Guowen Zhang
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View article: LIBERO-PRO: Towards Robust and Fair Evaluation of Vision-Language-Action Models Beyond Memorization
LIBERO-PRO: Towards Robust and Fair Evaluation of Vision-Language-Action Models Beyond Memorization Open
LIBERO has emerged as a widely adopted benchmark for evaluating Vision-Language-Action (VLA) models; however, its current training and evaluation settings are problematic, often leading to inflated performance estimates and preventing fair…
View article: Identification of cellular senescence-associated hub genes and molecular targeting mechanisms of thalidomide in lupus nephritis (LN)
Identification of cellular senescence-associated hub genes and molecular targeting mechanisms of thalidomide in lupus nephritis (LN) Open
Systemic lupus erythematosus (SLE), a chronic autoimmune disease, progresses to lupus nephritis (LN) in 50-60% of patients, driving end-stage renal disease (ESRD). Identifying LN-associated cellular senescence hub genes and drug targets is…
View article: Modulatory Role of Hesperetin–Copper(II) on Gut Microbiota in Type 2 Diabetes Mellitus Mice
Modulatory Role of Hesperetin–Copper(II) on Gut Microbiota in Type 2 Diabetes Mellitus Mice Open
Background: Exploring new strategies to improve type 2 diabetes mellitus (T2DM) is one of the frontier hotspots in the field of healthy food. Flavonoid–metal complexes have become one of the research hotspots in the field of health foods d…
View article: Diagnostic value of choroidal vascular density in predicting the progression of diabetic retinopathy
Diagnostic value of choroidal vascular density in predicting the progression of diabetic retinopathy Open
By utilizing widefield swept-source optical coherence tomography angiography (WSS-OCTA) to quantify choroidal vascular density (VD) in order to identify early fundus changes in diabetic patients and to predict the progression of diabetic r…
View article: Transient receptor potential vanilloid 4 blockage attenuates pyroptosis in hippocampus of mice following pilocarpine‑induced status epilepticus
Transient receptor potential vanilloid 4 blockage attenuates pyroptosis in hippocampus of mice following pilocarpine‑induced status epilepticus Open
Pyroptosis contributes to the neuronal damage that occurs during epilepsy. Calcium-activated neutral protease (calpain) dissociates cysteinyl aspartate specific proteinase-1 (caspase-1, cas-1) from the cytoskeleton, and the activated cas-1…
View article: Exploring the Necessity of Reasoning in LLM-based Agent Scenarios
Exploring the Necessity of Reasoning in LLM-based Agent Scenarios Open
The rise of Large Reasoning Models (LRMs) signifies a paradigm shift toward advanced computational reasoning. Yet, this progress disrupts traditional agent frameworks, traditionally anchored by execution-oriented Large Language Models (LLM…
View article: Study on the interaction mechanism and physicochemical properties of luteolin and its glucoside compounds with β-lactoglobulin
Study on the interaction mechanism and physicochemical properties of luteolin and its glucoside compounds with β-lactoglobulin Open
View article: Novel sulphur-selective method for simultaneous determination of thiram and asomate based on carbon dots and its application in fruits
Novel sulphur-selective method for simultaneous determination of thiram and asomate based on carbon dots and its application in fruits Open
View article: Elucidating the Interaction of Indole-3-Propionic Acid and Calf Thymus DNA: Multispectroscopic and Computational Modeling Approaches
Elucidating the Interaction of Indole-3-Propionic Acid and Calf Thymus DNA: Multispectroscopic and Computational Modeling Approaches Open
Indole-3-propionic acid (IPA) is a plant growth regulator with good specificity and long action. IPA may be harmful to human health because of its accumulation in vegetables and fruits. Therefore, in this study, the properties of the inter…
View article: OCDB: Revisiting Causal Discovery with a Comprehensive Benchmark and Evaluation Framework
OCDB: Revisiting Causal Discovery with a Comprehensive Benchmark and Evaluation Framework Open
