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View article: A Unified Multiplex Digital PCR-based Platform for Multi-class Biomarker Quantification from Low-volume Blood
A Unified Multiplex Digital PCR-based Platform for Multi-class Biomarker Quantification from Low-volume Blood Open
Simultaneous quantification of multiple biomarker classes from blood is essential for improving diagnostic accuracy, yet current methods remain limited by low multiplexing capacity, reliance on separate instruments and workflows, and incon…
View article: Multiplex digital profiling of DNA methylation heterogeneity for sensitive and cost-effective cancer detection in low-volume liquid biopsies
Multiplex digital profiling of DNA methylation heterogeneity for sensitive and cost-effective cancer detection in low-volume liquid biopsies Open
Molecular alterations in cancerous tissues exhibit intercellular genetic and epigenetic heterogeneity, complicating the performance of diagnostic assays, particularly for early cancer detection. Conventional liquid biopsy methods have limi…
View article: A Workflow Investigating the Information behind the Time-Series Energy Consumption Condition via Data Mining
A Workflow Investigating the Information behind the Time-Series Energy Consumption Condition via Data Mining Open
The purpose of this study is to develop a framework to understand building energy usage pattern finding using data mining algorithms. Developing advanced techniques and requirements for carbon emission reduction provides higher demands for…
View article: Tumor Mutational Burden Associated With Response to Hyperthermic Intraperitoneal Chemotherapy
Tumor Mutational Burden Associated With Response to Hyperthermic Intraperitoneal Chemotherapy Open
Background Gastric cancer (GC) is one of the most common cancer types, especially in Asian countries. Hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to improve the progression-free survival among gastric cancer patients w…
View article: Noncoding RNAs and hyperthermic intraperitoneal chemotherapy in advanced gastric cancer
Noncoding RNAs and hyperthermic intraperitoneal chemotherapy in advanced gastric cancer Open
Gastric cancer (GC) is one of the most common malignant tumors globally. About 20-30% of patients with gastric cancer show peritoneal implantation metastasis at the first diagnosis. Peritoneal metastasis is responsible for 70% of deaths of…
View article: Implementation of Point Cloud and BIM Technologies in a Construction Workflow: A Case Study of a Building Project in Yuecheng District, China
Implementation of Point Cloud and BIM Technologies in a Construction Workflow: A Case Study of a Building Project in Yuecheng District, China Open
In recent years, there has been a surge of retrofitting and building projects in rural China, to elevate the living standards in local areas.However, with the conventional use of surveying and inspection instruments, the amount of construc…
View article: An energy efficiency solution based on time series data mining algorithm—a case study of small hotel
An energy efficiency solution based on time series data mining algorithm—a case study of small hotel Open
This study aims to conduct data mining research on the time series energy consumption dataset of a small hotel. Earlier studies on data mining have demonstrated that cluster and association analysis had been commonly used methods today, wh…
View article: Multifunctional Non-Coding RNAs Mediate Latent Infection and Recurrence of Herpes Simplex Viruses
Multifunctional Non-Coding RNAs Mediate Latent Infection and Recurrence of Herpes Simplex Viruses Open
Herpes simplex viruses (HSVs) often cause latent infection for a lifetime, leading to repeated recurrence. HSVs have been engineered as oncolytic HSVs. The mechanism of the latent infection and recurrence remains largely unknown, which bri…
View article: Raltitrexed as a synergistic hyperthermia chemotherapy drug screened in patient-derived colorectal cancer organoids
Raltitrexed as a synergistic hyperthermia chemotherapy drug screened in patient-derived colorectal cancer organoids Open
Our results primarily demonstrated the use of patient-derived colorectal cancer organoids as in vitro models to evaluate hyperthermia synergistic chemotherapeutics. We found that hyperthermia enhanced the effect of raltitrexed the most amo…
View article: Non-radioactive and sensitive tracking of neutrophils towards inflammation using antibody functionalized magnetic particle imaging tracers
Non-radioactive and sensitive tracking of neutrophils towards inflammation using antibody functionalized magnetic particle imaging tracers Open
White blood cells (WBCs) are a key component of the mammalian immune system and play an essential role in surveillance, defense, and adaptation against foreign pathogens. Apart from their roles in the active combat of infection and the dev…
View article: Towards to a Hybrid Model-Making Method based on Translations between Physical and Digital Models - A case study of the freeform architectural design
Towards to a Hybrid Model-Making Method based on Translations between Physical and Digital Models - A case study of the freeform architectural design Open
The extensive applications of digital models might decrease the capacity of physical model-making for perceptual thinking and enlarge the gap between architects and physical space with limited visual experience.This study aims to propose a…