Wenjing Zhang
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View article: Postoperative early recurrence prediction of pancreatic cancer based on CT and pathomics
Postoperative early recurrence prediction of pancreatic cancer based on CT and pathomics Open
View article: PD-1 prelimits both cytotoxic and exhaustion potential in thymic CD8+ T cells and affects sustaining peripheral tumor immunity 2875
PD-1 prelimits both cytotoxic and exhaustion potential in thymic CD8+ T cells and affects sustaining peripheral tumor immunity 2875 Open
Description A durable T cell immunity against cancer is dependent on a continually refilling of effector CD8+ T cells. Thymic output has been correlated with favorable prognosis in cancer patients of advanced ages, suggesting thymus is an …
View article: Pan-cancer analysis reveals context-dependent roles of LINE-1 ORF1p in immune regulation and copy number alterations
Pan-cancer analysis reveals context-dependent roles of LINE-1 ORF1p in immune regulation and copy number alterations Open
L1 comprises 17% of the human genome, with 50-150 full-length sequences capable of retrotransposition. Although largely inactive in normal somatic tissues, tumorigenesis leads to L1 derepression and overexpression of its RNA binding chaper…
View article: BAF60a-dependent chromatin remodeling preserves β cell function and contributes to the therapeutic benefits of GLP-1R agonists
BAF60a-dependent chromatin remodeling preserves β cell function and contributes to the therapeutic benefits of GLP-1R agonists Open
Impaired glucose-stimulated insulin secretion (GSIS) is a hallmark of β cell dysfunction in diabetes. Epigenetic mechanisms govern cellular glucose sensing and GSIS by β cells, but they remain incompletely defined. Here, we found that BAF6…
View article: Targeting PD-L1-CMTM6 interactions in myeloid cells triggers PD-L1 degradation and enhances cytotoxic T-cell expansion
Targeting PD-L1-CMTM6 interactions in myeloid cells triggers PD-L1 degradation and enhances cytotoxic T-cell expansion Open
Background Immune checkpoint therapies targeting programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) have been met with limited clinical responses in the treatment of patients of varying cancer types. Current US Fo…
View article: The Role of Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Cancer Stem Cell Signaling
The Role of Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Cancer Stem Cell Signaling Open
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a key regulator of cancer stem cell (CSC) biology and signaling. In CSCs, ROR1 acts as a receptor or co-receptor, interacting with non-canonical WNT ligands, and forming complexes w…
View article: NLRP13 mutation as a predictive indicator for immune checkpoint inhibitor efficacy in melanoma and NSCLC
NLRP13 mutation as a predictive indicator for immune checkpoint inhibitor efficacy in melanoma and NSCLC Open
Background Robustly predictive indicators could assist in maximizing immune checkpoint inhibitor (ICI) treatment responses. A key point in immunotherapies is to select tumor patients who will respond to immune checkpoint inhibitor (ICI). E…
View article: FAT1 mutation-related signature predicts survival risk and tumor immunogenicity in lung adenocarcinoma
FAT1 mutation-related signature predicts survival risk and tumor immunogenicity in lung adenocarcinoma Open
Background FAT atypical cadherin 1 (FAT1) is a well-known tumor regulator that plays a crucial role in multiple cancer signaling pathways. Its mutations have been linked to tumor progression and immune regulation in various cancers, includ…
View article: Fabrication of subnanometric Ni clusters over the Ni/SAPO-11 hydroisomerization catalyst
Fabrication of subnanometric Ni clusters over the Ni/SAPO-11 hydroisomerization catalyst Open
The preparation of subnanometric non-noble metal catalyst remains difficult especially when the metal loading is more than 1 wt%. Herein, the subnanometric nickel clusters (0.87 nm) were fabricated over the Ni/SAPO-11 catalyst for n-hexane…
View article: Controllable Fabrication of Submicron‐Thick Polyimide Films by Piezoelectric Spraying
Controllable Fabrication of Submicron‐Thick Polyimide Films by Piezoelectric Spraying Open
Polyimide (PI) films have been extensively utilized as flexible substrates in various cutting‐edge fields, including aerospace, microelectronics, and healthcare. However, existing techniques to prepare PI films typically exhibit a limited …
View article: Exploring the neuroprotective mechanisms of Jiawei Suanzaoren decoction in depression: insights from network pharmacology and molecular docking
Exploring the neuroprotective mechanisms of Jiawei Suanzaoren decoction in depression: insights from network pharmacology and molecular docking Open
This study provides novel insights into the neuroprotective mechanisms of JWSZR in depression, suggesting that it may act through multi-target interactions involving immune modulation and apoptosis inhibition.
