Weizhu Wu
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View article: Adjuvant Epirubicin Plus Cyclophosphamide Followed by Taxanes With or Without Carboplatin in Early-Stage Triple-Negative Breast Cancer (RJBC 1501): A Randomized Phase III Trial
Adjuvant Epirubicin Plus Cyclophosphamide Followed by Taxanes With or Without Carboplatin in Early-Stage Triple-Negative Breast Cancer (RJBC 1501): A Randomized Phase III Trial Open
PURPOSE To evaluate the efficacy and safety of adjuvant epirubicin plus cyclophosphamide followed by taxanes (EC-T) versus EC-T plus carboplatin (EC-TCb) in patients with early-stage triple-negative breast cancer (TNBC). PATIENTS AND METHO…
View article: PT<sub>f</sub>‐SRiApt Targeting SCAF4‐POLR2A Interaction Suppresses Tumor Growth and Promotes Antitumor Immunity in Triple‐Negative Breast Cancer
PT<sub>f</sub>‐SRiApt Targeting SCAF4‐POLR2A Interaction Suppresses Tumor Growth and Promotes Antitumor Immunity in Triple‐Negative Breast Cancer Open
The interaction between SCAF4 and RNA polymerase II (POLR2A) is crucial for proper mRNA termination, with its dysregulation leading to truncated mRNAs and nonfunctional proteins, impairing cellular growth. Despite its potential relevance, …
View article: Causal effects of genetically predicted endometriosis on breast cancer: a two-sample Mendelian randomization study
Causal effects of genetically predicted endometriosis on breast cancer: a two-sample Mendelian randomization study Open
View article: Artificial intelligence in breast cancer: application and future perspectives
Artificial intelligence in breast cancer: application and future perspectives Open
View article: Diagnosis and prognosis model for breast cancer based on DNAH10 which contributes to tumor immune infiltration and progression
Diagnosis and prognosis model for breast cancer based on DNAH10 which contributes to tumor immune infiltration and progression Open
Background Targeted therapy plays an important role in the treatment of breast cancer. However, more biomarkers are still needed to distinguish breast cancer subgroups and further achieve precise targeted therapy. Methods This study analyz…
View article: “Elastic stretch cavity building” system in endoscopic thyroidectomy via the axillary approach: a case series
“Elastic stretch cavity building” system in endoscopic thyroidectomy via the axillary approach: a case series Open
Background Patients undergoing conventional endoscopic thyroidectomy via the axillary approach, which is commonly used clinically, suffered from a range of postoperative complications. This study aimed to prevent postoperative complication…
View article: An autophagy-related long non-coding RNA prognostic model and related immune research for female breast cancer
An autophagy-related long non-coding RNA prognostic model and related immune research for female breast cancer Open
Introduction Breast cancer (BRCA) is the most common malignancy among women worldwide. It was widely accepted that autophagy and the tumor immune microenvironment play an important role in the biological process of BRCA. Long non-coding RN…
View article: “Elastic Stretch Cavity Building” System in Endoscopic Thyroidectomy of Giant Thyroid Tumors
“Elastic Stretch Cavity Building” System in Endoscopic Thyroidectomy of Giant Thyroid Tumors Open
Objective To analyze the clinical characteristics of patients with large thyroid tumors underwent endoscopic thyroidectomy using the “elastic stretch cavity builder” system. Methods This retrospective case series study included thyroid tum…
View article: Validation of the Prognostic Stage from the American Joint Committee on Cancer 8th Staging Manual in Luminal B-Like Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer
Validation of the Prognostic Stage from the American Joint Committee on Cancer 8th Staging Manual in Luminal B-Like Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer Open
Jinhua Ding,1,2,* Li Jiang,3,* Zheng Xu,4 Yong Chen,4 Weizhu Wu,2 Jian Huang1,5 1Department of Breast Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, People’s Republic of China; 2Dep…
View article: Role of lncRNA AGAP2-AS1 in Breast Cancer Cell Resistance to Apoptosis by the Regulation of MTA1 Promoter Activity
Role of lncRNA AGAP2-AS1 in Breast Cancer Cell Resistance to Apoptosis by the Regulation of MTA1 Promoter Activity Open
Introduction Breast cancer (BC) is a common malignant tumor affecting women across the world. LncRNAs are frequently implicated in the course of BC. The current study set out to determine the specific effect of lncRNA AGAP2-AS1 on BC cell …
View article: SOX4 promotes the growth and metastasis of breast cancer
