Wei Luo
YOU?
Author Swipe
View article: Integrated metabolomic analysis and network medicine to investigate the mechanisms of Jingling oral liquid in treating ADHD
Integrated metabolomic analysis and network medicine to investigate the mechanisms of Jingling oral liquid in treating ADHD Open
View article: Application of "Internet Plus" Ideological and Political Education in Vocational Colleges
Application of "Internet Plus" Ideological and Political Education in Vocational Colleges Open
View article: SHEP1 alleviates cardiac ischemia reperfusion injury via targeting G3BP1 to regulate macrophage infiltration and inflammation
SHEP1 alleviates cardiac ischemia reperfusion injury via targeting G3BP1 to regulate macrophage infiltration and inflammation Open
View article: hUCMSCs Regulate Bile Acid Metabolism to Prevent Heart Failure–Induced Intestinal Injury by Inhibiting the Activation of the STAT3/NF‐κB/MAPK Signaling Pathway via TGR5
hUCMSCs Regulate Bile Acid Metabolism to Prevent Heart Failure–Induced Intestinal Injury by Inhibiting the Activation of the STAT3/NF‐κB/MAPK Signaling Pathway via TGR5 Open
The protective effects of human umbilical cord mesenchymal stem cells (hUCMSCs) on heart failure (HF)‐induced intestinal injury have not been fully understood. Flow cytometry and immunofluorescence analysis revealed that hUCMSCs renewed th…
View article: The Chinese herbal prescription Kang-Gong-Yan alleviates cervicitis by modulating metabolites and gut microbiota
The Chinese herbal prescription Kang-Gong-Yan alleviates cervicitis by modulating metabolites and gut microbiota Open
The Chinese herbal prescription KGY may alleviate cervicitis by modulating metabolites and gut microbiota disorders. These findings provide a scientific basis for the clinical application of KGY and a new strategy for treating cervicitis i…
View article: SHEP1 alleviates cardiac ischemia reperfusion injury via targeting G3BP1 to regulate macrophage infiltration and inflammation
SHEP1 alleviates cardiac ischemia reperfusion injury via targeting G3BP1 to regulate macrophage infiltration and inflammation Open
Background: The macrophage-associated inflammation response plays an important role in myocardial ischemia-reperfusion injury (MIRI). During MIRI, the role and molecular mechanism of SHEP1 regulating macrophage remains unclear. Methods: By…
View article: A novel intracoronary hypothermia device reduces myocardial reperfusion injury in pigs
A novel intracoronary hypothermia device reduces myocardial reperfusion injury in pigs Open
Background: Hypothermia therapy has been suggested to attenuate myocardial necrosis; however, the clinical implementation as a valid therapeutic strategy has failed, and new approaches are needed to translate into clinical applications. Th…
View article: TEA domain transcription factor 1 (TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway
TEA domain transcription factor 1 (TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway Open
Cardiac fibroblasts (CFs) are the primary cells tasked with depositing and remodeling collagen and significantly associated with heart failure (HF). TEAD1 has been shown to be essential for heart development and homeostasis. However, fibro…
View article: Distribution and Health Risk of Chromium in Wheat Grains at the National Scale of China
Distribution and Health Risk of Chromium in Wheat Grains at the National Scale of China Open
View article: On the Translation of Chinese Traditional Culture Film Subtitles from the Perspective of the Skopos Theory---A Case Study on “Chang'An”
On the Translation of Chinese Traditional Culture Film Subtitles from the Perspective of the Skopos Theory---A Case Study on “Chang'An” Open
View article: Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production Open
Background The cGAS-STING signaling pathway is an essential section of the natural immune system. In recent years, an increasing number of studies have shown a strong link between abnormal activation of the cGAS-STING signaling pathway, a …
View article: 108 The role of Interleukin-1 driven inflammation in recessive dystrophic epidermolysis bullosa
108 The role of Interleukin-1 driven inflammation in recessive dystrophic epidermolysis bullosa Open
View article: Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms and Dissections
Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms and Dissections Open
BACKGROUND: Smooth muscle cell (SMC) phenotypic switching has been increasingly detected in aortic aneurysm and dissection (AAD) tissues. However, the diverse SMC phenotypes in AAD tissues and the mechanisms driving SMC phenotypic alterati…
View article: Tanshinone I specifically suppresses NLRP3 inflammasome activation by disrupting the association of NLRP3 and ASC
Tanshinone I specifically suppresses NLRP3 inflammasome activation by disrupting the association of NLRP3 and ASC Open
Background Abnormal activation of NLRP3 inflammasome is related to a series of inflammatory diseases, including type 2 diabetes, gouty arthritis, non-alcoholic steatohepatitis (NASH), and neurodegenerative disorders. Therefore, targeting N…
View article: Critical Role of the cGAS-STING Pathway in Doxorubicin-Induced Cardiotoxicity
Critical Role of the cGAS-STING Pathway in Doxorubicin-Induced Cardiotoxicity Open
Background: Doxorubicin is an effective chemotherapy drug for treating various types of cancer. However, lethal cardiotoxicity severely limits its clinical use. Recent evidence has indicated that aberrant activation of the cytosolic DNA-se…
View article: Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis
Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis Open
Background: Inflammation and fibrosis are typical symptoms of non-alcoholic steatohepatitis (NASH), which is one of the most common chronic liver diseases. The cGAS-STING signaling pathway has been implicated in the progression of NASH, an…
View article: Therapeutic delivery of microRNA-125a-5p oligonucleotides improves recovery from myocardial ischemia/reperfusion injury in mice and swine
