Weixin Ke
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View article: Persister cells in human fungal pathogens
Persister cells in human fungal pathogens Open
Microbicidal persistence refers to the phenomenon whereby a subpopulation of microbial cells enters a dormant state to evade drug killing. This phenomenon is associated with antibiotic treatment failure in bacterial infections, and thus, t…
View article: Macrophage‐derived reactive oxygen species promote <i>Salmonella</i> aggresome formation contributing to bacterial antibiotic persistence
Macrophage‐derived reactive oxygen species promote <i>Salmonella</i> aggresome formation contributing to bacterial antibiotic persistence Open
In this study, we reveal that macrophage-derived reactive oxygen species (ROS) can trigger the rapid formation of Salmonella aggresomes, which substantially contribute to the increased frequency of persisters induced by phagocytosis. Salmo…
View article: Macrophage-derived reactive oxygen species promote <i>Salmonella</i> aggresome formation contributing to bacterial antibiotic persistence
Macrophage-derived reactive oxygen species promote <i>Salmonella</i> aggresome formation contributing to bacterial antibiotic persistence Open
In this study, we reveal that macrophage-derived reactive oxygen species (ROS) can trigger the rapid formation of Salmonella aggresomes, which substantially contribute to the increased frequency of persisters induced by phagocytosis. Salmo…
View article: Ultrasound treatment improved gelling and emulsifying properties of myofibrillar proteins from Antarctic krill (Euphausia superba)
Ultrasound treatment improved gelling and emulsifying properties of myofibrillar proteins from Antarctic krill (Euphausia superba) Open
Antarctic krill is a promising source of marine proteins with abundant biomass and excellent nutritional profile, but has poor technological properties. Ultrasonic treatment at power levels of 0, 100, 200, 300, 400 and 500 W was applied to…
View article: Pan-omics-based characterization and prediction of highly multidrug-adapted strains from an outbreak fungal species complex
Pan-omics-based characterization and prediction of highly multidrug-adapted strains from an outbreak fungal species complex Open
Strains from the Cryptococcus gattii species complex (CGSC) have caused the Pacific Northwest cryptococcosis outbreak, the largest cluster of life-threatening fungal infections in otherwise healthy human hosts known to date. In this study,…
View article: Dietary Hemin Remodels Gut Microbiota and Mediates Tissue Inflammation and Injury in the Small Intestine
Dietary Hemin Remodels Gut Microbiota and Mediates Tissue Inflammation and Injury in the Small Intestine Open
Scope Epidemiological studies have linked excessive red and processed meat intake to gut disorders. Under laboratory conditions, high heme content is considered the primary health risk factor for red meat. However, heme in meat is present …
View article: TLR2 regulates <i>Moraxella catarrhalis</i> adhesion to and invasion into alveolar epithelial cells and mediates inflammatory responses
TLR2 regulates <i>Moraxella catarrhalis</i> adhesion to and invasion into alveolar epithelial cells and mediates inflammatory responses Open
Moraxella catarrhalis is a major cause of chronic obstructive pulmonary disease. Toll-like receptor 2 (TLR2) plays an important role in the inflammatory response in host respiratory epithelial cells. M. catarrhalis induces an inflammatory …
View article: Virulence profiling of <i>Cryptococcus gattii</i> isolates in China: insights from a multi-center study
Virulence profiling of <i>Cryptococcus gattii</i> isolates in China: insights from a multi-center study Open
Cryptococcus gattii ( C. gattii ) is emerging as a life-threatening fungus worldwide. However, few data were available in China. In this study, 27 isolates and 32 patient information were collected from several hospitals in China, together…
View article: Polysaccharides from Platycodon grandiflorus attenuates high-fat diet induced obesity in mice through targeting gut microbiota
Polysaccharides from Platycodon grandiflorus attenuates high-fat diet induced obesity in mice through targeting gut microbiota Open
The root of Platycodon grandiflorus (PG), abundant in soluble polysaccharides, has a long history in traditional Asian diets and herbal medicine due to its anti-inflammatory activity and anti-obesity effects. Our previous study was the fir…
View article: Serine, glutamate, and proline in a high‐fat diet exacerbated metabolite reduction‐induced memory and cognitive decline
Serine, glutamate, and proline in a high‐fat diet exacerbated metabolite reduction‐induced memory and cognitive decline Open
Epidemiological studies have shown that excessive consumption of meat may cause memory loss and cognitive decline, but the underlying mechanism is unknown. Here, a high‐chicken‐protein diet but not a high‐pork diet was found to have a mark…
View article: Correction: Molecular epidemiology and microbiological characteristics of Cryptococcus gattii VGII isolates from China
Correction: Molecular epidemiology and microbiological characteristics of Cryptococcus gattii VGII isolates from China Open
[This corrects the article DOI: 10.1371/journal.pntd.0010078.].
