Weiyang Jin
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View article: A Prospective Open‐Label Study of Tolerance and Effectiveness of Sequential Dermocosmetic Treatments Combining Poly‐<scp>l</scp>‐Lysine Biovectors With Vitamins A and C
A Prospective Open‐Label Study of Tolerance and Effectiveness of Sequential Dermocosmetic Treatments Combining Poly‐<span>l</span>‐Lysine Biovectors With Vitamins A and C Open
Background and Objectives Atopic dermatitis (AD) is a common chronic inflammatory skin condition, affecting 15%–20% of children and up to 10% of adults. It has a significant impact on patients' quality of life and represents a considerable…
View article: Author Correction: Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity
Author Correction: Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity Open
View article: Effects of extremely low frequency electromagnetic fields on the tumor cell inhibition and the possible mechanism
Effects of extremely low frequency electromagnetic fields on the tumor cell inhibition and the possible mechanism Open
Low-frequency magnetic fields exert a significant inhibitory effect on tumor growth and have been developed as a therapeutic modality. However, the effect of a low-frequency magnetic field on the interaction between cells is still poorly u…
View article: Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity
Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity Open
Cytotoxic lymphocytes fight pathogens and cancer by forming immune synapses with infected or transformed target cells and then secreting cytotoxic perforin and granzyme into the synaptic space, with potent and specific killing achieved by …
View article: Mechanically active integrins direct cytotoxic secretion at the immune synapse
Mechanically active integrins direct cytotoxic secretion at the immune synapse Open
The secretory output of cell-cell interfaces must be tightly controlled in space and time to ensure functional efficacy. This is particularly true for the cytotoxic immune synapse (IS), the stereotyped junction formed between a cytotoxic l…
View article: Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis
Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis Open
Dysregulated crosstalk between different signaling pathways contributes to tumor development, including resistance to cancer therapy. In the present study, we found that the mitogen-activated extracellular signal-regulated kinase (MEK) inh…
View article: Actinidia eriantha Polysaccharide and PD1-Antibody Combination Therapy Enhances Antitumor Efficacy in Colorectal Cancer–Xenograft Mice
Actinidia eriantha Polysaccharide and PD1-Antibody Combination Therapy Enhances Antitumor Efficacy in Colorectal Cancer–Xenograft Mice Open
AEPS and PD1 antibody-combination therapy can suppresses tumor growth and prolong survival of colorectal cancer-xenograft mice by regulating immunofunction, and the combined therapy showed better therapeutic efficacy than the single treatm…
View article: Identification, Structure–Activity Relationships of Marine-Derived Indolocarbazoles, and a Dual PKCθ/δ Inhibitor with Potent Antipancreatic Cancer Efficacy
Identification, Structure–Activity Relationships of Marine-Derived Indolocarbazoles, and a Dual PKCθ/δ Inhibitor with Potent Antipancreatic Cancer Efficacy Open
Protein kinases C (PKCs) are a family of serine/threonine kinases involved in various cellular processes, including proliferation, differentiation, cell survival, and apoptosis. Here, we report the identification, structure-activity relati…
View article: Physapubescin B enhances the sensitivity of gastric cancer cells to trametinib by inhibiting the STAT3 signaling pathway
Physapubescin B enhances the sensitivity of gastric cancer cells to trametinib by inhibiting the STAT3 signaling pathway Open
Given the poor prognosis of unresectable advanced gastric cancer (GC), novel therapeutic strategies are needed. The mitogen-activated protein kinase (MAPK) signaling cascade, the most frequently activated pathway in GC, plays an important …
View article: WNT2-Mediated FZD2 Stabilization Regulates Esophageal Cancer Metastasis via STAT3 Signaling
WNT2-Mediated FZD2 Stabilization Regulates Esophageal Cancer Metastasis via STAT3 Signaling Open
Esophageal cancer micro environment factor WNT2 was critical in cancer metastasis. However, very little is known about WNT2 receptors and their role in the malignant progression of ESCC. The clinical significance and underlying molecular m…
View article: Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing
Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing Open
Significance CTLs fight intracellular pathogens and cancer by forming a close cell–cell interaction, called the immunological synapse with an infected or transformed target cell and then releasing toxic proteins directionally into the syna…
View article: The Antipsychotic Agent Sertindole Exhibited Antiproliferative Activities by Inhibiting the STAT3 Signaling Pathway in Human Gastric Cancer Cells
The Antipsychotic Agent Sertindole Exhibited Antiproliferative Activities by Inhibiting the STAT3 Signaling Pathway in Human Gastric Cancer Cells Open
Gastric cancer (GC) is the third leading cause of cancer-related death. Although the therapeutic approaches have improved, the 5-year survival rate of GC patients after surgical resection remains low due to the high rates of metastasis and…
View article: T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces
T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces Open
Cells have the remarkable ability to sense the mechanical stiffness of their surroundings. This has been studied extensively in the context of cells interacting with planar surfaces, a conceptually elegant model that also has application i…
View article: Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing
Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing Open
Immunological synapse formation between cytotoxic T lymphocytes (CTLs) and the target cells they aim to destroy is accompanied by reorientation of the CTL centrosome to a position beneath the synaptic membrane. Centrosome polarization is t…
View article: Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells
Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells Open
Cytotoxic T cells use actin-rich protrusions at the immunological synapse to enhance perforin-mediated target cell killing.
View article: T cells sense rigidity of microscale structures
T cells sense rigidity of microscale structures Open
Cells have the remarkable ability to sense the mechanical stiffness of their surroundings. This has been studied extensively in the context of cells interacting with planar surfaces, a conceptually elegant model that also has application i…
View article: Datasets.xlsx
Datasets.xlsx Open
Quantitative data of T cell activation and function
View article: Interfacial actin protrusions mechanically potentiate killing by cytotoxic T cells
Interfacial actin protrusions mechanically potentiate killing by cytotoxic T cells Open
Cytotoxic T lymphocytes (CTLs) kill by forming immunological synapses with target cells and secreting toxic proteases and the pore forming protein perforin into the intercellular space. Immunological synapses are highly dynamic structures …
View article: UV RESISTANCE LOCUS 8 From Chrysanthemum morifolium Ramat (CmUVR8) Plays Important Roles in UV-B Signal Transduction and UV-B-Induced Accumulation of Flavonoids
UV RESISTANCE LOCUS 8 From Chrysanthemum morifolium Ramat (CmUVR8) Plays Important Roles in UV-B Signal Transduction and UV-B-Induced Accumulation of Flavonoids Open
UV Resistance Locus 8 (UVR8), an ultraviolet-B (UV-B; 280-315 nm) photoreceptor, participates in the regulation of various plant growth and developmental processes. UV-B radiation is an important factor enhancing the production of active c…
View article: Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation
Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation Open
View article: Multidimensional T Cell Mechanosensing
Multidimensional T Cell Mechanosensing Open
T cells are key agents in the adaptive immune response, responsible for robust and selective protection of the body against foreign pathogens. T cells are activated through their interaction with antigen-presenting cells (APCs) via a dynam…
View article: Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing
Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing Open