Weixia Li
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View article: Epidemiology, drug resistance, and molecular features of Klebsiella pneumoniae in Southwest Shandong, China
Epidemiology, drug resistance, and molecular features of Klebsiella pneumoniae in Southwest Shandong, China Open
This study aims to delineate the antimicrobial resistance profiles and virulence gene carriage of Klebsiella pneumoniae (KP) in Southwest Shandong region of China, investigate the differences in clinical infection characteristics between c…
View article: Deep learning-based automated assessment of hepatic fibrosis via magnetic resonance images and nonimage data
Deep learning-based automated assessment of hepatic fibrosis via magnetic resonance images and nonimage data Open
The proposed DL algorithm provides a noninvasive method for hepatic fibrosis staging and screening, outperforming both radiologists and conventional biomarkers, and may facilitate improved clinical decision-making.
View article: Clinical Characteristics and Epidemiological Features of Hepatitis E Virus Infection Among People Living with HIV in Shanghai, China.
Clinical Characteristics and Epidemiological Features of Hepatitis E Virus Infection Among People Living with HIV in Shanghai, China. Open
Hepatitis E virus (HEV) poses a significant public health concern, particularly among immunocompromised populations. This study aimed to investigate HEV seroprevalence, clinical characteristics, and associated risk factors in people living…
View article: Emergency Wound Infection Monitoring and Treatment Based on Wearable Electrochemical Detection and Drug Release with Conductive Hydrogel
Emergency Wound Infection Monitoring and Treatment Based on Wearable Electrochemical Detection and Drug Release with Conductive Hydrogel Open
At emergency sites, bacteria in the environment can cause secondary wound infections. Timely treatment of infected wounds can improve the prognosis. In this study, we designed a closed-loop system for real-time wound infection monitoring a…
View article: Bidirectional longitudinal associations between estimated muscle mass and self-reported chronic lung disease in middle-aged and older adults: findings from the China health and retirement longitudinal study
Bidirectional longitudinal associations between estimated muscle mass and self-reported chronic lung disease in middle-aged and older adults: findings from the China health and retirement longitudinal study Open
View article: Roles of nanomagnetic beads on biosensing: From fabrication to application
Roles of nanomagnetic beads on biosensing: From fabrication to application Open
As magnetic nanomaterials, nanomagnetic beads are constantly being innovated in various applications. With the advantages of superparamagnetism and rapid magnetic response, nanomagnetic beads can be controlled for various type of movements…
View article: Systemic therapy with pemigatinib and sintilimab followed by resection for recurrent FGFR-2-positive intrahepatic cholangiocarcinoma: a case report
Systemic therapy with pemigatinib and sintilimab followed by resection for recurrent FGFR-2-positive intrahepatic cholangiocarcinoma: a case report Open
Background Fibroblast growth factor receptor-2 (FGFR-2) mutations are frequently observed in intrahepatic cholangiocarcinoma (ICC). While FGFR2-targeted therapies are primarily studied in advanced ICC, this report presents a rare case of l…
View article: Rapid Mental Stress Evaluation Based on Non-Invasive, Wearable Cortisol Detection with the Self-Assembly of Nanomagnetic Beads
Rapid Mental Stress Evaluation Based on Non-Invasive, Wearable Cortisol Detection with the Self-Assembly of Nanomagnetic Beads Open
The rapid and timely evaluation of the mental health of emergency rescuers can effectively improve the quality of emergency rescues. However, biosensors for mental health evaluation are now facing challenges, such as the rapid and portable…
View article: Characterizing metabolomic and transcriptomic changes, and investigating the therapeutic mechanism of Psoralea corylifolia linn. In the treatment of kidney-yang deficiency syndrome in rats
Characterizing metabolomic and transcriptomic changes, and investigating the therapeutic mechanism of Psoralea corylifolia linn. In the treatment of kidney-yang deficiency syndrome in rats Open
Kidney-yang deficiency syndrome (KYDS) is characterized by a metabolic disorder stemming from neuroendocrine dysregulation, often associated with hepatic dysfunction. In traditional Chinese medicine, Psoralea corylifolia Linn. (BGZ)…
View article: Expression Level of Autoimmune Regulator In B Cells Correlates With Residual Islet β Cell Function In Type 1 Diabetes Mellitus
Expression Level of Autoimmune Regulator In B Cells Correlates With Residual Islet β Cell Function In Type 1 Diabetes Mellitus Open
