Wen‐Zhao Zhong
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View article: Quantifying Early-Stage Lung Adenocarcinoma Progression with a Radiomic Trajectory
Quantifying Early-Stage Lung Adenocarcinoma Progression with a Radiomic Trajectory Open
Determining tumor progression status is critical for early-stage lung adenocarcinoma (esLUAD) diagnosis and treatment, yet histopathology-based grading often overlooks heterogeneity within grades. We propose RadioTrace, a deep contrastive …
View article: Cellular dynamics in cerebrospinal fluid unveils the key regulators of intracranial response to immune checkpoint inhibitors in NSCLC brain metastases
Cellular dynamics in cerebrospinal fluid unveils the key regulators of intracranial response to immune checkpoint inhibitors in NSCLC brain metastases Open
Background Brain metastases (BrM) in non-small cell lung cancer (NSCLC) present a significant challenge due to poor prognosis. While immune checkpoint inhibitors (ICIs) have been standard treatments for NSCLC, their efficacy in BrM is vari…
View article: Induction alectinib or crizotinib for stage III NSCLC harboring ALK fusion: A study with 4-year follow-up
Induction alectinib or crizotinib for stage III NSCLC harboring ALK fusion: A study with 4-year follow-up Open
Background: Despite increased response and long-term benefit of anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors (TKIs) in advanced non-small cell lung cancer (NSCLC) harboring ALK -fusion, the role of induction ALK-TKIs in loca…
View article: Advances in Cytoplasmic Male Sterility in Sugar Beet from Mitochondrial Genome Structural Dynamics and Nuclear-Cytoplasmic Coordination
Advances in Cytoplasmic Male Sterility in Sugar Beet from Mitochondrial Genome Structural Dynamics and Nuclear-Cytoplasmic Coordination Open
Sugar beet (Beta vulgaris L.) is a globally important sugar crop whose hybrid breeding system relies heavily on cytoplasmic male sterility (CMS) lines. Recent advances in sugar beet genomics, particularly the release of high-quality refere…
View article: Single-cell RNA profiling reveals an immunosuppressive microenvironment in EGFR double-mutant non-small cell lung cancer
Single-cell RNA profiling reveals an immunosuppressive microenvironment in EGFR double-mutant non-small cell lung cancer Open
scFocuSCOPE precisely delineated tumor heterogeneity and immune suppression in EGFR-DM NSCLC. The complex immune landscape of EGFR-DM tumors offers valuable insights for future mechanistic studies and personalized therapies.
View article: Impact of preoperative SARS-CoV-2 infection on post-prostatectomy urinary continence and erectile function
Impact of preoperative SARS-CoV-2 infection on post-prostatectomy urinary continence and erectile function Open
Preoperative COVID-19 infection was linked to reduced erectile function in univariable analysis but not after multivariable adjustment, and it had no significant effect on urinary continence. Sexual and urinary function were correlated in …
View article: Deciphering genomic evolution of metastatic organotropism with 535 paired primary lung cancers and metastases
Deciphering genomic evolution of metastatic organotropism with 535 paired primary lung cancers and metastases Open
Metastasis is the leading cause of death in lung cancer patients, yet our understanding of its genomic determinants and evolution remains limited. Here, we analyzed whole-exome sequencing data from 535 paired primary and metastatic tumors …
View article: Multiomics elucidation of surrounding AT2 cells impeding tertiary lymphoid structures function in neoadjuvant chemoimmunotherapy response of multiple primary lung cancers
Multiomics elucidation of surrounding AT2 cells impeding tertiary lymphoid structures function in neoadjuvant chemoimmunotherapy response of multiple primary lung cancers Open
The inconsistent immunotherapy response among lesions in patients with multiple primary lung cancer (MPLC) remains poorly understood, presenting a significant challenge for effective treatment. In this study, we conducted a comprehensive m…
View article: Characterization of the extrinsic and intrinsic signatures and therapeutic vulnerability of small cell lung cancers
Characterization of the extrinsic and intrinsic signatures and therapeutic vulnerability of small cell lung cancers Open
Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor strongly associated with exposure to tobacco carcinogens, is characterized by early dissemination and dismal prognosis with a five-year overall survival of less than 7%. Hig…
View article: Clinical characteristics and factors associated with severe COVID-19 among hospitalized pediatric patients: a retrospective cohort study in the Chaoshan region of China
Clinical characteristics and factors associated with severe COVID-19 among hospitalized pediatric patients: a retrospective cohort study in the Chaoshan region of China Open
Background Since 2019, COVID-19 has substantially impacted global public health. Although pediatric cases generally manifest with mild symptoms, severe and even fatal outcomes have occurred. Despite the decreased viral transmissibility and…
View article: Unveiling Lymph Node Metastasis (LNM) in pleural-attached lung mucinous adenocarcinoma: A Predictive Model Using Pleural Contact Parameters
Unveiling Lymph Node Metastasis (LNM) in pleural-attached lung mucinous adenocarcinoma: A Predictive Model Using Pleural Contact Parameters Open
Objective: This study seeks to evaluate the prognostic significance of pleural-attached parameters and computed tomography (CT) imaging characteristics in predicting lymph node metastasis (LNM) in cases of pleural-attached invasive mucinou…
View article: Lung Cancer with Isolated Pleural Dissemination as a Potential ctDNA Non-Shedding Tumor Type
