Weiping Han
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View article: Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer
Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer Open
Tumor-initiating cells (TICs) preferentially reside in poorly vascularized, nutrient-stressed tumor regions, yet how they adapt to glucose limitation is unclear. We show that lung TICs, unlike bulk tumor cells, can switch from glucose to k…
View article: N-Glycosylation Is Essential for Vesicular Targeting of Synaptotagmin 1
N-Glycosylation Is Essential for Vesicular Targeting of Synaptotagmin 1 Open
View article: Maternal blood glucose level is correlated to offspring brain fatty acid composition in a mouse model for gestational diabetes mellitus
Maternal blood glucose level is correlated to offspring brain fatty acid composition in a mouse model for gestational diabetes mellitus Open
Gestational diabetes mellitus (GDM) may increase the risk of suboptimal neurocognitive development in infants. Maternal supply of omega-3 and -6 long chain polyunsaturated fatty acids (LCPUFAs), including eicosapentaeonic acid, docosahexae…
View article: Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution
Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution Open
The regulation of PKC epsilon (PKCε) and its downstream effects is still not fully understood, making it challenging to develop targeted therapies or interventions. A more precise tool that enables spatiotemporal control of PKCε activity i…
View article: Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution
Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution Open
The regulation of PKC epsilon (PKCε) and its downstream effects is still not fully understood, making it challenging to develop targeted therapies or interventions. A more precise tool that enables spatiotemporal control of PKCε activity i…
View article: Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution
Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution Open
The regulation of PKC epsilon (PKCepsilon) and its downstream effects is still not fully understood, making it challenging to develop targeted therapies or interventions. A more precise tool that enables spatiotemporal control of PKCepsilo…
View article: Enhancing Mouse Fundus Imaging with OCT Embedding Medium: Prolonging Imaging Duration and Improving Image Quality
Enhancing Mouse Fundus Imaging with OCT Embedding Medium: Prolonging Imaging Duration and Improving Image Quality Open
View article: Exploring RNF213 in Ischemic Stroke and Moyamoya Disease: From Cellular Models to Clinical Insights
Exploring RNF213 in Ischemic Stroke and Moyamoya Disease: From Cellular Models to Clinical Insights Open
Advances in stroke genetics have highlighted the critical role of rare genetic variants in cerebrovascular diseases, with RNF213 emerging as a key player in ischemic stroke and Moyamoya disease (MMD). Initially identified as the primary su…
View article: Amino acid is a major carbon source for hepatic lipogenesis
Amino acid is a major carbon source for hepatic lipogenesis Open
Increased de novo lipogenesis is a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD) in obesity, but the macronutrient carbon source for over half of hepatic fatty acid synthesis remains undetermined. Here, we di…
View article: EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake
EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake Open
BACKGROUND: Atherosclerotic plaques form unevenly due to disturbed blood flow, causing localized endothelial cell (EC) dysfunction. Obesity exacerbates this process, but the underlying molecular mechanisms are unclear. The transcription fa…
View article: Disentangling the detrimental effects of local from systemic adipose tissue dysfunction on articular cartilage in the knee
Disentangling the detrimental effects of local from systemic adipose tissue dysfunction on articular cartilage in the knee Open
Our findings emphasise the prevalent role of systemic metabolic and inflammatory effects in impairing cartilage homeostasis, with a modulatory role for intra-articular adipose tissue.