View article: Standardized training assessment of residents in obstetrics and gynecology on entrustable professional activities
Standardized training assessment of residents in obstetrics and gynecology on entrustable professional activities Open
Background Entrustable professional activity (EPA) presents trainees’ tasks or responsibilities which are entrusted to the unsupervised execution once they have attained sufficient specific competence. EPAs evaluation emphasize the integri…
View article: Modulation of senescent Lepr+ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression
Modulation of senescent Lepr+ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression Open
View article: DAST: Difficulty-Adaptive Slow-Thinking for Large Reasoning Models
DAST: Difficulty-Adaptive Slow-Thinking for Large Reasoning Models Open
Recent advancements in slow thinking reasoning models have shown exceptional performance in complex reasoning tasks. However, these models often exhibit overthinking (generating redundant reasoning steps for simple problems), leading to ex…
View article: PD-1 prelimits both the cytotoxic and exhaustion potential in thymic CD8+ T cells and impacts the maintenance of peripheral tumor immunity
PD-1 prelimits both the cytotoxic and exhaustion potential in thymic CD8+ T cells and impacts the maintenance of peripheral tumor immunity Open
Durable T cell immunity against cancer depends on the continual replenishment of effector CD8+ T cells. Thymic output has been correlated with favorable prognosis in cancer patients across a range of ages, suggesting that the thymus is an …
View article: DAST: Difficulty-Adaptive Slow-Thinking for Large Reasoning Models
DAST: Difficulty-Adaptive Slow-Thinking for Large Reasoning Models Open
View article: An improved cell nuclear isolation method
An improved cell nuclear isolation method Open
Nuclear isolation is crucial for studying gene expression and regulatory mechanisms in eukaryotic cells. This study aimed to improve nuclear isolation and compare the yield, purity, and efficiency of several methods. Human umbilical vein e…
View article: Study on the clinical efficacy of acupuncture combined with Tuina in the treatment of visual fatigue in the visual display terminal
Study on the clinical efficacy of acupuncture combined with Tuina in the treatment of visual fatigue in the visual display terminal Open
View article: Associations of combined accelerated biological aging and genetic susceptibility with incidence of heart failure in a population‐based cohort study
Associations of combined accelerated biological aging and genetic susceptibility with incidence of heart failure in a population‐based cohort study Open
The global aging population raises concerns about heart failure (HF), yet its association with accelerated biological age (BA) remains inadequately understood. We aimed to examine the longitudinal association between BA acceleration and in…
View article: Bioprinting PDLSC-Laden Collagen Scaffolds for Periodontal Ligament Regeneration
Bioprinting PDLSC-Laden Collagen Scaffolds for Periodontal Ligament Regeneration Open
Periodontitis and severe trauma are major causes of damage to the periodontal ligament (PDL). Repairing the native conditions of the PDL is essential for the stability of the tissue and its interfaces. Bioprinting periodontal ligament stem…
View article: Pacemaker lead extraction saved a severe lead-induced tricuspid regurgitation: a case report
Pacemaker lead extraction saved a severe lead-induced tricuspid regurgitation: a case report Open
Background Pacemaker lead-induced tricuspid regurgitation is a common complication after cardiac implantable electronic device (CIED) implantation. Cardiac implantable electronic device lead removal is a challenge procedure. Case summary A…
View article: Structure based release kinetics analysis of doxazosin mesylate sustained-release tablets using micro-computed tomography
Structure based release kinetics analysis of doxazosin mesylate sustained-release tablets using micro-computed tomography Open
The structures of solid dosage forms determine their release behaviors and are critical attributes for the design and evaluation of the solid dosage forms. Here, the 3D structures of doxazosin mesylate sustained-release tablets were parall…
View article: B2MAPO: A Batch-by-Batch Multi-Agent Policy Optimization to Balance Performance and Efficiency
B2MAPO: A Batch-by-Batch Multi-Agent Policy Optimization to Balance Performance and Efficiency Open
Most multi-agent reinforcement learning approaches adopt two types of policy optimization methods that either update policy simultaneously or sequentially. Simultaneously updating policies of all agents introduces non-stationarity problem.…
View article: [Clinical diagnosis and treatment analysis of spontaneous cerebrospinal fluid otorrhoea].
