Weiping Jia
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View article: Effect of Skeletal Muscle Mass and Its Associated Mediators on the Development of Steatotic Liver Disease: A Cohort Study in China
Effect of Skeletal Muscle Mass and Its Associated Mediators on the Development of Steatotic Liver Disease: A Cohort Study in China Open
Background Understanding the relationship between relative skeletal muscle mass and newly proposed steatotic liver disease (SLD) is crucial, but research gaps still exist. Based on a cohort study, we investigated the impact of relative ske…
View article: Association between targeted inflammatory proteomics and insulin sensitivity as well as beta-cell function in subjects with normal glucose tolerance
Association between targeted inflammatory proteomics and insulin sensitivity as well as beta-cell function in subjects with normal glucose tolerance Open
Obese individuals even with normal glucose tolerance (NGT) are at higher risk for developing type 2 diabetes (T2D), and obesity is associated with inflammation. However, mechanisms linking inflammation to beta-cell function and insulin sen…
View article: Intervention effects of optimised carbohydrate diet in patients with type 2 diabetes: study protocol for a randomised controlled crossover trial
Intervention effects of optimised carbohydrate diet in patients with type 2 diabetes: study protocol for a randomised controlled crossover trial Open
Introduction Dietary intervention is fundamental for the management of type 2 diabetes (T2D), playing a crucial role in stabilising blood glucose levels and improving quality of life. As the major contributor to daily energy intake, the qu…
View article: Urgent needs, opportunities and challenges of virtual reality in healthcare and medicine in the era of large language models
Urgent needs, opportunities and challenges of virtual reality in healthcare and medicine in the era of large language models Open
The convergence of large language models (LLMs) and virtual reality (VR) technologies has led to significant breakthroughs across multiple domains, particularly in healthcare and medicine. Owing to its immersive and interactive capabilitie…
View article: Cooperativity and Communication between the Active Sites of the Dimeric SARS-CoV-2 Main Protease
Cooperativity and Communication between the Active Sites of the Dimeric SARS-CoV-2 Main Protease Open
The coronaviral main protease (M pro ) is essential for the replication of the virus, and has been the subject of various biochemical, structural and enzymatic studies, as well as a drug target against SARS-CoV-2 infections. SARS-CoV-2 M p…
View article: Multimodal analysis stratifies genetic susceptibility and reveals the pathogenic mechanism of kidney injury in diabetic nephropathy
Multimodal analysis stratifies genetic susceptibility and reveals the pathogenic mechanism of kidney injury in diabetic nephropathy Open
The genetic etiology of diabetic nephropathy (DN) is masked by inaccurate phenotyping and ethnic disparities. Here, we conduct a stepwise genome-wide association study (GWAS) in the Chinese Han population, using a precise phenotype of biop…
View article: Research on the impact of artificial intelligence on the pollution governance mechanism and pathways in border regions
Research on the impact of artificial intelligence on the pollution governance mechanism and pathways in border regions Open
Boundary pollution poses obstacles to environmental governance and industrial upgrading, while traditional monitoring methods fail to provide a fundamental solution. Drawing on data from boundary prefecture-level cities between 2016 and 20…
View article: World health Organization’s guidance for tracking non-communicable diseases towards sustainable development goals 3.4: an initiative for facility-based monitoring
World health Organization’s guidance for tracking non-communicable diseases towards sustainable development goals 3.4: an initiative for facility-based monitoring Open
This study was funded internally by WHO.
View article: An adaptive AI-based virtual reality sports system for adolescents with excess body weight: a randomized controlled trial
An adaptive AI-based virtual reality sports system for adolescents with excess body weight: a randomized controlled trial Open
Adolescents with obesity face numerous health risks and encounter barriers that lead to physical inactivity. We developed a virtual reality sports system, named REVERIE (Real-World Exercise and VR-Based Exercise Research in Education), whi…
View article: Non-invasive biopsy diagnosis of diabetic kidney disease via deep learning applied to retinal images: a population-based study
Non-invasive biopsy diagnosis of diabetic kidney disease via deep learning applied to retinal images: a population-based study Open
National Key R & D Program of China, National Natural Science Foundation of China, Beijing Natural Science Foundation, Shanghai Municipal Key Clinical Specialty, Shanghai Research Centre for Endocrine and Metabolic Diseases, Innovative res…
View article: Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50
Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50 Open
The SARS-CoV-2 main protease (M pro ) is essential for viral replication and is a primary target for COVID-19 antivirals. Direct-acting antivirals such as nirmatrelvir, the active component of Paxlovid, target the M pro active site to bloc…
View article: Community-Based Peer Support for Diabetes Management: 24-Month Changes Relative to Comparison Communities
Community-Based Peer Support for Diabetes Management: 24-Month Changes Relative to Comparison Communities Open
Objective Evaluate effectiveness of community-based peer support for diabetes self-management with HbA1c and other clinical and psychosocial outcomes over 24 months. Research design and methods Intervention comparison design with 12 Interv…