Lung Cancer with Isolated Pleural Dissemination as a Potential ctDNA Non-Shedding Tumor Type Open
Objectives: Circulating tumor DNA (ctDNA) has emerged as a reliable prognostic biomarker in both early- and late-stage non-small cell lung cancer (NSCLC) patients. However, its role in NSCLC with pleural dissemination (M1a), a subset of di…
View article: Intelligent Diagnosis Method for Early Weak Faults Based on Wave Intercorrelation–Convolutional Neural Networks
Intelligent Diagnosis Method for Early Weak Faults Based on Wave Intercorrelation–Convolutional Neural Networks Open
Rolling bearings are widely used in rotating machinery, and their health status is crucial for the safe operation of the equipment. The research on relevant fault diagnosis algorithms is a hot topic in the field. As a leading deep learning…
View article: Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy
Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy Open
The retention of galactose-deficient IgA1 (Gd-IgA1) in the mesangium is central to IgA nephropathy (IgAN), but its intracellular fate remains unclear. Here, we show that transferrin receptor 1 (TfR1) mediates Gd-IgA1 uptake into mesangial …
View article: Impaired natural killer cell maturation in lung adenocarcinoma driven by FABP4 and SPON2 downregulation through disrupted lipid metabolism
Impaired natural killer cell maturation in lung adenocarcinoma driven by FABP4 and SPON2 downregulation through disrupted lipid metabolism Open
The study findings present new evidence showing that low FABP4 and SPON2 gene expression may impair NK cell maturity by affecting lipid metabolism in lung adenocarcinoma. These results provide a new perspective on restoring immune function…
View article: Perioperative SARS-CoV-2 infection and postoperative complications: a single-centre retrospective cohort study in China
Perioperative SARS-CoV-2 infection and postoperative complications: a single-centre retrospective cohort study in China Open
Objective To explore the association between perioperative SARS-CoV-2 infection and the postoperative complications during the breakout of the Omicron epidemic wave. Design Observational retrospective cohort study. Multivariable logistic r…
View article: Expert Consensus on the Diagnosis and Treatment of Malignant Pericardial Mesothelioma
Expert Consensus on the Diagnosis and Treatment of Malignant Pericardial Mesothelioma Open
Primary malignant pericardial mesothelioma (PMPM), a rare pericardium‐derived malignancy, urgently requires standardized diagnostic and therapeutic protocols. This consensus, established by the Chinese Alliance of Research for Mesothelioma…
View article: Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration
Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration Open
Alterations in the mesenchymal-epithelial transition factor (MET) gene are critical drivers of non-small cell lung cancer (NSCLC). In recent years advances in precision therapies targeting MET alterations have significantly expanded treatm…
View article: Supplementary Table S6 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Table S6 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Table S6. The circulating tumor DNA mutation results for 4 patients with lead time over 30 months.
View article: Supplementary Figure S4 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Figure S4 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Supplementary Figure S4. Kaplan-Meier analysis of the survival time since last blood, comparing patients with longitudinal undetectable MRD to those with longitudinal detectable MRD (last blood draw positive), excluding synchronous recurre…
View article: Supplementary Figure S2 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Figure S2 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Supplementary Figure S2. Kaplan-Meier Analysis of Disease-Free Survival (DFS) in the Overall Population.
View article: Data from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Data from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Purpose:The prognostic value of molecular residual disease (MRD) in non–small cell lung cancer (NSCLC) is well established, with treatment-guiding results anticipated. Here, we present updated analyses from our previously published cohort …
View article: Supplementary Figure S5 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Figure S5 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Supplementary Figure S5. CT and MRI images of patients with brain-only metastases who had longitudinal undetectable MRD. The red arrows indicate the location of metastatic lesions.
View article: Supplementary Figure S6 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Figure S6 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Supplementary Figure S6. Kaplan-Meier Analysis of Disease-Free Survival (DFS) for patients with intermittently detectable MRD versus persistently detectable MRD. Patients who spontaneously converted to undetectable MRD after the first posi…
View article: Supplementary Figure S8 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Figure S8 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Supplementary Figure S8. (A) Estimated hazard rate curves for event occurrences in stage II/III patients with landmark undetectable MRD, who received adjuvant therapy. (B) Estimated hazard rate curves for event occurrences in stage II/III …
View article: Supplementary Table S3 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Table S3 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Table S3. Univariate and Multivariate Cox Regression Analysis.
View article: Supplementary Table S5 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Table S5 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Table S5. The circulating tumor DNA mutation results for 5 MRD+ patients without recurrence.