[Clinical diagnosis and treatment analysis of spontaneous cerebrospinal fluid otorrhoea]. Open
Objective:To investigate the clinical features, imaging findings, surgical methods， diagnostic and treatment experience of spontaneous cerebrospinal fluid otorrhoea. Methods:The clinical data of 11 patients with spontaneous c…
View article: Cell membrane-Anchored and tumor-Targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors
Cell membrane-Anchored and tumor-Targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors Open
Background Adoptive T-cell transfer has become an attractive therapeutic approach for hematological malignancies but shows poor activity against large and heterogeneous solid tumors. Interleukin-12 (IL-12) exhibits potent antitumor efficac…
View article: Hazel Leaf Polyphenol Extract Alleviated Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis through Inhibiting Hippo Signaling
Hazel Leaf Polyphenol Extract Alleviated Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis through Inhibiting Hippo Signaling Open
Derived from hazelnuts, hazel leaf has been utilized in traditional folk medicine for centuries in countries such as Portugal, Sweden, and Iran. In our previous investigations, we conducted a preliminary assessment of the hazel leaf polyph…
View article: Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53
Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53 Open
Cell cycle-dependent kinase 2 (CDK2) is located downstream of CDK4/6 in the cell cycle and regulates cell entry into S-phase by binding to Cyclin E and hyper-phosphorylating Rb. Proto-oncogene murine double minute 2 (MDM2) is a key negativ…
View article: Left Atrial Low Voltage Areas Predicts Recurrence of Atrial Fibrillation after Catheter Ablation: A Meta-Analysis
Left Atrial Low Voltage Areas Predicts Recurrence of Atrial Fibrillation after Catheter Ablation: A Meta-Analysis Open
Background: Low voltage areas (LVAs) on left atrial (LA) voltage mapping correlate with atrial fibrosis. However, there is no uniform standard for the definition of LVAs, or mapping techniques and mapping rhythms, so that the predictive va…
View article: Detection and isolation of genotype 3 subtype b hepatitis E viruses from wild boars in Japan
Detection and isolation of genotype 3 subtype b hepatitis E viruses from wild boars in Japan Open
To conduct an epidemiological study of hepatitis E virus (HEV) in Japanese wild boars, we collected 179 serum and 162 fecal specimens from wild boars in eight Japanese prefectures; 39 of the serum samples (21.8%) were positive for anti-HEV…
View article: Exploring the mechanism of tenghuang jiangu wan in osteoporosis treatment based on network pharmacology, molecular docking and experimental pharmacology
Exploring the mechanism of tenghuang jiangu wan in osteoporosis treatment based on network pharmacology, molecular docking and experimental pharmacology Open
In this study, we employed network pharmacology and molecular docking techniques, complemented by experimental validation, to assess the pharmacodynamic effects of Tenghuang Jiangu Wan (THJGW) in the context of osteoporosis (OP) treatment.…