Background Autoimmune modulators (Aire) mediate immune tolerance by inducing expression of tissue-restricted antigen (TRA) in thymic medullary epithelial cells. However, the function of Aire in peripheral B cells remains unknown. We aimed …
View article: Electroacupuncture reduced airway inflammation by activating somatosensory–sympathetic pathways in allergic asthmatic rats
Electroacupuncture reduced airway inflammation by activating somatosensory–sympathetic pathways in allergic asthmatic rats Open
Background: Electroacupuncture (EA) treatment is efficacious in patients with respiratory disorders, although the mechanisms of its action in lung-function protection are poorly understood. This study aimed to explore the neuroanatomical m…
View article: A Dual-Branch Model Integrating CNN and Swin Transformer for Efficient Apple Leaf Disease Classification
A Dual-Branch Model Integrating CNN and Swin Transformer for Efficient Apple Leaf Disease Classification Open
Apples, as the fourth-largest globally produced fruit, play a crucial role in modern agriculture. However, accurately identifying apple diseases remains a significant challenge as failure in this regard leads to economic losses and poses t…
View article: A Cross-Chain Access Control Mechanism Based on Blockchain and the Threshold Paillier Cryptosystem
A Cross-Chain Access Control Mechanism Based on Blockchain and the Threshold Paillier Cryptosystem Open
View article: A Decade of Liver Health: Analyzing Trends in Liver Function Tests Among Beijing Residents (2009-2019)
A Decade of Liver Health: Analyzing Trends in Liver Function Tests Among Beijing Residents (2009-2019) Open
View article: A secure cross-domain interaction scheme for blockchain-based intelligent transportation systems
A secure cross-domain interaction scheme for blockchain-based intelligent transportation systems Open
In the intelligent transportation system (ITS), secure and efficient data communication among vehicles, road testing equipment, computing nodes, and transportation agencies is important for building a smart city-integrated transportation s…
View article: Prediction of reported monthly incidence of hepatitis B in Hainan Province of China based on SARIMA-BPNN model
Prediction of reported monthly incidence of hepatitis B in Hainan Province of China based on SARIMA-BPNN model Open
In recent years, the incidence of hepatitis B has been serious in Hainan Province of China. To construct a statistical model of the monthly incidence of hepatitis B in Hainan Province of China and predict the monthly incidence of hepatitis…
View article: A gene expression profile-based approach to screen the occurrence and predisposed host characteristics of drug-induced liver injury: a case study of Psoralea corylifolia Linn
A gene expression profile-based approach to screen the occurrence and predisposed host characteristics of drug-induced liver injury: a case study of Psoralea corylifolia Linn Open
Drug-induced liver injury (DILI) is one of the most common causes of a drug being withdrawn, and identifying the culprit drugs and the host factors at risk of causing DILI has become a current challenge. Recent studies have found that immu…
View article: Drug repurposing based on the similarity gene expression signatures to explore for potential indications of quercetin: a case study of multiple sclerosis
Drug repurposing based on the similarity gene expression signatures to explore for potential indications of quercetin: a case study of multiple sclerosis Open
Quercetin (QR) is a natural flavonol compound widely distributed in the plant kingdom with extensive pharmacological effects. To find the potential clinical indications of QR, 156 differentially expressed genes (DEGs) regulated by QR were …
View article: The Associations between Organophosphate Pesticides (OPs) and Respiratory Disease, Diabetes Mellitus, and Cardiovascular Disease: A Review and Meta-Analysis of Observational Studies
The Associations between Organophosphate Pesticides (OPs) and Respiratory Disease, Diabetes Mellitus, and Cardiovascular Disease: A Review and Meta-Analysis of Observational Studies Open
Although some epidemiological studies have identified the associations between exposure to organophosphate pesticides (Ops) and respiratory diseases, diabetes mellitus (DM), and cardiovascular diseases (CVDs), controversial results still e…
View article: Yin/Yang associated differential responses to Psoralea corylifolia Linn. In rat models: an integrated metabolomics and transcriptomics study
Yin/Yang associated differential responses to Psoralea corylifolia Linn. In rat models: an integrated metabolomics and transcriptomics study Open
View article: A new dyslipidemia-based scoring model to predict transplant-free survival in patients with hepatitis E-triggered acute-on-chronic liver failure
