Wen-Chien Lan
YOU?
Author Swipe
View article: An Innovative Design to Enhance Osteoinductive Efficacy and Biomechanical Behavior of a Titanium Dental Implant
An Innovative Design to Enhance Osteoinductive Efficacy and Biomechanical Behavior of a Titanium Dental Implant Open
The present study investigated the in vivo bone-forming efficacy of an innovative titanium (Ti) dental implant combined with a collagen sponge containing recombinant human bone morphogenetic protein-2 (BMP-2) in a pig model. Two different …
View article: An innovative three-dimensional printed titanium implant with a biomimetic structure design for promoting osseointegration potential
An innovative three-dimensional printed titanium implant with a biomimetic structure design for promoting osseointegration potential Open
The present study aimed to investigate the surface characteristic, biocompatibility, and bone regeneration behavior of an innovative three-dimensional (3D) printed titanium (Ti) implant with a biomimetic cancellous bone-like spherical part…
View article: An Innovative Biofunctional Composite Hydrogel with Enhanced Printability, Rheological Properties, and Structural Integrity for Cell Scaffold Applications
An Innovative Biofunctional Composite Hydrogel with Enhanced Printability, Rheological Properties, and Structural Integrity for Cell Scaffold Applications Open
The present study was conducted to manipulate various biomaterials to find potential hydrogel formulations through three-dimensional (3D) bioprinting fabrication for tissue repair, reconstruction, or regeneration. The hydrogels were prepar…
View article: An Innovative Bioactive Surface with Potential Hemocompatibility for Enhancing Osseointegration at Early-Stage Implantation
An Innovative Bioactive Surface with Potential Hemocompatibility for Enhancing Osseointegration at Early-Stage Implantation Open
View article: Fabrication of Biofunctional Oxide Layer with Potential Self-Antibacterial Performance on Titanium Implant for Promoting Osseointegration
Fabrication of Biofunctional Oxide Layer with Potential Self-Antibacterial Performance on Titanium Implant for Promoting Osseointegration Open
View article: Design of Three-Dimensional Bioprinting Bioinks Based on Biopolymers Scaffolds for Tissue Regeneration Applications
Design of Three-Dimensional Bioprinting Bioinks Based on Biopolymers Scaffolds for Tissue Regeneration Applications Open
View article: An innovative biomimetic porous bioceramic to facilitate bone tissue regeneration: microstructural characteristics, biocompatibility, and in vivo rabbit model evaluation
An innovative biomimetic porous bioceramic to facilitate bone tissue regeneration: microstructural characteristics, biocompatibility, and in vivo rabbit model evaluation Open
The present study aimed to develop a highly pure and crystalline beta-tricalcium phosphate (β-TCP) bone graft substitute using the propagated Scleractinian coral. The solid-state reaction followed by heat-treatment (1050 °C–1100 °C for 1 h…
View article: Fabrication of a Potential Electrodeposited Nanocomposite for Dental Applications
Fabrication of a Potential Electrodeposited Nanocomposite for Dental Applications Open
In the present study, a nanocrystalline Ni-Fe matrix with reinforced TiO2 nanoparticles as a functional nanocomposite material was fabricated by pulsed current electroforming in UV-LIGA (lithography, electroplating, and molding). The influ…
View article: A Three-Dimensional Bioprinted Copolymer Scaffold with Biocompatibility and Structural Integrity for Potential Tissue Regeneration Applications
A Three-Dimensional Bioprinted Copolymer Scaffold with Biocompatibility and Structural Integrity for Potential Tissue Regeneration Applications Open
The present study was to investigate the rheological property, printability, and cell viability of alginate–gelatin composed hydrogels as a potential cell-laden bioink for three-dimensional (3D) bioprinting applications. The 2 g of sodium …
View article: Three-Dimensional Printing of a Hybrid Bioceramic and Biopolymer Porous Scaffold for Promoting Bone Regeneration Potential
Three-Dimensional Printing of a Hybrid Bioceramic and Biopolymer Porous Scaffold for Promoting Bone Regeneration Potential Open
