Chao Cheng
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View article: PSsurvival: Propensity Score Methods for Survival Analysis
PSsurvival: Propensity Score Methods for Survival Analysis Open
View article: Supplementary Data from VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance
Supplementary Data from VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance Open
Supplementary Figure Legends
View article: Figure S1 from VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance
Figure S1 from VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance Open
Quality control and cluster identification of CD45-enriched scRNAseq data. In the I/V model, BALB/c mice were administered 100k CT26 cells and treated when tumors reached a size of 40mm3 with isotype (I) or anti-VISTA (V). In the CPV model…
View article: Figure S2 from VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance
Figure S2 from VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance Open
Additional data supporting Figure 3. (A) Pathway enrichment for each cluster described in figure 3. (B) Comparison of myeloid clusters from this study with those identified by [30]. Dots represent the proportion of myeloid clusters describ…
View article: Figure S3 from VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance
Figure S3 from VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance Open
Supplementary Figure S3. Anti-VISTA-induced changes to tumor-infiltrating immune cells in MB49. B6 mice were injected intra-dermally with 100k MB49 cells and treated when tumors reached a size of 100mm3 with isotype (I) or anti-VISTA (V). …
View article: Supplementary Figures and Table legends from Clonal Hematopoiesis Mutations in Patients with Lung Cancer Are Associated with Lung Cancer Risk Factors
Supplementary Figures and Table legends from Clonal Hematopoiesis Mutations in Patients with Lung Cancer Are Associated with Lung Cancer Risk Factors Open
Supplementary Figures S1-S3, corresponded figure legends, and legends of supplementary table S1-S3
View article: Table S1-S3 from Clonal Hematopoiesis Mutations in Patients with Lung Cancer Are Associated with Lung Cancer Risk Factors
Table S1-S3 from Clonal Hematopoiesis Mutations in Patients with Lung Cancer Are Associated with Lung Cancer Risk Factors Open
Table S1-S3
View article: Dietary vitamin E modulates the hypothalamic-pituitary-gonadal (HPG) axis and antioxidant capacity during early gonadal development in juvenile Chinese sturgeon (Acipenser sinensis)
Dietary vitamin E modulates the hypothalamic-pituitary-gonadal (HPG) axis and antioxidant capacity during early gonadal development in juvenile Chinese sturgeon (Acipenser sinensis) Open
A two-month feeding trial was conducted to investigate the effects of dietary vitamin E on the hypothalamic-pituitary-gonadal (HPG) axis and antioxidant capacity during early gonadal development in juvenile Chinese sturgeon. Three experime…
View article: CoCo-ST detects global and local biological structures in spatial transcriptomics datasets
CoCo-ST detects global and local biological structures in spatial transcriptomics datasets Open
Spatial domain detection methods often focus on high-variance structures, such as tumour-adjacent regions with sharp gene expression changes, while missing low-variance structures with subtle gene expression shifts, like those between adja…
View article: Evaluation of the efficacy of platelet-rich plasma in the treatment of training-induced knee traumatic osteoarthritis: a retrospective study based on a multidimensional quantitative evaluation
Evaluation of the efficacy of platelet-rich plasma in the treatment of training-induced knee traumatic osteoarthritis: a retrospective study based on a multidimensional quantitative evaluation Open
Objective In this study, we retrospectively evaluated the efficacy of platelet-rich plasma (PRP) for the treatment of training-induced knee traumatic osteoarthritis (KTOA) by means of a functional scale and MRI cartilage score, and analyse…
View article: Unravelling the distinct effects of VHL mutations and chromosome 3p loss in clear cell renal cell carcinoma: Implications for prognosis and treatment
Unravelling the distinct effects of VHL mutations and chromosome 3p loss in clear cell renal cell carcinoma: Implications for prognosis and treatment Open
View article: Functional characterization of LSM12 as a driver in uveal melanoma oncogenesis
Functional characterization of LSM12 as a driver in uveal melanoma oncogenesis Open
View article: GASPS: A Multi-Omics Framework for Defining Genomic Aberration-Driven Signatures and Predicting Patient Outcomes in Lung Cancer
GASPS: A Multi-Omics Framework for Defining Genomic Aberration-Driven Signatures and Predicting Patient Outcomes in Lung Cancer Open
Summary Lung cancer is the most common cause of cancer-related death worldwide. Recent advancements in targeted therapies and immunotherapies have achieved remarkable success. However, patient responses to treatments with lung cancer vary …
View article: Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells
Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells Open
View article: Gene signatures characterizing driver mutations in lung squamous carcinoma are predictive of the progression of pre-cancer lesions
Gene signatures characterizing driver mutations in lung squamous carcinoma are predictive of the progression of pre-cancer lesions Open
Patients with lung squamous cell carcinoma (LUSC) are often diagnosed at advanced stages, limiting opportunities for early intervention. LUSC develops through a multistep progression from low-grade lesions to high-grade lesions, including …
