Explanipedia

Mesenchymal stem cell-derived small extracellular vesicles-loaded GelMA microspheres enhance diabetic wound healing by promoting M2 macrophage polarization through p38 MAPK inhibition Open

Weizhao Li, J. C.F. Chen, Lu Yu, Lu Ding, Xiaoying Zhang , et al. · 2025

Diabetic foot ulcers (DFUs) represent a serious complication of diabetes, typically exhibiting persistent inflammation and impaired tissue repair. Although small extracellular vesicles derived from mesenchymal stem cells (MSC-sEVs) possess…

Differential Retention and Loss of a Mycotoxin in Fungal Evolution Open

Lin Chen, Ziying Yan, Bolei Yang, Bowen Tai, Weizhao Li , et al. · 2025

Ochratoxin A (OTA) is designated as a mycotoxin and is regulated worldwide due to its harmful effects on humans and animals, but the evolutionary history and ecological significance of OTA in fungi remain poorly understood. Phylogenetic an…

Let-7a-5p derived from parathyroid hormone (1–34)-preconditioned BMSCs exosomes delays the progression of osteoarthritis by promoting chondrocyte proliferation and migration Open

Litao Shao, Lu Ding, Weizhao Li, Chi Zhang, Yu Xia , et al. · 2025

TDP‐43/ALKBH5‐mediated m6A modification of CDC25A mRNA promotes glioblastoma growth by facilitating G1/S cell cycle transition Open

Yunxiao Zhang, Sidi Xie, Weizhao Li, Junwei Gu, Xian Zhang , et al. · 2025

Glioblastoma (GBM) exhibits significant intratumor heterogeneity (ITH), indicating the presence of tumor cells with diverse growth rates. Here, we aimed to identify fast‐growing cells in GBM and elucidate the underlying mechanisms. Precise…

Integrated analysis of time-driven sensory deterioration and microbial dynamics in NFC pitaya juice during storage Open

Bing Xia, Lin Shi, Susu Han, Jing Kang, Z. G. Zhao , et al. · 2025

Human umbilical cord mesenchymal stem cells small extracellular vesicles-derived miR-370-3p inhibits cervical precancerous lesions by targeting DHCR24 Open

Weizhao Li, Chi Zhang, Tianshun Gao, Yazhou Sun, Huan Yang , et al. · 2024

Background Cervical cancer is often caused by persistent high-risk human papillomavirus (HPV) infection, causing precancerous lesions. Human umbilical cord mesenchymal stem cells-derived small extracellular vesicles (hucMSC-sEV) exhibit di…

Robust 3D multi‐material hydrodynamics using discontinuous Galerkin methods Open

Weizhao Li, Aditya Pandare, Hong Luo, József Bakosi, Jacob Waltz · 2024

A high‐order discontinuous Galerkin (DG) method is presented for nonequilibrium multi‐material () flow with sharp interfaces. Material interfaces are reconstructed using the algebraic THINC approach, resulting in a sharp interface resoluti…

DDB2 promotes melanoma cell growth by transcriptionally regulating the expression of KMT2A and predicts a poor prognosis Open

Changlin Zhang, Weizhao Li, Lixiang Liu, Miao Li, Haohui Sun , et al. · 2024

Identification of potential key targets of melanoma, a fatal skin malignancy, is critical to the development of new cancer therapies. Lysine methyltransferase 2A (KMT2A) promotes melanoma growth by activating the human telomerase reverse t…

Experimental and Numerical Simulation of Reinforced Concrete-Filled Square GFRP Tubular Columns under Axial Compression Open

Chenggui Jing, Lin Zhao, Tong Wu, Weizhao Li · 2024

To investigate the axial compressive behavior of reinforced concrete-filled square glass-fiber-reinforced polymer(GFRP) tubular (RCFSGT) columns, 17 specimens were designed with variations in GFRP tube wall thickness, spiral reinforcement …

