosis and treatment in diffuse large B-cell lymphoma
Hi-c FFPE sequencing analysis is highly concordant with FISH and detects additional variants informing diagnosis and treatment in diffuse large B-cell lymphoma Open
Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL), accounting for approximately 30% of all NHL cases. DLBCL diagnosis relies on histologic examination, immunophenotyping, molecular and …
View article: Cytoplasmic but not nuclear cleaved gsdmd expression in live macrophages and DLBCL cells marks proinflammatory cognate interactions rather than pyroptosis and predicts better patient survival in DLBCL
Cytoplasmic but not nuclear cleaved gsdmd expression in live macrophages and DLBCL cells marks proinflammatory cognate interactions rather than pyroptosis and predicts better patient survival in DLBCL Open
Background: Pyroptosis is a form of programmed cell death characterized by cleavage of gasdermin (GSDM) family proteins that form pores in the plasma membrane, cell rupture, and release of pro-inflammatory cytokines. Its pro-inflammatory p…
View article: Lnc‐HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage
Lnc‐HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage Open
Unexplained recurrent miscarriage (RM) is a clinical challenge due to its unclear pathogenesis. TGFβ2 plays essential roles in reproductive events. Migrasomes are newly identified organelles. Herein, whether TGFβ2 might regulate trophoblas…
View article: Acute Leukemias of Ambiguous Lineage With <i>RUNX1</i> Mutations Show Similar Prognosis Compared to Acute Myeloid Leukemia With <i>RUNX1</i> Mutations: A Study From the Bone Marrow Pathology Group
Acute Leukemias of Ambiguous Lineage With <i>RUNX1</i> Mutations Show Similar Prognosis Compared to Acute Myeloid Leukemia With <i>RUNX1</i> Mutations: A Study From the Bone Marrow Pathology Group Open
The World Health Organization (WHO) 5th Edition and International Consensus Classification (ICC) have continued to delineate more genetically defined acute leukemias. Both recognize genetic aberrations associated with myelodysplastic syndr…
View article: B/T Mixed Phenotype Acute Leukaemia Harbouring <i>NUP98::BPTF</i> Fusion
B/T Mixed Phenotype Acute Leukaemia Harbouring <i>NUP98::BPTF</i> Fusion Open
Background NUP98 :: BPTF rearranged (r) leukaemia is rare with only five reported cases, including acute myeloid leukemia and T‐lymphoblastic leukemia (T‐ALL). Results Herein, we report a case of NUP98::BPTF ‐r mixed phenotype acute leukem…
View article: Loss of vitamin C biosynthesis protects from a parasitic infection
Loss of vitamin C biosynthesis protects from a parasitic infection Open
The ability to synthesize essential molecules is sometimes lost in evolution. A classic example is ascorbate (Vitamin C), which is synthesized in most animals by L-Gulonolactone Oxidase (GULO), an enzyme lost multiple independent times in …
View article: Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma
Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma Open
Primary testicular (PT) diffuse large B-cell lymphoma (DLBCL) is a rare and aggressive lymphoma with distinct clinical and molecular characteristics. To identify prognostic biomarkers in PT-DLBCL, in this study we analyzed DNA and RNA samp…
View article: Efficacy and safety of immunotherapy-based neoadjuvant regimens in locally advanced gastric cancer: a meta-analysis based on high-quality clinical trials
Efficacy and safety of immunotherapy-based neoadjuvant regimens in locally advanced gastric cancer: a meta-analysis based on high-quality clinical trials Open
Background: The integration of chemotherapy, targeted therapy, and immunotherapy has emerged as the latest research focus for locally advanced gastric cancer (LAGC). This study aims to evaluate the efficacy and safety of various immunother…
View article: Genomic Landscape of Mixed Phenotype Acute Leukemia Associated With Immunophenotypic Lineage Predominance: Impact on Diagnosis and Treatment
Genomic Landscape of Mixed Phenotype Acute Leukemia Associated With Immunophenotypic Lineage Predominance: Impact on Diagnosis and Treatment Open
Objectives Mixed phenotype acute leukemia ( MPAL ) often poses challenges in diagnosis and clinical management. This is the first study to assess the lineage/immunophenotype‐genotype association and the significance of AML ‐myelodysplasia‐…
View article: Acute Leukemia of Ambiguous Lineage: Diagnosis and Evaluation by Flow Cytometry
Acute Leukemia of Ambiguous Lineage: Diagnosis and Evaluation by Flow Cytometry Open
Acute leukemia of ambiguous lineage (ALAL) includes mixed-phenotype acute leukemia (MPAL), which exhibits immunophenotypic evidence of differentiation along more than one cell lineage, and acute undifferentiated leukemia (AUL), which lacks…
View article: Imatinib-Induced Clinical Response in ETV6::ACSL6 Myeloid Neoplasm with Eosinophilic Pneumonitis: A Case Report