View article: Gene expression in tumor and adjacent normal tissues in lung adenocarcinoma subtypes
Gene expression in tumor and adjacent normal tissues in lung adenocarcinoma subtypes Open
n We identified subtype-specific genes, biological functions, and potential drivers of subtype-specific carcinogenesis for LUAD subtypes. The study showed importance of gene expression in adjacent normal tissue for subtype-specific tumorig…
View article: Spatial Proximity of Immune Cell Pairs to Cancer Cells in the Tumor Microenvironment as Biomarkers for Patient Stratification
Spatial Proximity of Immune Cell Pairs to Cancer Cells in the Tumor Microenvironment as Biomarkers for Patient Stratification Open
Background/Objectives: The tumor microenvironment (TME) plays a critical role in cancer progression by shaping immune responses and influencing patient outcomes. We hypothesized that the relative proximity of specific immune cell pairs to …
View article: Integrative Analysis Reveals the Prognostic Effects of Epigenetic Regulators in Bladder Cancer
Integrative Analysis Reveals the Prognostic Effects of Epigenetic Regulators in Bladder Cancer Open
Background Epigenetic regulatory genes (epiRG) are pivotal in the epigenetic regulation of the human genome, primarily through DNA and histone modifications. These genes are frequently mutated in human cancers, particularly bladder cancer …
View article: Complete genome sequences of <i>Streptomyces</i> phages HazuAndZazu and Tubberson
Complete genome sequences of <i>Streptomyces</i> phages HazuAndZazu and Tubberson Open
Bacteriophages HazuAndZazu and Tubberson, belonging to the BI1 and BC1 subclusters, are Caudoviricetes with a siphoviral morphology that infect Streptomyces species. They have GC contents of 59.5% and 71.5%, and genomes 55,823 and 39,028 b…
View article: Neoadjuvant Osimertinib for Resectable <i>EGFR</i> -Mutated Non–Small Cell Lung Cancer
Neoadjuvant Osimertinib for Resectable <i>EGFR</i> -Mutated Non–Small Cell Lung Cancer Open
PURPOSE Adjuvant osimertinib is the standard of care for patients with resected epidermal growth factor receptor ( EGFR )–mutated non–small cell lung cancer (NSCLC). Neoadjuvant treatment could improve surgical and long-term outcomes. METH…
View article: Genome-wide analysis of genetic loci and candidate genes related to teat number traits in Dongliao black pigs
Genome-wide analysis of genetic loci and candidate genes related to teat number traits in Dongliao black pigs Open
This study investigated the genetic basis of teat number variation in Dongliao black pigs. A total of 765 pigs were genotyped using the Porcine 50K SNP chip, and their teat numbers were recorded. Heritability estimates for total teat numbe…
View article: Reply to: “Comments on the paper ‘Extensive epigenomic dysregulation is a hallmark of homologous recombination deficiency in triple‐negative breast cancer’ by Y. Chen et al.”
Reply to: “Comments on the paper ‘Extensive epigenomic dysregulation is a hallmark of homologous recombination deficiency in triple‐negative breast cancer’ by Y. Chen et al.” Open
View article: Neural systems underlying autobiographical memory dysregulations in depressive and at-risk individuals: A neuroimaging meta-analysis
Neural systems underlying autobiographical memory dysregulations in depressive and at-risk individuals: A neuroimaging meta-analysis Open
Background Autobiographical memory (AM) dysfunction has been proposed as a neurocognitive mechanism underlying the development and maintenance of depression. However, case-control neuroimaging studies investigating the neural correlates of…
View article: An Air‐Operated, High‐Performance Fe‐Ion Secondary Battery Using Acidic Electrolyte
An Air‐Operated, High‐Performance Fe‐Ion Secondary Battery Using Acidic Electrolyte Open
Fe 2+ have emerged as the ideal charge carriers to construct aqueous batteries as one of the most competitive candidates for next‐generation low‐cost and safe energy storage. Unfortunately, the fast oxidation of Fe 2+ into Fe 3+ at ambient…
View article: Enriched pathways in gut microbiome predict response to immune checkpoint inhibitor treatment across demographic regions and various cancer types
Enriched pathways in gut microbiome predict response to immune checkpoint inhibitor treatment across demographic regions and various cancer types Open
View article: Author Correction: Assessment of human leukocyte antigen-based neoantigen presentation to determine pan-cancer response to immunotherapy
Author Correction: Assessment of human leukocyte antigen-based neoantigen presentation to determine pan-cancer response to immunotherapy Open
View article: Does Adiponectin Inform Cardiovascular Risk in Older Adults?
Does Adiponectin Inform Cardiovascular Risk in Older Adults? Open
View article: Erythritol, Erythronate, and Cardiovascular Outcomes in Older Adults in the ARIC Study
Erythritol, Erythronate, and Cardiovascular Outcomes in Older Adults in the ARIC Study Open
Circulating erythritol and erythronate levels are markers of cardiometabolic health and cardiovascular outcomes in an older adult population. In particular, erythronate is associated with all cardiovascular outcomes assessed. Future studie…
View article: Heterogeneity and plasticity of the naïve CD4+ T cell compartment
Heterogeneity and plasticity of the naïve CD4+ T cell compartment Open
View article: Cytotoxic and regulatory T cell interactions calculated from image mass cytometry predict immunochemotherapy response in triple‐negative breast cancer
Cytotoxic and regulatory T cell interactions calculated from image mass cytometry predict immunochemotherapy response in triple‐negative breast cancer Open