SOX4 promotes the growth and metastasis of breast cancer Open
Purpose Increasing evidence has shown that the transcription factor SOX4 is closely associated with the development and progression of many malignant tumors. However, the effect of SOX4 on breast cancer is unclear. In this study, we purpos…
View article: SOX4 promotes the growth and metastasis of breast cancer
SOX4 promotes the growth and metastasis of breast cancer Open
Purpose Increasing evidence has shown that the transcription factor SOX4 is closely associated with the development and progression of many malignant tumors. However, the effect of SOX4 on breast cancer is unclear. In this study, we purpos…
View article: Sex differences in subclinical hypothyroidism and associations with metabolic risk factors: a health examination-based study in mainland China
Sex differences in subclinical hypothyroidism and associations with metabolic risk factors: a health examination-based study in mainland China Open
View article: Spectrum of <i>PALB2</i> germline mutations and characteristics of <i>PALB2</i>‐related breast cancer: Screening of 16,501 unselected patients with breast cancer and 5890 controls by next‐generation sequencing
Spectrum of <i>PALB2</i> germline mutations and characteristics of <i>PALB2</i>‐related breast cancer: Screening of 16,501 unselected patients with breast cancer and 5890 controls by next‐generation sequencing Open
Background Partner and localizer BRCA2 ( PALB2 ) is a breast cancer predisposition gene, but the clinical relevance of PALB2 germline mutations in Chinese patients with breast cancer remains unknown. This study attempted to investigate the…
View article: Silencing of rhomboid domain containing 1 to inhibit the metastasis of human breast cancer cells <i>in vitro</i>.
Silencing of rhomboid domain containing 1 to inhibit the metastasis of human breast cancer cells <i>in vitro</i>. Open
Our data indicate that RHBDD1 overexpression may promote breast cancer metastasis via the regulation of EMT, suggesting that RHBDD1 may be an important regulator of breast cancer metastasis.
View article: Changes of breast cancer staging when AJCC prognostic staging manual is used: a retrospective analysis of a Chinese cohort
Changes of breast cancer staging when AJCC prognostic staging manual is used: a retrospective analysis of a Chinese cohort Open
Background: This study aimed to investigate staging changes for Chinese breast cancer patients assessed by the 7 th (anatomic) and 8 th (prognostic) editions of the AJCC staging manual, and to explore the predictive factors for these chang…
View article: Predictive Value of Clinicopathological Characteristics for Sentinel Lymph Node Metastasis in Early Breast Cancer
Predictive Value of Clinicopathological Characteristics for Sentinel Lymph Node Metastasis in Early Breast Cancer Open
BACKGROUND Sentinel lymph node biopsy (SLNB) is one of the preferred treatments for breast cancer including clinically negative lymph node breast cancer. However, for 60-70% of patients this invasive axilla surgery is unnecessary. Our stud…
View article: Predictive factors of pathologic complete response in HER2-positive and axillary lymph node positive breast cancer after neoadjuvant paclitaxel, carboplatin plus with trastuzumab
Predictive factors of pathologic complete response in HER2-positive and axillary lymph node positive breast cancer after neoadjuvant paclitaxel, carboplatin plus with trastuzumab Open
Preoperative PCH regimen was an effective neoadjuvant therapy in HER2 positive and axillary lymph node positive patients, and patients coexisting with HR-negative and high Ki67 index may benefit more from this regimen.
View article: Health-related quality of life of postmenopausal Chinese women with hormone receptor-positive early breast cancer during treatment with adjuvant aromatase inhibitors: a prospective, multicenter, non-interventional study
Health-related quality of life of postmenopausal Chinese women with hormone receptor-positive early breast cancer during treatment with adjuvant aromatase inhibitors: a prospective, multicenter, non-interventional study Open
Clinicaltrials.gov NCT01144572.
View article: A rare case of secretory breast carcinoma in a male adult with axillary lymph node metastasis.
A rare case of secretory breast carcinoma in a male adult with axillary lymph node metastasis. Open
Secretory breast carcinoma is a rare tumor originally described in children but occurring equally in adult population, especially in women. This unusual subtype has a generally favorable prognosis, although several cases have been describe…