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View article: Cytology‐Radiology Correlation Series: Thyroid cytopathology
Cytology‐Radiology Correlation Series: Thyroid cytopathology Open
Thyroid ultrasound is typically the first step in the workup of thyroid nodules. Ultrasonographic features of thyroid nodules can be used to evaluate their risk of malignancy using risk stratification systems to determine whether a nodule …
View article: A Hybrid Human–Machine Learning Approach for Screening Prostate Biopsies Can Improve Clinical Efficiency Without Compromising Diagnostic Accuracy
A Hybrid Human–Machine Learning Approach for Screening Prostate Biopsies Can Improve Clinical Efficiency Without Compromising Diagnostic Accuracy Open
Context.— Prostate cancer is a common malignancy, and accurate diagnosis typically requires histologic review of multiple prostate core biopsies per patient. As pathology volumes and complexity increase, new tools to improve the efficiency…
View article: Tissue based biomarkers in non-clear cell RCC: Correlative analysis from the ASPEN clinical trial
Tissue based biomarkers in non-clear cell RCC: Correlative analysis from the ASPEN clinical trial Open
Biomarkers are needed in patients with non-clear cell renal cell carcinomas (NC-RCC), particularly papillary renal cell carcinoma, in order to inform on initial treatment selection and identify potentially novel targets for therapy. We enr…
View article: Evaluation of pelvic washing specimens in patients with endometrial cancer: Cytomorphological features, diagnostic agreement, and pathologist experience
Evaluation of pelvic washing specimens in patients with endometrial cancer: Cytomorphological features, diagnostic agreement, and pathologist experience Open
Background Pelvic washings for patients with endometrial cancer is recommended but not used for staging. The International System for Reporting Serous Fluid Cytology (TIS) has standardized diagnostic categories, but the criteria remain inc…
View article: Metastatic Urothelial Carcinoma from Transplanted Kidney with Complete Response to an Immune Checkpoint Inhibitor
Metastatic Urothelial Carcinoma from Transplanted Kidney with Complete Response to an Immune Checkpoint Inhibitor Open
Background. Donor-derived malignancy is a rare complication in patients who undergo organ transplant. Approaches to treatment have largely been individualized based on clinical circumstances given the lack of evidence-based guidelines, wit…
View article: High‐risk and intermediate‐high–risk results from the ThyroSeq v2 and v3 thyroid genomic classifier are associated with neoplasia: Independent performance assessment at an academic institution
High‐risk and intermediate‐high–risk results from the ThyroSeq v2 and v3 thyroid genomic classifier are associated with neoplasia: Independent performance assessment at an academic institution Open
Background The ThyroSeq panel tests for genetic alterations to risk‐stratify cytologically indeterminate nodules. The authors assessed the test performance of the tests, including the latest version (v3), at an academic center. Methods Res…
View article: Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes
Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes Open
Summary Adaptation of cancer cells to targeted therapy follows ecological paradigms observed in natural populations that encounter resource depletion and changing environments, including activation of pro-survival mechanisms, migration to …
View article: Discordant and heterogeneous clinically relevant genomic alterations in circulating tumor cells vs plasma DNA from men with metastatic castration resistant prostate cancer
Discordant and heterogeneous clinically relevant genomic alterations in circulating tumor cells vs plasma DNA from men with metastatic castration resistant prostate cancer Open
Circulating tumor cell (CTC) and cell‐free (cf) DNA‐based genomic alterations are increasingly being used for clinical decision‐making in oncology. However, the concordance and discordance between paired CTC and cfDNA genomic profiles rema…
View article: Correction to: N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ ATM pathway
Correction to: N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ ATM pathway Open
Following publication of the original article [1], the authors reported that name that appeared in published online version is incorrect. Aifeng Wang should be Aifen Wang. Corrected name is provided in the author group section above.
View article: Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer
Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer Open
Osteomimicry may contribute in part to the uptake of radium-223 within bone metastases and may thereby enhance the therapeutic benefit of this bone targeting radiotherapy.
View article: N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway
N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway Open
N-Myc differentially regulating miR-421/ATM pathway contributes to ADT resistance and Enzalutamide resistance development respectively. Combination treatment with ATM inhibitor re-sensitizes N-Myc overexpressed CRPC cells to Enzalutamide. …
View article: Additional file 4: of N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway
Additional file 4: of N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway Open
Figure S4. N-Myc overexpression in LNCaP and 22RV1 cells differentially regulates the expression of the same target genes. A subset of gene list has been summarized in four different groups: upregulated in both LNCaP/N-Myc and 22RV1/N-Myc,…
View article: Additional file 1: of N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway
Additional file 1: of N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway Open
Figure S1. (A) Endogenous protein expression of AR, PSA, NSE and CgA in RWPE-1 cells with and without N-Myc overexpression. Immunoblot showed no significant difference between RWPE-1/vector and RWPE-1/N-Myc cells for these protein markers.…
View article: Diabetic bladder dysfunction is associated with bladder inflammation triggered through hyperglycemia, not polyuria
Diabetic bladder dysfunction is associated with bladder inflammation triggered through hyperglycemia, not polyuria Open
Inflammation in the bladder of diabetic mice correlates with the development of DBD and is triggered by hyperglycemia, not polyuria.
View article: Immunocytochemistry for SOX‐11 and TFE3 as diagnostic markers for solid pseudopapillary neoplasms of the pancreas in FNA biopsies
Immunocytochemistry for SOX‐11 and TFE3 as diagnostic markers for solid pseudopapillary neoplasms of the pancreas in FNA biopsies Open
BACKGROUND Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare malignant tumors that can be sampled via endoscopic ultrasound–guided fine‐needle aspiration (EUS‐FNA). Although diagnosing SPNs can be straightforward in cases wit…
View article: PD12-06 INFLAMMASOME ACTIVATION EARLY IN THE DEVELOPMENT OF DIABETIC BLADDER DYSFUNCTION
PD12-06 INFLAMMASOME ACTIVATION EARLY IN THE DEVELOPMENT OF DIABETIC BLADDER DYSFUNCTION Open
You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder I1 Apr 2017PD12-06 INFLAMMASOME ACTIVATION EARLY IN THE DEVELOPMENT OF DIABETIC BLADDER DYSFUNCTION Brian Inouye, Francis …
View article: Issue Information
Issue Information Open
In the mid-1990s, cytopathologists believed they were at the pinnacle of lung cancer diagnosis.Herein, Dr. Leiman reviews the past 20 years of Cancer Cytopathology, and discusses the developments that have carried pulmonary cytopathology i…
View article: MP01-09 CAN A GENE METHYLATION ASSAY IMPROVE THE PERFORMANCE OF CYTOLOGY?
MP01-09 CAN A GENE METHYLATION ASSAY IMPROVE THE PERFORMANCE OF CYTOLOGY? Open
You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation I1 Apr 2016MP01-09 CAN A GENE METHYLATION ASSAY IMPROVE THE PERFORMANCE OF CYTOLOGY? Thomas Longo, Ajay Gopalakrishna, Joseph Fantony, Richmond Owusu, Raymond Lance…
View article: Usefulness of translocation‐associated immunohistochemical stains in the fine‐needle aspiration diagnosis of salivary gland neoplasms
Usefulness of translocation‐associated immunohistochemical stains in the fine‐needle aspiration diagnosis of salivary gland neoplasms Open
BACKGROUND Fine‐needle aspiration diagnosis of pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) is challenging due to cytologic overlap with one another and with other salivary gland tumors having prominent epithelial and myoepi…