Explanipedia

Research on Evaluation Methods for Lighting Layout of Manned Submersibles Open

Weizhe Xu, Jun Cao, Wenxin Qu, Dan Xing, Hongtao Ji · 2025

Comparative Metabolome and Transcriptome analyses Reveal Mechanisms for Differences in Ginsenoside Profiles of Herbal Medicines Derived from Panax Species Open

Yungang Tian, Zilong Wang, Lei Ye, Yingping Wang, Peng Di , et al. · 2025

A minimalist self-assembly nanosystem for cancer immunotherapy via multiple immune activation Open

Weizhe Xu, Shiyuan Wang, Jiayi Zhang, Fang Wang, Zhaogang Sun , et al. · 2025

Complete biosynthetic pathway of furochromones in Saposhnikovia divaricata and its evolutionary mechanism in Apiaceae plants Open

Jianlin Zou, Hongye Li, Bao Nie, Zilong Wang, Chunxue Zhao , et al. · 2025

Furochromones are specific bioactive secondary metabolites of many Apiaceae plants. Their biosynthesis remains largely unexplored. In this work, we dissect the complete biosynthetic pathway of major furochromones in the medicinal plant Sap…

Broadband signal DOA estimation based on two‐sided correlation transformation using array manifold interpolation Open

Cao Jun, J. Xiong, Weizhe Xu, Wenxin Qu, Yao Wang , et al. · 2025

The two‐sided correlation transformation (TCT) algorithm is widely used to estimate the direction of arrival (DOA) for broadband signals. However, the traditional TCT algorithm requires DOA pre‐estimation, which results in a high computati…

A Spatiotemporally Controlled Gene‐Regulation Strategy for Combined Tumor Therapy Based on Upconversion Hybrid Nanosystem Open

Fang Wang, Zechao Liu, Yuechen Liu, Jiayi Zhang, Weizhe Xu , et al. · 2024

The lack of precise spatiotemporal gene modulation and therapy impedes progress in medical applications. Herein, a 980 nm near‐infrared (NIR) light‐controlled nanoplatform, namely URMT, is developed, which can allow spatiotemporally contro…

Complete biosynthetic pathway of furochromones and its evolutionary mechanism in Apiaceae plants Open

Min Ye, Jianlin Zou, Hongye Li, Bao Nie, Zilong Wang , et al. · 2024

Furochromones are bioactive and specific secondary metabolites of many Apiaceae plants. Their biosynthesis remains largely unexplored. In this work, we dissected the complete biosynthetic pathway of major furochromones in the medicinal pla…

Fabrication and Degradation Behavior of Mao-Ha Coating on Zn-Mg-Ag Alloy Open

Hongzhou Dong, Weizhe Xu, Xiaoru Zhuo, Dongpeng Wang, Sannakaisa Virtanen , et al. · 2024

Amelioration of Hepatic Steatosis by the Androgen Receptor Inhibitor EPI-001 in Mice and Human Hepatic Cells Is Associated with the Inhibition of CYP2E1 Open

Shuqin Wang, Xue Li, Weizhe Xu, Jing Gao, Yin Wang , et al. · 2022

Nonalcoholic fatty liver disease (NAFLD) is recognized as a metabolic disease characterized by hepatic steatosis. Despite the growing burden of NAFLD, approved pharmacological treatment is lacking. As an inhibitor of androgen receptor (AR)…

Oncolytic Vaccinia Virus Carrying Aphrocallistes vastus Lectin (oncoVV-AVL) Enhances Inflammatory Response in Hepatocellular Carcinoma Cells Open

Xinnan Zheng, Weizhe Xu, Qi Ying, Jiajun Ni, Xiaoyuan Jia , et al. · 2022

Aphrocallistes vastus lectin (AVL) is a C-type marine lectin derived from sponges. Our previous study demonstrated that oncolytic vaccinia virus carrying AVL (oncoVV-AVL) significantly enhanced the cytotoxicity of oncoVV in cervical cancer…

Light-activated nanomaterials for tumor immunotherapy Open

Fang Wang, Huijuan Duan, Weizhe Xu, Gang Sheng, Zhaogang Sun , et al. · 2022

Tumor immunotherapy mainly relies on activating the immune system to achieve antitumor treatment. However, the present tumor immunotherapy used in the clinic showed low treatment efficacy with high systematic toxicity. To overcome the shor…

Multi‐Dimensional Printing for Bone Tissue Engineering Open

Moyuan Qu, Canran Wang, Xingwu Zhou, Alberto Libanori, Xing Jiang , et al. · 2021

The development of 3D printing has significantly advanced the field of bone tissue engineering by enabling the fabrication of scaffolds that faithfully recapitulate desired mechanical properties and architectures. In addition, computer‐bas…

Roles of Porphyromonas gingivalis and its virulence factors in periodontitis Open

Weizhe Xu, Wei Zhou, Huizhi Wang, Shuang Liang · 2020

Canonical Wnt5b Signaling Directs Outlying Nkx2.5+ Mesoderm into Pacemaker Cardiomyocytes Open

Jie Ren, Peidong Han, Xuanyi Ma, Elie N. Farah, Joshua Bloomekatz , et al. · 2019

Rapid continuous 3D printing of customizable peripheral nerve guidance conduits Open

Wei Zhu, Kathryn R. Tringale, Sarah A. Woller, Shangting You, Susie Johnson , et al. · 2018

Receptor and transporter binding and activity profiles of albiflorin extracted from Radix paeoniae Alba Open

Zengliang Jin, Nana Gao, Weizhe Xu, Pingxiang Xu, Shuaiqi Li , et al. · 2016

Comparison of Pharmacokinetics and Tissue Distribution Kinetics of Roxithromycin and Expression of<span>CYP</span>3A1 between Pregnant Mice and Foetuses Open

Yi Qin, Weizhe Xu, Lanjian Mo, Xiaorong Li, Beikang Ge , et al. · 2016

The roxithromycin, macrolide antibiotics, is recommended for treating mycoplasma infection and has the potential to be administered to pregnant women who are susceptible to the infection. This study compared the pharmacokinetic properties …

Enhancement of Exposure and Reduction of Elimination for Paeoniflorin or Albiflorin via Co-Administration with Total Peony Glucosides and Hypoxic Pharmacokinetics Comparison Open

Weizhe Xu, Yan Zhao, Yi Qin, Beikang Ge, Wenwen Gong , et al. · 2016

There is evidence suggesting that herbal extracts demonstrate greater bioactivities than their isolated constituents at an equivalent dose. This phenomenon could be attributed to the absence of interacting substances present in the extract…

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