Explanipedia

Low-Molecular-Weight Heparin Plus Insulin in Hypertriglyceridemic Acute Pancreatitis Open

Wenhua He, Ling Ding, Zhijun Liu, Mingqing Hua, Yuming Zhou , et al. · 2025

Importance Although insulin is widely used for early lipid lowering in hypertriglyceridemic acute pancreatitis, the clinical benefit of heparin combined with insulin remains unclear. Objective To examine whether low-molecular-weight hepari…

Genetically Predict Diet‐derived Antioxidants and Risk of Neurodegenerative Diseases Among Individuals of European Descent: A Mendelian Randomization Study Open

Qing‐Qing Duan, Wei‐Ming Su, Xiaojing Gu, Jiang Long, Zheng Jiang , et al. · 2025

Background The incidence of neurodegenerative disorders (NDDs) is increasing, and currently, there are no curative treatments available for these conditions. The potential benefits of supplementation with diet‐derived antioxidants and thei…

Ascites characteristics in acute pancreatitis: A prognostic indicator of organ failure and mortality Open

Jingwen Rao, Jiarong Li, Yao Wu, Tianming Lai, Zongke Zhou , et al. · 2025

BACKGROUND Acute pancreatitis (AP) is a severe condition, and abdominal effusion is a significant predictor of its severity and prognosis. However, the relationship between ascites characteristics and AP outcomes remains undefined. AIM To …

[Machine Learning-Assisted Efficacy Evaluation of Resveratrol Therapy in a Mouse Model of Acute Pancreatitis]. Open

Ziyu Li, Yuxing Tian, Wenhao Cai, Yongzi Wu, Shiyu Liu , et al. · 2025

A regimen of 20 mg/kg RES administered four times effectively alleviates the severity of CER-induced AP. The therapeutic benefits appear to arise from a multi-target regulatory network that simultaneously suppresses inflammatory cascades, …

Histones are critical toxic factors in gut lymph of severe acute pancreatitis: Neutralization by baicalin and baicalein for protection Open

Shiyu Liu, Qiqi Wang, Wenjuan Luo, Lijia Huang, Lan Li , et al. · 2025

Histones are key toxic factors in the gut lymph of SAP and their antagonism by baicalin and baicalein offers a novel therapeutic strategy.

Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implications Open

Yongzi Wu, Chenxia Han, Rong Luo, Wenhao Cai, Qing Xia , et al. · 2023

Although severe abdominal pain is the main symptom of acute pancreatitis, its mechanisms are poorly understood. An emerging body of literature evidence indicates that neurogenic inflammation might play a major role in modulating the percep…

Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients Open

Di Wu, Yan Jia, Wenhao Cai, Yilin Huang, Arjun Kattakayam , et al. · 2022

Introduction Multiple drug-resistant Gram-negative bacterial (MDR-GNB) bacteraemia poses a serious threat to patients in hospital. Infected pancreatic necrosis (IPN) patients are a vulnerable population to infectious complications during h…

Joint Beamforming Design for Intelligent Omni Surface Assisted Wireless Communication Systems Open

Wenhao Cai, Ming Li, Yang Liu, Qingqing Wu, Qian Liu · 2022

Intelligent reflecting surface (IRS) has been widely considered as one of the key enabling techniques for future wireless communication networks owing to its ability of dynamically controlling the phase shift of reflected electromagnetic (…

Non-Cooperative Resource Management for Intelligent Reflecting Surface Aided Networks Open

Wenhao Cai, Ming Li, Qian Liu · 2022

Intelligent reflecting surface (IRS) has emerged as a promising and revolutionizing technology for future wireless networks. Most existing IRS studies focus on simple cooperative systems which usually have a single frequency band. In reali…

Acute Pancreatitis: Diagnosis and Treatment Open

Peter Szatmary, Tassos Grammatikopoulos, Wenhao Cai, Wei Huang, Rajarshi Mukherjee , et al. · 2022

Acute pancreatitis is a common indication for hospital admission, increasing in incidence, including in children, pregnancy and the elderly. Moderately severe acute pancreatitis with fluid and/or necrotic collections causes substantial mor…

Predicting persistent organ failure on admission in patients with acute pancreatitis: development and validation of a mobile nomogram Open

Na Shi, Xiaoxin Zhang, Yin Zhu, Lihui Deng, Lan Li , et al. · 2022

This nomogram can predict POF of AP patients and should be considered for clinical practice and trial allocation.

IRS-assisted Multi-cell Multi-band Systems: Practical Reflection Model and Joint Beamforming Design Open

Wenhao Cai, Rang Liu, Ming Li, Yang Liu, Qingqing Wu , et al. · 2022

Intelligent reflecting surface (IRS) has been regarded as a promising and revolutionary technology for future wireless communication systems owing to its capability of tailoring signal propagation environment in an energy/spectrum/hardware…

Defined, low threshold for cesarean section and multidisciplinary team management improves fetal outcome from acute pancreatitis in pregnancy Open

Wenhua He, Zhi Zhang, Wenhao Cai, Lingyu Luo, Hongrong Xu , et al. · 2022

Background Acute pancreatitis in pregnancy (APIP) is associated with increased maternal and fetal mortality. We sought to determine whether a low threshold for cesarean section (C-section) in severe acute pancreatitis (SAP) improves matern…

