Weiwei Chu
YOU?
Author Swipe
View article: G9a epigenetically suppresses <scp>CXCL10</scp> expression and inhibits anti‐tumor immunity in hepatocellular carcinoma
G9a epigenetically suppresses <span>CXCL10</span> expression and inhibits anti‐tumor immunity in hepatocellular carcinoma Open
The immunosuppressive tumor microenvironment, characterized by limited immune cell infiltration, represents a major challenge for effective immunotherapy in hepatocellular carcinoma (HCC). Epigenetic dysregulation has emerged as a critical…
View article: LncRNA-like MMP14 RNA facilitates colorectal cancer metastasis by suppressing H3K27cr at the STARD13 promoter region
LncRNA-like MMP14 RNA facilitates colorectal cancer metastasis by suppressing H3K27cr at the STARD13 promoter region Open
The study elucidated an lncRNA-like mechanism by which MMP14 RNA facilitated CRC metastasis via RNA-directed chromatin remodeling.
View article: Exosomal miR-146a-3p modulates neural stem cell fate through UCHL1 downregulation in spinal cord injury: implications for neuroregeneration
Exosomal miR-146a-3p modulates neural stem cell fate through UCHL1 downregulation in spinal cord injury: implications for neuroregeneration Open
Spinal cord injury (SCI) poses a substantial challenge within the field of regenerative medicine, primarily because of its high incidence of disability and the paucity of effective therapeutic interventions. This study explores the involve…
View article: Gut-brain axis and exosome-mediated communication in postoperative cognitive dysfunction associated with colorectal cancer
Gut-brain axis and exosome-mediated communication in postoperative cognitive dysfunction associated with colorectal cancer Open
Postoperative cognitive dysfunction (POCD) is a serious complication in patients undergoing colorectal cancer (CRC) surgery. It is characterized by significant impairments in memory, information processing and attention, and may also resul…
View article: Hypomethylation‐Triggered SERPINE1 (Serpin Family E Member 1) Exacerbates Polycystic Ovary Syndrome with Hyperandrogenism Induced by Circadian Disruption
Hypomethylation‐Triggered SERPINE1 (Serpin Family E Member 1) Exacerbates Polycystic Ovary Syndrome with Hyperandrogenism Induced by Circadian Disruption Open
Polycystic ovary syndrome (PCOS), a prevalent cause of female infertility, arises from complex interactions between genetic and environmental factors, with hyperandrogenism serving as a core pathological feature. While growing evidence lin…
View article: The mediating effect of shift sleep disorder on work- family conflict and burnout among shift nurses
The mediating effect of shift sleep disorder on work- family conflict and burnout among shift nurses Open
Objective To examine the prevalence of shift-related sleep disorders, work-family conflict, and job burnout among shift-working nurses, as well as to analyze the mediating role of shift-related sleep disorders in the relationship between w…
View article: Study on the regulation of renal tubular cell apoptosis by SIRT1/NF-κB signaling pathway in septic acute kidney injury
Study on the regulation of renal tubular cell apoptosis by SIRT1/NF-κB signaling pathway in septic acute kidney injury Open
SIRT1 regulates gene transcription via various signaling pathways, mitigating oxidative stress damage in renal tubular epithelial cells, reducing renal inflammation, and decreasing apoptosis in tubular cells. This study explores the…
View article: Corrigendum: Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome
Corrigendum: Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome Open
[This corrects the article DOI: 10.3389/fendo.2023.1233145.].
