Weinian Li
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View article: METTL3 facilitates kidney injury through promoting IRF4-mediated plasma cell infiltration via an m6A-dependent manner in systemic lupus erythematosus
METTL3 facilitates kidney injury through promoting IRF4-mediated plasma cell infiltration via an m6A-dependent manner in systemic lupus erythematosus Open
Our study confirmed that upregulated METTL3 promoting IRF4 expression in an m6A-dependent manner, thus causing plasma cell infiltration-mediated kidney damage of SLE. This provides new evidence for the role of m6A in SLE kidney injury.
View article: #2074 Aberrant m6A modification pattern and m6A-related proteins expression in SLE
#2074 Aberrant m6A modification pattern and m6A-related proteins expression in SLE Open
Background and Aims Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown cause. N6-methyladenosine (m6A) is the most common mRNA modification and is involved in various immune processes leading to immune homeostasis disor…
View article: Diagnostic Values of METTL1-Related Genes and Immune Characteristics in Systemic Lupus Erythematosus
Diagnostic Values of METTL1-Related Genes and Immune Characteristics in Systemic Lupus Erythematosus Open
Our findings suggested that METTL1 and its candidate targets LAMP3, CD83, PDCD1LG2 may be used for diagnosing SLE and could be explored for developing targeted molecular therapy for SLE.
View article: Comprehensive mapping of immune perturbations associated with Acute Gouty Arthritis
Comprehensive mapping of immune perturbations associated with Acute Gouty Arthritis Open
Background Acute gout is a form of inflammatory arthritis characterized by a sudden, acute onset of pain, swelling, warmth, erythema, and decreased range of motion in the affected joint. Although numerous studies have focused on the phenot…
View article: Phenotypical changes and clinical significance of CD4<sup>+</sup>/CD8<sup>+</sup> T cells in SLE
Phenotypical changes and clinical significance of CD4<sup>+</sup>/CD8<sup>+</sup> T cells in SLE Open
Objective T cells display significant phenotypical changes and play multiple roles in promoting the immune response in SLE. The frequencies of T cell subpopulations in SLE are still not well understood. To better understanding the phenotyp…
View article: miR-98 Modulates Cytokine Production from Human PBMCs in Systemic Lupus Erythematosus by Targeting IL-6 mRNA
miR-98 Modulates Cytokine Production from Human PBMCs in Systemic Lupus Erythematosus by Targeting IL-6 mRNA Open
Objective . There is evidence that interleukin-6 (IL-6) upregulation plays a critical role in immunopathology of systemic lupus erythematosus (SLE). MicroRNA- (miRNA-) 98 was predicted to bind with the 3-untranslated region (3-UTR) of IL-6…
View article: Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study
Fetal and Maternal Outcomes of Planned Pregnancy in Patients with Systemic Lupus Erythematosus: A Retrospective Multicenter Study Open
Objective . To investigate the fetal and maternal outcomes as well as predictors of APOs in women with SLE who conceived when the disease was stable, the so-called “planned pregnancy.” Methods . A retrospective multicenter study of 243 pat…