Weizhong Tang
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View article: Identification and predictive machine learning models construction of gut microbiota associated with lymph node metastasis in colorectal cancer
Identification and predictive machine learning models construction of gut microbiota associated with lymph node metastasis in colorectal cancer Open
This study focuses on the significant role between gut microbiota and lymph node metastasis (LNM) in colorectal cancer (CRC). By conducting 16S rRNA sequencing on fecal samples from 147 CRC patients and combining it with the linear discrim…
View article: 575 | RISK AND PROGNOSIS OF SECOND PRIMARY MALIGNANCIES IN PATIENTS WITH FOLLICULAR LYMPHOMA IN THE ERA OF RITUXIMAB
575 | RISK AND PROGNOSIS OF SECOND PRIMARY MALIGNANCIES IN PATIENTS WITH FOLLICULAR LYMPHOMA IN THE ERA OF RITUXIMAB Open
View article: 776 | PROGNOSTIC RISK STRATIFICATION MODEL FOR MULTIPLE MYELOMA BASED ON GROUP‐BASED TRAJECTORY MODELING
776 | PROGNOSTIC RISK STRATIFICATION MODEL FOR MULTIPLE MYELOMA BASED ON GROUP‐BASED TRAJECTORY MODELING Open
View article: Spatially Targeted PD‐L1 Blockade for Restoring Exhausted Cytotoxic T Lymphocyte Rejuvenation to Potentiate Multimodal‐Immune Synergistic Therapies for Breast Cancer Treatment
Spatially Targeted PD‐L1 Blockade for Restoring Exhausted Cytotoxic T Lymphocyte Rejuvenation to Potentiate Multimodal‐Immune Synergistic Therapies for Breast Cancer Treatment Open
The spatial dynamics and heterogeneity of programmed death‐ligand 1 (PD‐L1) expression within tumors pose significant challenges to the efficacy of PD‐L1/programmed death receptor‐1 (PD‐1) immune checkpoint therapies. This study addresses …
View article: OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression
OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression Open
Ferroptosis, a regulated cell demise predicated on iron metabolism and lipid peroxidation, has increasingly become a focal point in oncological therapies. Nonetheless, its governance, particularly the role of deubiquitination, is not fully…
View article: Dual-modality immune nano-activator harnessing Mn2⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy
Dual-modality immune nano-activator harnessing Mn2⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy Open
Manganese ions (Mn2+) have emerged as promising activators of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway. However, their clinical application was hindered by low bioavailability and limited i…
View article: Anticancer, Apoptotic, Cell Migration and Invasion Inhibition and in silico Molecular Docking Studies of Naringetol in A-549 Human Lung Cancer Cells
Anticancer, Apoptotic, Cell Migration and Invasion Inhibition and in silico Molecular Docking Studies of Naringetol in A-549 Human Lung Cancer Cells Open
View article: Integrin α6 and integrin β4 in exosomes promote lung metastasis of colorectal cancer
Integrin α6 and integrin β4 in exosomes promote lung metastasis of colorectal cancer Open
Background: Colorectal cancer (CRC) is one of the most common cancers worldwide. The mechanisms underlying metastasis, which contributes to poor outcomes, remain elusive. Methods: We used the Cancer Genome Atlas dataset to compare mRNA exp…
View article: Association analysis of gut microbiota with LDL-C metabolism and microbial pathogenicity in colorectal cancer patients
Association analysis of gut microbiota with LDL-C metabolism and microbial pathogenicity in colorectal cancer patients Open
The intestinal microbiota in CRC patients influences the LDL-C metabolic status. With elevated LDL-C levels, gut microbiota can regulate the function of immune cells and gene expression within the tumor microenvironment, affecting cancer-r…
View article: Isobutyric Acid Promotes Immune Evasion in Colorectal Cancer via Increased <scp>PD</scp> ‐ <scp>L1</scp> Expression
Isobutyric Acid Promotes Immune Evasion in Colorectal Cancer via Increased <span>PD</span> ‐ <span>L1</span> Expression Open
Introduction Isobutyric acid (IBA), a short‐chain fatty acid, has been unequivocally demonstrated to exert significant influence on the progression of colorectal cancer (CRC). Nevertheless, a comprehensive understanding of its intricate re…
View article: Identification and predictive machine learning models construction of gut microbiota associated with lymph node metastasis in colorectal cancer