Flexural Performance of Reinforced Concrete Beams Strengthened with a Novel High-Strength and High-Toughness Epoxy Mortar Thin Layer Open

Weizhao Li, Xuesong Huang, Xianhui Liu, Tianhao Wen, Chenggui Jing , et al. · 2024

The flexural performance of RC beams strengthened with a novel high-strength and high-toughness epoxy mortar thin layer was investigated through four-point flexural tests on two contrast beams and two strengthened beams. The effects of thi…

Effect of growth hormone on cell proliferation and biological behavior of adamantinomatous craniopharyngioma cells Open

Zhiwei Xiong, Kai Li, Milai Yu, Zijing Wang, Yihan Wang , et al. · 2024

Purpose: This study aims to investigate the impact of growth hormone therapy on the postoperative management of craniopharyngioma and to evaluate the direct influence of GH on craniopharyngioma. Methods: The research involved the applicati…

Experimental Study and Bearing Capacity Calculation of Compression-Reinforced Concrete Columns Strengthened with Ultra-High-Performance Concrete Open

Xianhui Liu, Meiqing Pan, Weizhao Li, Chenggui Jing, Wenlong Chang , et al. · 2024

A total of five ultra-high-performance concrete (UHPC)-strengthened reinforced concrete (RC) columns and one RC column were built and subjected to eccentric compression testing to examine the force performance of UHPC-strengthened eccentri…

Advances in Research on Aging in Female Infertility and Pathologic Pregnancy Open

Bin Liu, Gendie E. Lash, Fengxiang Wei, Priyadarshini Pantham, Bin Liu -Baoan , et al. · 2024

it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed.The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge.Front…

Upregulation of FAM83F by c-Myc promotes cervical cancer growth and aerobic glycolysis via Wnt/β-catenin signaling activation Open

Changlin Zhang, Lixiang Liu, Weizhao Li, Mengxiong Li, Xunzhi Zhang , et al. · 2023

Cervical cancer (CC) seriously affects women’s health. Therefore, elucidation of the exact mechanisms and identification of novel therapeutic targets are urgently needed. In this study, we identified FAM83F, which was highly expressed in C…

Jagged1 contained in MSC-derived small extracellular vesicles promotes squamous differentiation of cervical cancer by activating NOTCH pathway Open

Weizhao Li, Xunzhi Zhang, Tianshun Gao, Lixiang Liu, Chi Zhang , et al. · 2023

Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system Open

Kai Li, Zhanpeng Feng, Zhiwei Xiong, Jun Pan, Mingfeng Zhou , et al. · 2023

JOURNAL/nrgr/04.03/01300535-202410000-00026/figure1/v/2025-03-16T123217Z/r/image-tiff Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has g…

Quorum‐sensing in Acetobacter pasteurianus and its effect on acetic acid fermentation Open

Hang Zhao, Zhiwei Feng, Xueli Han, Jiao Wang, Ying Xu , et al. · 2023

Quorum‐sensing (QS) is an essential mechanism of microbial self‐regulation. In this work, the presence of QS in Acetobacter pasteurianus was demonstrated, and N ‐acyl‐homoserine lactones N‐C4‐HSL and N‐C8‐HSL were identified as the signal …

A parallelp‐adaptive discontinuous Galerkin method for the Euler equations with dynamicload‐balancingon tetrahedral grids Open

Weizhao Li, Aditya Pandare, Hong Luo, József Bakosi, Jacob Waltz · 2023

A novel p ‐adaptive discontinuous Galerkin (DG) method has been developed to solve the Euler equations on three‐dimensional tetrahedral grids. Hierarchical orthogonal basis functions are adopted for the DG spatial discretization while a th…

On the design of stable, consistent, and conservative high-order methods for multi-material hydrodynamics Open

Aditya Pandare, Jacob Waltz, Weizhao Li, Hong Luo, József Bakosi · 2023

Human umbilical cord mesenchymal stem cells derived extracellular vesicles alleviate salpingitis by promoting M1–to–M2 transformation Open