View article: Adipose‐Derived Stem Cell Exosomes Promote Scar‐Free Healing of Diabetic Wounds via miR‐204‐5p/TGF‐<i>β</i>1/Smad Pathway
Adipose‐Derived Stem Cell Exosomes Promote Scar‐Free Healing of Diabetic Wounds via miR‐204‐5p/TGF‐<i>β</i>1/Smad Pathway Open
Numerous researches have demonstrated the therapeutic potential of adipose‐derived stem cell exosomes (ADSC‐Exos) in promoting wound healing. In this study, we aimed to investigate the impact of ADSC‐Exos on diabetic wound fibroblasts and …
View article: Higher oxidative balance score was associated with decreased risk of erectile dysfunction: a population-based study
Higher oxidative balance score was associated with decreased risk of erectile dysfunction: a population-based study Open
View article: Aged polystyrene microplastics exacerbate alopecia associated with tight junction injuries and apoptosis via oxidative stress pathway in skin
Aged polystyrene microplastics exacerbate alopecia associated with tight junction injuries and apoptosis via oxidative stress pathway in skin Open
Microplastics (MPs) are pervasive pollutants in the natural environment and contribute to increased levels of illness in both animals and humans. However, thespecific impacts of MPs on skin damage and alopeciaare not yet well understood. I…
View article: Risk factor analysis and nomogram for predicting gastroparesis in patients with type 2 diabetes mellitus
Risk factor analysis and nomogram for predicting gastroparesis in patients with type 2 diabetes mellitus Open
View article: Development of a method and an assessment construct for person-centered translation of dementia public stigma scales
Development of a method and an assessment construct for person-centered translation of dementia public stigma scales Open
Background With the number of people with dementia dramatically increasing over time and dementia becoming a major health concern worldwide, scales have been developed to assess the stigma socially attached to this neurodegenerative disord…
View article: Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome
Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome Open
Background The oxidative balance score (OBS), an encompassing scoring mechanism for assessing oxidative stress, is formulated based on nutritional and lifestyle components. The emergence of metabolic syndrome (MetS) is intricately linked t…
View article: Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via the β2 adrenergic pathway suppression
Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via the β2 adrenergic pathway suppression Open
Norepinephrine (NA), a stress hormone, can accelerate hair graying by binding to β2 adrenergic receptors (β 2 AR) on melanocyte stem cells (McSCs). From this, NA-β 2 AR axis could be a potential target for preventing the stress effect. How…
View article: Rankitect: Ranking Architecture Search Battling World-class Engineers at Meta Scale
Rankitect: Ranking Architecture Search Battling World-class Engineers at Meta Scale Open
Neural Architecture Search (NAS) has demonstrated its efficacy in computer vision and potential for ranking systems. However, prior work focused on academic problems, which are evaluated at small scale under well-controlled fixed baselines…
View article: UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury
UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury Open
Activation of endogenous neural stem cells (NSCs) is greatly significant for the adult neurogenesis; however, it is extremely limited in the spinal cord after injury. Recent evidence suggests that accumulation of protein aggregates impairs…
View article: Alleviation of Limosilactobacillus reuteri in polycystic ovary syndrome protects against circadian dysrhythmia-induced dyslipidemia via capric acid and GALR1 signaling
Alleviation of Limosilactobacillus reuteri in polycystic ovary syndrome protects against circadian dysrhythmia-induced dyslipidemia via capric acid and GALR1 signaling Open
View article: Retraction Note: MiR-519d-3p enhances the sensitivity of non-small-cell lung cancer to tyrosine kinase inhibitors
Retraction Note: MiR-519d-3p enhances the sensitivity of non-small-cell lung cancer to tyrosine kinase inhibitors Open
View article: Cooperation of <scp>TGF</scp>‐β and <scp>FGF</scp> signalling pathways in skin development
Cooperation of <span>TGF</span>‐β and <span>FGF</span> signalling pathways in skin development Open
The skin is a multi‐layered structure composed of the epidermis, dermis and hypodermis. The epidermis originates entirely from the ectoderm, whereas the dermis originates from various germ layers depending on its anatomical location; thus,…
View article: UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury
UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury Open
Activation of endogenous neural stem cells (NSCs) is greatly significant for the adult neurogenesis, which is extremely limited in the non-neurogenic spinal cord after injury. Recent evidence suggests that accumulation of protein aggregate…
View article: Development and Validation of a Risk Nomogram Model for Predicting Constipation in Patients with Type 2 Diabetes Mellitus
Development and Validation of a Risk Nomogram Model for Predicting Constipation in Patients with Type 2 Diabetes Mellitus Open
In this study, the nomogram for pretreatment risk management of constipation in patients with T2DM was developed which could help in making timely personalized clinical decisions for different risk populations.