Therapeutic delivery of microRNA-125a-5p oligonucleotides improves recovery from myocardial ischemia/reperfusion injury in mice and swine Open
Rationale: Clinical application of mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exos) to alleviate myocardial ischemia/reperfusion (I/R) injury is compromised by the low cell engraftment rate and uncontrolled exosomal…
View article: Aortic Stress Activates an Adaptive Program in Thoracic Aortic Smooth Muscle Cells That Maintains Aortic Strength and Protects Against Aneurysm and Dissection in Mice
Aortic Stress Activates an Adaptive Program in Thoracic Aortic Smooth Muscle Cells That Maintains Aortic Strength and Protects Against Aneurysm and Dissection in Mice Open
Background: When aortic cells are under stress, such as increased hemodynamic pressure, they adapt to the environment by modifying their functions, allowing the aorta to maintain its strength. To understand the regulation of this adaptive …
View article: GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression
GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression Open
Regulatory T cells (Tregs) are critically involved in neovascularization, an important compensatory mechanism in peripheral artery disease. The contribution of G protein coupled receptor 174 (GPR174), which is a regulator of Treg function …
View article: Sugammadex Versus Neostigmine for Recovery of Respiratory Muscle Strength Measured by Ultrasonography in the Postextubation Period: A Randomized Controlled Trial
Sugammadex Versus Neostigmine for Recovery of Respiratory Muscle Strength Measured by Ultrasonography in the Postextubation Period: A Randomized Controlled Trial Open
BACKGROUND: Although sugammadex is well known for its use in reducing the incidence of residual neuromuscular blockade, this has not always been translated to improved clinical measures of postoperative respiratory muscle strength. Expirat…
View article: Systematical Ingredient Investigations of Ficus tikoua Bur. Fruit and Immunoregulatory and Antioxidant Effects of Different Fractions
Systematical Ingredient Investigations of Ficus tikoua Bur. Fruit and Immunoregulatory and Antioxidant Effects of Different Fractions Open
Although the fruit of Ficus tikoua Bur. has been consumed by montanic people in China for centuries, its chemical and biological composition was still unclear. A series of comprehensive investigations on its chemical constituents and bioac…
View article: Systematical Ingredient Investigations of Ficus tikoua Bur. Fruit and Immunoregulatory and Antioxidant Effects of Different Fractions
Systematical Ingredient Investigations of Ficus tikoua Bur. Fruit and Immunoregulatory and Antioxidant Effects of Different Fractions Open
Although the fruit of Ficus tikoua Bur. has been consumed by montanic people in China over centuries, its chemical and biological composition was still unclear. A series of comprehensive investigations on its chemical constituents and bioa…
View article: Environmental eustress improves postinfarction cardiac repair via enhancing cardiac macrophage survival
Environmental eustress improves postinfarction cardiac repair via enhancing cardiac macrophage survival Open
Macrophages play a vital role in cardiac repair following myocardial infarction (MI). An enriched environment (EE) is involved in the regulation of macrophage-related activities and disease progression; however, whether EE affects the phen…
View article: Asiatic acid alleviates ischemic myocardial injury in mice by modulating mitophagy- and glycophagy-based energy metabolism
Asiatic acid alleviates ischemic myocardial injury in mice by modulating mitophagy- and glycophagy-based energy metabolism Open
View article: A Novel Treatment for Ewing’s Sarcoma: Chimeric Antigen Receptor-T Cell Therapy
A Novel Treatment for Ewing’s Sarcoma: Chimeric Antigen Receptor-T Cell Therapy Open
Ewing’s sarcoma (EWS) is a malignant and aggressive tumor type that predominantly occurs in children and adolescents. Traditional treatments such as surgery, radiotherapy and chemotherapy, while successful in the early disease stages, are …
View article: Effects of HBeAg Status on cellular immune function of patients with Hepatitis B virus/Treponema Pallidum Co-infection
Effects of HBeAg Status on cellular immune function of patients with Hepatitis B virus/Treponema Pallidum Co-infection Open
Objectives: This study was aimed at exploring the effects of hepatitis B envelope antigen (HBeAg) status on the cellular immune function of patients with hepatitis B virus/treponema pallidum (HBV/TP) co-infection.
Methods: The clinical da…
View article: Chimeric Antigen Receptor T-Cell Therapy: The Light of Day for Osteosarcoma
Chimeric Antigen Receptor T-Cell Therapy: The Light of Day for Osteosarcoma Open
Osteosarcoma (OS) is the most common malignant bone tumor, arising mainly in children and adolescents. With the introduction of multiagent chemotherapy, the treatments of OS have remarkably improved, but the prognosis for patients with met…
View article: Alteration of m6A RNA Methylation in Heart Failure With Preserved Ejection Fraction
Alteration of m6A RNA Methylation in Heart Failure With Preserved Ejection Fraction Open
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disease, in which its pathogenesis is very complex and far from defined. Here, we explored the N 6 -methyladenosine (m6A) RNA methylation alteration in p…
View article: MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm
MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm Open
View article: Do racial and ethnic disparities in following stay-at-home orders influence COVID-19 health outcomes? A mediation analysis approach
Do racial and ethnic disparities in following stay-at-home orders influence COVID-19 health outcomes? A mediation analysis approach Open
Racial/ethnic disparities are among the top-selective underlying determinants associated with the disproportional impact of the COVID-19 pandemic on human mobility and health outcomes. This study jointly examined county-level racial/ethnic…