Weinan Xue
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View article: Transsulfuration pathway activation attenuates oxidative stress and ferroptosis in sickle primary erythroblasts and transgenic mice
Transsulfuration pathway activation attenuates oxidative stress and ferroptosis in sickle primary erythroblasts and transgenic mice Open
The transsulfuration (TSS) pathway is an alternative source of cysteine for glutathione synthesis. Little of the TSS pathway in antioxidant capacity in sickle cell disease (SCD) is known. Here, we evaluate the effects of TSS pathway activa…
View article: Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth
Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth Open
View article: A Novel Quantification System Combining iTRAQ Technology and Multi-Omics Assessment to Predict Prognosis and Immunotherapy Efficacy in Colon Cancer
A Novel Quantification System Combining iTRAQ Technology and Multi-Omics Assessment to Predict Prognosis and Immunotherapy Efficacy in Colon Cancer Open
Background: Colon cancer is one of the most common cancer types, although it has certain unique genetic features. This study aimed to develop a unique score for assessing prognosis and immunotherapy efficacy using integrated multi-omics an…
View article: Identification and Validation in a Novel Quantification System of Ferroptosis Patterns for the Prediction of Prognosis and Immunotherapy Response in Left- and Right-Sided Colon Cancer
Identification and Validation in a Novel Quantification System of Ferroptosis Patterns for the Prediction of Prognosis and Immunotherapy Response in Left- and Right-Sided Colon Cancer Open
Background This study aimed to establish a novel quantification system of ferroptosis patterns and comprehensively analyze the relationship between ferroptosis score (FS) and the immune cell infiltration (ICI) characterization, tumor mutat…
View article: Discovery of plasma biomarkers for colorectal cancer diagnosis via untargeted and targeted quantitative metabolomics
Discovery of plasma biomarkers for colorectal cancer diagnosis via untargeted and targeted quantitative metabolomics Open
Colorectal cancer (CRC) is a major cause of cancer-related mortality worldwide.1 Shifting the detection of CRC to earlier stages via massive screening has considerably reduced mortality.2 Metabolomics has shown great potential in the ident…
View article: Prognostic and therapeutic significance of a novel ferroptosis related signature in colorectal cancer patients
Prognostic and therapeutic significance of a novel ferroptosis related signature in colorectal cancer patients Open
Increasing studies have highlighted the importance of ferroptosis in colorectal cancer (CRC). However, how to use ferroptosis-related genes (FRGs) to predict the prognosis and guide the treatment of CRC remains unknown. To build a prognost…
View article: Early Postoperative Serum Carcinoembryonic Antigen Is a Stronger Independent Prognostic Factor for Stage II Colorectal Cancer Patients Than T4 Stage and Preoperative CEA
Early Postoperative Serum Carcinoembryonic Antigen Is a Stronger Independent Prognostic Factor for Stage II Colorectal Cancer Patients Than T4 Stage and Preoperative CEA Open
Background Serum carcinoembryonic antigen (CEA) is an important biomarker for diagnosis, prognosis, recurrence, metastasis monitoring, and the evaluation of the effect of chemotherapy in colorectal cancer (CRC). However, few studies have f…
View article: Prognostic Immunity and Therapeutic Sensitivity Analyses Based on Differential Genomic Instability-Associated LncRNAs in Left- and Right-Sided Colon Adenocarcinoma
Prognostic Immunity and Therapeutic Sensitivity Analyses Based on Differential Genomic Instability-Associated LncRNAs in Left- and Right-Sided Colon Adenocarcinoma Open
Background: The purpose of our study was to develop a prognostic risk model based on differential genomic instability-associated (DGIA) long non-coding RNAs (lncRNAs) of left-sided and right-sided colon cancers (LCCs and RCCs); therefore, …
View article: Phase II, Non-Randomized Study of Chemo-Chemoradio-Chemo Sequential Therapy Compared With Concomitant Chemoradiotherapy In Magnetic Resonance Imaging Defined, Locally Mid/Low Advanced Rectal Cancer
Phase II, Non-Randomized Study of Chemo-Chemoradio-Chemo Sequential Therapy Compared With Concomitant Chemoradiotherapy In Magnetic Resonance Imaging Defined, Locally Mid/Low Advanced Rectal Cancer Open
Objective The conventional preoperative CRT provides local tumor control in most LARC patients. However, long-term survival has not obviously improved. Thus, the optimal neoadjuvant treatment is still controversial. Sandwich therapy may be…
View article: The oncogenic role of LncRNA FAM83C-AS1 in colorectal cancer development by epigenetically inhibits SEMA3F via stabilizing EZH2
The oncogenic role of LncRNA FAM83C-AS1 in colorectal cancer development by epigenetically inhibits SEMA3F via stabilizing EZH2 Open
Inactivation of Semaphorin 3F (SEMA3F) is involved in colorectal cancer development. However, the mechanism by which SEMA3F is regulated remains elusive. Deregulation of lncRNAs have been implicated in multiple human malignancies, includin…
View article: <p>Differential Metabolic Alterations and Biomarkers Between Gastric Cancer and Colorectal Cancer: A Systematic Review and Meta-Analysis</p>
Differential Metabolic Alterations and Biomarkers Between Gastric Cancer and Colorectal Cancer: A Systematic Review and Meta-Analysis Open
The altered metabolic pathways showed signatures of abnormal metabolism in gastric cancer and colorectal cancer; the potential metabolic biomarkers proposed in this study have important implications for the prospective validation of gastri…
View article: Long noncoding RNA SNHG14 facilitates colorectal cancer metastasis through targeting EZH2-regulated EPHA7
Long noncoding RNA SNHG14 facilitates colorectal cancer metastasis through targeting EZH2-regulated EPHA7 Open
View article: Genome-wide methylation analysis identifies novel prognostic methylation markers in colon adenocarcinoma
Genome-wide methylation analysis identifies novel prognostic methylation markers in colon adenocarcinoma Open
Previous studies have indicated that abnormal methylation is a critical and early event in the pathogenesis of most types of human cancer, which contributes to tumorigenesis. However, there has been little focus on the potential of DNA met…
View article: Plasma Biomarkers for Colorectal Cancer Diagnosis Based on Metabolomics
Plasma Biomarkers for Colorectal Cancer Diagnosis Based on Metabolomics Open
View article: A long non-coding RNA expression signature to predict survival of patients with colon adenocarcinoma
A long non-coding RNA expression signature to predict survival of patients with colon adenocarcinoma Open
Colon cancer is the most common type of gastrointestinal cancer and is still the leading cause of cancer-related mortality worldwide. Long non-coding RNAs (lncRNAs) have been proved to be superior biomarkers in cancer diagnosis and prognos…
View article: Identification of potential long non-coding RNA biomarkers associated with the progression of colon cancer
Identification of potential long non-coding RNA biomarkers associated with the progression of colon cancer Open
Increasing evidence has suggested that dysregulated lncRNA expression played important roles in the development and progression of human cancers. Although prognostic roles of lncRNAs have been recognized for colon cancer (CC) patients, the…