Randomized controlled trial: neostigmine for intra-abdominal hypertension in acute pancreatitis Open

Wenhua He, Peng Chen, Yupeng Lei, Liang Xia, Pi Liu , et al. · 2022

Background Intra-abdominal hypertension (IAH) in acute pancreatitis (AP) is associated with deterioration in organ function. This trial aimed to assess the efficacy of neostigmine for IAH in patients with AP. Methods In this single-center,…

Pain Management in Acute Pancreatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials Open

Wenhao Cai, Fei Liu, Yongjian Wen, Chenxia Han, Manya Prasad , et al. · 2021

Background: Pain management is an important priority in the treatment of acute pancreatitis (AP). Current evidence and guideline recommendations are inconsistent on the most effective analgesic protocol. This systematic review and meta-ana…

Randomized Controlled Trial: Neostigmine for Intra-abdominal Hypertension in Acute Pancreatitis Open

Wenhua He, Peng Chen, Yupeng Lei, Liang Xia, Pi Liu , et al. · 2021

Background: Intra-abdominal hypertension (IAH) in acute pancreatitis (AP) is associated with deterioration in organ function. This trial aimed to assess the efficacy of neostigmine for IAH in patients with AP. Methods: In this single-centr…

A Mobile Terminal-based Nomogram for Early Predicting Severity of Acute Pancreatitis Open

Na Shi, Xiaoxin Zhang, Wenhua He, Lihui Deng, Lan Li , et al. · 2021

Background: Early prediction of the severity of acute pancreatitis (AP) is important but there is no preferred method in China. We aimed to develop and validate a simple-to-use predictive nomogram for persistent organ failure (POF) on admi…

Stress Hyperglycemia Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis Open

Xinmin Yang, Ruwen Zhang, Tao Jin, Ping Zhu, Linbo Yao , et al. · 2021

Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1 Open

Yulin Ouyang, Li Wen, J. A. Armstrong, Michael Chvanov, Diane Latawiec , et al. · 2021

Acute pancreatitis (AP) is a severe and potentially fatal disease caused predominantly by alcohol excess and gallstones, which lacks a specific therapy. The role of Receptor-Interacting Protein Kinase 1 (RIPK1), a key component of programm…

Targeting Macrophage Migration Inhibitory Factor in Acute Pancreatitis and Pancreatic Cancer Open

Yongjian Wen, Wenhao Cai, Jingyu Yang, Xianghui Fu, Lohitha Putha , et al. · 2021

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in the pathogenesis of inflammation and cancer. It is produced by various cells and circulating MIF has been identified as a biomarker for a range of disease…

Quantitative Research Based on Parametric Simulation of Waterlogging on Bridge Deck Open

Wenhao Cai, Ling Huang · 2021

With the rise of the bridge construction wave, the problem of waterlogging on bridge deck (WBD) also followed. The problems of WBD will cause serious economic losses, restrict the benign development of urban traffic and reduce the life qua…

Efficacy of early prone or lateral positioning in patients with severe COVID-19: a single-center prospective cohort Open

Zhong Ni, Kaige Wang, Ting Wang, Yue-Nan Ni, Wei Huang , et al. · 2020

Background Position intervention has been shown to improve oxygenation, but its role in non-invasively ventilated patients with severe COVID-19 has not been assessed. The objective of this study was to investigate the efficacy of early pos…

Chaiqin chengqi decoction alleviates severity of acute pancreatitis via inhibition of TLR4 and NLRP3 inflammasome: Identification of bioactive ingredients via pharmacological sub-network analysis and experimental validation Open

Yongjian Wen, Chenxia Han, Tingting Liu, Rui Wang, Wenhao Cai , et al. · 2020

CQCQD attenuated the severity of AP at least in part by inhibiting the TLR4/NLRP3 pro-inflammatory pathways. Its active ingredients, emodin, baicalin, rhein and chrysin contributed to these beneficial effects.

Exocrine Pancreatic Insufficiency Following Acute Pancreatitis: Systematic Review and Meta-Analysis Open

Wei Huang, Daniel de la Iglesia, Iria Bastón‐Rey, Cristina Suárez, José Lariño‐Noia , et al. · 2019

The prevalence of EPI during admission and follow-up is substantial in patients with a first attack of AP. Unanswered questions remain about the way this is managed, and further RCTs are indicated.

Underexpression of Receptor for Activated C Kinase 1 (RACK1) in Leukocytes from Patients with Severe Acute Pancreatitis Open

Xiaoxin Zhang, Jia Guo, Haoyang Wang, Chenlong Zhang, Na Shi , et al. · 2018

Receptor for activated C kinase 1 (RACK1) plays an important role in regulating the immune response and cytokine expression. However, little is known about its role in acute pancreatitis (AP). We therefore investigated the role of RACK1 in…

Plasma cytokines can help to identify the development of severe acute pancreatitis on admission Open

Lihui Deng, Cheng Hu, Wenhao Cai, Weiwei Chen, Xiao-Xin Zhang , et al. · 2017

Severe acute pancreatitis (AP) is associated with high morbidity and mortality. Early severity stratification remains a challenging issue to overcome to improve outcomes. We aim to find novel plasma cytokines for the early identification o…

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