Weihong Zeng
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View article: Estimating cardiovascular effects of influenza vaccination in older adults: a target trial emulation using proximal causal inference
Estimating cardiovascular effects of influenza vaccination in older adults: a target trial emulation using proximal causal inference Open
View article: Spatial metabolomics and transcriptomics reveal cell type-specific dynamics in the placenta of patients with late-onset preeclampsia
Spatial metabolomics and transcriptomics reveal cell type-specific dynamics in the placenta of patients with late-onset preeclampsia Open
Introduction The placenta is vital for fetal development, but its growth can become disordered in pregnancy complications, particularly at the maternal–fetal interface. Preeclampsia, a severe condition that arises after the 20th week of pr…
View article: A Retrospective Study of Clinicopathological Features and Survival Outcomes in 305 Surgically Treated Patients with Stage IB–IIA Cervical Squamous Cell Carcinoma
A Retrospective Study of Clinicopathological Features and Survival Outcomes in 305 Surgically Treated Patients with Stage IB–IIA Cervical Squamous Cell Carcinoma Open
The pathological features of patients with CSCC are closely associated with ADC values derived from diffusion-weighted imaging (DWI). Vaginal bleeding, depth of invasion, FIGO stage, postoperative treatment, and lymph node metastasis are k…
View article: Estimating cardiovascular effects of influenza vaccination in older adults: a target trial emulation using proximal causal inference
Estimating cardiovascular effects of influenza vaccination in older adults: a target trial emulation using proximal causal inference Open
National Natural Science Foundation of China; Science and Technology Project of Science and Technology Bureau of Yinzhou District, Ningbo City; Zhejiang Provincial Centre for Disease Control and Prevention Science and Technology Program; B…
View article: Garlic-Derived Allicin Attenuates Parkinson’s Disease via PKA/p-CREB/BDNF/DAT Pathway Activation and Apoptotic Inhibition
Garlic-Derived Allicin Attenuates Parkinson’s Disease via PKA/p-CREB/BDNF/DAT Pathway Activation and Apoptotic Inhibition Open
Allicin (ALC), a naturally occurring organosulfur compound derived from garlic (Allium sativum), exhibits potential neuroprotective properties. Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by degenerati…
View article: Insights into microbial dysbiosis and Cutibacterium acnes CAMP factor interactions in acne vulgaris
Insights into microbial dysbiosis and Cutibacterium acnes CAMP factor interactions in acne vulgaris Open
Acne vulgaris is a common skin condition marked by the formation of comedones, papules, pustules and nodules, with its underlying causes still not fully understood. This study explores the impact of microbial dysbiosis and virulence factor…
View article: Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats
Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats Open
This study evaluated the therapeutic effects of fecal microbiota transplantation (FMT) on lipopolysaccharide (LPS)‐induced acute respiratory distress syndrome (ARDS) in rats. The study focused on the balance of T‐helper 17 (Th17) and regul…
View article: AlignHuman: Improving Motion and Fidelity via Timestep-Segment Preference Optimization for Audio-Driven Human Animation
AlignHuman: Improving Motion and Fidelity via Timestep-Segment Preference Optimization for Audio-Driven Human Animation Open
Recent advancements in human video generation and animation tasks, driven by diffusion models, have achieved significant progress. However, expressive and realistic human animation remains challenging due to the trade-off between motion na…
View article: Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on cardiovascular outcomes in older adults with type 2 diabetes mellitus: a target trial emulation study
Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on cardiovascular outcomes in older adults with type 2 diabetes mellitus: a target trial emulation study Open
View article: Synergistic Antioxidant and Anti-Ferroptosis Therapy via BPNS-Encapsulated Thermoresponsive Chitosan Hydrogel for Spinal Cord Injury Regeneration
Synergistic Antioxidant and Anti-Ferroptosis Therapy via BPNS-Encapsulated Thermoresponsive Chitosan Hydrogel for Spinal Cord Injury Regeneration Open
Background: Spinal cord injury (SCI) is a devastating neurological condition with limited therapeutic options. Current clinical interventions predominantly rely on prolonged or high-dose pharmacological regimens, often causing systemic tox…
View article: Driven by feelings or stimulated by context: how childhood nature experience shaped adulthood pro-environmental behavior?
