Weipeng Cui
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View article: Gut microbiota drives structural variation of exogenous probiotics to enhance colonization
Gut microbiota drives structural variation of exogenous probiotics to enhance colonization Open
Probiotics encounter colonization resistance from native gut microbiomes, affecting their effectiveness. Genetic engineering of probiotics lacks universal applicability, as gut microbiotas are highly individualized. Here, we employed probi…
View article: Distinct Effects of Lactiplantibacillus plantarum HNU082 on Microbial Single-Nucleotide Variants in Large Intestine and Small Intestine
Distinct Effects of Lactiplantibacillus plantarum HNU082 on Microbial Single-Nucleotide Variants in Large Intestine and Small Intestine Open
The intestinal tract extends several times the length of bodies, with varying environmental conditions across different segments (small intestinal and large intestinal), thereby harboring distinct gut microbiota. Most studies focused on th…
View article: Different intestinal ecological niches drive the divergent evolution of probiotics in the gut
Different intestinal ecological niches drive the divergent evolution of probiotics in the gut Open
Previously, we described the divergent evolution of probiotics in the gut, which potentially compromises their health-promoting effects. Here, we employed a spatiotemporal multiomic approach to explore the distribution and evolutionary tre…
View article: Metabolites of the gut microbiota may serve as precise diagnostic markers for sarcopenia in the elderly
Metabolites of the gut microbiota may serve as precise diagnostic markers for sarcopenia in the elderly Open
Sarcopenia, a disease recognized by the World Health Organization, has posed a great challenge to the world in the current aging society. The vital role of the gut microbiome through the gut-muscle axis in sarcopenia is increasingly recogn…
View article: Native microbiome dominates over host factors in shaping the probiotic genetic evolution in the gut
Native microbiome dominates over host factors in shaping the probiotic genetic evolution in the gut Open
Probiotics often acquire potentially adaptive mutations in vivo, gaining new functional traits through gut selection. While both the host and microbiome can contribute to probiotics’ genetic evolution, separating the microbiome and the hos…
View article: Native microbiome dominates over host factors in shaping the probiotic genetic evolution in the gut
Native microbiome dominates over host factors in shaping the probiotic genetic evolution in the gut Open
Probiotics often acquire adaptive mutations in vivo gaining new functional traits through gut selection. However, it remains challenging to separate microbiome and host contribution to such selective pressures. Here, we tracked and compare…