Identification and predictive machine learning models construction of gut microbiota associated with lymph node metastasis in colorectal cancer Open
This study focuses on the significant role between gut microbiota and lymph node metastasis (LNM) in colorectal cancer (CRC). By conducting 16S rRNA sequencing on fecal samples from 147 CRC patients and combining it with the linear discrim…
View article: The circular RNA circ_0001742 regulates colorectal carcinoma proliferation and migration via the MicroRNA-431-5p/ALG8 axis
The circular RNA circ_0001742 regulates colorectal carcinoma proliferation and migration via the MicroRNA-431-5p/ALG8 axis Open
View article: Identification of KRAS mutation-associated gut microbiota in colorectal cancer and construction of predictive machine learning model
Identification of KRAS mutation-associated gut microbiota in colorectal cancer and construction of predictive machine learning model Open
Gut microbiota has demonstrated an increasingly important role in the onset and development of colorectal cancer (CRC). Nonetheless, the association between gut microbiota and KRAS mutation in CRC remains enigmatic. We conducted 16S rRNA s…
View article: Highly Sensitive Electrochemical Determination of Butylated Hydroxyanisole in Food Samples Using Electrochemical-Pretreated Three-Dimensional Graphene Electrode Modified with Silica Nanochannel Film
Highly Sensitive Electrochemical Determination of Butylated Hydroxyanisole in Food Samples Using Electrochemical-Pretreated Three-Dimensional Graphene Electrode Modified with Silica Nanochannel Film Open
The sensitive detection of antioxidants in food is essential for the rational control of their usage and reducing potential health risks. A simple three-dimensional (3D) electrode integrated with an anti-fouling/anti-interference layer pos…
View article: Analysis of differences in intestinal flora associated with different BMI status in colorectal cancer patients
Analysis of differences in intestinal flora associated with different BMI status in colorectal cancer patients Open
Background Overweight is known to be an important risk factor for colorectal cancer (CRC), and the differences in intestinal flora among CRC patients with different BMI status have not been clearly defined. The purpose of this study was to…
View article: Establishing a carcinoembryonic antigen-associated competitive endogenous RNA network and forecasting an important regulatory axis in colon adenocarcinoma patients
Establishing a carcinoembryonic antigen-associated competitive endogenous RNA network and forecasting an important regulatory axis in colon adenocarcinoma patients Open
The LCMT1-AS2/RPS6KA5 axis may be instrumental in tumor progression, potentially acting as a prognostic biomarker and therapeutic target.
View article: Identification of HSP90B1 in pan-cancer hallmarks to aid development of a potential therapeutic target
Identification of HSP90B1 in pan-cancer hallmarks to aid development of a potential therapeutic target Open
Heat shock proteins play crucial roles in various biochemical processes, encompassing protein folding and translocation. HSP90B1, a conserved member of the heat shock protein family, growing evidences have demonstrated that it might be clo…
View article: Rational Design of Dual-Agonist Peptides Targeting Glp-1 and Npy2 Receptors for Regulating Glucose Homeostasis and Body Weight with Minimal Nausea and Emesis
Rational Design of Dual-Agonist Peptides Targeting Glp-1 and Npy2 Receptors for Regulating Glucose Homeostasis and Body Weight with Minimal Nausea and Emesis Open
View article: Identification of Gut Microbiota in Colorectal Cancer Patients with Different Tumor Volumes
Identification of Gut Microbiota in Colorectal Cancer Patients with Different Tumor Volumes Open
View article: Case Report: Colon malignant tumor caused by retroperitoneal small round cell undifferentiated sarcoma
Case Report: Colon malignant tumor caused by retroperitoneal small round cell undifferentiated sarcoma Open
Small round cell undifferentiated sarcoma is a rare and highly invasive group of malignant bone and soft tissue tumors, often associated with a high misdiagnosis rate. The patient in this case was a 34-year-old male who presented with a tw…
View article: Integrated single-cell and bulk RNA sequencing analysis identifies a prognostic signature related to ferroptosis dependence in colorectal cancer
