Weiyang Sun
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View article: Efficient airborne transmission of influenza D virus in ferret models and serological evidence of human exposure in Northeast China
Efficient airborne transmission of influenza D virus in ferret models and serological evidence of human exposure in Northeast China Open
Newly emerging influenza D virus (IDV), first identified in swine in 2011, has demonstrated broad mammalian tropism with notable prevalence in bovine populations and occupational exposure-associated seroprevalence among cattle workers. Thi…
View article: Progress in combination vaccines and the co-administration of influenza virus and SARS-CoV-2 vaccines
Progress in combination vaccines and the co-administration of influenza virus and SARS-CoV-2 vaccines Open
COVID-19 and seasonal influenza have taken a huge toll on the global economy and global health. Given the potential of COVID-19 to transform into a chronic epidemic akin to seasonal influenza, the influenza virus and SARS-CoV-2 will contin…
View article: Taurultam shows antiviral activity against SARS-CoV-2 and influenza virus
Taurultam shows antiviral activity against SARS-CoV-2 and influenza virus Open
Not applicable.
View article: Taurolidine inhibits influenza virus infection and prevents influenza-induced cytokine storm, vasoconstriction and lung damage
Taurolidine inhibits influenza virus infection and prevents influenza-induced cytokine storm, vasoconstriction and lung damage Open
Influenza virus causes worldwide outbreaks and seasonal epidemics, posing a severe threat to public health and social development. Effective prevention and treatment of influenza infections remain major challenge for global healthcare. In …
View article: Trade-Offs, Synergies, and Driving Factors of Ecosystem Services in the Urban–Rural Fringe of Beijing at Multiple Scales
Trade-Offs, Synergies, and Driving Factors of Ecosystem Services in the Urban–Rural Fringe of Beijing at Multiple Scales Open
Urban–rural fringe areas are critical transition zones where ecological functions and human activities interact intensely, often leading to complex spatial patterns and trade-offs among ecosystem services (ESs). Understanding these pattern…
View article: Taurolidine resists pulmonary artery vasoconstriction induced by influenza virus infection via inhibiting Ca 2+ influx and MLCK/p-MLC signaling pathway
Taurolidine resists pulmonary artery vasoconstriction induced by influenza virus infection via inhibiting Ca 2+ influx and MLCK/p-MLC signaling pathway Open
Background Influenza virus causes worldwide outbreaks and seasonal epidemics, severely threatening public health and social development. Effective prevention and therapy for influenza infections are a major challenge to global healthcare. …
View article: Spatial Vulnerability Assessment for Mountain Cities Based on the GA-BP Neural Network: A Case Study in Linzhou, Henan, China
Spatial Vulnerability Assessment for Mountain Cities Based on the GA-BP Neural Network: A Case Study in Linzhou, Henan, China Open
Mountain cities with complex topographies have always been highly vulnerable areas to global environmental change, prone to geological hazards, climate change, and human activities. Exploring and analyzing the vulnerability of coupling sys…
View article: A live attenuated influenza B virus vaccine expressing RBD elicits protective immunity against SARS-CoV-2 in mice
A live attenuated influenza B virus vaccine expressing RBD elicits protective immunity against SARS-CoV-2 in mice Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a significant threat to human health globally. It is crucial to develop a vaccine to reduce the effect of the virus on public health, economy, and society and regulate the …
View article: Transgenic expression of PB2 in 293T cells increases avian influenza virus packaging in reverse genetic systems
Transgenic expression of PB2 in 293T cells increases avian influenza virus packaging in reverse genetic systems Open
Plasmid-based reverse genetics has transformed influenza virus research by enabling the production of recombinant influenza viruses from cloned cDNA copies of viral genome segments. Reverse genetic production of influenza viruses requires …
View article: A potential Chinese medicine monomer against influenza A virus and influenza B virus: isoquercitrin
A potential Chinese medicine monomer against influenza A virus and influenza B virus: isoquercitrin Open
Background Influenza viruses, especially Influenza A virus and Influenza B virus, are respiratory pathogens and can cause seasonal epidemics and pandemics. Severe influenza viruses infection induces strong host-defense response and excessi…
View article: A novel hACE2 knock-in mouse model recapitulates pulmonary and intestinal SARS-CoV-2 infection
A novel hACE2 knock-in mouse model recapitulates pulmonary and intestinal SARS-CoV-2 infection Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is responsible for the coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) receptor to enter the host, and the g…
View article: SARS-CoV-2 ORF8 Protein Induces Endoplasmic Reticulum Stress-like Responses and Facilitates Virus Replication by Triggering Calnexin: an Unbiased Study
SARS-CoV-2 ORF8 Protein Induces Endoplasmic Reticulum Stress-like Responses and Facilitates Virus Replication by Triggering Calnexin: an Unbiased Study Open
Although SARS-CoV-2 is basically regarded as a homolog of SARS-CoV, with their genomic structure and the majority of their genes being highly homologous, the ORF8 genes of SARS-CoV and SARS-CoV-2 are distinct. The SARS-CoV-2 ORF8 protein a…
View article: Cross-species infection potential of avian influenza H13 viruses isolated from wild aquatic birds to poultry and mammals
Cross-species infection potential of avian influenza H13 viruses isolated from wild aquatic birds to poultry and mammals Open
Wild aquatic birds are the primary hosts of H13 avian influenza viruses (AIVs). Herein, we performed a genetic analysis of two H13 AIVs isolated from wild birds in China and evaluated their infection potential in poultry to further explore…
