Weisi Wang
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View article: Effect of SO42– Concentration on Electrochemical Corrosion Behavior of PCB-Cu under Thin Liquid Film
Effect of SO42– Concentration on Electrochemical Corrosion Behavior of PCB-Cu under Thin Liquid Film Open
The electrochemical corrosion behavior of PCB-Cu under thin liquid film was investigated with varying concentrations of SO42– through polarization curves and electrochemical impedance spectroscopy (EIS). The results indicate that the corro…
View article: Halogen Modulation: Novel Fluoropyridylphenylurea Derivatives as Potent Molluscicides Unveiling Snail‐Killing Mechanisms
Halogen Modulation: Novel Fluoropyridylphenylurea Derivatives as Potent Molluscicides Unveiling Snail‐Killing Mechanisms Open
Pomacea canaliculata is an invasive species that poses significant threats to agriculture and human health. The development of environmentally friendly molluscicides is crucial for its management. In this study, we synthesized 17 fluoropyr…
View article: Drug repurposing for hard-to-treat human alveolar echinococcosis: pyronaridine and beyond
Drug repurposing for hard-to-treat human alveolar echinococcosis: pyronaridine and beyond Open
Human alveolar echinococcosis is a hard-to-treat and largely untreated parasitic disease with high associated health care costs. The current antiparasitic treatment for alveolar echinococcosis relies exclusively on albendazole, which does …
View article: Angelicae dahuricae radix alleviates simulated microgravity induced bone loss by promoting osteoblast differentiation
Angelicae dahuricae radix alleviates simulated microgravity induced bone loss by promoting osteoblast differentiation Open
Bone loss caused by long-duration spaceflight seriously affects the skeletal health of astronauts. There are many shortcomings in currently available treatments for weightlessness-induced bone loss. The aim of this study was to evaluate th…
View article: Case report: Clinical, imaging, and genetic characteristics of type B niemann pick disease combined with segawa syndrome diagnosed via dual gene sequencing
Case report: Clinical, imaging, and genetic characteristics of type B niemann pick disease combined with segawa syndrome diagnosed via dual gene sequencing Open
Niemann Pick disease B (NPB) often presents with hepatosplenomegaly and lung pathological changes, but it usually does not present with central nervous system symptoms. This report presents the unique case of a 21-year-old woman with a 10-…
View article: Nomogram model for predicting cancer-specific mortality in patients with early-onset colorectal cancer: a competing risk analysis insight from the SEER database and an external validation cohort
Nomogram model for predicting cancer-specific mortality in patients with early-onset colorectal cancer: a competing risk analysis insight from the SEER database and an external validation cohort Open
In this study, a competing risk model for CSM was developed in EOCRC patients. The model demonstrates a high level of predictive accuracy, providing valuable insights into the treatment decision-making process.
View article: The Variation in Chemical Composition and Source Apportionment of PM2.5 before, during, and after COVID-19 Restrictions in Zhengzhou, China
The Variation in Chemical Composition and Source Apportionment of PM2.5 before, during, and after COVID-19 Restrictions in Zhengzhou, China Open
Despite significant improvements in air quality during and after COVID-19 restrictions, haze continued to occur in Zhengzhou afterwards. This paper compares ionic compositions and sources of PM2.5 before (2019), during (2020), and after (2…
View article: Nomogram model for predicting cause-specific mortality in patients with Early-Onset Colorectal Cancer: a competing risk analysis Insight from the SEER Database and a Chinese Cohort.
Nomogram model for predicting cause-specific mortality in patients with Early-Onset Colorectal Cancer: a competing risk analysis Insight from the SEER Database and a Chinese Cohort. Open
Objective This study aims to analyze the risk factors for Cancer-Specific Mortality (CSM) and Other-Cause Mortality (OCM) in early-onset colorectal cancer (EOCRC) patients,and to construct a nomogram for predicting CSM based on a competiti…
View article: Oral Delivery of Anti-Parasitic Agent-Loaded PLGA Nanoparticles: Enhanced Liver Targeting and Improved Therapeutic Effect on Hepatic Alveolar Echinococcosis
Oral Delivery of Anti-Parasitic Agent-Loaded PLGA Nanoparticles: Enhanced Liver Targeting and Improved Therapeutic Effect on Hepatic Alveolar Echinococcosis Open
Our findings demonstrate the advantages of encapsulating H1402 into PLGA nanoparticles and highlight the potential of H1402-NPs as a promising liver-targeting therapeutic strategy for hepatic AE.
