Weixi Shan
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View article: Glucose absorption in the duodenum is modulated by an estrogen receptor α-dependent regulation of glucose transporter functional expression
Glucose absorption in the duodenum is modulated by an estrogen receptor α-dependent regulation of glucose transporter functional expression Open
Introduction The mechanisms of estrogen in glucose metabolism are well established; however, the role of this hormone in glucose absorption remains unclear. In this study, we investigated the effects of estrogen on glucose absorption in hu…
View article: Estrogen regulates duodenal glucose absorption through the effect of estrogen receptor-α on glucose transporters
Estrogen regulates duodenal glucose absorption through the effect of estrogen receptor-α on glucose transporters Open
Estrogen deficiency is an important reason for the obesity of menopause, but the specific mechanism is unclear. Here, we investigated the effect of estrogen on glucose absorption. The experiments were performed in human, mice and SCBN cell…
View article: Pathophysiological Role of Purinergic P2X Receptors in Digestive System Diseases
Pathophysiological Role of Purinergic P2X Receptors in Digestive System Diseases Open
P2X receptors (P2XRs) are trimeric, non-selective cation channels activated by extracellular ATP and widely distributed in the digestive system. P2XRs have an important role in the physiological function of the digestive system, such as ne…
View article: Effects of calcium‑permeable ion channels on various digestive diseases in the regulation of autophagy (Review)
Effects of calcium‑permeable ion channels on various digestive diseases in the regulation of autophagy (Review) Open
Autophagy is a process of degradation and catabolism in cells. By removing damaged or dysfunctional organelles, autophagy interacts with the ubiquitin‑proteasome degradation system to jointly regulate cell function and energy homeostasis. …
View article: Pathophysiologic Role of Neurotransmitters in Digestive Diseases
Pathophysiologic Role of Neurotransmitters in Digestive Diseases Open
Neurotransmitters are special molecules that serve as messengers in chemical synapses between neurons, cells, or receptors, including catecholamines, serotonin, dopamine, and other neurotransmitters, which play an important role in both hu…
View article: Advances in research on the regulatory mechanism of NHE1 in tumors (Review)
Advances in research on the regulatory mechanism of NHE1 in tumors (Review) Open
Tumors pose a major threat to human health and present with difficulties that modern medicine has yet to overcome. It has been demonstrated that the acid-base balance of the tumor microenvironment is closely associated with the dynamic bal…
View article: Role of gut microbiota via the gut-liver-brain axis in digestive diseases
Role of gut microbiota via the gut-liver-brain axis in digestive diseases Open
The gut-brain axis is a bidirectional information interaction system between the central nervous system (CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex network with the ent…
View article: Advances in Ca<sup>2+</sup> modulation of gastrointestinal anion secretion and its dysregulation in digestive disorders (Review)
Advances in Ca<sup>2+</sup> modulation of gastrointestinal anion secretion and its dysregulation in digestive disorders (Review) Open
Intracellular calcium (Ca2+) is a critical cell signaling component in gastrointestinal (GI) physiology. Cytosolic calcium ([Ca2+]cyt), as a secondary messenger, controls GI epithelial fluid and ion transpo…