Changlin Zhang, Wei Liao, Weizhao Li, Mengxiong Li, Xiaoyu Xu , et al. · 2023

Background: With an increasing number of patients experiencing infertility due to chronic salpingitis after Chlamydia trachomatis (CT) infection, there is an unmet need for tissue repair or regeneration therapies. Treatment with human umbi…

The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma Open

Xiaonan Wang, Wancui Zhu, Long Qian, Enni Chen, Haohui Sun , et al. · 2023

Background Renal cell carcinoma (RCC) is not sensitive to immunotherapy and has poor prognosis. DNA methylation regulates gene expression, and its abnormal changes are related to many human diseases. Recently, DNA methylation has been foun…

Quinoa, Version 1.0 Open

Aditya Pandare, Weizhao Li, József Bakosi · 2023

Quinoa is a set of computational tools that enables research and numerical analysis in fluid and solid dynamics.

Additional file 2 of The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma Open

Xiaonan Wang, Wancui Zhu, Long Qian, Enni Chen, Haohui Sun , et al. · 2023

Additional file 2. The supplementary tables in this study.

The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma Open

Xiaonan Wang, Wancui Zhu, Enni Chen, Long Qian, Haohui Sun , et al. · 2022

Background: Renal cell carcinoma (RCC) is not sensitive to immunotherapy and have poor prognosis. DNA methylation regulates gene expression, and its abnormal changes are related to many human diseases. Recently, DNA methylation has been fo…

Improving the Acetic Acid Fermentation of Acetobacter pasteurianus by Enhancing the Energy Metabolism Open

Jia Song, Jun Wang, Xinyu Wang, Hang Zhao, Tao Hu , et al. · 2022

Energy metabolism is important for cell growth and tolerance against environment stress. In acetic acid fermentation by Acetobacter pasteurianus , the correlation coefficients of acid production rate with energy charge and ATP content were…

Mitigating Contradictions in Dialogue Based on Contrastive Learning Open

Weizhao Li, Junsheng Kong, Ben Liao, Yi Cai · 2022

Chatbot models have achieved remarkable progress in recent years but tend to yield contradictory responses. In this paper, we exploit the advantage of contrastive learning technique to mitigate this issue. To endow the model with the abili…

Learning Large-scale Network Embedding from Representative Subgraph Open

Junsheng Kong, Weizhao Li, Ben Liao, Jiezhong Qiu, Changyu , et al. · 2021

We study the problem of large-scale network embedding, which aims to learn low-dimensional latent representations for network mining applications. Recent research in the field of network embedding has led to significant progress such as De…

Fast Extraction of Word Embedding from Q-contexts Open

Junsheng Kong, Weizhao Li, Zeyi Liu, Ben Liao, Jiezhong Qiu , et al. · 2021

The notion of word embedding plays a fundamental role in natural language\nprocessing (NLP). However, pre-training word embedding for very large-scale\nvocabulary is computationally challenging for most existing methods. In this\nwork, we …

Cobalta-Electrocatalyzed C–H Allylation with Unactivated Alkenes Open

Uttam Dhawa, Cong Tian, Weizhao Li, Lutz Ackermann · 2020

Versatile and robust cobalt catalysis enabled the electrochemical C–H allylation with nonactivated alkenes. In contrast to precious palladium, rhodium, iridium, and ruthenium catalysts that are limited to electronically activated styrenes …

A p -adaptive Discontinuous Galerkin Method for Compressible Flows Using Charm++ Open

Weizhao Li, Hong Luo, Aditya Pandare, József Bakosi · 2020

A parallel p-adaptive discontinuous Galerkin (DG) method was presented for compressible flows on 3D tetrahedral grids. Hierarchical orthogonal basis functions are adopted to facilitate the p-adaptation. Unlike the traditional data parallel…

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