View article: The degree of doneness affected molecular changes and protein digestibility of pork
The degree of doneness affected molecular changes and protein digestibility of pork Open
The degree of doneness has been shown to have a great impact on eating quality of meat, however, it is little known whether it affects protein digestibility of meat. In this study, we explored molecular changes and protein digestibility of…
View article: Effect of natural plant extracts on the quality of meat products: a meta-analysis
Effect of natural plant extracts on the quality of meat products: a meta-analysis Open
Natural plant extracts (NPE) from some organs of plants are rich in bioactive substances. They have special nutritional characteristics with strong antioxidant and antimicrobial activities. The potential of NPEs to maintain and improve the…
View article: Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen
Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen Open
Pathogenic fungi of the genus Cryptococcus can undergo two sexual cycles, involving either bisexual diploidization (after fusion of haploid cells of different mating type) or unisexual diploidization (by autodiploidization of a single cell…
View article: A Velvet Transcription Factor Specifically Activates Mating through a Novel Mating-Responsive Protein in the Human Fungal Pathogen Cryptococcus deneoformans
A Velvet Transcription Factor Specifically Activates Mating through a Novel Mating-Responsive Protein in the Human Fungal Pathogen Cryptococcus deneoformans Open
The human fungal pathogen C. deneoformans is a model organism for studying fungal sexual reproduction, which is considered to be important to infection. However, the specific regulatory determinants for activation of sexual reproduction re…
View article: A forkhead transcription factor contributes to the regulatory differences of pathogenicity in closely related fungal pathogens
A forkhead transcription factor contributes to the regulatory differences of pathogenicity in closely related fungal pathogens Open
Cryptococcus neoformans and its sister species Cryptococcus deuterogattii are important human fungal pathogens. Despite their phylogenetically close relationship, these two Cryptococcus pathogens are greatly different in their clinical cha…
View article: Molecular epidemiology and microbiological characteristics of Cryptococcus gattii VGII isolates from China
Molecular epidemiology and microbiological characteristics of Cryptococcus gattii VGII isolates from China Open
Cryptococcus gattii ( C . gattii ) is a fungal pathogen that once caused an outbreak of cryptococcosis on Vancouver Island, and had spread worldwide, while few data were available in China. In this study, seven clinical isolates of C . gat…
View article: Molecular Epidemiology and Microbiological Characteristics of <i>Cryptococcus gattii</i> VGII isolates from China
Molecular Epidemiology and Microbiological Characteristics of <i>Cryptococcus gattii</i> VGII isolates from China Open
Cryptococcus gattii ( C. gattii ) is a fungal pathogen that once caused an outbreak of cryptococcosis on Vancouver Island, and had spread worldwide, while few data were available in China. In this study, seven clinical isolates of C. gatti…
View article: Cryptococcus gattii VGI Subtypes: Geographical Distribution, Molecular Traits, and Virulence Difference
Cryptococcus gattii VGI Subtypes: Geographical Distribution, Molecular Traits, and Virulence Difference Open
Background: As a life-threatening fungus, Cryptococcus gattii (C gattii) species complex is emerging worldwide. However, the geographical distribution, molecular traits, and virulence difference are poorly characterized in China.Results: F…
View article: Dietary Platycodon grandiflorus Attenuates Hepatic Insulin Resistance and Oxidative Stress in High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease
Dietary Platycodon grandiflorus Attenuates Hepatic Insulin Resistance and Oxidative Stress in High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease Open
The root of Platycodon grandiflorus (PG), with hepatoprotective and anti-oxidation effects, has a long history of being used as food and herbal medicine in Asia. However, the mechanism of PG against non-alcoholic fatty liver disease (NAFLD…