In this study, we proposed a three-dimensional (3D) printed porous (termed as 3DPP) scaffold composed of bioceramic (beta-tricalcium phosphate (β-TCP)) and thermoreversible biopolymer (pluronic F-127 (PF127)) that may provide bone tissue i…
View article: An Innovative Customized Biomimetic Hydrogel for Drug Screening Application Potential: Biocompatibility and Cell Invasion Ability
An Innovative Customized Biomimetic Hydrogel for Drug Screening Application Potential: Biocompatibility and Cell Invasion Ability Open
The ability of Pluronic F127 (PF127) conjugated with tetrapeptide Gly-Arg-Gly-Asp (GRGD) as a sequence of Arg-Gly-Asp (RGD) peptide to form the investigated potential hydrogel (hereafter referred to as 3DG bioformer (3BE)) to produce spher…
View article: Biomimetic Ceramic Composite: Characterization, Cell Response, and In Vivo Biocompatibility
Biomimetic Ceramic Composite: Characterization, Cell Response, and In Vivo Biocompatibility Open
The present study aimed to synthesize biphasic calcium phosphate ceramics (CaPs) composed of β-tricalcium phosphate (β-TCP) and hydroxyapatite (HAp) from the propagated Scleractinian coral and dicalcium phosphate anhydrous using a solid-st…
View article: Anodized Biomedical Stainless-Steel Mini-Implant for Rapid Recovery in a Rabbit Model
Anodized Biomedical Stainless-Steel Mini-Implant for Rapid Recovery in a Rabbit Model Open
The study aimed to analyze the recovery period of the anodized 316L biomedical stainless steel (BSS) mini-implant through its implantation on femur of rabbit model. The 316L BSS mini-implant was modified by an electrochemical anodization a…
View article: Surface Properties and Biocompatibility of Anodized Titanium with a Potential Pretreatment for Biomedical Applications
Surface Properties and Biocompatibility of Anodized Titanium with a Potential Pretreatment for Biomedical Applications Open
The effects of anodized titanium (Ti) with a potential hydrogen fluoride (HF) acid pretreatment through cathodization on the formation of nano-porous Ti dioxide (TiO2) layer were characterized using field-emission scanning electron microsc…
View article: An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model
An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model Open
This study aimed to investigate the effect of combining an innovative bioceramic α-calcium sulfate hemihydrate (α-CSH, CaSO4⋅0.5H2O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. T…
View article: The Potential of a Surface-Modified Titanium Implant with Tetrapeptide for Osseointegration Enhancement
The Potential of a Surface-Modified Titanium Implant with Tetrapeptide for Osseointegration Enhancement Open
In this study, the innovative dip-coating technique treated titanium (IDCT-Ti) implant with tetrapeptide Gly-Arg-Gly-Asp (GRGD) coating was investigated for its potential to enhance osseointegration. The L929 fibroblast cells were cultured…
View article: Calcium Release from Different Toothpastes after the Incorporation of Tricalcium Phosphate and Amorphous Calcium Phosphate
Calcium Release from Different Toothpastes after the Incorporation of Tricalcium Phosphate and Amorphous Calcium Phosphate Open
This study aimed to investigate the free calcium released from different brands of toothpaste after incorporation with a beta-tricalcium phosphate (β-TCP)/amorphous calcium phosphate (ACP) mixed powder and with β-TCP powder alone. Four bra…
View article: A Tailored Biomimetic Hydrogel as Potential Bioink to Print a Cell Scaffold for Tissue Engineering Applications: Printability and Cell Viability Evaluation
A Tailored Biomimetic Hydrogel as Potential Bioink to Print a Cell Scaffold for Tissue Engineering Applications: Printability and Cell Viability Evaluation Open
The present study established a maximum standard for printing quality and developed a preliminary ideal index to print three-dimensional (3D) construct using the Gly-Arg-Gly-Asp (GRGD) peptide modified Pluronic-F127 hydrogel (hereafter def…
View article: Fabrication of an Innovative Three-Dimensional Printed Bioceramic Porous Scaffold for Biomedical Applications: Wettability, Mechanical Property, and Biocompatibility
