Weldon Wright
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View article: Bioluminescent Multi-Characteristic Opsin for Simultaneous Optical Stimulation and Continuous Monitoring of Cortical Activities
Bioluminescent Multi-Characteristic Opsin for Simultaneous Optical Stimulation and Continuous Monitoring of Cortical Activities Open
Stimulation and continuous monitoring of neural activities at cellular resolution are required for the understanding of the sensory processing of stimuli and development of effective neuromodulation therapies. We present bioluminescence mu…
View article: Monitoring Visual Cortical Activities During Progressive Retinal Degeneration Using Functional Bioluminescence Imaging
Monitoring Visual Cortical Activities During Progressive Retinal Degeneration Using Functional Bioluminescence Imaging Open
Mouse models of inherited retinal degenerative diseases such as retinitis pigmentosa are characterized by degeneration of photoreceptors, which hinders the generation of signal to be transmitted to the visual cortex. By monitoring Ca 2+ -b…
View article: Near-Infrared Laser-Based Spatially Targeted Nano-enhanced Optical Delivery of Therapeutic Genes to Degenerated Retina
Near-Infrared Laser-Based Spatially Targeted Nano-enhanced Optical Delivery of Therapeutic Genes to Degenerated Retina Open
Non-viral delivery of therapeutic genes into targeted areas of retina is essential for re-functionalizing the retinal circuitry. While a focused ultrafast laser beam has been recently used for intra-ocular delivery of molecules, it poses t…
View article: Nano-enhanced Optical Gene Delivery to Retinal Degenerated Mice
Nano-enhanced Optical Gene Delivery to Retinal Degenerated Mice Open
Background: The efficient and targeted delivery of genes and other impermeable therapeutic molecules into retinal cells is of immense importance for the therapy of various visual disorders. Traditional methods for gene delivery require vir…
View article: Nano-enhanced optical gene delivery to retinal degenerated mice
Nano-enhanced optical gene delivery to retinal degenerated mice Open
The efficient and targeted delivery of genes and other impermeable therapeutic molecules into retinal cells is of immense importance for therapy of various visual disorders. Traditional methods for gene delivery require viral transfection,…
View article: Bioluminescent Multi-Characteristic Opsin for monitoring visual cortical activity upon optical stimulation
Bioluminescent Multi-Characteristic Opsin for monitoring visual cortical activity upon optical stimulation Open
Non-invasive detection of neural activity is important for the diagnosis of neurological diseases, evaluation of therapeutic outcomes, and collection of real-time feedback for stimulation based therapeutic approaches. In the case of vision…
View article: Publisher’s note: Restoring vision in mice with retinal degeneration using multicharacteristic opsin
Publisher’s note: Restoring vision in mice with retinal degeneration using multicharacteristic opsin Open
[This corrects the article DOI: 10.1117/1.NPh.4.4.041412.].
View article: Restoring vision in mice with retinal degeneration using multicharacteristic opsin
Restoring vision in mice with retinal degeneration using multicharacteristic opsin Open
Retinal degenerative diseases, such as retinitis pigmentosa (RP) and dry age-related macular degeneration, have led to loss of vision in millions of individuals. Currently, no surgical or medical treatment is available, although optogeneti…
View article: Restoring vision in mice with retinal degeneration using multicharacteristic opsin
Restoring vision in mice with retinal degeneration using multicharacteristic opsin Open
Retinal degenerative diseases, such as retinitis pigmentosa (RP) and dry age-related macular degeneration, have led to loss of vision in millions of individuals. Currently, no surgical or medical treatment is available, although optogeneti…