Weiyi Qu
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View article: Integrated screening identifies GPR31 as a key driver and druggable target for metabolic dysfunction–associated steatohepatitis
Integrated screening identifies GPR31 as a key driver and druggable target for metabolic dysfunction–associated steatohepatitis Open
Metabolic dysfunction-associated steatohepatitis (MASH) is a globally prevalent but intractable disease lacking effective pharmacotherapies. Here, we performed an integrated multilayered screening for pathogenic genes and druggable targets…
View article: Forecast of Tobacco Raw Material Demand Based on Combination Prediction Model
Forecast of Tobacco Raw Material Demand Based on Combination Prediction Model Open
In order to improve the prediction accuracy of tobacco raw material demand, this paper presented a combined prediction model. Combined prediction model first used Holt-winters exponential smoothing method and SARIMA model to forecast the d…
View article: The Performance and Mechanism of Solvothermal Synthesis of a Ca-Fe-La Composite for Enhanced Removal of Phosphate from Aqueous Solutions
The Performance and Mechanism of Solvothermal Synthesis of a Ca-Fe-La Composite for Enhanced Removal of Phosphate from Aqueous Solutions Open
Since it is a limiting nutrient element in rivers and lakes, the effective removal of phosphorus is key to alleviating eutrophication. In this study, the one-pot solvothermal method was adopted to prepare an environmentally friendly Ca-Fe-…
View article: Histone demethylase KDM1A promotes hepatic steatosis and inflammation by increasing chromatin accessibility in NAFLD
Histone demethylase KDM1A promotes hepatic steatosis and inflammation by increasing chromatin accessibility in NAFLD Open
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease without specific Food and Drug Administration-approved drugs. Recent advances suggest that chromatin remodeling and epigenetic alteration contribute to th…
View article: Fabricating a hepatocyte-targeted fullerene derivative as a new lipid droplet regulator
Fabricating a hepatocyte-targeted fullerene derivative as a new lipid droplet regulator Open
Lipid droplets (LDs) are crucial organelles in organisms and hold a critical function in modulating intracellular lipid metabolism and bioenergetic regulation. The homeostasis of LDs directly participates in the onset and progression of no…
View article: Study on Planning and Design of Ecological Pastoral Cultural Landscape Belt of Luliang River System in Yunnan Province, China
Study on Planning and Design of Ecological Pastoral Cultural Landscape Belt of Luliang River System in Yunnan Province, China Open
Luliang County of Yunnan Province has identified tourism as one of the four pillar industries, and established the new concept of large tourism, large resources, large market and large development, so as to make tourism a new growth point …
View article: Study on the Design of Ecological Green Corridor Project for Comprehensive River Treatment in Luliang County, Yunnan Province
Study on the Design of Ecological Green Corridor Project for Comprehensive River Treatment in Luliang County, Yunnan Province Open
Luliang County is located in the east of Yunnan Province, knew as the “Pearl of eastern Yunnan”. It is located in the upper reaches of the Nanpan River and is under the jurisdiction of Qujing City. In the modern era, higher requirements ar…
View article: Profound Perturbation in the Metabolome of a Canine Obesity and Metabolic Disorder Model
Profound Perturbation in the Metabolome of a Canine Obesity and Metabolic Disorder Model Open
Canine models are increasingly being used in metabolic studies due to their physiological similarity with humans. The present study aimed to identify changes in metabolic pathways and biomarkers with potential clinical utility in a canine …
View article: Liver Fibrosis and MAFLD: From Molecular Aspects to Novel Pharmacological Strategies
Liver Fibrosis and MAFLD: From Molecular Aspects to Novel Pharmacological Strategies Open
Metabolic-associated fatty liver disease (MAFLD) is a new disease definition, and this nomenclature MAFLD was proposed to renovate its former name, non-alcoholic fatty liver disease (NAFLD). MAFLD/NAFLD have shared and predominate causes f…
Selective ablation of the ligament of Marshall reduces ischemia and reperfusion-induced ventricular arrhythmias Open
Cardiac sympathetic tone overdrive is a key mechanism of arrhythmia. Cardiac sympathetic nerves denervation, such as LSG ablation or renal sympathetic denervation, suppressed both the prevalence of VAs and the incidence of SCD. Accumulatin…