Fabrication of an Innovative Three-Dimensional Printed Bioceramic Porous Scaffold for Biomedical Applications: Wettability, Mechanical Property, and Biocompatibility Open
View article: The Potential of a Tailored Biomimetic Hydrogel for In Vitro Cell Culture Applications: Characterization and Biocompatibility
The Potential of a Tailored Biomimetic Hydrogel for In Vitro Cell Culture Applications: Characterization and Biocompatibility Open
In this study, the Pluronic F127 with modified tripeptide Gly-Arg-Gly-Asp copolymer (hereafter defined as 3BE) hydrogel was evaluated in terms of its biocompatibility potentials. The fibroblasts (Swiss 3T3 cell line) and human hair follicl…
View article: Development of a Surface-Functionalized Titanium Implant for Promoting Osseointegration: Surface Characteristics, Hemocompatibility, and In Vivo Evaluation
Development of a Surface-Functionalized Titanium Implant for Promoting Osseointegration: Surface Characteristics, Hemocompatibility, and In Vivo Evaluation Open
This study aimed to evaluate the impact of surface-modified biomedical titanium (Ti) dental implant on osseointegration. The surfaces were modified using an innovative dip-coating technique (IDCT; sandblasted, large-grit, and acid-etched, …
View article: An Innovative Bioceramic Bone Graft Substitute for Bone Defect Treatment: In Vivo Evaluation of Bone Healing
An Innovative Bioceramic Bone Graft Substitute for Bone Defect Treatment: In Vivo Evaluation of Bone Healing Open
This study aimed to analyze characteristics of an innovative α-calcium sulfate hemihydrate (α-CSH) bioceramic and bone healing and regeneration characteristics following its implantation on artificially created defects of rat models and hu…
View article: Regulation of the regenerative activity of dental pulp stem cells from exfoliated deciduous teeth (SHED) of children by TGF-β1 is associated with ALK5/Smad2, TAK1, p38 and MEK/ERK signaling
Regulation of the regenerative activity of dental pulp stem cells from exfoliated deciduous teeth (SHED) of children by TGF-β1 is associated with ALK5/Smad2, TAK1, p38 and MEK/ERK signaling Open
Transforming growth factor-β1 (TGF-β1) regulates wound healing/regeneration and aging processes. Dental pulp stem cells from human exfoliated deciduous teeth (SHED) are cell sources for treatment of age-related disorders. We studied the ef…
View article: Fabrication of a Promising Hierarchical Porous Surface on Titanium for Promoting Biocompatibility
Fabrication of a Promising Hierarchical Porous Surface on Titanium for Promoting Biocompatibility Open
The effects of the nano-titanium hydrides (nano-γ-TiH) phase on the formation of nanoporous Ti oxide layer by the potential approach (hydrogen fluoride (HF) pretreatment and sodium hydroxide (NaOH) anodization) were investigated using scan…
View article: Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin Film
Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin Film Open
In the present study, the piezoelectric aluminum nitride (AlN)/tantalum (Ta) (PAT) thin film was investigated as a biocompatible film and osseointegrated with biomedical devices such as implants. The stress variation on the interaction of …
View article: The Potential of a Nanostructured Titanium Oxide Layer with Self-Assembled Monolayers for Biomedical Applications: Surface Properties and Biomechanical Behaviors
The Potential of a Nanostructured Titanium Oxide Layer with Self-Assembled Monolayers for Biomedical Applications: Surface Properties and Biomechanical Behaviors Open
This study investigated the surface properties and biomechanical behaviors of a nanostructured titanium oxide (TiO) layer with different self-assembled monolayers (SAMs) of phosphonate on the surface of microscope slides. The surface prope…
View article: Application of a Promising Bone Graft Substitute in Bone Tissue Regeneration: Characterization, Biocompatibility, and <i>In Vivo</i> Animal Study
Application of a Promising Bone Graft Substitute in Bone Tissue Regeneration: Characterization, Biocompatibility, and <i>In Vivo</i> Animal Study Open
The purpose of the present study was to investigate the effect of local hydroxyapatite (HA) combined with extracted sea cucumber ( Stichopus hermanni ) collagen as a promising bone graft substitute on bone remodeling. Fourier-transform inf…