View article: The Biosafety Evaluation for Crustaceans: A Novel Molluscicide PBQ Using against Oncomelania hupensis, the Intermediate Host of Schistosoma japonica
The Biosafety Evaluation for Crustaceans: A Novel Molluscicide PBQ Using against Oncomelania hupensis, the Intermediate Host of Schistosoma japonica Open
A new formulation (suspension concentrate, SC) of PBQ [1-(4-chlorophenyl)-3-(pyridin-3-yl) urea] was used in water network schistosomiasis-endemic areas to test its molluscicidal efficacy and the acute toxicity to crustaceans. PBQ (20% SC)…
View article: Haze Occurrence Caused by High Gas-to-Particle Conversion in Moisture Air under Low Pollutant Emission in a Megacity of China
Haze Occurrence Caused by High Gas-to-Particle Conversion in Moisture Air under Low Pollutant Emission in a Megacity of China Open
Haze occurred in Zhengzhou, a megacity in the northern China, with the PM2.5 as high as 254 μg m−3 on 25 December 2019, despite the emergency response measure of restriction on the emission of anthropogenic pollutants which was implemented…
View article: Multi-model Evaluation and Bayesian Model Averaging in Quantitative Air Quality Forecasting in Central China
Multi-model Evaluation and Bayesian Model Averaging in Quantitative Air Quality Forecasting in Central China Open
There has been much interest in air pollution and the forecasting skill of air quality models in China since winter 2013. Different air quality models use different parameters (e.g., meteorological fields, emission sources and the initial …
View article: Additional file 5 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine
Additional file 5 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine Open
Additional file 5:Table S2 All genes with RPKM values and FDRs
View article: Additional file 6 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine
Additional file 6 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine Open
Additional file 6: Table S3 Enriched GO terms of DEGs
View article: Additional file 7 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine
Additional file 7 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine Open
Additional file 7:Table S4 Enriched KEGG pathways of DEGs
View article: Methnaridine is an orally bioavailable, fast‐killing and long‐acting antimalarial agent that cures <i>Plasmodium</i> infections in mice
Methnaridine is an orally bioavailable, fast‐killing and long‐acting antimalarial agent that cures <i>Plasmodium</i> infections in mice Open
Background and Purpose Malaria is one of the deadliest diseases in the world. Novel chemotherapeutic agents are urgently required to combat the widespread Plasmodium resistance to frontline drugs. Here, we report the discovery of a novel b…
View article: Elevated expression of mitochondrial transcription elongation factor (TEFM) predicts poor prognosis in low grade glioma—an analysis of the Cancer Genome Atlas (TCGA) dataset
Elevated expression of mitochondrial transcription elongation factor (TEFM) predicts poor prognosis in low grade glioma—an analysis of the Cancer Genome Atlas (TCGA) dataset Open
Our findings disclosed that the expression of TEFM mRNA was significantly upregulated in human LGG tissues compared to non-tumor brain tissues. More importantly, the elevated expression of TEFM mRNA may potentially predict poor OS in LGG p…
View article: Effect of ammonia on fine-particle pH in agricultural regions of China: comparison between urban and rural sites
Effect of ammonia on fine-particle pH in agricultural regions of China: comparison between urban and rural sites Open
Particle acidity is a fundamental property that affects atmospheric particulate chemistry. Synchronous online monitoring was performed at two urban sites, Zhengzhou (U-ZZ) and Anyang (U-AY), and three rural sites, Anyang (R-AY), Xinxiang (…
View article: Role of ammonia on fine-particle pH in agricultural regions of China: Comparison between urban and rural sites
Role of ammonia on fine-particle pH in agricultural regions of China: Comparison between urban and rural sites Open
Particle acidity is a fundamental property that affects atmospheric particulate chemistry. Synchronous online monitoring was performed in two urban sites (e.g., Zhengzhou (U-ZZ) and Anyang (U-AY)) and three rural sites (e.g., Anyang (R-AY)…
View article: Supplementary material to "Role of ammonia on fine-particle pH in agricultural regions of China: Comparison between urban and rural sites"
Supplementary material to "Role of ammonia on fine-particle pH in agricultural regions of China: Comparison between urban and rural sites" Open
Correlation is significant at the 0.05 level (two-tailed).** Correlation is significant at the 0.01 level (two-tailed).
View article: A high expression of MTERF3 correlates with tumor progression and predicts poor outcomes in patients with brain glioma.
A high expression of MTERF3 correlates with tumor progression and predicts poor outcomes in patients with brain glioma. Open
Mitochondrial transcription termination factor 3 (MTERF3) is a negative regulator of mitochondrial transcription. MTERF3 is overexpressed in liver cancer, pancreatic cancer, lung cancer, and breast cancer. However, whether MTERF3 is up-reg…
View article: Molluscicidal activity and mechanism of toxicity of a novel salicylanilide ester derivative against Biomphalaria species
Molluscicidal activity and mechanism of toxicity of a novel salicylanilide ester derivative against Biomphalaria species Open
Salicylanilidate not only had deleterious effects on Biomphalaria species and S. mansoni cercariae but also showed very low toxicity to D. rerio, suggesting that it has broad potential applications.
View article: In vitro and in vivo efficacies of novel carbazole aminoalcohols in the treatment of cystic echinococcosis
In vitro and in vivo efficacies of novel carbazole aminoalcohols in the treatment of cystic echinococcosis Open
Our study identifies carbazole aminoalcohols as a class of novel anti-CE agents. Compounds 2 and 24 represent promising drug candidates in anti-CE chemotherapy.