Integrated single-cell and bulk RNA sequencing analysis identifies a prognostic signature related to ferroptosis dependence in colorectal cancer Open
View article: Radiotherapy plus anti-PD1 versus radiotherapy for hepatic toxicity in patients with hepatocellular carcinoma
Radiotherapy plus anti-PD1 versus radiotherapy for hepatic toxicity in patients with hepatocellular carcinoma Open
Purpose In this study, we aimed to compare the radiation-induced hepatic toxicity (RIHT) outcomes of radiotherapy (RT) plus antibodies against programmed cell death protein 1 (anti-PD1) versus RT alone in patients with hepatocellular carci…
View article: Isobutyric acid promotes colorectal cancer metastasis through activating <scp>RACK1</scp>
Isobutyric acid promotes colorectal cancer metastasis through activating <span>RACK1</span> Open
Colorectal cancer (CRC) metastasis plays a crucial role in disease progression, yet the regulatory mechanisms underlying metastasis remain incompletely understood. Isobutyric acid (IBA), a short‐chain fatty acid found at high levels in ser…
View article: Sequential Ubiquitination and Phosphorylation Epigenetics Reshaping by MG132‐Loaded Fe‐MOF Disarms Treatment Resistance to Repulse Metastatic Colorectal Cancer
Sequential Ubiquitination and Phosphorylation Epigenetics Reshaping by MG132‐Loaded Fe‐MOF Disarms Treatment Resistance to Repulse Metastatic Colorectal Cancer Open
Abnormal epigenetic regulation is identified to correlate with cancer progression and renders tumor refractory and resistant to reactive oxygen species (ROS)‐based anti‐tumor actions. To address it, a sequential ubiquitination and phosphor…
View article: Identification of colorectal cancer progression-associated intestinal microbiome and predictive signature construction
Identification of colorectal cancer progression-associated intestinal microbiome and predictive signature construction Open
View article: A PREDICTIVE MODEL FOR ULTRA‐HIGH RISK IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA: A SINGLE‐CENTER STUDY IN CHINA
A PREDICTIVE MODEL FOR ULTRA‐HIGH RISK IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA: A SINGLE‐CENTER STUDY IN CHINA Open
Introduction: Although novel therapies have significantly improved the prognosis of multiple myeloma (MM) patients, there are still a subgroup of MM patients experienced early relapse or disease progression. To early identify the patients …
View article: Identification of intestinal microbiome associated with lymph-vascular invasion in colorectal cancer patients and predictive label construction
Identification of intestinal microbiome associated with lymph-vascular invasion in colorectal cancer patients and predictive label construction Open
Objective To identify differences between the composition, abundance, and biological function of the intestinal microbiome of patients with and without lymph-vascular invasion (LVI) colorectal cancer (CRC) and to construct predictive label…
View article: Increased Kremen2 predicts worse prognosis in colon cancer
Increased Kremen2 predicts worse prognosis in colon cancer Open
Background: Colon cancer (CC) is the fifth most prevalent cancer around the globe and poses a major risk to human health. Even though Kremen2 serves as a prognostic indicator in individuals with malignant tumours, its role in evaluating th…
View article: D-dimer to lymphocyte ratio can serve as a potential predictive and prognostic value in colorectal cancer patients with liver metastases
D-dimer to lymphocyte ratio can serve as a potential predictive and prognostic value in colorectal cancer patients with liver metastases Open
Background The intent of this research was to generate and investigate the D-dimer to lymphocyte ratio (DLR) capacity to forecast the risk and prognosis of colorectal cancer liver metastases (CRCLM). Methods From January 2010 to December 2…
View article: Weight Loss During Neoadjuvant Therapy Is Associated With Poor Response Among the Patients With Gastrointestinal Cancer: A Propensity Score Matching Analysis
Weight Loss During Neoadjuvant Therapy Is Associated With Poor Response Among the Patients With Gastrointestinal Cancer: A Propensity Score Matching Analysis Open
Purpose The aim of the current study was to identify the relationship between body composition changes during neoadjuvant therapy (NAT) and the treatment efficiency of NAT in gastrointestinal cancer (GC) patients. Methods From January 2015…