Weiwei Da
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Five-Step Knee Adjustment Manipulation Based on the ‘Muscle and Bone Balance’ Principle for Treating Knee Osteoarthritis: Study Protocol for a Randomized Controlled Trial Open
The study was approved by the Ethics Committee of Shanghai Municipal Hospital of Traditional Chinese Medicine (Ethics No.: 2024SHL-KY-70-01). Registered in Chinese Clinical Trial Registry (No. ChiCTR2400085536).
Quantitative Analysis of Relationship Between Paraspinal Muscle Degeneration and Degree of Degenerative Lumbar Spondylolisthesis Open
Study Design. Clinical retrospective study. Objective. The authors aim to analyze the relationship between paraspinal muscle degeneration and degree of L4–5 Degenerative lumbar spondylolisthesis (DLS). Summary of Background Data. While par…
Association Between Paraspinal Muscle Parameters and Single-Segment Degenerative Lumbar Spondylolisthesis Open
Study Design. A retrospective, cross-sectional cohort study. Objective. This study aimed to investigate the association between paraspinal muscle parameters and single-segment degenerative lumbar spondylolisthesis (DLS). Summary of Backgro…
Evaluating the clinical efficacy of five-step knee adjustment manipulation based on the ‘muscle and bone balance’ principle in treating KOA and the influence on the biomechanical characteristics of soft tissues Open
Background Knee osteoarthritis (KOA) is the leading cause of knee joint dysfunction. While manual treatments are effective, most traditional methods focus solely on the knee joint or its surrounding tissues, neglecting the impact of the wa…
Efficacy of "Zha Tiao" electroacupuncture for patients with knee osteoarthritis: study protocol for a randomized controlled trial Open
Background: Both Acupuncture and electroacupuncture have demonstrated effectiveness in treating knee osteoarthritis (KOA). Variations in acupuncturists' manipulations may lead to differing therapeutic outcomes. The aim of this trial is to …
Efficacy of manual therapy on shoulder pain and function in patients with rotator cuff injury: A systematic review and meta‑analysis Open
To critically evaluate the effects of manual therapy (MT) on pain and functional improvement in patients with rotator cuff injury (RCI), a systematic review of all randomized controlled trials (RCTs) on MT for RCI was conducted in the foll…
Aconine attenuates osteoclast-mediated bone resorption and ferroptosis to improve osteoporosis via inhibiting NF-κB signaling Open
Osteoporosis (OP), a prevalent public health concern primarily caused by osteoclast-induced bone resorption, requires potential therapeutic interventions. Natural compounds show potential as therapeutics for postmenopausal OP. Emerging evi…
Efficacy of Combining Traditional Chinese Manual Therapy (Tuina) and Specific Therapeutic Neck Exercise in Young Adults with Non-Specific Chronic Neck Pain: Study Protocol for a Randomized Controlled Trial Open
Chinese Clinical Trials Registry, ChiCTR2300067903. Registered on 31 January 2023.
Bioinformatics analysis identification of AKT3 and RAC1 as key genes in postmenopausal osteoporosis Open
Postmenopausal osteoporosis (PMO) is an aging-associated disease that manifests as degradation of bone tissue microstructure leading to decreased bone mass and increased bone fragility. Differentiation of peripheral blood mononuclear cells…
Quercetin Attenuates Osteoporosis in Orchiectomy Mice by Regulating Glucose and Lipid Metabolism via the GPRC6A/AMPK/mTOR Signaling Pathway Open
Quercetin, a flavonoid found in natural medicines, has shown a role in disease prevention and health promotion. Moreover, because of its recently identified contribution in regulating bone homeostasis, quercetin may be considered a promisi…
Role of skeletal muscle satellite cells in the repair of osteoporotic fractures mediated by β‐catenin Open
Background Osteoporosis is a metabolic disease, and osteoporotic fracture (OPF) is one of its most serious complications. It is often ignored that the influence of the muscles surrounding the fracture on the healing of OPF. We aimed to cla…
Osthole enhances the bone mass of senile osteoporosis and stimulates the expression of osteoprotegerin by activating β-catenin signaling Open
Introduction Osthole has a potential therapeutic application for anti-osteoporosis. The present study verified whether osthole downregulates osteoclastogenesis via targeting OPG. Methods In vivo, 12-month-old male mice were utilized to eva…
Osthole Inhibits Osteoclast Formation and Enhances Bone Mass of Bone Marrow Mesenchymal Stem cells by Activating β-catenin-OPG Signaling Pathway Open
Summary Osthole has potential therapeutic applications due to its antiosteoporotic. Our study suggested that osthole attenuates osteoclast formation by stimulating the activation of β -catenin-OPG signaling and could be a potential agent t…
Association between serum vitamin B <sub>6</sub> concentration and risk of osteoporosis in the middle-aged and older people in China: a cross-sectional study Open
Objective To determine the relationship between serum vitamin B 6 (Vit B 6 ) concentration and the status of bone mineral density and identify the relationship between serum Vit B6 and bone metabolism parameters in middle-aged and older pe…