Large language models (LLMs) have excelled in various natural language processing tasks, but challenges in interpretability and trustworthiness persist, limiting their use in high-stakes fields. Causal discovery offers a promising approach…
View article: Hesperitin-Copper(II) Complex Regulates the NLRP3 Pathway and Attenuates Hyperuricemia and Renal Inflammation
Hesperitin-Copper(II) Complex Regulates the NLRP3 Pathway and Attenuates Hyperuricemia and Renal Inflammation Open
Background: Hyperuricaemia (HUA) is a disorder of purine metabolism in the body. We previously synthesized a hesperitin (Hsp)-Cu(II) complex and found that the complex possessed strong uric acid (UA)-reducing activity in vitro. In this stu…
View article: Protein Glycosylation Inhibitory Effects and Mechanisms of Phloretin and Phlorizin
Protein Glycosylation Inhibitory Effects and Mechanisms of Phloretin and Phlorizin Open
View article: Development of a Novel Hplc-Cdcl Method Utilizing N-Carbon Dots for Highly Sensitive and Selective Determination of Dithiocarbamate Pesticides in Tea
Development of a Novel Hplc-Cdcl Method Utilizing N-Carbon Dots for Highly Sensitive and Selective Determination of Dithiocarbamate Pesticides in Tea Open
View article: Spontaneous suprachoroidal hemorrhage treated by gas tamponade in a refractory glaucoma patient with rhegmatogenous retinal detachment: a case report
Spontaneous suprachoroidal hemorrhage treated by gas tamponade in a refractory glaucoma patient with rhegmatogenous retinal detachment: a case report Open
We are reporting the successful treatment of a rare case of spontaneous suprachoroidal hemorrhage (SSCH) in a young refractory glaucoma patient with rhegmatogenous retinal detachment (RRD). The 34-year-old male was admitted to our hospital…
View article: Effects of Processing Conditions and Simulated Digestion In Vitro on the Antioxidant Activity, Inhibition of Xanthine Oxidase and Bioaccessibility of Epicatechin Gallate
Effects of Processing Conditions and Simulated Digestion In Vitro on the Antioxidant Activity, Inhibition of Xanthine Oxidase and Bioaccessibility of Epicatechin Gallate Open
The bioactivity and gastrointestinal stability of epicatechin gallate (ECG) may be affected by processing conditions. Results showed that the antioxidant ability and inhibitory activity on xanthine oxidase (XO) of ECG were higher at low pH…
View article: Improving the gel properties of salted egg white/cooked soybean protein isolate composite gels by ultrasound treatment: Study on the gelling properties and structure
Improving the gel properties of salted egg white/cooked soybean protein isolate composite gels by ultrasound treatment: Study on the gelling properties and structure Open
View article: Novel Reactive Distillation Process for Cyclohexyl Acetate Production: Design, Optimization, and Control
Novel Reactive Distillation Process for Cyclohexyl Acetate Production: Design, Optimization, and Control Open
A side-reactor column (SRC) configuration, comprising a vacuum column coupled with atmospheric side reactors, is proposed to overcome the thermodynamic restriction in the esterification of cyclohexene with acetic acid to produce cyclohexyl…
View article: Comment on: “Risk of Erectile Dysfunction in Male Patients with Gout Treated with Febuxostat or Allopurinol: A Propensity Score-Matched Cohort Study”
Comment on: “Risk of Erectile Dysfunction in Male Patients with Gout Treated with Febuxostat or Allopurinol: A Propensity Score-Matched Cohort Study” Open
View article: New Insights into the Inhibition of Hesperetin on Polyphenol Oxidase: Inhibitory Kinetics, Binding Characteristics, Conformational Change and Computational Simulation
New Insights into the Inhibition of Hesperetin on Polyphenol Oxidase: Inhibitory Kinetics, Binding Characteristics, Conformational Change and Computational Simulation Open
The inhibitory activity of hesperetin on polyphenol oxidase (PPO) and their interaction characteristics were investigated using multiple spectroscopic methods and computational simulation. Hesperetin, a mixed inhibitor, reversibly inhibite…
View article: Improvement of Antioxidation, Emulsification Properties and Thermal Stability of Egg White Protein by Covalent Binding Togallic Acid/Tannic Acid and Xanthan Gum
