Wei Chen
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View article: Denosumab attenuates knee osteoarthritis progression by inhibiting synovial inflammation via the RANK/TRAF6/FSTL1 signalling
Denosumab attenuates knee osteoarthritis progression by inhibiting synovial inflammation via the RANK/TRAF6/FSTL1 signalling Open
Synovitis has recently been shown to be a critical early stage in development of osteoarthritis (OA), and inhibiting synovitis significantly alleviates OA symptoms. Denosumab, a monoclonal antibody targeting RANKL, previously developed for…
View article: Association of HLA-DQA1*06:01 and DPB1*05:01:01G alleles with susceptibility to end-stage liver disease with HBV infection in liver transplant recipients from the Zhejiang Han population, China
Association of HLA-DQA1*06:01 and DPB1*05:01:01G alleles with susceptibility to end-stage liver disease with HBV infection in liver transplant recipients from the Zhejiang Han population, China Open
Background It has been reported that HLA was associated with susceptibility to various liver diseases. However, data on HLA in end-stage liver disease (ESLD) patients are limited. Therefore, this study aimed to explore the association of H…
View article: Integrative Multi‐Omics Analysis Unveils the Molecular Mechanisms by Which TP53 Mutation Influence Early Decitabine Resistance in Myelodysplastic Syndrome
Integrative Multi‐Omics Analysis Unveils the Molecular Mechanisms by Which TP53 Mutation Influence Early Decitabine Resistance in Myelodysplastic Syndrome Open
The myelodysplastic syndrome (MDS) is group of clonal hematopoietic stem cell disorders typified by peripheral cytopenia, dysplastic hematopoietic progenitors, a hypercellular or hypocellular bone marrow, and a high risk of conversion to a…
View article: Challenges of ECMO use for severe trauma: a narrative review
Challenges of ECMO use for severe trauma: a narrative review Open
Background Patients with severe trauma are at high risk of developing life-threatening complications, including acute respiratory failure and circulatory collapse. Extracorporeal membrane oxygenation (ECMO) offers critical support when con…
View article: Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9
Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9 Open
Background The golden Syrian hamster is a valuable animal model for studying carcinogenesis, metabolic disorders, cardiovascular diseases, and viral infections due to its biological and pathological similarities to humans. However, the dev…
View article: Genetic causal association between metabolic syndrome and idiopathic pulmonary fibrosis: A 2-sample Mendelian randomization
Genetic causal association between metabolic syndrome and idiopathic pulmonary fibrosis: A 2-sample Mendelian randomization Open
Prior epidemiological investigations have indicated a linkage between metabolic syndrome (MetS) and idiopathic pulmonary fibrosis (IPF). The objective of the present research was to elucidate the inherited causal relationship of MetS with …
View article: Systematic review and meta‑analysis of risk prediction models for retinopathy of prematurity in preterm infants
Systematic review and meta‑analysis of risk prediction models for retinopathy of prematurity in preterm infants Open
Retinopathy of prematurity (ROP) is a proliferative vascular disease affecting preterm infants with incompletely developed retinal vasculature, characterized by abnormal vascular proliferation that can lead to retinal detachment and blindn…
View article: Genomic insights into young stock survival in Danish Jersey cattle: A breed-specific QTL on chromosome 10 and its regulatory potential
Genomic insights into young stock survival in Danish Jersey cattle: A breed-specific QTL on chromosome 10 and its regulatory potential Open
Calf mortality during the rearing period is a major concern for dairy producers, impacting both profitability and animal welfare. A genome-wide association analysis of young stock survival (YSS) in Jersey cattle using whole-genome sequence…
View article: Rhabdomyolysis Induced by Irbesartan‐Hydrochlorothiazide in an Elderly Patient
Rhabdomyolysis Induced by Irbesartan‐Hydrochlorothiazide in an Elderly Patient Open
A 90‐year‐old male with hypertension and diabetes presented with acute limb weakness and dizziness. Laboratory tests revealed severe hyponatremia (Na + 111.6 mmol/L) and rhabdomyolysis (CK 1771 U/L), which occurred after the recent initiat…
View article: Associations of 35 Serum and Urine Biomarkers With Vascular Dementia—A Mendelian Randomization Study
Associations of 35 Serum and Urine Biomarkers With Vascular Dementia—A Mendelian Randomization Study Open
Background The relationship between serum and urine biomarkers with vascular dementia (VD) has been increasingly highlighted by observational studies. Yet, the causal nature underlying these associations remains elusive. Objective This res…
View article: TFOS DEWS III: Executive Summary
TFOS DEWS III: Executive Summary Open
This article presents an executive summary of the conclusions and recommendations of the third Tear Film and Ocular Surface Society Dry Eye Workshop (TFOS DEWS III) reports, published in the American Journal of Ophthalmology (AJO) in the s…
View article: Mechanism of Piezo1 regulating chondrocyte mitochondrial function and promoting fracture healing through β-catenin/LARS2 signaling pathway
Mechanism of Piezo1 regulating chondrocyte mitochondrial function and promoting fracture healing through β-catenin/LARS2 signaling pathway Open
Piezo1, a key mechanosensor in bone homeostasis, plays a crucial role in fracture healing. However, the mechanisms through which Piezo1 regulates chondrocytes and affects endochondral ossification remain poorly understood. This study aimed…
View article: International Evidence‐Based Guidelines for Traditional Chinese Medicine Management of Allergic Rhinitis
International Evidence‐Based Guidelines for Traditional Chinese Medicine Management of Allergic Rhinitis Open
Allergic rhinitis (AR) is a prevalent chronic condition that significantly impacts patients' quality of life and poses challenges to effective management. Traditional Chinese medicine (TCM) offers a holistic approach, emphasizing syndrome …
View article: Preliminarily evaluation the safety and immunogenicity of tetanus, reduced diphtheria and acellular pertussis (five components) combined vaccine, adsorbed (Tdcp) in participants aged 6 years and above: a blinded and randomised, and controlled phase I clinical trial
Preliminarily evaluation the safety and immunogenicity of tetanus, reduced diphtheria and acellular pertussis (five components) combined vaccine, adsorbed (Tdcp) in participants aged 6 years and above: a blinded and randomised, and controlled phase I clinical trial Open
Pertussis remains a significant global public health challenge, particularly in China, where no licensed pertussis-containing vaccines are available for individuals aged 6 years and older. This blind, randomised, and controlled phase I cli…
View article: An Interpretable Radiomics-Based Model Using Susceptibility-Weighted Imaging for Non-Invasive Prediction of Tertiary Lymphoid Structures in Hepatocellular Carcinoma
An Interpretable Radiomics-Based Model Using Susceptibility-Weighted Imaging for Non-Invasive Prediction of Tertiary Lymphoid Structures in Hepatocellular Carcinoma Open
The SWI-based radiomics model provided a non-invasive tool for predicting iTLSs+ in HCC and identifying patients who might benefit from TKI-ICI therapy, and it showed potential for future integration into clinical decision-making workflows.