A new dyslipidemia-based scoring model to predict transplant-free survival in patients with hepatitis E-triggered acute-on-chronic liver failure Open
Background/Aims Hepatitis E virus (HEV)-triggered acute-on-chronic liver failure (ACLF) has unacceptably high short-term mortality. However, it is unclear whether the existing predictive scoring models are applicable to evaluate the progno…
View article: The Levels of Polycyclic Aromatic Hydrocarbons and Their Derivatives in Plasma and Their Effect on Mitochondrial DNA Methylation in the Oilfield Workers
The Levels of Polycyclic Aromatic Hydrocarbons and Their Derivatives in Plasma and Their Effect on Mitochondrial DNA Methylation in the Oilfield Workers Open
This study focuses on the components and levels of polycyclic aromatic hydrocarbons (PAHs) and their derivatives (MPAHs and OPAHs) in plasma samples from 19 oil workers, pre- and post-workshift, and their exposure–response relationship wit…
View article: Prediction of reported monthly incidence of hepatitis B in Hainan Province of China based on SARIMA-BPNN model
Prediction of reported monthly incidence of hepatitis B in Hainan Province of China based on SARIMA-BPNN model Open
Background To construct a statistical model of the monthly incidence of hepatitis B in Hainan Province of China and predict the monthly incidence of hepatitis B in 2022. Methods Simple central moving average method and seasonal index were …
View article: Management of Suspected Life-Threatening Perioperative Anaphylaxis and Risk Factors for Near-Fatal and Fatal Outcomes: A Retrospective Study in China
Management of Suspected Life-Threatening Perioperative Anaphylaxis and Risk Factors for Near-Fatal and Fatal Outcomes: A Retrospective Study in China Open
Most cases in this study were managed in a timely manner, but the epinephrine application should be optimized according to the guidelines. Age ≥65 years, ASA physical status IV, and long-term hypotension were risk factors for near-fatal an…
View article: Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation
Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation Open
Background Phthalates (PAEs) are important synthetic substances in plastics, attracting much attention due to their potential effects on the cardiovascular system. Methods In this study, urine and blood samples from 39 individuals were col…
View article: Data from Efficacy and Biomarker Analysis of Camrelizumab in Combination with Apatinib in Patients with Advanced Nonsquamous NSCLC Previously Treated with Chemotherapy
Data from Efficacy and Biomarker Analysis of Camrelizumab in Combination with Apatinib in Patients with Advanced Nonsquamous NSCLC Previously Treated with Chemotherapy Open
Purpose:Our preclinical work suggests that appropriate angiogenesis inhibition could potentiate PD-1/PD-L1 blockade via alleviating hypoxia, increasing infiltration of CD8+ T cells and reducing recruitment of tumor-associated ma…
View article: Supplementary Data from Efficacy and Biomarker Analysis of Camrelizumab in Combination with Apatinib in Patients with Advanced Nonsquamous NSCLC Previously Treated with Chemotherapy
Supplementary Data from Efficacy and Biomarker Analysis of Camrelizumab in Combination with Apatinib in Patients with Advanced Nonsquamous NSCLC Previously Treated with Chemotherapy Open
Supplementary figures and tables
View article: Data from Efficacy and Biomarker Analysis of Camrelizumab in Combination with Apatinib in Patients with Advanced Nonsquamous NSCLC Previously Treated with Chemotherapy
Data from Efficacy and Biomarker Analysis of Camrelizumab in Combination with Apatinib in Patients with Advanced Nonsquamous NSCLC Previously Treated with Chemotherapy Open
Purpose:Our preclinical work suggests that appropriate angiogenesis inhibition could potentiate PD-1/PD-L1 blockade via alleviating hypoxia, increasing infiltration of CD8+ T cells and reducing recruitment of tumor-associated ma…
View article: Supplementary Data from Efficacy and Biomarker Analysis of Camrelizumab in Combination with Apatinib in Patients with Advanced Nonsquamous NSCLC Previously Treated with Chemotherapy
Supplementary Data from Efficacy and Biomarker Analysis of Camrelizumab in Combination with Apatinib in Patients with Advanced Nonsquamous NSCLC Previously Treated with Chemotherapy Open
Supplementary figures and tables
View article: FibroScan Predicts Liver Fibrosis Progression in Chronic HBV Infection Patients with No Clear Indication for Antiviral Therapy: A Retrospective Cohort Study
FibroScan Predicts Liver Fibrosis Progression in Chronic HBV Infection Patients with No Clear Indication for Antiviral Therapy: A Retrospective Cohort Study Open
LFP is non-negligible in patients with active HBV replication, persistently normal or minimally elevated ALT, and initially no or minimal hepatic necroinflammation or fibrosis. Serial LSM tests would be more reliable in identifying LFP tha…