Driven by feelings or stimulated by context: how childhood nature experience shaped adulthood pro-environmental behavior? Open
Introduction In recent years, China has vigorously promoted sustainable social development, aiming to enhance residents’ environmental protection awareness and encourage their active participation in environmental protection through variou…
View article: Consumption, relative deprivation and mental health: evidence from hedonic consumption
Consumption, relative deprivation and mental health: evidence from hedonic consumption Open
Introduction In recent years, relative deprivation related to consumption has sparked intense debate, particularly as the COVID-19 pandemic caused incalculable economic losses worldwide. However, the relationship between relative deprivati…
View article: Is leisure sedentary time associated with mental health issues? Evidence from China Health and Nutrition Survey
Is leisure sedentary time associated with mental health issues? Evidence from China Health and Nutrition Survey Open
Background The relationship between leisure sedentary behaviors and mental health remains inconclusive. This study aims to provide evidence on leisure sedentary behaviors on mental health using longitudinal data, along with its moderating …
View article: FcRn-guided antigen trafficking enhances cancer vaccine efficacy
FcRn-guided antigen trafficking enhances cancer vaccine efficacy Open
View article: Interconnected Pathways of Alzheimer's Disease and Osteoporosis: A Review of Genetic, Hormonal, and Environmental Influences
Interconnected Pathways of Alzheimer's Disease and Osteoporosis: A Review of Genetic, Hormonal, and Environmental Influences Open
Alzheimer's disease (AD) and osteoporosis (OP) are both age-related multifactorial degenerative diseases that share overlapping pathogenic mechanisms. While genetic factors contribute significantly to their onset and progression, environme…
View article: Leisure sedentary time and elevated blood pressure: evidence from the statutory retirement policy
Leisure sedentary time and elevated blood pressure: evidence from the statutory retirement policy Open
Objectives The relationship between sedentary behaviors and elevated blood pressure remains inconclusive, and the socioeconomic mechanisms underlying the linkage are rarely discussed. Since retirement is often associated with behavioral ch…
View article: Identification of transcriptional signature change and critical transcription factors involved during the differentiation of mouse trophoblast stem cell into maternal blood vessel associated trophoblast giant cell
Identification of transcriptional signature change and critical transcription factors involved during the differentiation of mouse trophoblast stem cell into maternal blood vessel associated trophoblast giant cell Open
The placenta is essential organ for oxygen and nutrient exchange between the mother and the developing fetus. Trophoblast lineage differentiation is closely related to the normal function of the placenta. Trophoblast stem cells (TSCs) can …
View article: Functional Transitions Among Older Adults in Rural China: Examining the Differential Roles of Care From Daughters’ and Sons’ Families
Functional Transitions Among Older Adults in Rural China: Examining the Differential Roles of Care From Daughters’ and Sons’ Families Open
Objectives Informal care provided by adult children is of great importance for older adults’ well-being in China. This paper investigates and compares the functional transitions among older adults living in rural areas who receive care fro…
View article: Chronic viral infection impairs immune memory to a different pathogen
Chronic viral infection impairs immune memory to a different pathogen Open
Chronic viral infections cause T cell dysfunction in both animal models and human clinical settings, thereby affecting the ability of the host immune system to clear viral pathogens and develop proper virus-specific immune memory. However,…
View article: Discoidin domain receptor 1 as a potent therapeutic target in solid tumors
Discoidin domain receptor 1 as a potent therapeutic target in solid tumors Open
Despite significant discoveries in basic cancer research and improvements in treatment options and clinical outcomes, cancer remains a major public health concern worldwide. Today, the main focus of cancer research is the signaling pathway…
View article: Fanconi anemia complementation group D2 promotes sensitivity of endometrial cancer cells to chemotherapeutic agents by inhibiting the ferroptosis pathway
Fanconi anemia complementation group D2 promotes sensitivity of endometrial cancer cells to chemotherapeutic agents by inhibiting the ferroptosis pathway Open
View article: Towards Lightweight Javascript Engine Acceleration for Privacy-Aware Distributed Learning in Large Language Models
Towards Lightweight Javascript Engine Acceleration for Privacy-Aware Distributed Learning in Large Language Models Open
View article: Immunoglobulin A response to SARS-CoV-2 infection and immunity
Immunoglobulin A response to SARS-CoV-2 infection and immunity Open
The novel coronavirus disease (COVID-19) and its infamous "Variants" of the etiological agent termed Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has proven to be a global health concern. The three antibodies, IgA, IgM, an…
View article: DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway
DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway Open
Abnormal trophoblast function is associated with diseases such as recurrent spontaneous abortion, pre-eclampsia, and preterm birth, and endangers maternal and fetal health. However, the underlying regulatory mechanisms remain unclear. In t…
View article: Information communication technology accessibility and mental health for older adults during the coronavirus disease in South Korea
Information communication technology accessibility and mental health for older adults during the coronavirus disease in South Korea Open
Introduction As society ages and the digital economy continues to develop, accessibility to information and communication technology (ICT) has emerged as a critical factor influencing the mental health of older adults. Particularly, in the…
View article: An engineered bispecific nanobody in tetrameric secretory IgA format confers broad neutralization against SARS-CoV-1&2 and most variants
An engineered bispecific nanobody in tetrameric secretory IgA format confers broad neutralization against SARS-CoV-1&2 and most variants Open
SARS-CoV-2, a type of respiratory virus, has exerted a great impact on global health and economy over the past three years. Antibody-based therapy was initially successful but later failed due to the accumulation of mutations in the spike …
View article: Gut microbiome and reproductive endocrine diseases: a Mendelian randomization study
Gut microbiome and reproductive endocrine diseases: a Mendelian randomization study Open
Background Observation studies have confirmed the association between the gut microbiome and reproductive endocrine diseases (REDs), namely, polycystic ovary syndrome (PCOS), endometriosis, and female infertility. However, their associatio…
View article: Comparison of the efficacy and safety of total laparoscopic hysterectomy without and with uterine manipulator combined with pelvic lymphadenectomy for early cervical cancer
Comparison of the efficacy and safety of total laparoscopic hysterectomy without and with uterine manipulator combined with pelvic lymphadenectomy for early cervical cancer Open
Objective Some studies have reported that the prognosis of total laparoscopic hysterectomy (TLH) for early‐stage cervical cancer (CC) is worse than that of open surgery. And this was associated with the use of uterine manipulator or not. T…
View article: SwiftAvatar: Efficient Auto-Creation of Parameterized Stylized Character on Arbitrary Avatar Engines
SwiftAvatar: Efficient Auto-Creation of Parameterized Stylized Character on Arbitrary Avatar Engines Open
The creation of a parameterized stylized character involves careful selection of numerous parameters, also known as the "avatar vectors" that can be interpreted by the avatar engine. Existing unsupervised avatar vector estimation methods t…
View article: The intestinal γδ T cells: functions in the gut and in the distant organs
The intestinal γδ T cells: functions in the gut and in the distant organs Open
Located in the frontline against the largest population of microbiota, the intestinal mucosa of mammals has evolved to become an effective immune system. γδ T cells, a unique T cell subpopulation, are rare in circulation blood and lymphoid…