View article: Application of digital design and 3D printing technology in repairing mandibular defects with fibula musculocutaneous flap
Application of digital design and 3D printing technology in repairing mandibular defects with fibula musculocutaneous flap Open
Background: Mandibular tumors are common in oral and maxillofacial surgery. Following tumor resection, significant bone tissue defects often occur, severely compromising both facial appearance and function. Currently, fibular myocutaneous …
View article: Association of renal cortical thickness and renal function in patients with malignant hypertension with thrombotic microangiopathy: a biopsy-based cohort study from China
Association of renal cortical thickness and renal function in patients with malignant hypertension with thrombotic microangiopathy: a biopsy-based cohort study from China Open
Background Malignant hypertension (mHTN) is an acute form of hypertension with multiorgan damage, including renal impairment. Renal cortical thickness (RCT) by ultrasonography is associated with renal function in kidney disease. However, t…
View article: The Mechanosensitive Ion Channel Piezo1 Regulates Chondrocyte Homeostasis Through the <scp>PI3K</scp>/<scp>AKT</scp>/<scp>mTORC1</scp> Pathway in Osteoarthritis
The Mechanosensitive Ion Channel Piezo1 Regulates Chondrocyte Homeostasis Through the <span>PI3K</span>/<span>AKT</span>/<span>mTORC1</span> Pathway in Osteoarthritis Open
Osteoarthritis (OA) is a highly prevalent chronic joint disease with complicated pathogenesis, causing pain and dysfunction. The mechanosensitive ion channel Piezo1 is an important mechanoreceptor on chondrocytes and may be involved in the…
View article: A novel web-based online nomogram was used to predict postoperative function in patients with femoral shaft fractures treated with intramedullary nails
A novel web-based online nomogram was used to predict postoperative function in patients with femoral shaft fractures treated with intramedullary nails Open
Objective: To investigate factors influencing postoperative functional recovery after intramedullary nailing (IMN) for femoral shaft fractures and to develop a clinical prediction model. Methods: Patients who underwent IMN for femoral shaf…
View article: 3D‐Printed Multidimensional Bionic Mg‐MC/PLGA Composite for Tailored Repair of Segmental Long Bone Defects
3D‐Printed Multidimensional Bionic Mg‐MC/PLGA Composite for Tailored Repair of Segmental Long Bone Defects Open
The management of long bone segmental defects represents a critical challenge in orthopedic medicine. This study focuses on developing an innovative bone repair material to overcome the inherent limitations of existing solutions. The mater…
View article: Effectiveness of acupuncture and moxibustion combined with rehabilitation training for post-stroke shoulder-hand syndrome: a systematic review and meta-analysis
Effectiveness of acupuncture and moxibustion combined with rehabilitation training for post-stroke shoulder-hand syndrome: a systematic review and meta-analysis Open
Background Post-stroke shoulder-hand syndrome (SHS) significantly impacts patients' quality of life and functional recovery. While both acupuncture and rehabilitation training have shown promise individually, their combined effect needs sy…
View article: An Examination of the Relationship Between Spinal-Pelvic Morphology and Lower Lumbar Facet Joint Remodeling in Individuals with Mild Degenerative Lumbar Spondylolisthesis
An Examination of the Relationship Between Spinal-Pelvic Morphology and Lower Lumbar Facet Joint Remodeling in Individuals with Mild Degenerative Lumbar Spondylolisthesis Open
Facet joint morphology is intricately tied to spinal-pelvic alignment, reflecting both post-DLS remodeling and variation across spinal-pelvic types. Facet joint changes significantly influence DLS progression and spinal balance. These find…
View article: Sepsis with Cancer is Marked by a Dysregulated Myeloid Cell Compartment: A Pilot Study
Sepsis with Cancer is Marked by a Dysregulated Myeloid Cell Compartment: A Pilot Study Open
In septic patients, particularly those patients with cancer, attenuated phagocytic activity of immature neutrophil (myelocytes, metamyelocytes, band neutrophils) and monocyte, and HLA-DRlowCCR2low classical monocyte and CD177+ myelocytes m…