View article: Community-Based Peer Support for Diabetes Management: 24-Month Changes Relative to Comparison Communities
Community-Based Peer Support for Diabetes Management: 24-Month Changes Relative to Comparison Communities Open
Objective Evaluate effectiveness of community-based peer support for diabetes self-management with HbA1c and other clinical and psychosocial outcomes over 24 months. Research design and methods Intervention comparison design with 12 Interv…
View article: Community-Based Peer Support for Diabetes Management: 24-Month Changes Relative to Comparison Communities
Community-Based Peer Support for Diabetes Management: 24-Month Changes Relative to Comparison Communities Open
OBJECTIVE To evaluate the effectiveness of community-based peer support for diabetes self-management with HbA1c and other clinical and psychosocial outcomes over 24 months. RESEARCH DESIGN AND METHODS This study used an intervention compar…
View article: Fibroblast Growth Factor 21 Levels Are Associated With Perception and Neural Responses to Sweetness in Type 2 Diabetes Mellitus
Fibroblast Growth Factor 21 Levels Are Associated With Perception and Neural Responses to Sweetness in Type 2 Diabetes Mellitus Open
Background: The relationship between fibroblast growth factor 21 (FGF21) and sweet taste perception and preference in type 2 diabetes mellitus (T2DM) remains unclear. This study aims to investigate this relationship and examine the neural …
View article: Application and prospect of artificial intellingence in diabetes care
Application and prospect of artificial intellingence in diabetes care Open
Diabetes is one of the fastest-growing non-communicable diseases, becoming an important public health concern worldwide as well as in China. Currently, China has the largest population living with diabetes. Artificial intelligence (AI) is …
View article: A pretrained transformer model for decoding individual glucose dynamics from continuous glucose monitoring data
A pretrained transformer model for decoding individual glucose dynamics from continuous glucose monitoring data Open
Continuous glucose monitoring (CGM) technology has grown rapidly to track real-time blood glucose levels and trends with improved sensor accuracy. The ease of use and wide availability of CGM will facilitate safe and effective decision mak…
View article: Fibroblast growth factor 23 predicts incident diabetic kidney disease: A 4.6‐year prospective study
Fibroblast growth factor 23 predicts incident diabetic kidney disease: A 4.6‐year prospective study Open
Aims Fibroblast growth factor (FGF) 23 is a bone‐derived phosphaturic hormone that participates in the regulation of mineral metabolism and the development of chronic kidney disease. This study aimed to investigate the association between …
View article: Molecular Mechanisms of Drug Resistance and Compensation in SARS-CoV-2 Main Protease: The Interplay Between E166 and L50
Molecular Mechanisms of Drug Resistance and Compensation in SARS-CoV-2 Main Protease: The Interplay Between E166 and L50 Open
The SARS-CoV-2 main protease (M pro ) is essential for viral replication, and a primary target for COVID-19 antivirals. Direct-acting antivirals such as nirmatrelvir, the active component of Paxlovid, target the M pro active site to block …
View article: Large language models for diabetes training: a prospective study
Large language models for diabetes training: a prospective study Open
Diabetes poses a considerable global health challenge, with varying levels of diabetes knowledge among healthcare professionals, highlighting the importance of diabetes training. Large Language Models (LLMs) provide new insights into diabe…
View article: Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease
Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease Open
Our research suggests that scRNA-seq can reflect the multifaceted mitochondrial landscape of DKD renal tubular cells after drug treatment, and these findings may provide new targets for DKD therapy at the organelle level.
View article: Discovery of robust and highly specific microbiome signatures of non-alcoholic fatty liver disease
Discovery of robust and highly specific microbiome signatures of non-alcoholic fatty liver disease Open
Our study reveals robust and highly specific NAFLD signatures and offers a more realistic microbiome-therapeutics approach over individual species for this complex disease. Video Abstract.
View article: BioCompNet: A Deep Learning Workflow Enabling Automated Body Composition Analysis toward Precision Management of Cardiometabolic Disorders
BioCompNet: A Deep Learning Workflow Enabling Automated Body Composition Analysis toward Precision Management of Cardiometabolic Disorders Open
Growing evidence highlights the importance of body composition (BC), including bone, muscle, and adipose tissue (AT), as a critical biomarker for cardiometabolic risk stratification. However, conventional methods for quantifying BC compone…
View article: Associations between multiple metabolic biomarkers with steatotic liver disease subcategories: A 5-year Chinese cohort study
Associations between multiple metabolic biomarkers with steatotic liver disease subcategories: A 5-year Chinese cohort study Open
The effectiveness of established biomarkers for non-alcoholic fatty liver disease (NAFLD) within the updated framework of steatotic liver disease (SLD) remains uncertain. This cohort study examines the association of four metabolic biomark…
View article: Identification and characterization of ternary complexes consisting of FKBP12, MAPRE1 and macrocyclic molecular glues
Identification and characterization of ternary complexes consisting of FKBP12, MAPRE1 and macrocyclic molecular glues Open
Protein array screening revealed a macrocyclic glue that recruits MAPRE1 to FKBP12. The corresponding ternary complex was characterized and the compound-dependent inhibition of a native MAPRE1 interaction was demonstrated in a cellular ass…