View article: A A212T Substitution in Hemagglutinin Impacts on the Rescue of Influenza A(H1N1)/B Chimeric Live-Attenuated Vaccine Candidate
A A212T Substitution in Hemagglutinin Impacts on the Rescue of Influenza A(H1N1)/B Chimeric Live-Attenuated Vaccine Candidate Open
The influenza virus, a viral respiratory pathogen, causes major morbidity and mortality worldwide. In this study, we com pared and analyzed the effectiveness of the rescued two chimeric H1N1 vaccine strains rA/B-California/04/2009 and rA/B…
View article: Cross-species infection potential of avian influenza H13 viruses isolated from wild aquatic birds to poultry and mammals
Cross-species infection potential of avian influenza H13 viruses isolated from wild aquatic birds to poultry and mammals Open
Wild aquatic birds are the primary hosts of H13 avian influenza viruses (AIVs). Herein, we performed a genetic analysis of two H13 AIVs isolated from wild birds in China and evaluated their infection potential in poultry to further explore…
View article: Taurolidine improved protection against highly pathogenetic avian influenza H5N1 virus lethal-infection in mouse model by regulating the NF-κB signaling pathway
Taurolidine improved protection against highly pathogenetic avian influenza H5N1 virus lethal-infection in mouse model by regulating the NF-κB signaling pathway Open
Taurolidine (TRD), a derivative of taurine, has anti-bacterial and anti-tumor effects by chemically reacting with cell-walls, endotoxins and exotoxins to inhibit the adhesion of microorganisms. However, its application in antiviral therapy…
View article: Safety, Immunogenicity, and Protective Efficacy of an H5N1 Chimeric Cold-Adapted Attenuated Virus Vaccine in a Mouse Model
Safety, Immunogenicity, and Protective Efficacy of an H5N1 Chimeric Cold-Adapted Attenuated Virus Vaccine in a Mouse Model Open
H5N1 influenza virus is a threat to public health worldwide. The virus can cause severe morbidity and mortality in humans. We constructed an H5N1 influenza candidate virus vaccine from the A/chicken/Guizhou/1153/2016 strain that was recomm…
View article: Amino acid sites related to the PB2 subunits of IDV affect polymerase activity
Amino acid sites related to the PB2 subunits of IDV affect polymerase activity Open
Background In 2011, a new influenza virus, named Influenza D Virus (IDV), was isolated from pigs, and then cattle, presenting influenza-like symptoms. IDV is one of the causative agents of Bovine Respiratory Disease (BRD), which causes hig…
View article: Characterization of Canine Influenza Virus A (H3N2) Circulating in Dogs in China from 2016 to 2018
Characterization of Canine Influenza Virus A (H3N2) Circulating in Dogs in China from 2016 to 2018 Open
Avian H3N2 influenza virus follows cross-host transmission and has spread among dogs in Asia since 2005. After 2015–2016, a new H3N2 subtype canine influenza epidemic occurred in dogs in North America and Asia. The disease prevalence was a…
View article: Amino Acid Sites Related to The PB2 Subunits of IDV Affect Polymerase Activity
Amino Acid Sites Related to The PB2 Subunits of IDV Affect Polymerase Activity Open
Background: In 2011, a new influenza virus, named Influenza D Virus (IDV), was isolated from pigs, and then cattle, presenting influenza-like symptoms. IDV is one of the causative agents of Bovine Respiratory Disease (BRD), which causes hi…
View article: H13 Subtype Avian Influenza Viruses Are Crossing Host Species Barrier From Wild Waterfowl to Land Fowl
H13 Subtype Avian Influenza Viruses Are Crossing Host Species Barrier From Wild Waterfowl to Land Fowl Open
The avian influenza virus H13 subtype circulates primarily in waterfowl. To explore the ability of the H13 virus to cross the host barriers, we genetically analysed two H13 isolates from wild birds in China and evaluated the infectivity of…
View article: Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone
Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone Open
West Nile virus disease (WND) is an arthropod-borne zoonosis responsible for nonspecific fever or severe encephalitis. The pathogen is West Nile virus belonging to the genus Flavivirus, family Flaviviridae. Every year, thousands of cases w…
View article: Viral and Host Transcriptomes in SARS-CoV-2-Infected Human Lung Cells
Viral and Host Transcriptomes in SARS-CoV-2-Infected Human Lung Cells Open
SARS-CoV-2 is responsible for the current severe global health emergency that began at the end of 2019. Although the universal transcriptional strategies of coronaviruses are preliminarily understood, the details of RNA synthesis, especial…
View article: PB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals
PB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals Open
Influenza H3N8 viruses have been recovered frequently from wild bird species, including Anseriformes (primarily from migratory ducks) and Charadriiformes (primarily from shorebirds). However, little attention has been given to the transmis…
View article: PB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals
PB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals Open
Influenza H3N8 viruses have been recovered frequently from wild bird species, including Anseriformes (primarily from migratory ducks) and Charadriiformes (primarily from shorebirds). However, little attention has been given to the transmis…
View article: Identification of mammalian-adapting mutations involved into antigenic change of H1N1 influenza virus
Identification of mammalian-adapting mutations involved into antigenic change of H1N1 influenza virus Open
Though the 2009 pandemic H1N1 virus has become a seasonal influenza A virus, continued host adaptation and antigenic drift may limit the effectiveness of current vaccines. Here, we assess viral antigenic change of a 2009 pandemic H1N1 viru…
View article: The application of a safe neutralization assay for Ebolavirus using lentivirus-based pseudotyped virus
The application of a safe neutralization assay for Ebolavirus using lentivirus-based pseudotyped virus Open
Ebolavirus (EBOV) is responsible for several EBOV disease (EVD) outbreaks in Africa, with a fatality rate of up to 90%. During 2014-2016, An epidemic of EVD spread throughout Sierra Leone, Guinea and Liberia, and killed over 11,000 people.…