View article: Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy
Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy Open
View article: Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy
Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy Open
Lipodystrophy is a rare disorder which can be life-threatening. Here individuals fail to develop or maintain appropriate adipose tissue stores. This typically causes severe metabolic complications, including hepatic steatosis and lipoatrop…
View article: Pre-treatment radiological factors associated with poor functional outcome in an Asian cohort of large vessel occlusion acute ischemic stroke patients undergoing mechanical thrombectomy
Pre-treatment radiological factors associated with poor functional outcome in an Asian cohort of large vessel occlusion acute ischemic stroke patients undergoing mechanical thrombectomy Open
Background and aims Endovascular thrombectomy (EVT) is the current standard of care for large vessel occlusion (LVO) acute ischemic stroke (AIS); however, up to two-thirds of EVT patients have poor functional outcomes despite successful re…
View article: Gene therapy targeting key beta cell regulators as a potential intervention for diabetes
Gene therapy targeting key beta cell regulators as a potential intervention for diabetes Open
Loss of functional beta cells is the central event of all forms of diabetes. Conventional therapies for type 2 diabetes (T2D) fail to preserve beta cells, leading to worsening glycemia as beta cell function progressively declines. While im…
View article: YAP/TAZ Drive Agrin–Matrix Metalloproteinase 12–Mediated Diabetic Skin Wound Healing
YAP/TAZ Drive Agrin–Matrix Metalloproteinase 12–Mediated Diabetic Skin Wound Healing Open
Macroscopic loss of extracellular matrix can lead to chronic defects in skin wound healing, but supplementation of extracellular matrix holds promise for facilitating wound closure, particularly in diabetic wound healing. We recently showe…
View article: Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT
Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT Open
The posttranslational modification of intracellular proteins through O-linked β-N-acetylglucosamine (O-GlcNAc) is a conserved regulatory mechanism in multicellular organisms. Catalyzed by O-GlcNAc transferase (OGT), this dynamic modificati…
View article: GLP-1 receptor agonist improves metabolic disease in a pre-clinical model of lipodystrophy
GLP-1 receptor agonist improves metabolic disease in a pre-clinical model of lipodystrophy Open
Aims Individuals with lipodystrophies typically suffer from metabolic disease linked to adipose tissue dysfunction including lipoatrophic diabetes. In the most severe forms of lipodystrophy, congenital generalised lipodystrophy, adipose ti…
View article: Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity
Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity Open
The SLC7A11/xCT cystine and glutamate antiporter has emerged as an attractive target for cancer therapy due to its selective overexpression in multiple cancers and its role in preventing ferroptosis. Utilizing pharmacological and genetic a…
View article: EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake
EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake Open
Background Atherosclerotic plaques form unevenly due to disturbed blood flow, causing localized endothelial cell (EC) dysfunction. Obesity exacerbates this process, but the underlying molecular mechanisms are unclear. The transcription fac…
View article: Nuanced contribution of gut microbiome in the early brain development of mice
Nuanced contribution of gut microbiome in the early brain development of mice Open
The complex symbiotic relationship between the mammalian body and gut microbiome plays a critical role in the health outcomes of offspring later in life. The gut microbiome modulates virtually all physiological functions through direct or …
View article: Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy Open
View article: GLP-1 Receptor Agonist Improves Metabolic Disease in a Pre-clinical Model of Lipodystrophy
GLP-1 Receptor Agonist Improves Metabolic Disease in a Pre-clinical Model of Lipodystrophy Open
Individuals with lipodystrophies typically suffer from significant metabolic disease linked to adipose tissue dysfunction including severe insulin resistance and lipoatrophic diabetes, hepatic steatosis and hyperphagia. Current treatment o…
View article: Functional activity of the caudate mediates the relation between early childhood microstructural variations and elevated metabolic syndrome scores
Functional activity of the caudate mediates the relation between early childhood microstructural variations and elevated metabolic syndrome scores Open
We found that variations in caudate microstructure at 4.5 years predict later variation in functional activity at 7.5 years. This later variation in functional activity fully mediates the relation between microstructural changes in early c…
View article: Genetic Ablation of LAT1 Inhibits Growth of Liver Cancer Cells and Downregulates mTORC1 Signaling
Genetic Ablation of LAT1 Inhibits Growth of Liver Cancer Cells and Downregulates mTORC1 Signaling Open
Through a comprehensive analysis of the gene expression and dependency in HCC patients and cell lines, LAT1 was identified as the top amino acid transporter candidate supporting HCC tumorigenesis. To assess the suitability of LAT1 as a HCC…
View article: CRISPR-Cas9 Long-Read Sequencing for Mapping Transgenes in the Mouse Genome
CRISPR-Cas9 Long-Read Sequencing for Mapping Transgenes in the Mouse Genome Open
Microinjected transgenes, both large and small, are known to insert randomly into the mouse genome. Traditional methods of mapping a transgene are challenging, thus complicating breeding strategies and accurate interpretation of phenotypes…
View article: Decision letter: Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1)
Decision letter: Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1) Open
Full text Figures and data Side by side Abstract Editor's evaluation eLife digest Introduction Methods Results Discussion Data availability References Decision letter Author response Article and author information Metrics Abstract Backgrou…
View article: Schizophrenia-Like Behaviors Arising from Dysregulated Proline Metabolism Are Associated with Altered Neuronal Morphology and Function in Mice with Hippocampal PRODH Deficiency
Schizophrenia-Like Behaviors Arising from Dysregulated Proline Metabolism Are Associated with Altered Neuronal Morphology and Function in Mice with Hippocampal PRODH Deficiency Open
Despite decades of research being conducted to understand what physiological deficits in the brain are an underlying basis of psychiatric diseases like schizophrenia, it has remained difficult to establish a direct causal relationship betw…
View article: Amino Acids as a Primary Carbon Source in Hepatic Lipogenesis
Amino Acids as a Primary Carbon Source in Hepatic Lipogenesis Open
View article: Maternal microbes and early brain development in mouse
Maternal microbes and early brain development in mouse Open
The complex symbiotic relationship between the mammalian body and gut microbiome plays a critical role in the health outcomes of offspring later in life. The gut microbiome modulates virtually all physiological functions through direct or …