Improvement of Antioxidation, Emulsification Properties and Thermal Stability of Egg White Protein by Covalent Binding Togallic Acid/Tannic Acid and Xanthan Gum Open
View article: Inhibition Mechanism of Fisetin on Acetylcholinesterase and its Synergistic Effect with Galantamine
Inhibition Mechanism of Fisetin on Acetylcholinesterase and its Synergistic Effect with Galantamine Open
View article: Exploring the Inhibition of Quercetin on Acetylcholinesterase by Multispectroscopic and In Silico Approaches and Evaluation of Its Neuroprotective Effects on PC12 Cells
Exploring the Inhibition of Quercetin on Acetylcholinesterase by Multispectroscopic and In Silico Approaches and Evaluation of Its Neuroprotective Effects on PC12 Cells Open
This study investigated the inhibitory mechanism of quercetin in acetylcholinesterase (AChE) and its neuroprotective effects on β-amyloid25–35-induced oxidative stress injury in PC12 cells. Quercetin inhibited AChE in a reversible mixed ma…
View article: Oxidative Stability of Frying Oil and Kinetics of Unsaturated Fatty Acids Oxidation under the Frying Condition of Western-style Fast Food Restaurants
Oxidative Stability of Frying Oil and Kinetics of Unsaturated Fatty Acids Oxidation under the Frying Condition of Western-style Fast Food Restaurants Open
This study investigated the oxidation stability of five common frying oils during frying under western fast food conditions. Their oxidation kinetics of unsaturated fatty acids (linolenic acid, linoleic acid, and oleic acid) were analyzed.…
View article: Improving the gel properties of duck egg white by synergetic phosphorylation/ultrasound: Gel properties, crystalline structures, and protein structure
Improving the gel properties of duck egg white by synergetic phosphorylation/ultrasound: Gel properties, crystalline structures, and protein structure Open
View article: Structure Identification and Functional Mechanism of Natural Active Components: A Special Issue
Structure Identification and Functional Mechanism of Natural Active Components: A Special Issue Open
The natural active components derived from plants have attracted widespread attention due to their abundant species and source advantages [...]
View article: Study on the mechanism of enhanced gel strength of heat-induced egg white by shikimic acid braising
Study on the mechanism of enhanced gel strength of heat-induced egg white by shikimic acid braising Open
View article: Effects of interaction between hesperetin/hesperidin and glutenin on the structure and functional properties of glutenin
Effects of interaction between hesperetin/hesperidin and glutenin on the structure and functional properties of glutenin Open
This research aimed to investigate the changes in the structure and functional properties of glutenin (Glu) induced by hesperetin (Ht) or hesperidin (Hd). Both Ht and Hd quenched the fluorescence of Glu through a static process and formed …
View article: Mechanism of ultrasound and tea polyphenol assisted ultrasound modification of egg white protein gel
Mechanism of ultrasound and tea polyphenol assisted ultrasound modification of egg white protein gel Open
View article: HAT: Hierarchical Aggregation Transformers for Person Re-identification
HAT: Hierarchical Aggregation Transformers for Person Re-identification Open
Recently, with the advance of deep Convolutional Neural Networks (CNNs), person Re-Identification (Re-ID) has witnessed great success in various applications. However, with limited receptive fields of CNNs, it is still challenging to extra…
View article: Multi-Spectroscopic and Molecular Simulation Approaches to Characterize the Intercalation Binding of 1-Naphthaleneacetic Acid With Calf Thymus DNA
Multi-Spectroscopic and Molecular Simulation Approaches to Characterize the Intercalation Binding of 1-Naphthaleneacetic Acid With Calf Thymus DNA Open
1–Naphthaleneacetic acid (NAA), having high-quality biological activity and great yield-increasing potential in agricultural production, is a broad-spectrum plant growth regulator. Although NAA is of low toxicity, it can affect the balance…