View article: Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice
Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice Open
Background The hair follicles (HFs) are barely regenerated after loss in injuries in mammals as well as in human beings. Recent studies have shown that the regenerative ability of HFs is age-related; however, the relationship between this …
View article: Natural Compound Isoliensinine Inhibits Stress‐Induced Hair Greying by Blocking <i>β</i>2‐Adrenoceptor
Natural Compound Isoliensinine Inhibits Stress‐Induced Hair Greying by Blocking <i>β</i>2‐Adrenoceptor Open
Chronic and acute stress caused by emotional or physical insults can affect the function of other organs via the brain‐body axis. As one of the smallest organs in mammalian, hair follicles are highly susceptible to stress. Under stress, th…
View article: UCHL1 inhibited by reactive astrocytes facilitates aggregates clearance to promote neural stem cell activation
UCHL1 inhibited by reactive astrocytes facilitates aggregates clearance to promote neural stem cell activation Open
Activation of the endogenous neural stem cells (NSCs) is critically important for the adult neurogenesis. However, NSC activation is extremely limited in the non-neurogenic spinal cord after spinal cord injury (SCI). Recent evidence sugges…
View article: Long-term environmental exposure of darkness induces hyperandrogenism in PCOS via melatonin receptor 1A and aromatase reduction
Long-term environmental exposure of darkness induces hyperandrogenism in PCOS via melatonin receptor 1A and aromatase reduction Open
Polycystic ovary syndrome (PCOS) is a common and complex disorder impairing female fertility, yet its etiology remains elusive. It is reported that circadian rhythm disruption might play a crucial role in PCOS pathologic progression. Here,…
View article: Reduction of H3K27cr Modification During DNA Damage in Colon Cancer
Reduction of H3K27cr Modification During DNA Damage in Colon Cancer Open
DNA damage plays an essential role in the initiation and development of colon cancer. Histone crotonylation is a newly discovered post-translational modification that is thought to promote gene expression. Whether histone crotonylation pla…
View article: Performance of Machine Learning Algorithms for Predicting Adverse Outcomes in Community-Acquired Pneumonia
Performance of Machine Learning Algorithms for Predicting Adverse Outcomes in Community-Acquired Pneumonia Open
Background: The ability to assess adverse outcomes in patients with community-acquired pneumonia (CAP) could improve clinical decision-making to enhance clinical practice, but the studies remain insufficient, and similarly, few machine lea…
View article: Circ-ATIC Serves as a Sponge of miR-326 to Accelerate Esophageal Squamous Cell Carcinoma Progression by Targeting ID1
Circ-ATIC Serves as a Sponge of miR-326 to Accelerate Esophageal Squamous Cell Carcinoma Progression by Targeting ID1 Open
In the previous studies, circular RNA (circRNA) has been shown to be closely related to the occurrence and development of various cancers. However, the role and mechanism of circ-ATIC in the progression of esophageal squamous cell carcinom…
View article: UCHL1 inhibited by A1 astrocytes facilitates aggregates clearance to promote neural stem cells activation after spinal cord injury
UCHL1 inhibited by A1 astrocytes facilitates aggregates clearance to promote neural stem cells activation after spinal cord injury Open
Spinal cord injury (SCI) is a devastating central nervous system (CNS) disease with no satisfying therapies available. Mobilizing endogenous neural stem cells (NSCs) to trigger intrinsic regeneration exhibits promising potentials for SCI r…