Imatinib-Induced Clinical Response in ETV6::ACSL6 Myeloid Neoplasm with Eosinophilic Pneumonitis: A Case Report Open
BACKGROUND Myeloid neoplasms with [em]ETV6::ACSL6[/em] fusions are extremely rare entities that are characterized by eosinophilic and/or basophilic leukocytosis. While they clinically mimic myeloid neoplasms with eosinophilia and tyrosine …
View article: Effects of Daratumumab (Anti-CD38) Monoclonal Antibody Therapy on Flow Cytometry Analysis in Multiple Myeloma
Effects of Daratumumab (Anti-CD38) Monoclonal Antibody Therapy on Flow Cytometry Analysis in Multiple Myeloma Open
Background: Plasma cell myeloma is an incurable malignancy of clonal plasma cells. Recent success in immunotherapeutic strategies has altered the landscape of myeloma treatment. Daratumumab is an anti-CD38 IgG kappa monoclonal antibody tha…
View article: Clinicopathologic and Molecular Characterization of <i>NUP98</i>‐Rearranged Acute Leukemias
Clinicopathologic and Molecular Characterization of <i>NUP98</i>‐Rearranged Acute Leukemias Open
Introduction NUP98 rearrangements are rare in acute leukemias and portend a poor prognosis. Methods This study explored clinicopathologic and molecular features of five patients with NUP98 rearranged ( NUP98‐ r) acute leukemias, including …
View article: Clinical, immunophenotypic, and genomic findings of acute myeloid leukemia with RAM immunophenotype: Comparison with other CD56‐positive acute leukemias
Clinical, immunophenotypic, and genomic findings of acute myeloid leukemia with RAM immunophenotype: Comparison with other CD56‐positive acute leukemias Open
Background Acute myeloid leukemia (AML) with RAM immunophenotype is a newly recognized high‐risk AML immunophenotypic subcategory characterized by blasts with bright expression of CD56 and weak to absent expression of CD45, HLA‐DR, and CD3…
View article: Inflammatory pseudotumor-like extranodal classic Hodgkin lymphoma manifesting as bowel perforation in acquired immunodeficiency syndrome patient with disseminated leishmaniasis: a case report and approach to differential diagnosis
Inflammatory pseudotumor-like extranodal classic Hodgkin lymphoma manifesting as bowel perforation in acquired immunodeficiency syndrome patient with disseminated leishmaniasis: a case report and approach to differential diagnosis Open
It is critical to identify secondary CHL in HIV/AIDS patients especially in the presence of immunodeficiency and disseminated opportunistic infection. Extranodal primary GI tract CHL is exceedingly rare and thus awareness of this entity, w…
View article: BCL2 Expression Correlates with New Molecular Classification of Anaplastic Large Cell Lymphoma
BCL2 Expression Correlates with New Molecular Classification of Anaplastic Large Cell Lymphoma Open
Background: Anaplastic large cell lymphomas represent a group of T-cell lymphomas that have long been broadly classified by the presence or absence of ALK fusion proteins (ALK+ or ALK−, respectively). However, recent discovery of extensive…
View article: Recurrent cytogenetic abnormalities reveal alterations that promote progression and transformation in myelodysplastic syndrome
Recurrent cytogenetic abnormalities reveal alterations that promote progression and transformation in myelodysplastic syndrome Open
This study identified a unique combination of RCAs that are components in distinct cytogenetic trajectories. Some of these were primary changes while others were secondary or tertiary changes. Acquiring specific additional aberrations pred…
View article: <i>RUNX1::CBFA2T2</i> rearranged acute myeloid leukemia transformed from <i>JAK2</i> V617F mutated primary myelofibrosis
<i>RUNX1::CBFA2T2</i> rearranged acute myeloid leukemia transformed from <i>JAK2</i> V617F mutated primary myelofibrosis Open
Acute myeloid leukemia (AML) with RUNX1::CBFA2T2 fusion is rare with largely unknown clinicopathological features and genomic characterization. We present one such case of AML transformed from JAK2 V617F mutated primary myelofibrosis and r…
View article: BaP/BPDE suppresses homologous recombination repair in human trophoblast cells to induce miscarriage: The roles of lnc-HZ08
BaP/BPDE suppresses homologous recombination repair in human trophoblast cells to induce miscarriage: The roles of lnc-HZ08 Open
Benzo(a)pyrene (BaP) or benzo (a) pyrene 7,8-dihydrodiol-9,10-epoxide (BPDE) exposure causes trophoblast cell dysfunctions and induces miscarriage, which is generally epigenetically regulated. Homologous recombination (HR) repair of DNA do…
View article: Copper exposure induces trophoblast cell cuproptosis by up-regulating lnc-HZ11
Copper exposure induces trophoblast cell cuproptosis by up-regulating lnc-HZ11 Open
Copper pollution has attracted global environmental concern. Widespread Cu pollution results in excessive Cu accumulation in human. Epidemiological studies and animal experiments revealed that Cu exposure might have reproductive toxicity. …